New Research On Angiogenesis Inhibitors

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New Research on Angiogenesis Inhibitors

Elmer T. Skinard
New Research on Angiogenesis Inhibitors Book PDF

Author : Elmer T. Skinard
Publisher : Nova Publishers
Page : 180 pages
File Size : 55,6 Mb
Release : 2007
Category : Blood-vessels
ISBN : 1600214738

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New Research on Angiogenesis Inhibitors by Elmer T. Skinard Pdf

Angiogenesis -- the growth of new blood vessels -- is an important natural process occurring in the body, both for health and as related to disease. Angiogenesis occurs in the healthy body to help heal wounds and to help to restore blood flow to tissues after injury or insult. In females, Angiogenesis also occurs during the monthly reproductive cycle (to rebuild the uterus lining, to mature the egg during ovulation) and during pregnancy (to build the placenta, the circulation between mother and foetus). The healthy body controls angiogenesis through a series of "on" and "off" switches. The main "on" switches are known as angiogenesis-stimulating growth factors. The main "off switches" are known as angiogenesis inhibitors. When angiogenic growth factors are produced in excess of angiogenesis inhibitors the balance is tipped in favour of blood vessel growth. When inhibitors are present in excess of stimulators, angiogenesis is stopped. The normal, healthy body maintains a perfect balance of angiogenesis modulators. In general, angiogenesis is "turned off" by the production of more inhibitors than stimulators. Tumour angiogenesis is the proliferation of a network of blood vessels that penetrates into cancerous growths, supplying nutrients and oxygen and removing waste products. Tumour angiogenesis actually starts with cancerous tumour cells releasing molecules that send signals to surrounding normal host tissue. This signalling activates certain genes in the host tissue that, in turn, cause proteins to encourage growth of new blood vessels. This book examines its angiogenesis within the context of theory and its applications to cancer treatment.

Anti-Angiogenesis Strategies in Cancer Therapies

Shaker Mousa,Paul Davis
Anti Angiogenesis Strategies in Cancer Therapies Book PDF

Author : Shaker Mousa,Paul Davis
Publisher : Academic Press
Page : 210 pages
File Size : 46,6 Mb
Release : 2016-11-28
Category : Medical
ISBN : 9780128026731

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Anti-Angiogenesis Strategies in Cancer Therapies by Shaker Mousa,Paul Davis Pdf

Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

History of Research on Tumor Angiogenesis

Domenico Ribatti
History of Research on Tumor Angiogenesis Book PDF

Author : Domenico Ribatti
Publisher : Springer Science & Business Media
Page : 126 pages
File Size : 45,6 Mb
Release : 2008-12-16
Category : Medical
ISBN : 9781402095634

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History of Research on Tumor Angiogenesis by Domenico Ribatti Pdf

In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis. Beginning in the 1980’s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy. This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.

Angiogenesis

William D. Figg,Judah Folkman
Angiogenesis Book PDF

Author : William D. Figg,Judah Folkman
Publisher : Springer Science & Business Media
Page : 592 pages
File Size : 43,8 Mb
Release : 2008-05-24
Category : Medical
ISBN : 9780387715186

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Angiogenesis by William D. Figg,Judah Folkman Pdf

Dr. Judah Folkman is considered the "father of angiogenesis." Because of Folkman's discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. Angiogenesis: An Integrative Approach from Science to Medicine is a comprehensive, concise summary of tumor angiogenesis. It is an up-to-date and authoritative reference for the angiogenesis field as it relates to oncology. This book represents the first collection in a volume of which Folkman is co-editor. Folkman has authored nearly 400 original papers and more than 100 book chapters.

The New Angiotherapy

Tai-Ping D. Fan,Elise C. Kohn
The New Angiotherapy Book PDF

Author : Tai-Ping D. Fan,Elise C. Kohn
Publisher : Springer Science & Business Media
Page : 618 pages
File Size : 50,7 Mb
Release : 2001-09-21
Category : Medical
ISBN : 9781592591268

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The New Angiotherapy by Tai-Ping D. Fan,Elise C. Kohn Pdf

An international team of experts critically review the recent progress in basic and applied research in angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel targets and the use angiotherapy in the clinic. They also detail the fundamental concepts in the physiology and pathophysiology of angiogenesis and evaluate the potential of angiotherapy in the management of angiogenic disease, highlighting some of the angiogenics and antiangiogenics both in development and in clinical trials.

