Molecular Biology Of Dna Topoisomerases And Its Application To Chemotherapy

Author : Toshiwo Andoh,Masao Oguro,Hideo Ikeda
Publisher : CRC Press
Page : 400 pages
File Size : 45,9 Mb
Release : 1992-10-26
Category : Medical
ISBN : 0849349702

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Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy by Toshiwo Andoh,Masao Oguro,Hideo Ikeda Pdf

Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy is based on conference proceedings from the International Symposium on DNA Topoisomerases in Chemotherapy, held in Nagoya, Japan, in November 1991. The book opens with a discussion of the structural and functional properties of various types of DNA topoisomerases identified in prokaryotes and eukaryotes, in addition to their roles as cellular targets of anticancer and antimicrobial agents. Other topics addressed include the genetics and biology of DNA topoisomerases, inhibitors of microbial DNA topoisomerases and drug resistance, inhibitors of mammalian DNA topoisomerases and drug resistance, and preclinical and clinical studies of DNA topoisomerase inhibitors. Molecular Biology of DNA Topoisomerases and Its Application to Chemotherapy will broaden the understanding of biology and genetics of DNA topoisomerases and contribute to the development of antimicrobial and anticancer agents-inhibitors of topoisomerases. It will be invaluable for oncologists, molecular biologists, cellular biologists, geneticists, biochemists, and pharmaceutical researchers.

Author : Yves Pommier
Publisher : Springer Science & Business Media
Page : 443 pages
File Size : 54,5 Mb
Release : 2011-09-21
Category : Medical
ISBN : 9781461403234

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DNA Topoisomerases and Cancer by Yves Pommier Pdf

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

Author : Toshiwo Andoh
Publisher : Springer Science & Business Media
Page : 208 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461501411

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DNA Topoisomerases in Cancer Therapy by Toshiwo Andoh Pdf

In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.

Author : Anonim
Publisher : Unknown
Page : 456 pages
File Size : 43,7 Mb
Release : 2011-09-21
Category : Electronic
ISBN : 1461403243

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DNA Topoisomerases and Cancer by Anonim Pdf

Author : Neil Osheroff,Mary-Ann Bjornsti
Publisher : Springer Science & Business Media
Page : 331 pages
File Size : 50,6 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592590575

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DNA Topoisomerase Protocols by Neil Osheroff,Mary-Ann Bjornsti Pdf

Beginning with the Escherichia coli ? protein, or bacterial DNA topoisomerase I, an ever-increasing number of enzymes have been identified that catalyze changes in the linkage of DNA strands. DNA topoisomerases are ubiquitous in nature and have been shown to play critical roles in most p- cesses involving DNA, including DNA replication, transcription, and rec- bination. These enzymes further constitute the cellular targets of a number of clinically important antibacterial and anticancer agents. Thus, further studies of DNA topology and DNA topoisomerases are critical to advance our und- standing of the basic biological processes required for cell cycle progression, cell division, genomic stability, and development. In addition, these studies will continue to provide critical insights into the cytotoxic action of drugs that target DNA topoisomerases. Such mechanistic studies have already played an important role in the development and clinical application of antimicrobial and chemotherapeutic agents. The two volumes of DNA Topoisomerase Protocols are designed to help new and established researchers investigate all aspects of DNA topology and the function of these enzymes. The chapters are written by prominent investigators in the field and provide detailed background information and st- by-step experimental protocols. The topics covered in Part I: DNA Topology and Enzymes, range from detailed methods to analyze various aspects of DNA structure, from linking number, knotting/unknotting, site-specific recombi- tion, and decatenation to the overexpression and purification of bacterial and eukaryotic DNA topoisomerases from a variety of cell systems and tissues.

Author : Anonim
Publisher : Academic Press
Page : 337 pages
File Size : 45,9 Mb
Release : 1994-11-07
Category : Science
ISBN : 9780080581200

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DNA Topoisomearases: Biochemistry and Molecular Biology by Anonim Pdf

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1628 pages
File Size : 47,8 Mb
Release : 1993
Category : Medicine
ISBN : UOM:39015074107676

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1536 pages
File Size : 52,8 Mb
Release : 1993
Category : Medicine
ISBN : MINN:31951D010928702

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Bruce A. Chabner,Dan L. Longo
Publisher : Lippincott Williams & Wilkins
Page : 836 pages
File Size : 43,8 Mb
Release : 2011-12-07
Category : Medical
ISBN : 9781451148206

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Cancer Chemotherapy and Biotherapy by Bruce A. Chabner,Dan L. Longo Pdf

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

Author : Khalil Ahmed,E. Chambaz,Olaf-Georg Issinger
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 53,6 Mb
Release : 2012-09-18
Category : Science
ISBN : 9781441986245

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A Molecular and Cellular View of Protein Kinase CK2 by Khalil Ahmed,E. Chambaz,Olaf-Georg Issinger Pdf

It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace. Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on `A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.

