Neoplasms Principles Of Development And Diversity

Author : Jules J. Berman
Publisher : Jones & Bartlett Learning
Page : 454 pages
File Size : 52,7 Mb
Release : 2009
Category : Medical
ISBN : 9780763755706

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Neoplasms: Principles of Development and Diversity by Jules J. Berman Pdf

This unique text is devoted to the full range of neoplastic properties exhibited by the comprehensive collection of human neoplasms. Like no other book of it's kind, it approaches cancer biology by surveying the diversity of neoplasms and by building a classification of neoplasms based on an understanding of the cellular options for tumor development. By grouping neoplasms into a comprehensive classification, we can develop class-specific methods to prevent, detect, and treat cancers. The book is divided into three broad units: speciation, classification and eradication. In the process of developing a classification for neoplasms, dozens of the fundamental questions in neoplastic development are asked and answered. Neoplasms provides readers with a fascinating and enjoyable way to learn the otherwise arcane and dense subject of human tumor diversity.

Author : Jules J. Berman
Publisher : Academic Press
Page : 398 pages
File Size : 44,8 Mb
Release : 2018-01-26
Category : Business & Economics
ISBN : 9780128143940

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Precision Medicine and the Reinvention of Human Disease by Jules J. Berman Pdf

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Author : Jules J. Berman
Publisher : Academic Press
Page : 357 pages
File Size : 50,7 Mb
Release : 2019-04-25
Category : Science
ISBN : 9780128171271

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Evolution's Clinical Guidebook by Jules J. Berman Pdf

Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. Offers an innovative approach, focusing on how disease-associated pathways evolved Explains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformatics Demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of precision medicine

Author : Jules J Berman
Publisher : Academic Press
Page : 480 pages
File Size : 51,8 Mb
Release : 2018-07-23
Category : Computers
ISBN : 9780128156100

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Principles and Practice of Big Data by Jules J Berman Pdf

Principles and Practice of Big Data: Preparing, Sharing, and Analyzing Complex Information, Second Edition updates and expands on the first edition, bringing a set of techniques and algorithms that are tailored to Big Data projects. The book stresses the point that most data analyses conducted on large, complex data sets can be achieved without the use of specialized suites of software (e.g., Hadoop), and without expensive hardware (e.g., supercomputers). The core of every algorithm described in the book can be implemented in a few lines of code using just about any popular programming language (Python snippets are provided). Through the use of new multiple examples, this edition demonstrates that if we understand our data, and if we know how to ask the right questions, we can learn a great deal from large and complex data collections. The book will assist students and professionals from all scientific backgrounds who are interested in stepping outside the traditional boundaries of their chosen academic disciplines. Presents new methodologies that are widely applicable to just about any project involving large and complex datasets Offers readers informative new case studies across a range scientific and engineering disciplines Provides insights into semantics, identification, de-identification, vulnerabilities and regulatory/legal issues Utilizes a combination of pseudocode and very short snippets of Python code to show readers how they may develop their own projects without downloading or learning new software

Author : Jules J. Berman
Publisher : CRC Press
Page : 413 pages
File Size : 51,7 Mb
Release : 2010-09-22
Category : Mathematics
ISBN : 1439841845

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Methods in Medical Informatics by Jules J. Berman Pdf

Too often, healthcare workers are led to believe that medical informatics is a complex field that can only be mastered by teams of professional programmers. This is simply not the case. With just a few dozen simple algorithms, easily implemented with open source programming languages, you can fully utilize the medical information contained in clini

Author : Jules J. Berman
Publisher : Academic Press
Page : 400 pages
File Size : 55,6 Mb
Release : 2014-05-26
Category : Medical
ISBN : 9780124200098

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Rare Diseases and Orphan Drugs by Jules J. Berman Pdf

Rare Diseases and Orphan Drugs shows that much of what we now know about common diseases has been achieved by studying rare diseases. It proposes that future advances in the prevention, diagnosis, and treatment of common diseases will come as a consequence of our accelerating progress in the field of rare diseases. Understanding the complex steps in the development of common diseases, such as cancer, cardiovascular disease, and metabolic diseases, has proven a difficult problem. Rare diseases, however, are often caused by aberrations of a single gene. In rare diseases, we may study how specific genetic defects can trigger a series of events that lead to the expression of a particular disease. Often, the disease process manifested in a certain rare disease is strikingly similar to the disease process observed in a common disease. This work ties the lessons learned about rare diseases to our understanding of common ones. Chapters covering the number of common diseases are minimized, while rare diseases are introduced as single diseases or as members of diseases classes. After reading this book, readers will appreciate how further research into the rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases, rare or common. Makes rare diseases relevant to clinicians and researchers by tying lessons learned about the rare diseases to our understanding of the common diseases Stresses basic pathologic mechanisms that account for human disease (e.g., disorders of cell development, replication, maintenance, function and structure), that can be understood without prior training in pathology Discusses advanced concepts in molecular biology and genetics in a simple, functional context appropriate for medical trainees and new researchers Offers insights into how further research into rare diseases may lead to new methods for preventing, diagnosing, and treating all diseases.

