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Author : Armand Marie Leroi
Publisher : Penguin Books
Page : 464 pages
File Size : 44,5 Mb
Release : 2005-01-25
Category : Science
ISBN : UCSC:32106019706206
Stepping effortlessly from myth to cutting-edge science, "Mutants" gives a brilliant narrative account of man's genetic code and the captivating people whose bodies have revealed it.
Author : Matt Forbeck
Publisher : Del Rey
Page : 290 pages
File Size : 55,8 Mb
Release : 2008-09-30
Category : Fiction
ISBN : 9780345509758
“It will be a dangerous mission. I don’t expect that any of us will survive. But it’s a chance to save mankind, to save our world. Maybe the last chance.” By the end of the twenty-third century, Earth is a plague-ridden, war-ravaged cesspool dominated by megacorporations whose ruthless armies fight one another for power and for the very scarce resources there are left. Capitol fighters Mitch Hunter and Nathan Rooker are battling the opposing forces of the Bauhaus corporation when a cannon blast exposes and destroys an ancient stone seal in the ground. From the bowels of the Earth crawl hordes of necromutants with razorlike boneblades for arms, hideous humanoids that thrive and multiply by commandeering the bodies of dying soldiers. Mitch barely escapes– only to discover that both the rise of the mutants and the “Deliverer” who will save humanity have been prophesied. Unless Mitch and a group of warriors from each of the megacorporations succeed in reaching the hidden horrors and wiping out the mutant scourge, ouir world will literally become a hell on Earth. Now a major motion picture
Author : Swati Palit Deb,Sumitra Deb
Publisher : Springer
Page : 376 pages
File Size : 54,5 Mb
Release : 2014-09-08
Category : Medical
ISBN : 9789401792110
This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.
Author : Anthony Faber
Publisher : Academic Press
Page : 150 pages
File Size : 51,8 Mb
Release : 2023-01-30
Category : Science
ISBN : 9780128228340
Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors Encompasses the current state of affairs in clinical trials to address resistance
Author : Edward C. Stites,Kendra Paskvan,Shumei Kato
Publisher : Cambridge University Press
Page : 59 pages
File Size : 54,8 Mb
Release : 2022-09-15
Category : Medical
ISBN : 9781009081023
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
Author : Q. Y. Shu
Publisher : CABI
Page : 612 pages
File Size : 49,6 Mb
Release : 2012
Category : Biotechnology
ISBN : 1780641028
This comprehensive book covers the underlying scientific principles, state-of-the-art technologies and methodologies of plant mutagenesis. It covers historical development and commonly used terminologies, chemical and physical mutagenesis, mutation induction, mutation breeding and mutations in functional genomics research. Suitable both as a manual for professionals and a resource for students in plant breeding and research, the book includes exemplary cases of practical applications and an appendix of recommended doses of gamma and fast neutron irradiation for almost 200 plant species. It is
Author : OECD
Publisher : OECD Publishing
Page : 18 pages
File Size : 53,9 Mb
Release : 2015-07-28
Category : Electronic
ISBN : 9789264243088
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...
Author : Masatoshi Nei
Publisher : OUP Oxford
Page : 261 pages
File Size : 53,6 Mb
Release : 2013-05-02
Category : Science
ISBN : 9780199661732
The purpose of this book is to present a new theory of mutation-driven evolution, which is based on recent advances in genomics and evolutionary developmental biology. This theory asserts that the driving force of evolution is mutation and natural selection is of secondary importance.
Author : Sj Whitby
Publisher : Unknown
Page : 416 pages
File Size : 53,6 Mb
Release : 2020-08
Category : Electronic
ISBN : 0473528649
My name is Dylan Taylor, human incarnation of the burning dumpster gif, and this is my life. I always wanted to be an X-Man. Except people and me never got along, and apparently you need social skills to run a successful team. Cue Emma Hall's party. One hot make out session with the host herself, and I can talk to objects like my pillow (who's far too invested in my love life) and my baseball bat (who was a pacifist before I got hold of him). Now there's a whole group of us with strange abilities, including super hot ice queen Dani Kim who doesn't approve of how reckless I can be. The bigger problem is a mysterious mutant causing unnatural disasters, and we're the ones who have to stop him. Except trying to make a difference makes things blow up in my face and the team's on the verge of falling apart. Can I bring them back together in time to stop the villain from taking revenge? Have I mentioned I'm not a people person? Magneto help us.
Author : Peter Clement
Publisher : Fawcett
Page : 387 pages
File Size : 46,7 Mb
Release : 2002
Category : Fiction
ISBN : 9780345443380
ER doctor Richard Steele is recruited into an anti-bioengineering movement which gathers steam at an explosive genetics conference in Hawaii. Activists warn that breakthroughs to create disease-resistant crops using new DNA strains will wreak havoc on the environment. But no one suspects the controversy could lead to the deadliest weapon of mass destruction ever unleashed upon the world. (May) Copyright © Libri GmbH. All rights reserved.
