Neurodegeneration And Alzheimer S Disease

Neurodegeneration And Alzheimer S Disease Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Neurodegeneration And Alzheimer S Disease book. This book definitely worth reading, it is an incredibly well-written.

Neurodegeneration and Alzheimer's Disease

Ralph N. Martins,Charles S. Brennan,Binosha Fernando,Margaret A. Brennan,Stephanie J. Fuller
Neurodegeneration and Alzheimer s Disease Book PDF

Author : Ralph N. Martins,Charles S. Brennan,Binosha Fernando,Margaret A. Brennan,Stephanie J. Fuller
Publisher : John Wiley & Sons
Page : 548 pages
File Size : 54,5 Mb
Release : 2019-07-10
Category : Technology & Engineering
ISBN : 9781119356783

Get Book

Neurodegeneration and Alzheimer's Disease by Ralph N. Martins,Charles S. Brennan,Binosha Fernando,Margaret A. Brennan,Stephanie J. Fuller Pdf

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Adeboye Adejare
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Book PDF

Author : Adeboye Adejare
Publisher : Academic Press
Page : 316 pages
File Size : 48,8 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9780128028117

Get Book

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders by Adeboye Adejare Pdf

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

Neurodegeneration

Dennis Dickson,Roy O. Weller
Neurodegeneration Book PDF

Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Page : 497 pages
File Size : 46,8 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9781444341232

Get Book

Neurodegeneration by Dennis Dickson,Roy O. Weller Pdf

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

The Molecular and Cellular Basis of Neurodegenerative Diseases

Michael S. Wolfe
The Molecular and Cellular Basis of Neurodegenerative Diseases Book PDF

Author : Michael S. Wolfe
Publisher : Academic Press
Page : 560 pages
File Size : 47,8 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9780128113059

Get Book

The Molecular and Cellular Basis of Neurodegenerative Diseases by Michael S. Wolfe Pdf

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Neurodegeneration and Alzheimer's Disease

Ralph N. Martins,Charles S. Brennan
Neurodegeneration and Alzheimer s Disease Book PDF

Author : Ralph N. Martins,Charles S. Brennan
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 51,6 Mb
Release : 2019-04-26
Category : Technology & Engineering
ISBN : 9781119356776

Get Book

Neurodegeneration and Alzheimer's Disease by Ralph N. Martins,Charles S. Brennan Pdf

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

The Molecular and Clinical Pathology of Neurodegenerative Disease

Patrick A. Lewis,Jennifer E. Spillane
The Molecular and Clinical Pathology of Neurodegenerative Disease Book PDF

Author : Patrick A. Lewis,Jennifer E. Spillane
Publisher : Academic Press
Page : 274 pages
File Size : 49,9 Mb
Release : 2018-11-16
Category : Science
ISBN : 9780128110706

Get Book

The Molecular and Clinical Pathology of Neurodegenerative Disease by Patrick A. Lewis,Jennifer E. Spillane Pdf

The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Neurodegenerative Diseases

Uday Kishore
Neurodegenerative Diseases Book PDF

Author : Uday Kishore
Publisher : BoD – Books on Demand
Page : 642 pages
File Size : 45,7 Mb
Release : 2013-05-15
Category : Medical
ISBN : 9789535110880

Get Book

Neurodegenerative Diseases by Uday Kishore Pdf

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Neurodegeneration

Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood
Neurodegeneration Book PDF

Author : Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood
Publisher : John Wiley & Sons
Page : 1314 pages
File Size : 50,6 Mb
Release : 2017-02-13
Category : Medical
ISBN : 9781118661918

Get Book

Neurodegeneration by Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood Pdf

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

The Benefits of Natural Products for Neurodegenerative Diseases

M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
The Benefits of Natural Products for Neurodegenerative Diseases Book PDF

Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
Publisher : Springer
Page : 496 pages
File Size : 44,9 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9783319283838

Get Book

The Benefits of Natural Products for Neurodegenerative Diseases by M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin Pdf

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Neuroprotection in Alzheimer's Disease

Illana Gozes
Neuroprotection in Alzheimer s Disease Book PDF

Author : Illana Gozes
Publisher : Academic Press
Page : 342 pages
File Size : 42,6 Mb
Release : 2016-12-30
Category : Medical
ISBN : 9780128037126

Get Book

Neuroprotection in Alzheimer's Disease by Illana Gozes Pdf

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Neurodegeneration

Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine
Neurodegeneration Book PDF

Author : Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine
Publisher : National Academies Press
Page : 0 pages
File Size : 41,9 Mb
Release : 2013-12-26
Category : Medical
ISBN : 0309285674

Get Book

Neurodegeneration by Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine Pdf

Neurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine\'s (IOM\'s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities. Neurodegenerative diseases, such as Alzheimer\'s disease, Parkinson\'s disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable - at least in some cases - to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics.

