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Author : Walter B. Essman
Publisher : Unknown
Page : 230 pages
File Size : 51,5 Mb
Release : 1980
Category : Acetylcholine
ISBN : UOM:39015004419787
Author : Roy Webster
Publisher : John Wiley & Sons
Page : 550 pages
File Size : 54,6 Mb
Release : 2001-11-28
Category : Medical
ISBN : 0471978191
Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.
Author : Michael S. Lidow
Publisher : CRC Press
Page : 274 pages
File Size : 55,8 Mb
Release : 2000-06-22
Category : Medical
ISBN : 9781420041774
Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a lower risk of developing tardive dyskinesia, have few
Author : W.B. Essman,L. Valzelli
Publisher : Springer
Page : 209 pages
File Size : 53,5 Mb
Release : 1980-07-31
Category : Medical
ISBN : 0852005245
Author : Shozo Kito
Publisher : Springer Science & Business Media
Page : 302 pages
File Size : 43,6 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781468448054
This meeting was held commemorating Dr. Kito's 10th Anniversary as Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito was born in 1927 in Nagoya, graduated from Tokyo University School of Medicine and received his M. D. in 1951. He spent his first academic years as a research associate (1952 - 1968) at the Third Department of Internal Medi cine, Tokyo University School of Medicine. During this period he studied for one year (1952 - 1953) at Illinois University School of Medicine, and acquired his Ph. D. in 1959. In 1968 he became Instructor and in 1971 he was appointed as Assistant Professor of Tokyo Women's Medical College. In 1973, he became Professor of the Third Department of Internal Medicine, Hiroshima University School of Medicine. Dr. Kito is a clinician but he is always enthusiastic about basic medicine. His major research field concerns neurotrans mitters and their receptors in the central nervous system. He prefers a combination of neurotransmitter immunohistochemistry and receptor autoradiography as research techniques. He is also engaged in biochemical studies on amyloid proteins. When the Eighth Inter national Congress of Pharmacology was held in Tokyo in 1981, Dr. Segawa, Dr. Yamamura, and Dr. Kuriyama organized a Satellite Symposium on Neurotransmitter Receptors in Hiroshima. Dr. Kito attended this meeting and was deeply impressed by the active presentations and discussions. In order to make some contribution to the progress of neuro sciences, Dr.
Author : G.N. Woodruff
Publisher : Springer
Page : 264 pages
File Size : 45,8 Mb
Release : 1986-06-18
Category : Medical
ISBN : 9781349080267
Author : Z.L. Kruk,C. Pycock
Publisher : Springer Science & Business Media
Page : 211 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401131346
This book is intended for students of medicine, pharmacy and other biological disciplines, who want to have a working knowledge of the mechanisms of action, uses and adverse effects of drugs which modify the activity of neurotransmitters in the peripheral and central nervous systems. It is suitable for undergraduates and for post-graduates on taught higher degree courses and diplomas. New information and concepts have been incorporated into the text as appropriate, and references have been updated. Excitatoryand inhibitory amino acids are considered in two chapters, and the last chapter of the first two editions (which considered drugs which do not interact selectively with neurotransmitters) has been subsumed into other sections. The third edition follows the tried format of previous editions. Following a chapter which introduces the biology and pharmacology of neurotransmission, subsequent chapters deal with synthesis, storage, release, receptors and inactivation of individual neurotransmitters, together with a consideration of therapeutic uses and mechanisms of adverse effects.
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 74 pages
File Size : 52,8 Mb
Release : 2011-08-05
Category : Medical
ISBN : 9780309212212
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Author : H. Yoshida,Y. Hagihara,S. Ebashi
Publisher : Elsevier
Page : 333 pages
File Size : 40,5 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483148472
Advances in Pharmacology and Therapeutics II, Volume 2: Neurotransmitters-Receptors is the second of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into seven parts, this book begins with an invited lecture on the kinetic analysis of the neuronal and extraneuronal uptake and metabolism of catecholamines. Subsequent parts discuss the regulation of receptor-mediated events; presynaptic receptors in the peripheral and central nervous system; neurotransmitters; and receptor antibodies. The isolated nervous systems in the research of neurotransmission and trophic interactions between nerve and muscle are also discussed.
