Modeling Electrochemical Dynamics And Signaling Mechanisms In Excitable Cells With Pathological Case Studies

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Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies

Tetsuya Watanabe
Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies Book PDF

Author : Tetsuya Watanabe
Publisher : Academic Press
Page : 248 pages
File Size : 43,7 Mb
Release : 2022-01-18
Category : Science
ISBN : 9780323972703

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Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies by Tetsuya Watanabe Pdf

Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies covers the neuronal cell communication system in excitable cells, recognizing the most relevant mechanisms of cell communication. Along with new findings in biotechnology, medicine and pathological cases for clinicians, the book highlights electrochemical potential in living nerve and muscle cells. Written for physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists, this book an essential read for a real understanding of the signals as we see them. Covers neuronal cell communication systems in excitable cells Presents new findings in biotechnology that are being applied in medicine and pathological cases Covers mathematical and physical bases for readers without background in these fields

Post-Genomic Cardiology

José Marín-García
Post Genomic Cardiology Book PDF

Author : José Marín-García
Publisher : Academic Press
Page : 944 pages
File Size : 53,7 Mb
Release : 2014-05-09
Category : Science
ISBN : 9780124046429

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Post-Genomic Cardiology by José Marín-García Pdf

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Clinical Arrhythmology and Electrophysiology E-Book

Ziad Issa,John M. Miller,Douglas P. Zipes
Clinical Arrhythmology and Electrophysiology E Book Book PDF

Author : Ziad Issa,John M. Miller,Douglas P. Zipes
Publisher : Elsevier Health Sciences
Page : 752 pages
File Size : 54,9 Mb
Release : 2018-08-07
Category : Medical
ISBN : 9780323568821

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Clinical Arrhythmology and Electrophysiology E-Book by Ziad Issa,John M. Miller,Douglas P. Zipes Pdf

Part of the highly regarded Braunwald’s family of cardiology references, Clinical Arrhythmology and Electrophysiology, 3rd Edition, offers complete coverage of the latest diagnosis and management options for patients with arrhythmias. Expanded clinical content and clear illustrations keep you fully abreast of current technologies, new syndromes and diagnostic procedures, new information on molecular genetics, advances in ablation, and much more.

Calcium Entry Channels in Non-Excitable Cells

Juliusz Ashot Kozak,James W. Putney, Jr.
Calcium Entry Channels in Non Excitable Cells Book PDF

Author : Juliusz Ashot Kozak,James W. Putney, Jr.
Publisher : CRC Press
Page : 343 pages
File Size : 52,6 Mb
Release : 2017-07-14
Category : Science
ISBN : 9781498752732

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Calcium Entry Channels in Non-Excitable Cells by Juliusz Ashot Kozak,James W. Putney, Jr. Pdf

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

RNA Methodologies

Robert E. Farrell, Jr.
RNA Methodologies Book PDF

Author : Robert E. Farrell, Jr.
Publisher : Elsevier
Page : 688 pages
File Size : 44,6 Mb
Release : 2010-07-22
Category : Science
ISBN : 9780080454764

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RNA Methodologies by Robert E. Farrell, Jr. Pdf

This laboratory guide represents a growing collection of tried, tested and optimized laboratory protocols for the isolation and characterization of eukaryotic RNA, with lesser emphasis on the characterization of prokaryotic transcripts. Collectively the chapters work together to embellish the RNA story, each presenting clear take-home lessons, liberally incorporating flow charts, tables and graphs to facilitate learning and assist in the planning and implementation phases of a project. RNA Methodologies, 3rd edition includes approximately 30% new material, including chapters on the more recent technologies of RNA interference including: RNAi; Microarrays; Bioinformatics. It also includes new sections on: new and improved RT-PCR techniques; innovative 5’ and 3’ RACE techniques; subtractive PCR methods; methods for improving cDNA synthesis. * Author is a well-recognized expert in the field of RNA experimentation and founded Exon-Intron, a well-known biotechnology educational workshop center * Includes classic and contemporary techniques * Incorporates flow charts, tables, and graphs to facilitate learning and assist in the planning phases of projects

Cell-based Biosensors

Qingjun Liu,Ping Wang
Cell based Biosensors Book PDF

Author : Qingjun Liu,Ping Wang
Publisher : Artech House
Page : 291 pages
File Size : 40,5 Mb
Release : 2009-10
Category : Medical
ISBN : 9781596934405

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Cell-based Biosensors by Qingjun Liu,Ping Wang Pdf

Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. You find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.

