Cancer Models

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Tumor Models in Cancer Research

Beverly A. Teicher
Tumor Models in Cancer Research Book PDF

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 745 pages
File Size : 41,5 Mb
Release : 2001-11-07
Category : Medical
ISBN : 9781592591008

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Tumor Models in Cancer Research by Beverly A. Teicher Pdf

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Patient-Derived Mouse Models of Cancer

Robert M. Hoffman
Patient Derived Mouse Models of Cancer Book PDF

Author : Robert M. Hoffman
Publisher : Humana
Page : 0 pages
File Size : 47,5 Mb
Release : 2018-06-15
Category : Medical
ISBN : 3319861581

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Patient-Derived Mouse Models of Cancer by Robert M. Hoffman Pdf

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems

Handbook of Cancer Models with Applications

W. Y. Tan
Handbook of Cancer Models with Applications Book PDF

Author : W. Y. Tan
Publisher : World Scientific
Page : 592 pages
File Size : 44,7 Mb
Release : 2008
Category : Political Science
ISBN : 9789812779489

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Handbook of Cancer Models with Applications by W. Y. Tan Pdf

Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer, and stochastic models of metastasis. The book also provides some important applications of cancer models to the assessment of cancer risk associated with various hazardous environmental agents, to cancer screening by MRI, and to drug resistance in cancer chemotherapy. An updated statistical design and analysis of xenograft experiments as well as a statistical analysis of cancer occult clinical data are also provided.The book will serve as a useful source of reference for researchers in biomathematics, biostatistics and bioinformatics; for clinical investigators and medical doctors employing quantitative methods to develop procedures for cancer diagnosis, prevention, control and treatment; and for graduate students.

The Drosophila Model in Cancer

Wu-Min Deng
The Drosophila Model in Cancer Book PDF

Author : Wu-Min Deng
Publisher : Springer Nature
Page : 251 pages
File Size : 45,5 Mb
Release : 2019-09-13
Category : Medical
ISBN : 9783030236298

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The Drosophila Model in Cancer by Wu-Min Deng Pdf

This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.

Cancer Models

Michael Breitenbach,Jens Hoffmann
Cancer Models Book PDF

Author : Michael Breitenbach,Jens Hoffmann
Publisher : Frontiers Media SA
Page : 176 pages
File Size : 55,9 Mb
Release : 2019-02-05
Category : Electronic
ISBN : 9782889457014

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Cancer Models by Michael Breitenbach,Jens Hoffmann Pdf

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.

Multiscale Modeling of Cancer

Vittorio Cristini,John Lowengrub
Multiscale Modeling of Cancer Book PDF

Author : Vittorio Cristini,John Lowengrub
Publisher : Cambridge University Press
Page : 299 pages
File Size : 43,7 Mb
Release : 2010-09-09
Category : Technology & Engineering
ISBN : 9781139491501

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Multiscale Modeling of Cancer by Vittorio Cristini,John Lowengrub Pdf

Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.

Multiscale Cancer Modeling

Thomas S. Deisboeck,Georgios Stamatakos
Multiscale Cancer Modeling Book PDF

Author : Thomas S. Deisboeck,Georgios Stamatakos
Publisher : CRC Press
Page : 492 pages
File Size : 53,7 Mb
Release : 2010-12-08
Category : Mathematics
ISBN : 9781439814420

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Multiscale Cancer Modeling by Thomas S. Deisboeck,Georgios Stamatakos Pdf

Cancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat

Cancer and Zebrafish

David M. Langenau
Cancer and Zebrafish Book PDF

Author : David M. Langenau
Publisher : Springer
Page : 0 pages
File Size : 48,6 Mb
Release : 2016-05-23
Category : Medical
ISBN : 3319306529

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Cancer and Zebrafish by David M. Langenau Pdf

This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.

Cancer Modelling and Simulation

Luigi Preziosi
Cancer Modelling and Simulation Book PDF

Author : Luigi Preziosi
Publisher : CRC Press
Page : 456 pages
File Size : 50,8 Mb
Release : 2003-06-18
Category : Mathematics
ISBN : 020349489X

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Cancer Modelling and Simulation by Luigi Preziosi Pdf

Understanding how cancer tumours develop and spread is vital for finding treatments and cures. Cancer Modelling and Simulation demonstrates how mathematical modelling and computer simulation techniques are used to discover and gain insight into the dynamics of tumour development and growth. It highlights the benefits of tumour modelling, such as discovering optimal tumour therapy schedules, identifying the most promising candidates for further clinical investigation, and reducing the number of animal experiments. By examining the analytical, mathematical, and biological aspects of tumour growth and modelling, the book provides a common language and knowledge for professionals in several disciplines.

Tumor Models in Cancer Research

Beverly A. Teicher
Tumor Models in Cancer Research Book PDF

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 682 pages
File Size : 47,7 Mb
Release : 2010-12-01
Category : Medical
ISBN : 9781607619680

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Tumor Models in Cancer Research by Beverly A. Teicher Pdf

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Optimal Control for Mathematical Models of Cancer Therapies

Heinz Schättler,Urszula Ledzewicz
Optimal Control for Mathematical Models of Cancer Therapies Book PDF

Author : Heinz Schättler,Urszula Ledzewicz
Publisher : Springer
Page : 496 pages
File Size : 54,9 Mb
Release : 2015-09-15
Category : Mathematics
ISBN : 9781493929726

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Optimal Control for Mathematical Models of Cancer Therapies by Heinz Schättler,Urszula Ledzewicz Pdf

This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style. Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.

Animal Models in Cancer Drug Discovery

Asfar Azmi,Ramzi M. Mohammad
Animal Models in Cancer Drug Discovery Book PDF

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Page : 470 pages
File Size : 44,6 Mb
Release : 2019-04-16
Category : Business & Economics
ISBN : 9780128147054

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Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Dynamics of Cancer

Steven A. Frank
Dynamics of Cancer Book PDF

Author : Steven A. Frank
Publisher : Princeton University Press
Page : 393 pages
File Size : 43,7 Mb
Release : 2018-06-05
Category : Medical
ISBN : 9780691186863

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Dynamics of Cancer by Steven A. Frank Pdf

The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer, Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer. This is the only book that presents a full analysis of the age of cancer onset. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For cancer biologists, population geneticists, evolutionary biologists, and demographers interested in aging, this book provides new insight into disease progression, the inheritance of predisposition to disease, and the evolutionary processes that have shaped organismal design.

CNS Cancer

Erwin G. Van Meir
CNS Cancer Book PDF

Author : Erwin G. Van Meir
Publisher : Springer Science & Business Media
Page : 1294 pages
File Size : 47,6 Mb
Release : 2009-08-15
Category : Medical
ISBN : 9781603275538

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CNS Cancer by Erwin G. Van Meir Pdf

Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.

Mouse Models of Cancer

Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive
Mouse Models of Cancer Book PDF

Author : Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive
Publisher : Unknown
Page : 0 pages
File Size : 47,9 Mb
Release : 2014
Category : SCIENCE
ISBN : 1621820033

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Mouse Models of Cancer by Cory Abate-Shen,Katerina Politi,Lewis A. Chodosh,Kenneth P. Olive Pdf

"99% of mouse protein-coding genes have an equivalent homolog in the human genome, despite the striking differences in appearance between mouse and man. This remarkable genetic similarity, together with our ability to finely engineer the murine genome, has made the mouse the ideal animal in which to model and analyze human biology and disease. This