Tumor Angiogenesis

Dieter Marmé,Norbert Fusenig
Tumor Angiogenesis Book PDF

Author : Dieter Marmé,Norbert Fusenig
Publisher : Springer Science & Business Media
Page : 845 pages
File Size : 40,6 Mb
Release : 2007-12-05
Category : Medical
ISBN : 9783540331773

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Tumor Angiogenesis by Dieter Marmé,Norbert Fusenig Pdf

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Recent Advances in Angiogenesis and Antiangiogenesis

Domenico Ribatti
Recent Advances in Angiogenesis and Antiangiogenesis Book PDF

Author : Domenico Ribatti
Publisher : Bentham Science Publishers
Page : 143 pages
File Size : 52,5 Mb
Release : 2010-05-04
Category : Medical
ISBN : 9781608050048

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Recent Advances in Angiogenesis and Antiangiogenesis by Domenico Ribatti Pdf

"The book presents recent advances in the field of angiogenesis and antiangiogenesis. Starting with the hypothesis of Judah Folkman that tumor growth is angiogenesis dependent, this area of research now has a solid scientific foundation. Tumor growth, meta"

Research Directions in Tumor Angiogenesis

Jianyuan Chai
Research Directions in Tumor Angiogenesis Book PDF

Author : Jianyuan Chai
Publisher : BoD – Books on Demand
Page : 304 pages
File Size : 52,8 Mb
Release : 2013-02-06
Category : Medical
ISBN : 9789535109631

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Research Directions in Tumor Angiogenesis by Jianyuan Chai Pdf

Angiogenesis is an extension process of the cardiovascular network within human body. It is usually triggered by the demand of oxygen and nutrients from the fast growing tissue and uncontrollably dividing cells, as seen during wound healing and tumor progression. This book focuses on tumor angiogenesis and includes 8 chapters written by highly experienced scholars from five different countries. It is the goal of this book to provide readers with an update on the molecular and cellular mechanisms of this biological process and hopefully to point out some new research directions for future therapeutic adventure.

Antiangiogenic Agents in Cancer Therapy

Beverly A. Teicher,Lee M. Ellis
Antiangiogenic Agents in Cancer Therapy Book PDF

Author : Beverly A. Teicher,Lee M. Ellis
Publisher : Springer Science & Business Media
Page : 559 pages
File Size : 47,9 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9781597451840

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Antiangiogenic Agents in Cancer Therapy by Beverly A. Teicher,Lee M. Ellis Pdf

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

Angiogenesis Inhibition

Rüdiger Liersch,Wolfgang E. Berdel,Torsten Kessler
Angiogenesis Inhibition Book PDF

Author : Rüdiger Liersch,Wolfgang E. Berdel,Torsten Kessler
Publisher : Springer Science & Business Media
Page : 238 pages
File Size : 51,9 Mb
Release : 2009-12-24
Category : Medical
ISBN : 9783540782810

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Angiogenesis Inhibition by Rüdiger Liersch,Wolfgang E. Berdel,Torsten Kessler Pdf

Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.

Adjuvant Therapy of Primary Breast Cancer VI

Hans-Jörg Senn,Richard D. Gelber,Aron Goldhirsch,Beat Thürlimann
Adjuvant Therapy of Primary Breast Cancer VI Book PDF

Author : Hans-Jörg Senn,Richard D. Gelber,Aron Goldhirsch,Beat Thürlimann
Publisher : Springer Science & Business Media
Page : 505 pages
File Size : 41,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642457692

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Adjuvant Therapy of Primary Breast Cancer VI by Hans-Jörg Senn,Richard D. Gelber,Aron Goldhirsch,Beat Thürlimann Pdf

