Microrna Detection And Pathological Functions

Microrna Detection And Pathological Functions Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Microrna Detection And Pathological Functions book. This book definitely worth reading, it is an incredibly well-written.

MicroRNA Detection and Pathological Functions

Xueji Zhang,Haifeng Dong,Yaping Tian
MicroRNA Detection and Pathological Functions Book PDF

Author : Xueji Zhang,Haifeng Dong,Yaping Tian
Publisher : Springer
Page : 108 pages
File Size : 49,9 Mb
Release : 2015-05-26
Category : Science
ISBN : 9783662472934

Get Book

MicroRNA Detection and Pathological Functions by Xueji Zhang,Haifeng Dong,Yaping Tian Pdf

This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets. The conventional techniques used for miRNA detection including standard PCR, Northern blotting, microarray and clone methods are addressed. Recent emerging strategies in miRNA detection and quantification with superior flexibility and adaptability, such as novel molecular biological techniques and locked nucleic acid (LNA) modified probes, as well as nanotechnology-based approaches, are also included. The book also highlights the latest advances in clinical-related miRNA detection methods in living cells, circulating blood and tissue, such as in situ hybridization (ISH) and molecular imaging techniques, which are useful to elucidate the biogenesis and biological function of miRNAs in vivo. Finally, the respective advantages and drawbacks of various detection techniques in this fast-moving field are discussed, along with the challenges and promising new directions. This book offers a valuable resource for analytical chemists, biologists and physicians involved in miRNA research. Dr. Xueji Zhang and Dr. Haifeng Dong are Professors at the School of Chemistry & Biological Engineering, University of Science & Technology Beijing (USTB), China. Dr. Yaping Tian is a Professor at the Department of Clinical Biochemistry, Chinese PLA General Hospital and Military Medical School, China.

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues

Haruo Sugi
Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues Book PDF

Author : Haruo Sugi
Publisher : IntechOpen
Page : 0 pages
File Size : 48,8 Mb
Release : 2012-07-18
Category : Technology & Engineering
ISBN : 9535106791

Get Book

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues by Haruo Sugi Pdf

This volume contains 17 short review articles classified into 3 parts. Part I consists of 7 articles dealing with basic aspects of contractile mechanism in skeletal and smooth muscle cells and also function of melanocytes having many properties common to those of smooth muscles. Part II and Part III contain articles dealing with pathological aspects of cardiac and smooth muscle cell functions, and dealing with factors influencing structure and function of cardiac and smooth muscle cells and tissues. The Editor believes that these articles are stimulating and informative for readers interested in basic, pathological and clinical aspects of muscle cells and tissues.

Current Trends in Cancer Management

Liliana Streba,Dan Ionut Gheonea,Michael Schenker
Current Trends in Cancer Management Book PDF

Author : Liliana Streba,Dan Ionut Gheonea,Michael Schenker
Publisher : BoD – Books on Demand
Page : 158 pages
File Size : 52,5 Mb
Release : 2019-09-25
Category : Medical
ISBN : 9781838800055

Get Book

Current Trends in Cancer Management by Liliana Streba,Dan Ionut Gheonea,Michael Schenker Pdf

The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques.

Regulatory microRNA

Y-h. Taguchi,Hsiuying Wang
Regulatory microRNA Book PDF

Author : Y-h. Taguchi,Hsiuying Wang
Publisher : MDPI
Page : 348 pages
File Size : 47,5 Mb
Release : 2019-04-16
Category : Science
ISBN : 9783038977681

Get Book

Regulatory microRNA by Y-h. Taguchi,Hsiuying Wang Pdf

This book includes updated information about microRNA regulation, for example, in the fields of circular RNAs, multiomics analysis, biomarkers and oncogenes. The variety of topics included in this book reaffirms the extent to which microRNA regulation affects biological processes. Although microRNAs are not translated to proteins, their importance for biological processes is not less than proteins. An understanding of their roles in various biological processes is critical to understanding gene function in these biological processes. Although non-coding RNAs other than microRNAs have recently come under investigation, microRNA still remains the front runner as the subject of genetic and biological studies. In reading the collection of papers, readers can grasp the most updated information regarding microRNA regulation, which will continue to be an important topic in genetics and biology.

