Metronomic Chemotherapy

Author : Guido Bocci,Giulio Francia
Publisher : Springer
Page : 295 pages
File Size : 42,6 Mb
Release : 2014-09-04
Category : Medical
ISBN : 9783662436042

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Metronomic Chemotherapy by Guido Bocci,Giulio Francia Pdf

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Author : Manzoor Ahmad Mir
Publisher : CRC Press
Page : 255 pages
File Size : 42,5 Mb
Release : 2024-05-28
Category : Medical
ISBN : 9781040013717

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Novel Approaches in Metronomic Chemotherapy for Breast Cancer Treatment by Manzoor Ahmad Mir Pdf

This book provides the latest research and developments in the field of metronomic chemotherapy for breast cancer. It presents the principles and mechanisms of metronomic chemotherapy, preclinical and clinical studies, and the latest developments in drug delivery systems and nanoformulations. The clinical pharmacology of metronomic chemotherapy, including pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions, are also examined. Key Features: Introduces metronomics therapy in the neoadjuvant and adjuvant treatment of breast cancer Explores the potential of metronomics in terms of personalized chemotherapy Present pharmacological bases of metronomic chemotherapy Covers the latest developments in drug delivery systems, nanotechnology, and nanoformulations Discusses antiangiogenic effects and the impact of metronomics on immunity This book is useful for students, researchers, oncologists, pharmacologists, and healthcare experts interested in understanding the clinical potential of metronomic chemotherapy in breast cancer.

Author : Benjamin Bonavida
Publisher : Springer Science & Business Media
Page : 431 pages
File Size : 46,6 Mb
Release : 2008-07-31
Category : Medical
ISBN : 9781597454742

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Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy by Benjamin Bonavida Pdf

This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.

Author : Beverly A. Teicher,Lee M. Ellis
Publisher : Springer Science & Business Media
Page : 559 pages
File Size : 45,7 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9781597451840

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Antiangiogenic Agents in Cancer Therapy by Beverly A. Teicher,Lee M. Ellis Pdf

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

Author : Guido Bocci,Giulio Francia
Publisher : Mdpi AG
Page : 0 pages
File Size : 42,9 Mb
Release : 2023-12-15
Category : Medical
ISBN : 3036592806

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Clinical Applications of Metronomic Chemotherapy by Guido Bocci,Giulio Francia Pdf

Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy.

Author : Rüdiger Liersch,Wolfgang E. Berdel,Torsten Kessler
Publisher : Springer Science & Business Media
Page : 238 pages
File Size : 54,8 Mb
Release : 2009-12-24
Category : Medical
ISBN : 9783540782810

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Angiogenesis Inhibition by Rüdiger Liersch,Wolfgang E. Berdel,Torsten Kessler Pdf

Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.

Author : Darren W. Davis,Roy S. Herbst,James L. Abbruzzese
Publisher : CRC Press
Page : 864 pages
File Size : 49,6 Mb
Release : 2007-07-25
Category : Science
ISBN : 1420004298

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Antiangiogenic Cancer Therapy by Darren W. Davis,Roy S. Herbst,James L. Abbruzzese Pdf

Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors. Compiles the results of four decades of progress Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject. Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment. Covers specific molecular targets for inhibiting angiogenesis in cancer therapy. Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors. Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers. This volume celebrates progress made in four decades, and more importantly, it provides a clear indication of the complex biology that needs further investigation to realize the possibilities envisioned for this beneficial therapeutic modality.

Author : Stephen J. Withrow
Publisher : Elsevier Health Sciences
Page : 863 pages
File Size : 47,5 Mb
Release : 2007-01-01
Category : Medical
ISBN : 9780721605586

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Withrow and MacEwen's Small Animal Clinical Oncology by Stephen J. Withrow Pdf

Focusing on cancer in dogs and cats, this extensively updated 4th edition provides comprehensive coverage of the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. Ideal for students, practitioners, and those involved in academic research, this book's full-color images and user-friendly format provide quick and easy access to today's most important information on cancer in the small animal patient. Full-color format throughout and full-color illustrations make information more accessible and provide accurate representations of clinical appearance.Chapters are clustered into four major sections: The Biology and Pathogenesis of Cancer, Diagnostic Procedures for the Cancer Patient, Therapeutic Modalities for the Cancer Patient, and Specific Malignancies in the Small Animal Patient.The consistent format includes incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies in the small animal cancer patient.Features cutting edge information on the complications of cancer, pain management, and the latest treatment modalities. The latest information on the etiology of cancer, including genetic, chemical, physical, and hormonal factors, as well as cancer-causing viruses.Coverage of molecular-targeted therapy of cancer, plus new and emerging therapeutic techniques.New information on molecular diagnostic procedures for the cancer patient.The latest diagnostic imaging techniques in clinical oncology.Discussions of compassion and supportive care, from chronic pain management and nutrition to end-of-life issues and grief support.