This RRCR-conference-volume marks "number six" in a 20-year evolution of international conferences on the adjuvant therapy of primary breast cancer. Starting in 1978, a handful of some 80 en thusiastic breast cancer surgeons and oncologists, met in a se cluded mountain resort near st. Gallen in Eastern Switzerland, to exchange their early data of some pioneer trials on adjuvant sys temic therapy of early breast cancer, and to correlate their future research efforts to overcome the frustrating prognostic stagna tion of this dominant neoplastic disease in Western females dur ing the past decades. Repeated every 3-4 years, these St. Gallen International Conferences on Adjuvant Therapy of Primary Breast Cancer have continuously grown in numbers of partici pants and in normative, therapeutic influence by being published in major oncology journals [1-3], the last (6th) conference hav ing taken place from February 25-28, 1998 with more than 1800 attendees from over 50 countries worldwide. What is the fascination of adjuvant therapy in primary (early) breast cancer, and what has changed,during the last 3 years since March 1995, to justify another international gathering of this size, and of the world's leading experts in the field? There is no question, that providing even more effective care and designing appropriate recommendations for the multitudes of patients with so-called early breast cancer or at high risk of developing the disease, remain highly important public health goals.

Angiogenesis Inhibitors and Stimulators

Shaker A. Mousa
Angiogenesis Inhibitors and Stimulators Book PDF

Author : Shaker A. Mousa
Publisher : CRC Press
Page : 184 pages
File Size : 55,9 Mb
Release : 2000-10
Category : Medical
ISBN : UOM:39015051595091

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Angiogenesis Inhibitors and Stimulators by Shaker A. Mousa Pdf

The regulation of blood vessel growth underlies many normal biological processes such as reproduction, development, repair and wound healing. It also is a critical feature of pathological processes such as cancer, diabetic retinopathy, macular degeneration, inflammatory arthritis and ischemic heart disease. What causes blood vessels to grow? What inhibits their growth? This book comprehensively describes the angiogenic proteins that enhance and inhibit normal and abnormal angiogenesis. It describes the potential therapeutic applications of basic fibroblast growth factor, vascular endothelial growth factor, PECAM-1 and thrombospondin as well as other factors. The book brings together information about new blood vessel formation in many organ systems and comprises an outstanding resource on the state-of-the art in angiogenesis.

Antiangiogenic Cancer Therapy

Darren W. Davis,Roy S. Herbst,James L. Abbruzzese
Antiangiogenic Cancer Therapy Book PDF

Author : Darren W. Davis,Roy S. Herbst,James L. Abbruzzese
Publisher : CRC Press
Page : 864 pages
File Size : 44,5 Mb
Release : 2007-07-25
Category : Science
ISBN : 1420004298

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Antiangiogenic Cancer Therapy by Darren W. Davis,Roy S. Herbst,James L. Abbruzzese Pdf

Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors. Compiles the results of four decades of progress Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject. Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment. Covers specific molecular targets for inhibiting angiogenesis in cancer therapy. Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors. Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers. This volume celebrates progress made in four decades, and more importantly, it provides a clear indication of the complex biology that needs further investigation to realize the possibilities envisioned for this beneficial therapeutic modality.

Angiogenesis Assays

Carolyn A. Staton,Claire Lewis,Roy Bicknell
Angiogenesis Assays Book PDF

Author : Carolyn A. Staton,Claire Lewis,Roy Bicknell
Publisher : John Wiley & Sons
Page : 410 pages
File Size : 52,6 Mb
Release : 2007-01-11
Category : Medical
ISBN : 9780470029343

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Angiogenesis Assays by Carolyn A. Staton,Claire Lewis,Roy Bicknell Pdf

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Molecular Mechanisms of Angiogenesis

Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin
Molecular Mechanisms of Angiogenesis Book PDF

Author : Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin
Publisher : Springer
Page : 505 pages
File Size : 49,9 Mb
Release : 2014-05-27
Category : Science
ISBN : 9782817804668

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Molecular Mechanisms of Angiogenesis by Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin Pdf

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.