Minimal Residual Disease Testing

Minimal Residual Disease Testing Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Minimal Residual Disease Testing book. This book definitely worth reading, it is an incredibly well-written.

Minimal Residual Disease Testing

Todd E. Druley
Minimal Residual Disease Testing Book PDF

Author : Todd E. Druley
Publisher : Springer
Page : 197 pages
File Size : 43,8 Mb
Release : 2018-11-15
Category : Medical
ISBN : 9783319948270

Get Book

Minimal Residual Disease Testing by Todd E. Druley Pdf

This volume provides a concise yet comprehensive overview of minimal residual disease (MRD) testing. The text reviews the history of MRD testing, MRD testing for acute lymphoblastic leukemia/lymphoma, molecular diagnostics for MRD analysis in hematopoietic malignancies, the use of "difference from normal" flow cytometry in monitoring AML response, ML-DS for measurable residual disease detection, and advancements in next generation sequencing for detecting MRD. Written by experts in the field, Minimal Residual Disease Testing: Current Innovations and Future Directions is a valuable resource for hematologists, oncologists, pathologists, and radiologists on the variety of technologies available to detect MRD and how best to integrate these platforms into clinical practice.

Minimal Residual Disease Testing

Todd E. Druley
Minimal Residual Disease Testing Book PDF

Author : Todd E. Druley
Publisher : Springer
Page : 197 pages
File Size : 49,8 Mb
Release : 2018-11-27
Category : Medical
ISBN : 3319948261

Get Book

Minimal Residual Disease Testing by Todd E. Druley Pdf

This volume provides a concise yet comprehensive overview of minimal residual disease (MRD) testing. The text reviews the history of MRD testing, MRD testing for acute lymphoblastic leukemia/lymphoma, molecular diagnostics for MRD analysis in hematopoietic malignancies, the use of "difference from normal" flow cytometry in monitoring AML response, ML-DS for measurable residual disease detection, and advancements in next generation sequencing for detecting MRD. Written by experts in the field, Minimal Residual Disease Testing: Current Innovations and Future Directions is a valuable resource for hematologists, oncologists, pathologists, and radiologists on the variety of technologies available to detect MRD and how best to integrate these platforms into clinical practice.

Minimal Residual Disease in Hematologic Malignancies

Raanani P Ed
Minimal Residual Disease in Hematologic Malignancies Book PDF

Author : Raanani P Ed
Publisher : S. Karger AG (Switzerland)
Page : 0 pages
File Size : 49,5 Mb
Release : 2004
Category : Blood
ISBN : 3805577737

Get Book

Minimal Residual Disease in Hematologic Malignancies by Raanani P Ed Pdf

Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.

Myeloma Therapy

Sagar Lonial
Myeloma Therapy Book PDF

Author : Sagar Lonial
Publisher : Springer Science & Business Media
Page : 674 pages
File Size : 47,9 Mb
Release : 2009-01-01
Category : Medical
ISBN : 9781597455640

Get Book

Myeloma Therapy by Sagar Lonial Pdf

Therapeutic options for patients with myeloma have dramatically changed over the past 10 years. Beginning with the advances in therapy resulting from the use of high-dose therapy and autologous bone marrow or stem cell tra- plant, we have more than doubled the median survival for patients as a whole, and have now have a wealth of different biology -based treatment approaches for our patients in all disease stages. This book represents state-of-the-art information from many of the leaders in the plasma cell disorders world. Sections focusing on disease pathogenesis and biology, chemotherapy-based approaches, immune -based therapies, currently approved novel agents, developing targets, supportive care, and other plasma cell disorders provides a comprehensive collection and an excellent resource in this time of rapid change in clinical and preclinical disease knowledge. It is important to realize that these changes did not occur in a vacuum. Partnerships between academic institutions, the pharmaceutical industry, patient advocacy groups, the National Cancer Institute, community onco- gists, and ultimately our patients worked closely together to realize these advances, and to effect the radical changes in therapy we have witnessed over the past few years. This book would not have been possible without contri- tions from each of the gifted scientists and clinicians who worked tirelessly to prepare their individual chapters all the while maintaining commitment to the scientific and clinical mission of advancing care.

Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies

Anna Porwit,Marie Christine Béné
Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies Book PDF

Author : Anna Porwit,Marie Christine Béné
Publisher : Cambridge University Press
Page : 247 pages
File Size : 54,5 Mb
Release : 2018-01-25
Category : Medical
ISBN : 9781107503830

Get Book

Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies by Anna Porwit,Marie Christine Béné Pdf

This practical manual offers an active understanding of how to implement flow-cytometry when facing complex, haematological diseases.

Childhood Acute Lymphoblastic Leukemia

Ajay Vora
Childhood Acute Lymphoblastic Leukemia Book PDF

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 43,7 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

Get Book

Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

The EBMT Handbook

Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
The EBMT Handbook Book PDF

Author : Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
Publisher : Unknown
Page : 688 pages
File Size : 46,5 Mb
Release : 2020-10-08
Category : Medical
ISBN : 1013273672

Get Book

The EBMT Handbook by Nicolaus Kröger,Mohamad Mohty,Carlo Dufour Pdf

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Practical Lymph Node and Bone Marrow Pathology

Endi Wang,Anand Shreeram Lagoo
Practical Lymph Node and Bone Marrow Pathology Book PDF

Author : Endi Wang,Anand Shreeram Lagoo
Publisher : Springer Nature
Page : 750 pages
File Size : 41,9 Mb
Release : 2020-03-28
Category : Medical
ISBN : 9783030321895

Get Book

Practical Lymph Node and Bone Marrow Pathology by Endi Wang,Anand Shreeram Lagoo Pdf

This book provides a step-by-step and practically applicable approach for the accurate and clinically relevant diagnosis of lymph node (LN) and bone marrow (BM) biopsies. Clinicians expect pathological guidance not only with accurate diagnosis, but also about disease progression, minimal residual disease, disease susceptibility to a particular therapy, effects of prior therapy on prognosis and subsequent therapy etc. This book provides brief but to the point guidance about the prognostic and therapeutic implications of key ancillary studies so that the pathologist is comfortable to answer clinician’s questions over the entire arc of manifestations and management of the disease. The text follows the WHO (2016) classification in essence but the material is organized in a fashion most useful to a practicing surgical pathologist. This is achieved by focusing on the morphological findings as the starting point. Using this morphological “backbone” and several frequently asked questions (FAQs) the reader is guided to a rational list of differential diagnoses leading to a definitive diagnosis. The contents of each chapter are carefully selected so that the practically important and directly applicable information is available in an easy-to-find and easy-to-grasp format. Practical Lymph Node and Bone Marrow Pathology serves as a practical introduction and handbook for pathology trainees and hematopathology fellows and will remain a useful reference to practicing pathologists when they are signing out lymph nodes or bone marrow specimens.

Allogeneic Stem Cell Transplantation

Hillard M. Lazarus,Mary J. Laughlin
Allogeneic Stem Cell Transplantation Book PDF

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 885 pages
File Size : 55,6 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

Get Book

Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Paediatric Haematology and Oncology

Simon Bailey,Rod Skinner
Paediatric Haematology and Oncology Book PDF

Author : Simon Bailey,Rod Skinner
Publisher : Oxford University Press, USA
Page : 624 pages
File Size : 47,5 Mb
Release : 2010
Category : Medical
ISBN : 9780199299676

Get Book

Paediatric Haematology and Oncology by Simon Bailey,Rod Skinner Pdf

While survival rates for children with cancer have increased in recent times, the increased use of more aggressive therapies has brought with it significant adverse effects. Therefore, the aim of pediatric oncologists has become to achieve "cure at least cost" by the appropriate reduction of the intensity and/or duration of treatment in carefully identified good prognosis patients. By comprehensively covering these issues, this handbook aims to provide residents in pediatric hematology and oncology, as well as staff in related medical or other healthcare disciplines, with an easily accessible source of information about the basic principles of childhood cancer and leukemia, as well as much of the more detailed specialist knowledge required to care for children with these conditions. Divided into sections to allow quick access to the necessary information, the handbook covers general principles of diagnosis and treatment, short and long term care, and oncological emergencies before moving on to chapters on specific disease. Normal values and useful websites are also included for reference.