Author : Jules J. Berman
Publisher : Jones & Bartlett Learning
Page : 201 pages
File Size : 45,6 Mb
Release : 2009-08-11
Category : Science
ISBN : 9781449631833

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Precancer: The Beginning and the End of Cancer by Jules J. Berman Pdf

Nearly every type of cancer passes through a precancer phase, during which it cannot metastasize or invade other tissues. While medicine is not always successful in treating or curing advanced stages of cancers, recent advances in our understanding of carcinogenesis have helped us to develop strategies to prevent, diagnose, and treat many cancers at the precancer stage. Research in this field is escalating rapidly as the evidence increasingly shows that the number of annual cancer deaths could be drastically reduced through the effective treatment and cure of precancer lesions. This book begins by explaining why it has been so difficult to cure cancers, followed by a review of precancer biology, with descriptions of the most common precancer lesions. The final chapters provide practical socio-political and medical goals for precancer treatment, including discussions of the economics and politics of treating precancers.

Author : Jules J. Berman
Publisher : Academic Press
Page : 446 pages
File Size : 53,6 Mb
Release : 2022-01-25
Category : Computers
ISBN : 9780323972581

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Classification Made Relevant by Jules J. Berman Pdf

Classification Made Relevant: How Scientists Build and Use Classifications and Ontologies explains how classifications and ontologies are designed and used to analyze scientific information. The book presents the fundamentals of classification, leading up to a description of how computer scientists use object-oriented programming languages to model classifications and ontologies. Numerous examples are chosen from the Classification of Life, the Periodic Table of the Elements, and the symmetry relationships contained within the Classification Theorem of Finite Simple Groups. When these three classifications are tied together, they provide a relational hierarchy connecting all of the natural sciences. The book's chapters introduce and describe general concepts that can be understood by any intelligent reader. With each new concept, they follow practical examples selected from various scientific disciplines. In these cases, technical points and specialized vocabulary are linked to glossary items where the item is clarified and expanded. Explains the theory and practice of classification, emphasizing the importance of classifications and ontologies to the modern fields of mathematics, physics, chemistry, biology and medicine Includes numerous real-world examples that demonstrate how bad construction technique can destroy the value of classifications and ontologies Explains how we define and understand the relationships among the classes within a classification and how the properties of a class are inherited by its subclasses Describes ontologies and how they differ from classifications and explains conditions under which ontologies are useful

Author : Jules J. Berman
Publisher : Morgan Kaufmann
Page : 398 pages
File Size : 54,7 Mb
Release : 2016-03-10
Category : Computers
ISBN : 9780128038543

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Data Simplification by Jules J. Berman Pdf

Data Simplification: Taming Information With Open Source Tools addresses the simple fact that modern data is too big and complex to analyze in its native form. Data simplification is the process whereby large and complex data is rendered usable. Complex data must be simplified before it can be analyzed, but the process of data simplification is anything but simple, requiring a specialized set of skills and tools. This book provides data scientists from every scientific discipline with the methods and tools to simplify their data for immediate analysis or long-term storage in a form that can be readily repurposed or integrated with other data. Drawing upon years of practical experience, and using numerous examples and use cases, Jules Berman discusses the principles, methods, and tools that must be studied and mastered to achieve data simplification, open source tools, free utilities and snippets of code that can be reused and repurposed to simplify data, natural language processing and machine translation as a tool to simplify data, and data summarization and visualization and the role they play in making data useful for the end user. Discusses data simplification principles, methods, and tools that must be studied and mastered Provides open source tools, free utilities, and snippets of code that can be reused and repurposed to simplify data Explains how to best utilize indexes to search, retrieve, and analyze textual data Shows the data scientist how to apply ontologies, classifications, classes, properties, and instances to data using tried and true methods

Author : Jules J. Berman
Publisher : Academic Press
Page : 308 pages
File Size : 48,8 Mb
Release : 2020-07-03
Category : Medical
ISBN : 9780128213711

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Logic and Critical Thinking in the Biomedical Sciences by Jules J. Berman Pdf

Science is not a collection of facts. Science is the process by which we draw inferences from facts. Volume I of Logic and Critical Thinking in the Biomedical Sciences invites readers to linger over a collection of common observations to see what inferences can be drawn, when one applies a bit of deductive logic. If we just think about what we observe, it is often possible to discover profound biomedical insights.Volumes 1 and 2 of Logic and Critical Thinking in the Biomedical Sciences are written for biomedical scientists and college-level students engaged in any of the life sciences, including bioinformatics and related data sciences. Provides a strong introduction to deductive methods that can be directly applied to the biomedical sciences Using hundreds of examples, shows how creative scientists draw important inferences from observations that are often ignored by their peers Discusses complex biological and medical concepts in a relaxed manner, intended to focus the reader’s attention on the deductive process, without dwelling excessively on details

