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Author : Henry J. Kaminski Publisher : Springer Science & Business Media Page : 396 pages File Size : 55,7 Mb Release : 2002-10-03 Category : Medical ISBN : 9781592593415
Myasthenia Gravis and Related Disorders by Henry J. Kaminski Pdf
An international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromytonia and Lambert-Eaton syndrome. For the clinician, the book describes the wide range of signs and symptoms that make these diseases difficult to diagnose, review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatments now emerging. For the basic scientist, the text illuminates neuromuscular structure and function, describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis), and illuminates the autoimmune pathogenesis.
Author : Henry J. Kaminski Publisher : Springer Science & Business Media Page : 314 pages File Size : 41,6 Mb Release : 2009-03-02 Category : Medical ISBN : 9781597451567
Myasthenia Gravis and Related Disorders by Henry J. Kaminski Pdf
Advances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common resource for understanding this complex disorder. This new edition begins with discussions of neuromuscular junction structure and function and follows with updated chapters covering a wide range of topics, such as the acetylcholine receptor, clinical presentation, diagnostic evaluation, and treatment. Importantly, new supplemental chapters have been added; these discuss rigorous clinical assessments of patients for research trials and the epidemiology and genetics of myasthenia gravis. The discussion of the most challenging aspects of myasthenia gravis, its impact on patients’ psychological make-up, has been expanded as well. Myasthenia Gravis and Related Disorders, Second Edition retains the “personal approach” of the authors regarding treatment and is a valuable resource for meeting the many and varied needs of patients with myasthenia gravis.
Myasthenia Gravis and Myasthenic Disorders by Andrew G. Engel Pdf
Myasthenia Gravis and Myasthenic Disorders, Second Edition is a thoroughly re-written and updated version of the highly successful first edition published in 1999. Comprehensively written by leaders at the forefront of research, not to mention thoroughly referenced throughout and gorgeously illustrated, this new edition of the classic 1999 text will cement its place as the text on Myasthenia Gravis and related disorders for years to come.
Myasthenia Gravis and Related Disorders by Henry J. Kaminski,Richard Barohn Pdf
Basic and clinical investigators have contributed reports to this volume in which they explore new findings in myasthenia gravis and related diseases, exploring topics in basic science, translational research, and clinical science, including advances in therapies and treatment strategies. Topics covered include the following: structure and function of the neuromuscular junction; communication between nerve and muscle; structure and function of the acetylcholine receptor; neuromuscular junction pathology; autoimmunity and signaling; immunology of autoimmune disorders involving the neuron and presynaptic nerve terminal; autoimmune pathogenesis of myasthenia gravis; clinical treatments including thymectomy; myasthenia gravis due to muscle-specific kinase antibodies. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.
Myasthenia Gravis and Related Disorders by Audrey S. Penn Pdf
This work on the neurosciences presents an update on normal physiological mechanisms at the neuromuscular junction, normal immune responses as these relate to auto-immunity, and pathogenic mechanisms responsible for myasthenia (the prototype human auto-immune disease), along with diagnostic and therapy information.
Handbook of Myasthenia Gravis and Myasthenic Syndromes by Robert P. Lisak Pdf
This practical resource provides up-to-the-minute examinations of every aspect of myasthenia gravis and myasthenic syndromes-presenting detailed descriptions of the etiology, pathogenesis, diagnosis, and treatment. Contains nearly 1900 helpful literature citations, tables, drawings, and photographs! Exploring new and emerging therapies for difficult cases, Handbook of Myasthenia Gravis and Myasthenic Syndromes discusses neuroophthalmological features of the disorders congenital, neonatal, and juvenile myasthenia gravis and myasthenic syndromes the clinical presentation and immunology of Lambert-Eaton syndrome the myasthenic neuromuscular junction, diagnostic tests in neuromuscular junction disorders, and the involvement of sites outside the junction the genetics of myasthenia gravis electrodiagnosis, serological diagnosis, and pharmacological diagnosis the value of experimental models in understanding acquired myasthenia gravis the immunopathogenesis of acquired myasthenia gravis and much more!
Acquired Neuromuscular Disorders by Corrado Angelini Pdf
This book provides a state-of-the-art overview of the pathogenesis, diagnosis, and treatment of a range of inflammatory, autoimmune, and idiopathic disorders. The opening section covers clinical tools with a particular focus on the role of electromyography and MRI imaging. The second section then presents the differential diagnosis of acquired myopathies based on clinical, electrophysiological, muscle biopsy, and serological criteria, discussing in detail relevant clinical conditions such as including myasthenia gravis, polymyositis, and statin myopathies. The third section examines acute and chronic immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic diseases, and diabetic polyneuropathy, offering clear guidance on available treatments and descriptions of the latest advances in immunotheraphy, drug therapy, and physiotherapy. This clinically oriented book also includes numerous illustrative figures and contributions by international authors from leading centers.
