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Author : Evgenia Sitnikova,Gilles van Luijtelaar,Filiz Onat
Publisher : Frontiers Media SA
Page : 110 pages
File Size : 52,9 Mb
Release : 2024-04-29
Category : Medical
ISBN : 9782832548547
Author : Jong Rho,Raman Sankar,Carl E. Stafstrom
Publisher : CRC Press
Page : 684 pages
File Size : 43,5 Mb
Release : 2010-06-18
Category : Medical
ISBN : 9781420085600
Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervo
Author : Scott C. Baraban
Publisher : Humana Press
Page : 276 pages
File Size : 55,7 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493961144
In this book, investigators examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species. This is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.
Author : Asla Pitkänen,Philip A. Schwartzkroin,Solomon L. Moshé
Publisher : Elsevier
Page : 705 pages
File Size : 40,9 Mb
Release : 2005-10-04
Category : Psychology
ISBN : 9780080457024
An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. The first comprehensive description of animal models of epilepsy since the early 1970's Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research World expert opinions on the clinical relevance of each model
Author : Anonim
Publisher : Academic Press
Page : 1853 pages
File Size : 40,9 Mb
Release : 2009-05-27
Category : Medical
ISBN : 9780123739612
As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research
Author : Simon Shorvon,Emilio Perucca,Jerome Engel, Jr.
Publisher : John Wiley & Sons
Page : 1072 pages
File Size : 45,8 Mb
Release : 2015-09-15
Category : Medical
ISBN : 9781118936986
Highly Commended at the British Medical Association Book Awards 2016 The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy. The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated The first two sections cover the background to, and principles of, treatment in different clinical situations Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries
Author : National Research Council,Institute of Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Policy and Global Affairs,Committee on Science, Technology, and Law,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 102 pages
File Size : 49,5 Mb
Release : 2012-06-26
Category : Science
ISBN : 9780309252119
Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research. To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.
Author : Jeffrey L. Noebels,Massimo Avoli
Publisher : OUP USA
Page : 1258 pages
File Size : 44,8 Mb
Release : 2012-06-29
Category : Medical
ISBN : 9780199746545
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 50,8 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.
Author : Jerome Engel Jr
Publisher : Oxford University Press
Page : 737 pages
File Size : 52,9 Mb
Release : 2013-01-31
Category : Medical
ISBN : 9780195328547
This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.
Author : James E. Barrett,Joseph T. Coyle,Michael Williams
Publisher : Cambridge University Press
Page : 379 pages
File Size : 47,8 Mb
Release : 2012-06-28
Category : Medical
ISBN : 9781139510301
Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.
Author : Francesco Pisani
Publisher : Elsevier Publishing Company
Page : 216 pages
File Size : 41,5 Mb
Release : 1991
Category : Medical
ISBN : UOM:39015024821962
The pharmacological fight against epilepsy began many centuries ago when Hippocrates discovered that the cause of epilepsy is natural, as opposed to supernatural and, as a consequence, must be treated with a natural remedy. Even though science has significantly progressed since that era, the challenge to find remedies for epilepsy is ever present. The aim of this particular volume is to offer an up-to-date review of the most recent advances in antiepileptic drug development, considered from various viewpoints: (i) general, by taking into account the size of refractory epilepsy and its related problems; (ii) experimental, by exploring the mechanisms of epileptogenesis and the possiblility of influencing it through drugs, and (iii) clinical, by describing the results obtained with compounds currently at an advanced stage of testing.
Author : P. Michael Conn
Publisher : Academic Press
Page : 776 pages
File Size : 55,8 Mb
Release : 2016-09-28
Category : Medical
ISBN : 9780128025963
Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment
Author : Arianna Carolina Rosa,Mitsunobu Mio,Ioanna Andreadou,Vadim V. Sumbayev
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 45,6 Mb
Release : 2020-12-18
Category : Science
ISBN : 9782889661787
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Elaine Wyllie,Gregory D. Cascino,Barry E. Gidal,Howard P. Goodkin
Publisher : Lippincott Williams & Wilkins
Page : 1040 pages
File Size : 41,9 Mb
Release : 2012-02-17
Category : Medical
ISBN : 9781451153484
In one convenient source, this book provides a broad, detailed, and cohesive overview of seizure disorders and contemporary treatment options. For this Fifth Edition, the editors have replaced or significantly revised approximately 30 to 50 percent of the chapters, and have updated all of them. Dr. Wyllie has invited three new editors: Gregory Cascino, MD, FAAN, at Mayo Clinic, adult epileptologist with special expertise in neuroimaging; Barry Gidal, PharmD, at University of Wisconsin, a pharmacologist with phenomenal expertise in antiepileptic medications; and Howard Goodkin, MD, PhD, a pediatric neurologist at the University of Virginia. A fully searchable companion website will include the full text online and supplementary material such as seizure videos, additional EEG tracings, and more color illustrations.
