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Author : Bin Ren,Xiaofeng Yang,Ramani Ramchandran
Publisher : Frontiers Media SA
Page : 332 pages
File Size : 44,7 Mb
Release : 2022-02-02
Category : Science
ISBN : 9782889742523
Author : Mirko HH Schmidt,Stefan Liebner
Publisher : Springer
Page : 401 pages
File Size : 48,7 Mb
Release : 2015-10-08
Category : Medical
ISBN : 9781493929078
This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.
Author : Jean-Jacques Feige,Gilles Pagès,Fabrice Soncin
Publisher : Springer
Page : 505 pages
File Size : 44,9 Mb
Release : 2014-05-27
Category : Science
ISBN : 9782817804668
Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.
Author : Gabor M. Rubanyi,Victor J. Dzau,John P. Cooke
Publisher : CRC Press
Page : 488 pages
File Size : 40,5 Mb
Release : 2002-02-21
Category : Medical
ISBN : 9780203166475
Vascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy. Written by leading experts in their respective fields, each chapter e
Author : John D. Catravas,Allan D. Callow,Una S. Ryan
Publisher : Unknown
Page : 312 pages
File Size : 43,6 Mb
Release : 1999
Category : Blood-vessels
ISBN : WISC:89065119828
Author : Marcelo González
Publisher : BoD – Books on Demand
Page : 230 pages
File Size : 54,5 Mb
Release : 2020-11-11
Category : Medical
ISBN : 9781839690358
The two main causes of death in the world are directly related to cardiovascular system disorders, ischemic heart disease, and stroke. These pathological conditions are caused by complex molecular mechanisms related to endothelial dysfunction and, finally, structural and functional alterations of blood vessels. Clinical evidence demonstrates the relevance of knowledge about vascular biology, from molecular mechanisms to clinical applications, especially for students of medical sciences or basic sciences. This book is an international effort of collaboration, with the purpose to create an academic tool for students or people interested in learning about vascular biology. I invite the readers to check the chapters and explore the topics developed by experts in the field.
Author : Lena Claesson-Welsh
Publisher : Unknown
Page : 208 pages
File Size : 44,7 Mb
Release : 1998-11-19
Category : Electronic
ISBN : 3642599540
This book focusses on a family of growth factors and their receptors, known as vascular endothelial growth factors (VEGF's). VEGF's are critical for endothelial cell function, both during physiological and pathological conditions. Thus, tumors depend on VEGF in order to promote ingrowth of blood vessels. Without VEGF, blood vessels will not form. There is growing awareness that deregulated production or action of VEGF is initiating or driving a large number of diseases. The book is written by the leading scientists in the field for an audience with medical or life science background, and presents an overview of the current knowledge in the area of VEGF and VEDG receptor structure and function in a series of reviews spanning from molecular signal transduction and cellular biology to the clinic.
Author : Eric A. Jaffe
Publisher : Springer Science & Business Media
Page : 471 pages
File Size : 46,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461328254
The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.
Author : Joyce Tombran-Tink,Colin J. Barnstable
Publisher : Springer Science & Business Media
Page : 412 pages
File Size : 48,9 Mb
Release : 2007-11-06
Category : Medical
ISBN : 9781597450478
Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.
Author : Sarah Y. Yuan,Robert R. Rigor
Publisher : Biota Publishing
Page : 160 pages
File Size : 52,6 Mb
Release : 2011-02-01
Category : Medical
ISBN : 9781615041213
The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell–cell and cell–matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.
Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 47,5 Mb
Release : 2011
Category : Science
ISBN : 9781615041237
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Author : Salvador Moncada,Annie Higgs
Publisher : Springer Science & Business Media
Page : 339 pages
File Size : 55,6 Mb
Release : 2006-12-22
Category : Medical
ISBN : 9783540329671
This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
Author : William C. Aird
Publisher : Cambridge University Press
Page : 25 pages
File Size : 43,9 Mb
Release : 2007-09-03
Category : Science
ISBN : 9781139465878
The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all areas of the human body. Clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. The endothelium has remarkable, though largely untapped, diagnostic and therapeutic potential. This volume bridges the bench-to-bedside gap in endothelial biomedicine, advancing research and development and improving human health. The book is the first to systematically integrate knowledge about the endothelium from different organ-specific disciplines, including neurology, pulmonary, cardiology, gastroenterology, rheumatology, infectious disease, hematology-oncology, nephrology, and dermatology. It's interdisciplinary approach, which draws on expertise from such diverse fields as evolutionary biology, comparative biology, molecular and cell biology, mathematical modeling and complexity theory, translational research, and clinical medicine.
Author : Anonim
Publisher : Unknown
Page : 1398 pages
File Size : 51,7 Mb
Release : 1987
Category : Medicine
ISBN : STANFORD:36105021766048
Author : Helena Lenasi
Publisher : BoD – Books on Demand
Page : 432 pages
File Size : 45,5 Mb
Release : 2018-10-24
Category : Medical
ISBN : 9781789842531
The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.