Myasthenia Gravis and Related Disorders I by Gil Wolfe,Emma Ciafalonia,Robert Ruff,Matthew Meriggioli Pdf
Myasthenia gravis (MG), an acquired immune syndrome affecting proteins at the neuromuscular junction, causes significant muscular functional impairment and can compromise patients’ quality of life, including fatigue, disability, and increased mortality rates. Continued efforts in the last decades have begun to produce significant progress in our understanding of this rare condition, yet considerable challenges remain for improving diagnosis and developing effective treatments for MG. The present volume comprises papers stemming from the “12th International Conference on Myasthenia Gravis and Related Disorders,” held May 21–23, 2012 at the New York Academy of Sciences in New York City. The papers collected in this first of two Annals volumes highlight some of the key developments in neuroscience and immunology in MG and related syndromes presented at the conference, including structure and function of the neuromuscular junction, advances in immunology and their relationship to myasthenia gravis, clinical and laboratory developments, outcome measurements and clinical trial development, and animal models of neuromuscular junction disease. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.
Myasthenia Gravis and Related Disorders by Anonim Pdf
"Myasthenia gravis (MG), an acquired immune syndrome affecting proteins at the neuromuscular junction, causes significant muscular functional impairment and can compromise patients' quality of life, including fatigue, disability, and increased mortality rates. Continued efforts in the last decades have begun to produce significant progress in our understanding of this rare condition, yet considerable challenges remain for improving diagnosis and developing effective treatments for MG. The present volume comprises papers stemming from the "12th International Conference on Myasthenia Gravis and Related Disorders, " held May 21-23, 2012 at the New York Academy of Sciences in New York City. The papers collected in this second of two Annals volumes highlight some of the key developments in neuroscience and immunology in MG and related syndromes presented at the conference, including treatment update and what lies ahead, congenital myasthenic syndromes, Lambert-Eaton myasthenic syndrome, the thymus, thymectomy, and the myasthenia gravis thymectomy trial, and hot topics selected from submitted abstracts."--Résumé de l'éditeur.
Myasthenia Gravis and Related Disorders by Mark A. Agius Pdf
Myasthenia gravis is the best-understood autoimmune disorder and its intense investigation has provided insights into the pathogenesis of autoimmune disease in general and the basic mechanisms of synaptic transmission. The papers in this volume report research findings on the mechanisms of disease, diagnosis and treatment of myasthenia gravis and related diseases. Other papers examine the advances in knowledge about the physiology, biochemistry, genetics, and the structure of the neuromuscular junction as well as advances in the immunology of pre-and post-synaptic disorders of the junction. Papers also discuss the clinical management of myasthenia gravis and related disorders.
Autoimmune myasthenia gravis (MG) is a classical autoimmune disease, for which the target antigen, nicotinic acetylcholine receptor, has been cloned, sequenced and biochemically characterized. Antibodies to acetylcholine receptors destroy acetylcholine receptor at the neuromuscular junction, thus leading to defective neuromuscular transmission, muscle fatigue, and weakness. In the last few years, rapid advances have been made in unraveling the cellular and molecular mechanisms involved in the pathogenesis of MG, both in the animal model, experimental autoimmune MG (EAMG), and in human MG. Significant advances are being made in characterizing the cells and molecules involved in the autoimmune response to the acetylcholine receptor (AChR). These advances are leading to the development of specific methods of immunointervention in EAMG. Further understanding of the intricate involvement of the major histocompatibility complex (MHC) and non-MHC genes, T cell receptors (TCR), costimulator molecules, and specific cytokines in the afferent and efferent autoimmune response of AChR should pave the way to future antigen/clone-specific therapy of MG. This book is the outcome of the MG workshop proceedings in Mysore, India, 1998. The majority of the chapters in this book are contributed by world-renowned authors and their students. The book not only contains a timely review of specific topics, but also up-to-date findings. Immunologists and neurologists will find, in this volume, the latest in MG/EAMG cutting-edge research. Clinicians will be interested in the applications of the various immunointervention strategies into clinical trials in MG patients. Finally, students will not only be interested in reading the latest in EAMG/MG research, but will also find information to help them develop a future strategy to unravel the precise mechanism of disease. To summarize, in this book, the readers should find up-to-date information related to immunological mechanisms involved in MG pathogenesis and various modalities for possible approaches to immunointervention to treat MG.
Author : Nicholas J. Silvestri,Jacqueline A. Palace Publisher : Karger Medical and Scientific Publishers Page : 49 pages File Size : 54,5 Mb Release : 2018-03-05 Category : Medical ISBN : 9781910797532
Fast Facts: Recognizing Refractory Myasthenia Gravis by Nicholas J. Silvestri,Jacqueline A. Palace Pdf
An in-depth look at a rare disease Myasthenia gravis (MG) is a rare autoimmune disorder of the neuromuscular junction, characterized by muscle fatigability. Patients often initially present with ocular symptoms, but in most cases the disease spreads beyond the eye muscles to more generalized involvement of bulbar, facial, neck, proximal limb and respiratory muscles. With adequate treatment, most patients with MG are able to live productive lives with few or no symptoms, but a distinct subset of patients do not respond to conventional treatment. With new treatment options on the horizon, it is important that these patients are identified. 'Fast Facts: Recognizing Refractory Myasthenia Gravis' takes an in-depth look at: • the immune-mediated nature of MG • classification of MG by disease type and severity, and antibody status • clinical presentation and diagnostic work-up • conventional management options • how patients with treatment-refractory MG present • the assessment tools that can be used to identify non-responders. This informative resource will be of value to neurologists, neurology trainees and ophthalmologists caring for patients with this rare disease, as well as patients with MG who wish to have a deeper dialog with their doctor or patient group. Contents: • Definition and epidemiology • Pathophysiology and classification • Diagnosis and management: an overview • Assessment of disease severity and treatment response