Pathology, Prevention and Therapeutics of Neurodegenerative Disease

Sarika Singh,Neeraj Joshi
Pathology Prevention and Therapeutics of Neurodegenerative Disease Book PDF

Author : Sarika Singh,Neeraj Joshi
Publisher : Springer
Page : 301 pages
File Size : 47,7 Mb
Release : 2018-09-24
Category : Medical
ISBN : 9789811309441

Get Book

Pathology, Prevention and Therapeutics of Neurodegenerative Disease by Sarika Singh,Neeraj Joshi Pdf

This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases

Neurodegenerative Diseases

M. Flint Beal,Anthony E. Lang,Albert C. Ludolph
Neurodegenerative Diseases Book PDF

Author : M. Flint Beal,Anthony E. Lang,Albert C. Ludolph
Publisher : Cambridge University Press
Page : 1009 pages
File Size : 54,5 Mb
Release : 2005-06-02
Category : Medical
ISBN : 9781139443456

Get Book

Neurodegenerative Diseases by M. Flint Beal,Anthony E. Lang,Albert C. Ludolph Pdf

Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Advances in Research on Neurodegeneration

R. Horowski,Y. Mizuno,C.W. Olanow,W. Poewe,P. Riederer,J.A. Stoessel,M.B.H. Youdim
Advances in Research on Neurodegeneration Book PDF

Author : R. Horowski,Y. Mizuno,C.W. Olanow,W. Poewe,P. Riederer,J.A. Stoessel,M.B.H. Youdim
Publisher : Springer Science & Business Media
Page : 244 pages
File Size : 51,7 Mb
Release : 2003-07-24
Category : Medical
ISBN : 3211839070

Get Book

Advances in Research on Neurodegeneration by R. Horowski,Y. Mizuno,C.W. Olanow,W. Poewe,P. Riederer,J.A. Stoessel,M.B.H. Youdim Pdf

The 10th International Winter Conference on Neurodegeneration (lWCN) has taken place from February 14-16,2002, at the lovely "SchloB Ziethen", an old prussian manor (in Prussia, 'faute de mieux', called 'SchloB', i. e. cas­ tle or residence). This place is 20 km off Tegel Airport, Berlin's main airport, and has been beautifully restored by baroness Edith von Thiingen (nee von BUlow, i. e. of historical Prussian aristocracy); it lends itself rather perfectly for the IWCN type of small interdisciplinary workshops on neurodegenera­ tion which combine short lectures with plenty of discussion. In this context, we could quote Alexander von Humboldt's famous opening words for one of the first international scientific meetings held at Berlin, on September 18, 1828: "The main purpose . . . does not consist in a mutual reading of manuscripts all to be printed after at least one year in specialised publications, but in the personal communication amongst those who work in similar scientific fields; the oral and thus more stimulating exchange of ideas, might they represent facts, opinions or doubts; the foundation of friendly relations which convey illumination to our sciences, serene grace to our lives and tolerance and mildness to our habits . . . Berlin, Sept. 18, 1828 Alexander von Humboldt To the IWCN aficionado, it may come as a little surprise that this is the pub­ lication of the 10th Winter Conference as this might mean that they must have missed number 9.

Molecular Mechanisms of Neurodegenerative Diseases

Marie-Francoise Chesselet
Molecular Mechanisms of Neurodegenerative Diseases Book PDF

Author : Marie-Francoise Chesselet
Publisher : Springer Science & Business Media
Page : 416 pages
File Size : 48,7 Mb
Release : 2000-10-19
Category : Medical
ISBN : 9781592590063

Get Book

Molecular Mechanisms of Neurodegenerative Diseases by Marie-Francoise Chesselet Pdf

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.