Author : Jules J. Berman
Publisher : Elsevier
Page : 176 pages
File Size : 48,7 Mb
Release : 2015-03-13
Category : Computers
ISBN : 9780128029152

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Repurposing Legacy Data by Jules J. Berman Pdf

Repurposing Legacy Data: Innovative Case Studies takes a look at how data scientists have re-purposed legacy data, whether their own, or legacy data that has been donated to the public domain. Most of the data stored worldwide is legacy data—data created some time in the past, for a particular purpose, and left in obsolete formats. As with keepsakes in an attic, we retain this information thinking it may have value in the future, though we have no current use for it. The case studies in this book, from such diverse fields as cosmology, quantum physics, high-energy physics, microbiology, psychiatry, medicine, and hospital administration, all serve to demonstrate how innovative people draw value from legacy data. By following the case examples, readers will learn how legacy data is restored, merged, and analyzed for purposes that were never imagined by the original data creators. Discusses how combining existing data with other data sets of the same kind can produce an aggregate data set that serves to answer questions that could not be answered with any of the original data Presents a method for re-analyzing original data sets using alternate or improved methods that can provide outcomes more precise and reliable than those produced in the original analysis Explains how to integrate heterogeneous data sets for the purpose of answering questions or developing concepts that span several different scientific fields

Author : You Han Bae,Randall J. Mrsny,Kinam Park
Publisher : Springer Science & Business Media
Page : 720 pages
File Size : 49,9 Mb
Release : 2013-08-31
Category : Medical
ISBN : 9781461478768

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Cancer Targeted Drug Delivery by You Han Bae,Randall J. Mrsny,Kinam Park Pdf

This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

Author : Daniel D. Chiras
Publisher : Jones & Bartlett Publishers
Page : 619 pages
File Size : 48,8 Mb
Release : 2013
Category : Electronic
ISBN : 9781284027716

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Human Biology by Daniel D. Chiras Pdf

Author : Robert I. Krasner,Teri Shors
Publisher : Jones & Bartlett Publishers
Page : 580 pages
File Size : 49,6 Mb
Release : 2014
Category : Medical
ISBN : 9781449673338

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The Microbial Challenge by Robert I. Krasner,Teri Shors Pdf

Microbes play a highly significant role in our daily lives as agents of infectious disease and are a major public health concern. The third edition of The Microbial Challenge: A Public Health Perspective addresses this topic and has been extensively revised and updated with the latest data in a fast-paced field. It focuses on human-microbe interactions and considers bacterial, viral, prion, protozoan, fungal and helminthic (worm) diseases. A chapter on beneficial aspects of microbes makes it clear that not all microbes are disease producers and that microbes are necessary for the sustenance of life on Earth. The response of the immune system, concepts of epidemiology, and measures of control from the individual to the international level to thwart potentially life-threatening epidemics are described. Sections on fungi and fungal diseases are new. The third edition includes new and contemporary information on vaccinations, antibiotic resistant microbes, practical disinfection information, virotherapy and emerging diseases. New boxes throughout the text feature items of human interest such as big and bizarre viruses, probiotics, rats, and synthetic biology. Ancillary instructor and student resources have been updated and expanded including the end of the chapter Self Evaluations. New and Key Features of the Third Edition: -New end-of-chapter questions included in every chapter. -A wealth of new feature boxes add a real-world perspective to the topics at hand. -New data on virotherapy and prions as infectious agents -New and updated statistics and data tables included throughout the text -Includes the latest on emerging and reemerging infectious diseases as major health problems

Author : Brian Keith Hall,Benedikt Hallgrímsson,Monroe W. Strickberger
Publisher : Jones & Bartlett Publishers
Page : 671 pages
File Size : 44,5 Mb
Release : 2014
Category : Science
ISBN : 9781449614843

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Strickberger's Evolution by Brian Keith Hall,Benedikt Hallgrímsson,Monroe W. Strickberger Pdf

Now with a new full color design and art program, the Fifth Edition of Strickberger's Evolution is updated with the latest data and updates from the field. The authors took care to carefully modify the chapter order in an effort to provide a more clear and student-friendly presentation of course material. The original scope and theme of this popular text remains, as it continues to present an overview of prevailing evidence and theories about evolution by discussing how the world and its organisms arose and changed over time. New boxed features concentrating on modern and exciting research in the field are included throughout the text.New and Key Features of the Fifth Edition- New Full color design and art program- Maintains the student-friendly engaging writing-style for which it is known- A reorganized chapter order provides a more clear and accessible presentation of course material.- Chapters on the evolution of biodiversity are now found on the text's website.- Access to the companion website is included with every new copy of the text.- New boxed features highlight new and exciting research in the field.