Models Of Seizures And Epilepsy

Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
Publisher : Academic Press
Page : 1178 pages
File Size : 41,9 Mb
Release : 2017-06-14
Category : Science
ISBN : 9780128040676

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Models of Seizures and Epilepsy by Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé Pdf

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. Provides a comprehensive reference detailing animal models of epilepsy and seizure Offers insights on the use of novel technologies that can be applied in experimental epilepsy research Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Author : Asla Pitkänen,Philip A. Schwartzkroin,Solomon L. Moshé
Publisher : Elsevier
Page : 705 pages
File Size : 41,6 Mb
Release : 2005-10-04
Category : Psychology
ISBN : 9780080457024

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Models of Seizures and Epilepsy by Asla Pitkänen,Philip A. Schwartzkroin,Solomon L. Moshé Pdf

An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. The first comprehensive description of animal models of epilepsy since the early 1970's Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research World expert opinions on the clinical relevance of each model

Author : Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé
Publisher : Academic Press
Page : 0 pages
File Size : 46,9 Mb
Release : 2017-06-16
Category : Science
ISBN : 0128040661

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Models of Seizures and Epilepsy by Asla Pitkänen,Paul Buckmaster, DVM, PhD,Aristea S Galanopoulou,Solomon L. Moshé Pdf

Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals.

Author : Jong Rho,Raman Sankar,Carl E. Stafstrom
Publisher : CRC Press
Page : 684 pages
File Size : 43,8 Mb
Release : 2010-06-18
Category : Medical
ISBN : 9781420085600

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Epilepsy by Jong Rho,Raman Sankar,Carl E. Stafstrom Pdf

Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo

Author : Andrea Varsavsky,Iven Mareels,Mark Cook
Publisher : CRC Press
Page : 370 pages
File Size : 46,8 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781439812044

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Epileptic Seizures and the EEG by Andrea Varsavsky,Iven Mareels,Mark Cook Pdf

A study of epilepsy from an engineering perspective, this volume begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG and provides an explanation of the type of brain activity likely to register in EEG measurements, offering an overview of how these EEG records are and have been analyzed in the past. The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, it addresses the fundamental question: can seizures be predicted? Based on the authors' extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.

Author : Jerome Engel Jr
Publisher : Oxford University Press
Page : 737 pages
File Size : 50,8 Mb
Release : 2013-01-31
Category : Medical
ISBN : 9780195328547

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Seizures and Epilepsy by Jerome Engel Jr Pdf

This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.

Author : Anonim
Publisher : Academic Press
Page : 1853 pages
File Size : 42,8 Mb
Release : 2009-05-27
Category : Medical
ISBN : 9780123739612

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Encyclopedia of Basic Epilepsy Research by Anonim Pdf

As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

Author : David W. McCandless
Publisher : Springer Science & Business Media
Page : 525 pages
File Size : 43,9 Mb
Release : 2011-11-02
Category : Medical
ISBN : 9781461403616

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Epilepsy by David W. McCandless Pdf

The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.

Author : Gonzalo Alarcón,Antonio Valentín
Publisher : Cambridge University Press
Page : 641 pages
File Size : 48,9 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780521691581

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Introduction to Epilepsy by Gonzalo Alarcón,Antonio Valentín Pdf

Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 41,6 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545

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Jasper's Basic Mechanisms of the Epilepsies by Jeffrey L. Noebels,Massimo Avoli Pdf

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Author : Mohd. Farooq Shaikh,Ayanabha Chakraborti,Annamaria Vezzani,Jafri Malin Abdullah
Publisher : Frontiers Media SA
Page : 175 pages
File Size : 42,8 Mb
Release : 2019-06-19
Category : Electronic
ISBN : 9782889458431

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Experimental Models of Epilepsy and Related Comorbidities by Mohd. Farooq Shaikh,Ayanabha Chakraborti,Annamaria Vezzani,Jafri Malin Abdullah Pdf

Epileptic patients live with epilepsy-associated complications such as cognitive dysfunction, psychological discomfort, and sexual function decline, and are more likely to experience emotional and mental health issues problems, including depression and anxiety. Many antiepileptic drugs are found to have a role in aggravating psychiatric symptoms. Animal models, which inform translational questions about epilepsy comorbidities, are used to study the relationship between epilepsy and related comorbidities. The aim of this Research Topic was to highlight basic, clinical and interdisciplinary research involved in studying the disease and its comorbid effects. Various experimental models are used to understand the mechansims of disease and to discover newer antiepileptic drugs. These experimental models combines the input from behavioral, biochemical and molecular level including genetic.

Author : Philip A. Schwartzkroin
Publisher : Cambridge University Press
Page : 560 pages
File Size : 43,9 Mb
Release : 1993-06-17
Category : Medical
ISBN : 9780521392983

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Epilepsy by Philip A. Schwartzkroin Pdf

This book considers a number of major concepts and models in epilepsy research, to advance understanding of the basic mechanisms involved.

Author : Evgenia Sitnikova,Gilles van Luijtelaar,Filiz Onat
Publisher : Frontiers Media SA
Page : 110 pages
File Size : 44,6 Mb
Release : 2024-04-29
Category : Medical
ISBN : 9782832548547

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Epileptic Seizure Disorders in Animal Models: Advances in Translational Approaches by Evgenia Sitnikova,Gilles van Luijtelaar,Filiz Onat Pdf

Author : Simon Shorvon,Renzo Guerrini,Eugen Trinka,Steven Schachter
Publisher : Cambridge University Press
Page : 1013 pages
File Size : 48,7 Mb
Release : 2019-05-02
Category : Medical
ISBN : 9781108420754

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The Causes of Epilepsy by Simon Shorvon,Renzo Guerrini,Eugen Trinka,Steven Schachter Pdf

Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.

Author : Bureau Michelle,Genton Pierre,Dravet Charlotte
Publisher : John Libbey Eurotext
Page : 682 pages
File Size : 42,9 Mb
Release : 2012-11-12
Category : Medical
ISBN : 9782742008292

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Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition by Bureau Michelle,Genton Pierre,Dravet Charlotte Pdf

The ultimate reference book : the 5th updated edition of the famous “blue guide”. Incluided : A DVD with new sequences completes each chapter! Epileptology changes. The syndromic approach is completed by an etiological approach, based on the major advances in genetics and functional genetics. New entities have found their place, and a purely descriptive, “electroclinical” approach is no longer adapted in many circumstances. The 5th edition of the Blue Guide includes the most recent advances. It was necessary to justify the physiological, epidemiologic, genetic and therapeutic approaches and to consider them in the light of the new classification efforts, which are still in the making. Nevertheless, the description of epileptic syndromes, both classical and recent, remains at the core of this book.