Disease Pathways

Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
Disease Pathways Book PDF

Author : Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
Publisher : Elsevier
Page : 732 pages
File Size : 52,8 Mb
Release : 2019-10-18
Category : Science
ISBN : 9780128170878

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Disease Pathways by Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev Pdf

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Sex and Cardiac Electrophysiology

Marek Malik
Sex and Cardiac Electrophysiology Book PDF

Author : Marek Malik
Publisher : Academic Press
Page : 986 pages
File Size : 47,8 Mb
Release : 2020-07-11
Category : Science
ISBN : 9780128177297

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Sex and Cardiac Electrophysiology by Marek Malik Pdf

Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women is a comprehensive investigation into all aspects of sex differences in cardiac electrophysiology. As there are substantial differences between female and male patients in physiology, pathology triggering factors, disease progression, clinical approaches and treatment outcome, this book provides a comprehensive examination. In cardiology, the differences between women and men are more recognized, hence this title summarizes these important differences, providing the essential information needed for clinical specialists and researchers involved in the design and implementation of clinical studies. Explores topics ranging from the physiologic differences between women and men to the differences in clinical handling of arrhythmic disorders between female and male patients Provides sex differences in cardiac electrophysiology in separate chapters Covers the sex differences of cardiac electrical disorders, providing insights beyond cardiac metabolic syndrome, hypertension, atherogenesis and heart failure

Modeling and Simulating Cardiac Electrical Activity

David J. Christini,Trine Krogh-Madsen
Modeling and Simulating Cardiac Electrical Activity Book PDF

Author : David J. Christini,Trine Krogh-Madsen
Publisher : Unknown
Page : 0 pages
File Size : 48,6 Mb
Release : 2020
Category : Electrocardiography
ISBN : 0750320648

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Modeling and Simulating Cardiac Electrical Activity by David J. Christini,Trine Krogh-Madsen Pdf

This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.

Electrochemical Methods for Neuroscience

Adrian C. Michael,Laura Borland
Electrochemical Methods for Neuroscience Book PDF

Author : Adrian C. Michael,Laura Borland
Publisher : CRC Press
Page : 544 pages
File Size : 41,6 Mb
Release : 2006-12-13
Category : Science
ISBN : 9781420005868

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Electrochemical Methods for Neuroscience by Adrian C. Michael,Laura Borland Pdf

Since the first implant of a carbon microelectrode in a rat 35 years ago, there have been substantial advances in the sensitivity, selectivity and temporal resolution of electrochemical techniques. Today, these methods provide neurochemical information that is not accessible by other means. The growing recognition of the versatility of electrochemical techniques indicates a need for a greater understanding of the scientific foundation and use of these powerful tools. Electrochemical Methods for Neuroscience provides an updated summary of the current, albeit evolving, state of the art and lays the scientific foundation for incorporating electrochemical techniques into on-going or newly emerging research programs in the neuroscience disciplines. With contributions from pioneers in the field, the text outlines the applications and benefits of a wide range of electrochemical techniques. It explores the methodology behind the acquisition of neurochemical and neurobiological data through continuous amperometry, fast scan cyclic voltammetry, high-speed chronoamperometry, ion-selective microelectrodes, enzyme based microelectrodes, and in vivo voltammetry with telemetry. The text also introduces emerging concepts in the field such as the correlation of electrochemical recordings with information obtained from patch clamp, electrophysiological, and behavioral techniques. By presenting up-to-date information on the growing collection of electrochemical methods, microsensors, and research techniques, Electrochemical Methods for Neuroscience assists seasoned researchers and newcomers to the field in making sound decisions about adopting the most appropriate of these tools for their future research objectives.