Perioperative Care for Organ Transplant Recipient

Alexander Vitin
Perioperative Care for Organ Transplant Recipient Book PDF

Author : Alexander Vitin
Publisher : BoD – Books on Demand
Page : 162 pages
File Size : 40,5 Mb
Release : 2019-10-02
Category : Medical
ISBN : 9781789844221

Get Book

Perioperative Care for Organ Transplant Recipient by Alexander Vitin Pdf

This book is addressed to physicians and researchers working in the ever-expanding research and practice fields of transplantation medicine. Its purpose is to present the transplantation community with a collection of works written by prominent experts in a variety of transplant-related fields, encompassing the most recent scientific and practical developments and accomplishments in the highly specialized segment of transplantation medicine, such as perioperative care for organ transplant candidates and recipients.

Circulating MicroRNAs

Takahiro Ochiya
Circulating MicroRNAs Book PDF

Author : Takahiro Ochiya
Publisher : Humana Press
Page : 0 pages
File Size : 53,7 Mb
Release : 2013-05-30
Category : Medical
ISBN : 1627034528

Get Book

Circulating MicroRNAs by Takahiro Ochiya Pdf

microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.

Advanced Techniques in Diagnostic Microbiology

Yi-Wei Tang,Charles W. Stratton
Advanced Techniques in Diagnostic Microbiology Book PDF

Author : Yi-Wei Tang,Charles W. Stratton
Publisher : Springer
Page : 760 pages
File Size : 40,5 Mb
Release : 2018-11-09
Category : Medical
ISBN : 9783319951119

Get Book

Advanced Techniques in Diagnostic Microbiology by Yi-Wei Tang,Charles W. Stratton Pdf

In recent years, advanced molecular techniques in diagnostic microbiology have been revolutionizing the practice of clinical microbiology in the hospital setting. Molecular diagnostic testing in general and nucleic acid-based amplification methods in particular have been heralded as diagnostic tools for the new millennium. This third edition covers not only the most recent updates and advances, but details newly invented omic techniques, such as next generation sequencing. It is divided into two distinct volumes, with Volume 1 describing the techniques, and Volume 2 addressing their applications in the field. In addition, both volumes focus more so on the clinical relevance of the test results generated by these techniques than previous editions.

Computational Non-coding RNA Biology

Yun Zheng
Computational Non coding RNA Biology Book PDF

Author : Yun Zheng
Publisher : Academic Press
Page : 320 pages
File Size : 55,6 Mb
Release : 2018-09-14
Category : Science
ISBN : 9780128143667

Get Book

Computational Non-coding RNA Biology by Yun Zheng Pdf

Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, quantifying, and visualizing non-coding RNAs from high throughput sequencing datasets at high volume is complex. Therefore, it is usually possible for biologists to complete all of the necessary steps for analysis. Presents a comprehensive resource of computational methods for the identification and quantification of non-coding RNAs Introduces 23 practical computational pipelines for various topics of non-coding RNAs Provides a guide to assist biologists and other researchers dealing with complex datasets Introduces basic computational methods and provides guidelines for their replication by researchers Offers a solution to researchers approaching large and complex sequencing datasets

Molecular Pathology of Neoplastic Gastrointestinal Diseases

Antonia R. Sepulveda,John P. Lynch
Molecular Pathology of Neoplastic Gastrointestinal Diseases Book PDF

Author : Antonia R. Sepulveda,John P. Lynch
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 44,9 Mb
Release : 2013-01-28
Category : Medical
ISBN : 9781461460152

Get Book

Molecular Pathology of Neoplastic Gastrointestinal Diseases by Antonia R. Sepulveda,John P. Lynch Pdf

Molecular Pathology of Neoplastic Gastrointestinal Diseases reviews the molecular aspects that characterize the spectrum of neoplastic conditions that affect the gastrointestinal tract, providing the reader with current up-to-date knowledge. For each disease entity chapters provide reviews on: the molecular basis of the individual disease molecular testing approaches currently available or in development for diagnosis or for gene target characterization for selective targeted therapies recommended guidelines for clinical application of molecular tests are included whenever available molecular testing for hereditary predisposition or disease risk animal models and cell culture models of disease

MicroRNAs

Krishnarao Appasani
MicroRNAs Book PDF

Author : Krishnarao Appasani
Publisher : Cambridge University Press
Page : 580 pages
File Size : 41,9 Mb
Release : 2009-08-20
Category : Science
ISBN : 0521118557

Get Book

MicroRNAs by Krishnarao Appasani Pdf

MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs

In Situ Molecular Pathology and Co-expression Analyses

Gerard J. Nuovo
In Situ Molecular Pathology and Co expression Analyses Book PDF

Author : Gerard J. Nuovo
Publisher : Academic Press
Page : 418 pages
File Size : 43,5 Mb
Release : 2020-09-03
Category : Science
ISBN : 9780128206546

