Mouse Models Of Cancer

Author : Robert M. Hoffman
Publisher : Humana
Page : 0 pages
File Size : 51,7 Mb
Release : 2018-06-15
Category : Medical
ISBN : 3319861581

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Patient-Derived Mouse Models of Cancer by Robert M. Hoffman Pdf

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems

Author : Robert Eferl,Emilio Casanova
Publisher : Humana
Page : 0 pages
File Size : 44,7 Mb
Release : 2016-10-05
Category : Medical
ISBN : 149394844X

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Mouse Models of Cancer by Robert Eferl,Emilio Casanova Pdf

This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 994 pages
File Size : 41,7 Mb
Release : 2001-11-07
Category : Medical
ISBN : 9781592591008

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Tumor Models in Cancer Research by Beverly A. Teicher Pdf

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Author : Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 2014
Category : SCIENCE
ISBN : 1621820033

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Mouse Models of Cancer by Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive Pdf

"99% of mouse protein-coding genes have an equivalent homolog in the human genome, despite the striking differences in appearance between mouse and man. This remarkable genetic similarity, together with our ability to finely engineer the murine genome, has made the mouse the ideal animal in which to model and analyze human biology and disease. This

Author : Anonim
Publisher : Unknown
Page : 124 pages
File Size : 44,8 Mb
Release : 2006
Category : Electronic
ISBN : OCLC:954030793

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Mouse Models of Cancer by Anonim Pdf

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Page : 470 pages
File Size : 48,6 Mb
Release : 2019-04-16
Category : Business & Economics
ISBN : 9780128147054

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Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Author : Eric C. Holland
Publisher : John Wiley & Sons
Page : 504 pages
File Size : 42,8 Mb
Release : 2004-08-27
Category : Science
ISBN : 9780471444602

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Mouse Models of Human Cancer by Eric C. Holland Pdf

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Author : Robert Eferl,Emilio Casanova
Publisher : Humana Press
Page : 463 pages
File Size : 46,8 Mb
Release : 2015-01-31
Category : Medical
ISBN : 149392298X

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Mouse Models of Cancer by Robert Eferl,Emilio Casanova Pdf

This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.

Author : Jeffrey E. Green,Thomas Ried
Publisher : Springer Science & Business Media
Page : 639 pages
File Size : 42,8 Mb
Release : 2011-12-09
Category : Medical
ISBN : 9780387698052

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Genetically Engineered Mice for Cancer Research by Jeffrey E. Green,Thomas Ried Pdf

Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.

Author : Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive
Publisher : Unknown
Page : 0 pages
File Size : 43,5 Mb
Release : 2014
Category : SCIENCE
ISBN : 1621820041

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Mouse Models of Cancer by Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive Pdf

The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics. Thus, the need for more sophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them. This laboratory manual provides cutting-edge methods for generating and characterizing mouse models that accurately recapitulate many features of human cancer. The contributors describe strategies for producing genetic models, including transgenic germline models, gene knockouts and knock-ins, and conditional and inducible systems, as well as models derived using transposon-based insertional mutagenesis, RNA interference, viral-mediated gene delivery, and chemical carcinogens. Tissue recombination, organ reconstitution, and transplantation methods to develop chimeric, allograft, and xenograft models are covered. Approaches to characterize tumor development, progression, and metastasis in these models using state-of-the-art imaging and histopathological, surgical, and other techniques are also included. Other chapters cover the use of mouse models to test and optimize drugs in pre-, co-, and postclinical trials. An appendix specifically addresses the use of mouse cancer models in translational studies and the integration of mouse and human clinical investigations. This manual is therefore an indispensable laboratory resource for all researchers, from the graduate level upward, who study cancer and its treatment.

Author : Shaoguang Li
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 46,8 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387691329

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Mouse Models of Human Blood Cancers by Shaoguang Li Pdf

In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.

Author : Ricardo Martínez Murillo,Alfredo Martínez
Publisher : Humana Press
Page : 0 pages
File Size : 50,5 Mb
Release : 2012-11-05
Category : Medical
ISBN : 1627032088

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Animal Models of Brain Tumors by Ricardo Martínez Murillo,Alfredo Martínez Pdf

Although the available models, whether at the cellular, tissue, or animal level, do not exactly represent the biology of human brain tumors, animal models can offer significant insights into these tumors, providing a better understanding of biological mechanisms underlying tumor generation, growth, angiogenesis, invasion, and metastasis. Animal Models of Brain Tumors brings together developments and discoveries in “in vivo” experimental tumor research that have provided advances in our understanding of the cellular and molecular mechanisms involved in the generation, progression, and clinical outcome of brain neoplasms. Broken into convenient sections, this thorough volume includes topics such as animal model insights into human brain neoplasms, the cellular, molecular, and genetic basis of brain tumors, therapies in the treatment of malignant glioma, as well as imaging technologies in animal tumor models, i.e. measuring brain tumor growth and metabolism. Written for the popular Neuromethods series, chapters include the kind of detailed description and implementation advice that is essential for achieving successful results. Authoritative and cutting-edge, Animal Models of Brain Tumors provides the key methods needed to validate, compare, and contrast the animal model with its proposed human counterpart and further the understanding of our own serious ailments.

Author : Vladimir Korinek
Publisher : Unknown
Page : 273 pages
File Size : 43,9 Mb
Release : 2021
Category : Electronic
ISBN : 3036512772

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Animal Modeling in Cancer by Vladimir Korinek Pdf

Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor.

Author : Marten H. Hofker,Jan van Deursen
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 45,9 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592593408

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Transgenic Mouse Methods and Protocols by Marten H. Hofker,Jan van Deursen Pdf

Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.

Author : Michael Breitenbach,Jens Hoffmann
Publisher : Frontiers Media SA
Page : 176 pages
File Size : 49,5 Mb
Release : 2019-02-05
Category : Electronic
ISBN : 9782889457014

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Cancer Models by Michael Breitenbach,Jens Hoffmann Pdf

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.