The Myocardium

Glenn A. Langer
The Myocardium Book PDF

Author : Glenn A. Langer
Publisher : Academic Press
Page : 405 pages
File Size : 52,9 Mb
Release : 1997-07-23
Category : Science
ISBN : 0080542565

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The Myocardium by Glenn A. Langer Pdf

The Myocardium, Second Edition is a comprehensive presentation of cardiac function, including ultrastructure, cellular development and morphogenesis, ion channels, ion transporters, excitation-contraction coupling and calcium compartmentation, mechanics and force production, and energy metabolism. The Second Edition presents the new molecular, subcellular, and cellular developments which have occurred in this rapidly expanding field during the past 22 years. Comprehensive overview of all aspects of heart function at the cellular, subcellular, and molecular level Integrates molecular events to give understanding of global cardiac function Includes basis of important pathological states

Textbook of Neural Repair and Rehabilitation

Michael Selzer,Stephanie Clarke,Leonardo Cohen,Gert Kwakkel,Robert Miller
Textbook of Neural Repair and Rehabilitation Book PDF

Author : Michael Selzer,Stephanie Clarke,Leonardo Cohen,Gert Kwakkel,Robert Miller
Publisher : Cambridge University Press
Page : 693 pages
File Size : 46,5 Mb
Release : 2014-04-24
Category : Medical
ISBN : 9781107011670

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Textbook of Neural Repair and Rehabilitation by Michael Selzer,Stephanie Clarke,Leonardo Cohen,Gert Kwakkel,Robert Miller Pdf

Volume 1 of the Textbook of Neural Repair and Rehabilitation covers the basic sciences relevant to recovery of function following injury to the nervous system.

Cellular Oscillatory Mechanisms

Miguel Maroto,Nick Monk
Cellular Oscillatory Mechanisms Book PDF

Author : Miguel Maroto,Nick Monk
Publisher : Springer Science & Business Media
Page : 166 pages
File Size : 48,7 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387097947

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Cellular Oscillatory Mechanisms by Miguel Maroto,Nick Monk Pdf

Oscillatory dynamics are a central feature of a wide range of biological processes. This text fully explores cellular oscillations, focusing particularly on elucidating the basic mechanisms that underlie these oscillations.

Voltage Gated Sodium Channels

Peter C. Ruben
Voltage Gated Sodium Channels Book PDF

Author : Peter C. Ruben
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 46,5 Mb
Release : 2014-04-15
Category : Medical
ISBN : 9783642415883

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Voltage Gated Sodium Channels by Peter C. Ruben Pdf

A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book

Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen
Kendig and Chernick s Disorders of the Respiratory Tract in Children E Book Book PDF

Author : Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen
Publisher : Elsevier Health Sciences
Page : 1163 pages
File Size : 48,9 Mb
Release : 2012-02-25
Category : Medical
ISBN : 9781455740505

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Kendig and Chernick's Disorders of the Respiratory Tract in Children E-Book by Robert W. Wilmott,Thomas F. Boat,Andrew Bush,Victor Chernick,Robin R Deterding,Felix Ratjen Pdf

Kendig, Chernick’s Disorders of the Respiratory Tract in Children is the definitive medical reference book to help you confront critical challenges using the latest knowledge and techniques. You’ll get the state-of-the-art answers you need to offer the best care to young patients. Tackle the toughest challenges and improve patient outcomes with coverage of all the common and rare respiratory problems found in newborns and children worldwide. Get a solid foundation of knowledge to better understand and treat your patients through coverage of the latest basic science and its relevance to clinical problems. Get comprehensive, authoritative coverage on today’s hot topics, such as interstitial lung disease, respiratory disorders in the newborn, congenital lung disease, swine flu, genetic testing for disease and the human genome, inflammatory cytokines in the lung, new radiologic techniques, diagnostic imaging of the respiratory tract, and pulmonary function tests. Learn from the experts with contributions from 100 world authorities in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, anesthesiology, otolaryngology, allergy, and surgery.