Get Book

In Situ Molecular Pathology and Co-expression Analyses by Gerard J. Nuovo Pdf

Major advancements in the field of in situ molecular pathology have occurred since publication of the first edition. In Situ Molecular Pathology and Co-expression Analyses, Second Edition, continues to teach both the molecular basis for the improvements and the actual protocols. This is the unique feature that separates it from the pack of other "cook-book" type approaches. The fields of in situ hybridization and immunohistochemistry have expanded rapidly where computer-based analyses systems have greatly expanded the power of these methods. Further, knowledge of the marked improvements in the reagents themselves since the first edition can make the difference of excellent versus misleading data. The automated platforms require that researchers and diagnostic biomedical investigators have a good understanding of the basics of in situ based tests, protocols, and biochemistry for troubleshooting in order to maximize the use of these platforms. This second edition focuses attention on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses. Practicing molecular pathologists, diagnostic pathologists, laboratory directors, and toxicologists, as well as clinicians and researchers in training, will benefit from this clear presentation of protocols and theoretical framework. Data derived from in situ hybridization and immunohistochemistry. Explains the theory and foundation of immunohistochemistry and in situ hybridization and presents easy-to-follow experimental protocols with tricks of the trade Includes two new chapters: Recent improvements in immunohistochemistry and in situ hybridization, Quality control for immunohistochemistry and in situ hybridization: How to know if the color change is signal or background The second edition also includes a detailed test to help one learn the basics of histologic interpretation of tissues and a separate detailed test in how to differentiate signal from background Includes chapter-ending summaries of Key Points to Remember, bringing beginners up to speed with any seasoned veteran in the field Thoughtfully tackles the molecular basis if IHC and ISH, along with application of that knowledge to improving the techniques is significant

MicroRNA Cancer Regulation

Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
MicroRNA Cancer Regulation Book PDF

Author : Ulf Schmitz,Olaf Wolkenhauer,Julio Vera
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 53,8 Mb
Release : 2013-02-03
Category : Medical
ISBN : 9789400755901

Get Book

MicroRNA Cancer Regulation by Ulf Schmitz,Olaf Wolkenhauer,Julio Vera Pdf

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

RNA Methodologies

Robert E. Farrell Jr.
RNA Methodologies Book PDF

Author : Robert E. Farrell Jr.
Publisher : Elsevier
Page : 794 pages
File Size : 47,5 Mb
Release : 2010-07-22
Category : Science
ISBN : 9780080454764

Get Book

RNA Methodologies by Robert E. Farrell Jr. Pdf

This laboratory guide represents a growing collection of tried, tested and optimized laboratory protocols for the isolation and characterization of eukaryotic RNA, with lesser emphasis on the characterization of prokaryotic transcripts. Collectively the chapters work together to embellish the RNA story, each presenting clear take-home lessons, liberally incorporating flow charts, tables and graphs to facilitate learning and assist in the planning and implementation phases of a project. RNA Methodologies, 3rd edition includes approximately 30% new material, including chapters on the more recent technologies of RNA interference including: RNAi; Microarrays; Bioinformatics. It also includes new sections on: new and improved RT-PCR techniques; innovative 5’ and 3’ RACE techniques; subtractive PCR methods; methods for improving cDNA synthesis. * Author is a well-recognized expert in the field of RNA experimentation and founded Exon-Intron, a well-known biotechnology educational workshop center * Includes classic and contemporary techniques * Incorporates flow charts, tables, and graphs to facilitate learning and assist in the planning phases of projects

MicroRNAs in Diseases and Disorders

Philip V Peplow,Bridget Martinez,George A Calin,Aurora Esquela-Kerscher
MicroRNAs in Diseases and Disorders Book PDF

Author : Philip V Peplow,Bridget Martinez,George A Calin,Aurora Esquela-Kerscher
Publisher : Royal Society of Chemistry
Page : 500 pages
File Size : 42,9 Mb
Release : 2019-05-07
Category : Science
ISBN : 9781788017817

Get Book

MicroRNAs in Diseases and Disorders by Philip V Peplow,Bridget Martinez,George A Calin,Aurora Esquela-Kerscher Pdf

From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.

Genomics in Drug Discovery and Development

Dimitri Semizarov,Eric Blomme
Genomics in Drug Discovery and Development Book PDF

Author : Dimitri Semizarov,Eric Blomme
Publisher : John Wiley & Sons
Page : 496 pages
File Size : 45,6 Mb
Release : 2008-11-03
Category : Medical
ISBN : 9780470409763

Get Book

Genomics in Drug Discovery and Development by Dimitri Semizarov,Eric Blomme Pdf

Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.