Author : Christopher J. Coulson
Publisher : CRC Press
Page : 318 pages
File Size : 45,8 Mb
Release : 1994-02-03
Category : Medical
ISBN : 0748400680
In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme inhibition and receptor binding by drugs. The next seven chapters deal with drugs that modulate biochemical pathways, both of synthesis and breakdown, while the last four chapters are concerned with organizational structures of the cell.; The book brings together the state of knowledge with respect to drug action and emphasizes mechanistic aspects of drug action. It encompasses the modes of action of drugs for infectious disease and those for endogenous conditions. There is a listing of reviews and essay questions are provided for each chapter.
Author : Antonio Blanco,Gustavo Blanco
Publisher : Academic Press
Page : 910 pages
File Size : 52,6 Mb
Release : 2022-03-23
Category : Science
ISBN : 9780323916004
This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance. Integrates basic biochemistry principles with molecular biology and molecular physiology Illustrates basic biochemical concepts through medical and physiological examples Utilizes a systems approach to understanding biological phenomena Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries
Author : Edythe D. London
Publisher : Routledge
Page : 454 pages
File Size : 41,8 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351439336
Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.
Author : Peter M. Haddad,David J. Nutt
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 2020
Category : Electronic
ISBN : 191162346X
"The 2nd edition of this book was edited by David King and published in 2004. Since then there have been major advances in psychopharmacology in terms of new medications coming to the market, increased understanding of the mechanisms of drug action and new data on the efficacy, tolerability, safety and clinical effectiveness of a range of medications. Partly as a result, clinical guidelines for many psychiatric disorders have altered. As such, a new edition of this textbook was essential and we were delighted when the College approached us to edit the 3rd edition. This was a major endeavor that was only possible with the commitment and expertise of the authors"--
Author : Zygmunt L. Kruk
Publisher : Springer
Page : 211 pages
File Size : 54,7 Mb
Release : 2014-11-14
Category : Science
ISBN : 9781461575177
Author : Hugo J. Bellen
Publisher : Unknown
Page : 466 pages
File Size : 42,9 Mb
Release : 1999
Category : Cellular signal transduction
ISBN : UOM:39015048547338
Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons thatcommunicate with each other and their targets. This fast and accurate intercellular signalling most occurs at synapses, specialized processes of neurons that release chemical signals, called neurotransmitters. Neurotransmitters: Frontiers in Molecular Biology will provide the reader withextensive background information on neurotransmitter release. It takes a multidisciplinary approach, but does not assume previous knowledge having basic introductions to most topics. Topics however are covered in enough detail to be of interest to experts in the field. Throughout, emphasis is placedon the rationale by which proteins are assigned specific functions rather than just providing facts about function. The first chapter provides an introduction to the basic features and properties of the synapse and is followed by a chapter detailing several important techniques used to elucidatevarious aspects of release. Chapters 3 describes many of the biochemical approaches used to identify proteins involved in neurotransmitter release and then chapters 4 and 5 focus on more specific aspects of synaptic transmission: the proteins that transport neurotransmitters and the role ofphosphlipids in the process. The next five chapters concentrate on approaches to unravel the function of many proteins in vivo by using toxins, giant squid axons, C. elegans, Drosophila, and mice. The final chapter summarizes current knowledge on endocytosis and recycling. Knowledge of themolecular mechanisms underlying neurotransmitter release has expanded tremendously over the last 10 years. Many of the proteins involved have been isolated, but their roles have yet to be determined. These discoveries will be a major challenge and it is therefore the major aim of this book not onlyto provide information but also to generate excitement.