Author : Society for General Microbiology. Symposium
Publisher : Cambridge University Press
Page : 396 pages
File Size : 41,5 Mb
Release : 1995-05-04
Category : Medical
ISBN : 0521481082

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Fifty Years of Antimicrobials by Society for General Microbiology. Symposium Pdf

A look back over the development of antibiotics since Fleming's day and a look forward to future challenges.

Author : Felipe C. Cabello,Dagmar Hulinska,Henry P. Godfrey
Publisher : IOS Press
Page : 426 pages
File Size : 53,7 Mb
Release : 2006
Category : Medical
ISBN : 9781586036652

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Molecular Biology of Spirochetes by Felipe C. Cabello,Dagmar Hulinska,Henry P. Godfrey Pdf

Diseases produced by spirochetes, including Lyme borreliosis, syphilis and leptospirosis, are on the rise worldwide. This volume focuses on a series of state-of-the-art presentations of the research taking place in the laboratories of the contributors, and serves as an introduction to those individuals entering in the field of spirochete research.

Author : M. Palumbo
Publisher : Elsevier
Page : 282 pages
File Size : 43,6 Mb
Release : 1997-11-19
Category : Science
ISBN : 008054455X

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Advances in DNA Sequence-specific Agents by M. Palumbo Pdf

In this volume the entire focus is devoted to the macromolecule target specificity of DNA interactive developmental therapeutic agents of current interest. A brief introduction to DNA interactive anticancer agents is included for readers who may benefit from an overview surrounding the developments that have contributed to our general understanding of this field. The following nine chapters have been carefully chosen so that they describe topics which are at the forefront of development in DNA-targeted cancer chemotherapy. Issues that have been addressed include the mechanisms of selective DNA topoisomerase I and II poisoning by antitumor agents (Chapters 1 and 2), sequence-specific recognition of DNA by groove-binding drugs and drug-conjugates (Chapters 3 and 4), recent developments in nitrogen mustard alkylating agents and their potential use for antibody-directed enzyme-prodrug therapy (Chapter 5), nonclassical platinum anticancer complexes, including dinuclear and trans-platinum derivatives (Chapter 6), DNA cleaving antitumor chromoproteins containing reactive enediyne moieties, which exhibit interesting free-radical chemistry along with selective targeting (Chapter 7), the potential of new sequence-specific antisense and antigene therapy in oncology (Chapter 8), and finally the conceivable chemotherapeutic use of mimetics of the DNA structure, obtained by substitution of the sugar-phosphate natural chain with a peptide backbone, the so-called peptide nucleic acids (Chapter 9). Important approaches being currently investigated for selective cancer treatment, such as gene therapy and immunochemotherapy, are not discussed in this volume since they fall beyond its scope.

Author : Anonim
Publisher : Elsevier
Page : 740 pages
File Size : 48,9 Mb
Release : 2001-07-31
Category : Medical
ISBN : 9780080496900

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Drug-Nucleic Acid Interactions by Anonim Pdf

This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.

Author : P. Banzet,J.F. Holland,D. Khayat,M. Weil
Publisher : Springer Science & Business Media
Page : 905 pages
File Size : 42,8 Mb
Release : 2013-12-14
Category : Medical
ISBN : 9782817807652

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Cancer Treatment An Update by P. Banzet,J.F. Holland,D. Khayat,M. Weil Pdf

This book gathers the educational lectures and the texts of the main presenta tions given at the 4th International Congress on Anticancer Chemotherapy which took place in February 1993 in Paris and was attended by 5 000 oncologists from all continents, physicians, students and nurses. This book aspires to give update of the most scientific and clinical aspects of modern oncology. It aims also at showing the prospects that are opened by the rapid progress of cancer biology. The editors are grateful to the authors whose scholarship de fines the quality of the book. Educational lectures The pathogenesis of human cancer metastasis I] Fidler Cancer is a collection of malignancies with each cancer of each organ consist ing of numerous subsets. This biologic and clinical heterogeneity is probably due to the different etiologies, origins, and selection pressures. Despite this heterogeneity, all malignant neoplasms have a uniform characteristic : the ability to invade host tissues and produce metastases. Clinical observations of cancer patients and studies with experimental rodent tumors have revealed that cer tain tumors produce metastasis to specific organs independent of vascular anat omy, rate of blood flow, and number of tumor cells delivered to each organ. The distribution and fate of hematogeneously disseminated, radiolabelled tumor cells in experimental rodent systems amply demonstrate that tumor cells reach the microvasculature of many organs.