Biological Mechanisms of Minimal Residual Disease and Systemic Cancer

Julio A. Aguirre-Ghiso
Biological Mechanisms of Minimal Residual Disease and Systemic Cancer Book PDF

Author : Julio A. Aguirre-Ghiso
Publisher : Springer
Page : 0 pages
File Size : 40,7 Mb
Release : 2018-11-22
Category : Medical
ISBN : 3319977458

Get Book

Biological Mechanisms of Minimal Residual Disease and Systemic Cancer by Julio A. Aguirre-Ghiso Pdf

This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.

Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 46,5 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

Get Book

Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Normal and Malignant B-Cell

Mourad Aribi
Normal and Malignant B Cell Book PDF

Author : Mourad Aribi
Publisher : BoD – Books on Demand
Page : 163 pages
File Size : 46,5 Mb
Release : 2020-02-26
Category : Medical
ISBN : 9781789854305

Get Book

Normal and Malignant B-Cell by Mourad Aribi Pdf

Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.

Flow Cytometry in Evaluation of Hematopoietic Neoplasms

Sindhu Cherian,Brent Wood
Flow Cytometry in Evaluation of Hematopoietic Neoplasms Book PDF

Author : Sindhu Cherian,Brent Wood
Publisher : Unknown
Page : 165 pages
File Size : 52,5 Mb
Release : 2012
Category : Medical
ISBN : 0983706824

Get Book

Flow Cytometry in Evaluation of Hematopoietic Neoplasms by Sindhu Cherian,Brent Wood Pdf

Flow Cytometry in Evaluation of Hematopoietic Neoplasms: A Case-Based Approach is a practical, case-based guide to flow cytometric analysis in the workup of hematopoietic neoplasms presenting in the peripheral blood, marrow, lymphoid tissue, and extranodal sites. Using multi-color techniques pioneered by Brent Wood, the text demonstrates a unique approach to diagnosis of hematopoietic malignancies as well as identification of small abnormal populations in the posttherapy setting (minimal residual disease testing). The publication contains an introduction to immunophenotypic changes seen in normal hematopoiesis along with an overview of the evaluation of lymphomas, leukemias, and myeloid stem- cell neoplasms. These concepts are further illustrated by a series of 36 cases, each dedicated to a specific disease entity. Each case provides detailed, full-color images of flow cytometric dot plots that clearly outline the features of the disease, accompanied by a clinical history and thorough discussion, enabling readers to develop and work through a differential diagnosis and recognize potential diagnostic pitfalls. Take-home points for each case emphasize critical concepts in flow cytometric diagnosis. Flow Cytometry in Evaluation of Hematopoietic Neoplasms provides pathologists, residents, laboratory technologists, and hematologists with both a study guide and an atlas for regular consultation in the clinical flow cytometry laboratory. The 2008 World Health Organization (WHO) classification system, French-American-British (FAB) classifications, and 2006 Bethesda Consensus recommendations are incorporated in the text.

Specialist Training in Oncology E-Book

Thankamma V Ajithkumar,Helen Hatcher
Specialist Training in Oncology E Book Book PDF

Author : Thankamma V Ajithkumar,Helen Hatcher
Publisher : Elsevier Health Sciences
Page : 409 pages
File Size : 46,9 Mb
Release : 2011-10-28
Category : Medical
ISBN : 9780723437437

Get Book

Specialist Training in Oncology E-Book by Thankamma V Ajithkumar,Helen Hatcher Pdf

This textbook of oncology is aimed at specialist registrars in the early phase of their training. The basic concepts of cancer practice is touched upon in undergraduate and junior postgraduate years, but new trainees frequently seek additional resources to boost their knowledge in the field of Oncology. This title offers a concise account of the multidisciplinary management of common cancers and cancer-related problems appropriate to doctors at the start of their careers in this specialty. The content of the book is based on latest available evidence and reflects the training guidelines. Readable and concise style, aimed at the beginner in this specialty. Well illustrated in colour with graphics, clinical photographs and radiographs. Section on research methodology. Approachable design in the ‘Specialist Training in...’ series style.