Author : Joseph J. Darowski
Publisher : Rowman & Littlefield
Page : 243 pages
File Size : 46,9 Mb
Release : 2014-04-10
Category : Literary Criticism
ISBN : 9781442232082
First appearing in 1963, The Uncanny X-Men had a rough start, lasting until 1970 when the comic book was canceled due to low sales. Following a relaunch in 1975, however, it found new popularity thanks to intricate scripting by Chris Claremont and the artwork of John Byrne. Within a few years, The Uncanny X-Men was one of Marvel Comics’ best-selling series and over the decades it became one of the most successful and popular franchises in comic book history. Spin-off titles, mini-series, multimedia adaptations, and a massively expanded cast of characters followed. One of the reasons for the success of X-Men is its powerful “mutant metaphor,” which enhances the stories with cultural significance and the exploration of themes such as societal prejudice and discrimination. In X-Men and the Mutant Metaphor: Race and Gender in the Comic Books, Joseph J. Darowski thoroughly analyzes The Uncanny X-Men, providing its historical background and dividing the long-running series into distinct eras. Each chapter examines the creators and general plot lines, followed by a closer analysis of the principal characters and key stories. The final chapter explores the literal use of race and gender rather than the metaphorical or thematic ways such issues have been addressed. This analysis includes insights gained from interviews with several comic book creators, and dozens of illustrations from the comic book series. Of particular significance are statistics that track the race and gender of every X-Men hero, villain, and supporting character. By delving into the historical background of the series and closely examining characters and stories, X-Men and the Mutant Metaphor illuminates an important popular culture phenomenon.
Author : Ramzi Fawaz
Publisher : NYU Press
Page : 368 pages
File Size : 51,5 Mb
Release : 2016-01-22
Category : Literary Criticism
ISBN : 9781479823499
How fantasy meets reality as popular culture evolves and ignites postwar gender, sexual, and race revolutions. 2017 The Association for the Studies of the Present Book Prize Finalist Mention, 2017 Lora Romero First Book Award Presented by the American Studies Association Winner of the 2012 CLAGS Fellowship Award for Best First Book Project in LGBT Studies In 1964, noted literary critic Leslie Fiedler described American youth as “new mutants,” social rebels severing their attachments to American culture to remake themselves in their own image. 1960s comic book creators, anticipating Fiedler, began to morph American superheroes from icons of nationalism and white masculinity into actual mutant outcasts, defined by their genetic difference from ordinary humanity. These powerful misfits and “freaks” soon came to embody the social and political aspirations of America’s most marginalized groups, including women, racial and sexual minorities, and the working classes. In The New Mutants, Ramzi Fawaz draws upon queer theory to tell the story of these monstrous fantasy figures and how they grapple with radical politics from Civil Rights and The New Left to Women’s and Gay Liberation Movements. Through a series of comic book case studies – including The Justice League of America, The Fantastic Four, The X-Men, and The New Mutants –alongside late 20th century fan writing, cultural criticism, and political documents, Fawaz reveals how the American superhero modeled new forms of social belonging that counterculture youth would embrace in the 1960s and after. The New Mutants provides the first full-length study to consider the relationship between comic book fantasy and radical politics in the modern United States.
Author : Louise Simonson,Chris Claremont
Publisher : Marvel Entertainment
Page : 523 pages
File Size : 42,8 Mb
Release : 2018-02-28
Category : Comics & Graphic Novels
ISBN : 9781302502690
Collects X-Terminators #1-4, New Mutants (1983) #71-85. From the horror of Limbo to the glory of Asgard! As the fires of Inferno burn, the New Mutants must escape Magik's dark domain - but that leaves the way open for S'ym and his demons to invade Earth! Luckily, X-Factor's former wards, the X-Terminators, are on the scene! Can Rusty, Skids, Boom-Boom, Rictor, Artie, Leech and Wiz Kid help the New Mutants repel an army of demons and save Magik's soul? Then, when Hela's evil spell corrupts Mirage's Valkyrie side, Doctor Strange lends a magical hand! But to cure Mirage completely, the New Mutants must travel to Asgard, home of the mighty Norse gods! The trouble is, Hela is scheming to murder Odin and conquer Asgard! Will a handful of mortal mutants be enough to defeat the Goddess of Death?
Author : Joanna Jankowicz-Cieslak,Thomas H. Tai,Jochen Kumlehn,Bradley J. Till
Publisher : Springer
Page : 343 pages
File Size : 51,9 Mb
Release : 2016-12-08
Category : Science
ISBN : 9783319450216
This book is open access under a CC BY-NC 2.5 license. This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.
Author : Eben Kirksey
Publisher : Policy Press
Page : 304 pages
File Size : 54,6 Mb
Release : 2021-03-03
Category : Science
ISBN : 9781529217292
Prologue: The World on Notice -- 1: I'm Quite Glad That I Wasn't First -- 2: A Typical Shenzhen Story -- 3: The Best Humans Haven't Been Produced Yet -- 4: Winner Takes All -- 5: Look at Those Muscles, Look at That Butt -- 6: A Moral Choice -- 7: Will I Have to Mortgage My House? -- 8: The Cancer Moonshot -- 9: Free Health Care for All -- 10: Silence = Death -- 11: Immortality Has to Be the Goal --12: I Don't Want to Walk, I Want to Fly -- 13: High-Quality Children -- 14: #Transracial -- 15: American Medicine and Only for You -- 16: He Was Busy, Busy, Always Doing Research -- 17: A Hammer, Looking for a Nail -- 18: Beautiful Lies -- 19: Two Healthy Baby Girls? -- 20: Mixed Wisdom -- 21: They Are Moving Forward -- 22: Chinese Scientists Are Creating CRISPR Babies -- 23: Bubbles Vanishing into Air -- 24: The Horse has Already Bolted -- Epilogue: We Have Never Been Human.