Author : Anonim
Publisher : Academic Press
Page : 296 pages
File Size : 42,5 Mb
Release : 2022-01-14
Category : Science
ISBN : 9780323905565

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Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy by Anonim Pdf

Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

Author : Marianne I. Martic-Kehl,Pius August Schubiger
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 51,6 Mb
Release : 2016-05-18
Category : Medical
ISBN : 9783527695911

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Animal Models for Human Cancer by Marianne I. Martic-Kehl,Pius August Schubiger Pdf

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Author : Dieter Marmé,Norbert Fusenig
Publisher : Springer Science & Business Media
Page : 845 pages
File Size : 41,5 Mb
Release : 2007-12-05
Category : Medical
ISBN : 9783540331773

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Tumor Angiogenesis by Dieter Marmé,Norbert Fusenig Pdf

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Author : Elmer T. Skinard
Publisher : Nova Publishers
Page : 180 pages
File Size : 55,9 Mb
Release : 2007
Category : Blood-vessels
ISBN : 1600214738

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New Research on Angiogenesis Inhibitors by Elmer T. Skinard Pdf

Angiogenesis -- the growth of new blood vessels -- is an important natural process occurring in the body, both for health and as related to disease. Angiogenesis occurs in the healthy body to help heal wounds and to help to restore blood flow to tissues after injury or insult. In females, Angiogenesis also occurs during the monthly reproductive cycle (to rebuild the uterus lining, to mature the egg during ovulation) and during pregnancy (to build the placenta, the circulation between mother and foetus). The healthy body controls angiogenesis through a series of "on" and "off" switches. The main "on" switches are known as angiogenesis-stimulating growth factors. The main "off switches" are known as angiogenesis inhibitors. When angiogenic growth factors are produced in excess of angiogenesis inhibitors the balance is tipped in favour of blood vessel growth. When inhibitors are present in excess of stimulators, angiogenesis is stopped. The normal, healthy body maintains a perfect balance of angiogenesis modulators. In general, angiogenesis is "turned off" by the production of more inhibitors than stimulators. Tumour angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Tumour angiogenesis actually starts with cancerous tumour cells releasing molecules that send signals to surrounding normal host tissue. This signalling activates certain genes in the host tissue that, in turn, cause proteins to encourage growth of new blood vessels. This book examines its angiogenesis within the context of theory and its applications to cancer treatment.

Author : Rebekka Kubisch
Publisher : Unknown
Page : 0 pages
File Size : 43,6 Mb
Release : 2013
Category : Electronic
ISBN : OCLC:859414477

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Mechanism of Cancer Evading Metronomic Chemotherapy and Action of Archazolid as an Anti-metastatic Drug by Rebekka Kubisch Pdf

Author : Emmanuel Donnadieu
Publisher : Springer
Page : 199 pages
File Size : 55,9 Mb
Release : 2016-08-30
Category : Medical
ISBN : 9783319422237

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Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy by Emmanuel Donnadieu Pdf

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

Author : Lisa M. Howe
Publisher : Elsevier Health Sciences
Page : 201 pages
File Size : 42,7 Mb
Release : 2015-06-03
Category : Medical
ISBN : 9780323376266

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Soft Tissue Surgery, An Issue of Veterinary Clinics of North America: Small Animal Practice by Lisa M. Howe Pdf

Drs. Lisa Howe and Harry Booth, Jr have assembled an expert panel of authors on the topics of Soft Tissue Surgery. Articles include:Current concepts in hepatobiliary surgery, Current concepts in portosystemic shunting,Current concepts in oncologic surgery,Current concepts in skin and reconstructive surgery,Medical device facilitation of soft tissue surgery,Considerations in perioperative drug use in the soft tissue surgery patient, and more!