Oral Drug Delivery For Modified Release Formulations

Author : Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts
Publisher : John Wiley & Sons
Page : 516 pages
File Size : 50,9 Mb
Release : 2022-04-26
Category : Medical
ISBN : 9781119772699

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Oral Drug Delivery for Modified Release Formulations by Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts Pdf

ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation’s oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC) Explains the different types of MR formulations and defines the key terms used in the field Discusses the present status of MR technologies and identifies current gaps in research Includes a summary of regulatory guidelines from both the US and the EU Shares industrial experiences and perspectives on the evaluation of MR dosage formulations Oral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Author : Clive G. Wilson,Patrick J. Crowley
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 49,6 Mb
Release : 2011-09-22
Category : Medical
ISBN : 1461410045

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Controlled Release in Oral Drug Delivery by Clive G. Wilson,Patrick J. Crowley Pdf

Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.

Author : Hong Wen,Kinam Park
Publisher : John Wiley & Sons
Page : 571 pages
File Size : 44,9 Mb
Release : 2011-01-14
Category : Science
ISBN : 9781118060322

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Oral Controlled Release Formulation Design and Drug Delivery by Hong Wen,Kinam Park Pdf

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Author : Michael J. Rathbone,Jonathan Hadgraft,Michael S. Roberts
Publisher : CRC Press
Page : 1021 pages
File Size : 53,5 Mb
Release : 2002-11-07
Category : Medical
ISBN : 9780824708696

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Modified-Release Drug Delivery Technology by Michael J. Rathbone,Jonathan Hadgraft,Michael S. Roberts Pdf

Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.

Author : Michael J. Rathbone,Jonathan Hadgraft,Michael S. Roberts,Majella E. Lane
Publisher : CRC Press
Page : 0 pages
File Size : 50,7 Mb
Release : 2008-05-28
Category : Medical
ISBN : 1420053566

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Modified-Release Drug Delivery Technology, Second Edition by Michael J. Rathbone,Jonathan Hadgraft,Michael S. Roberts,Majella E. Lane Pdf

This two volume Second Edition describes the anatomical, physiological, pharmaceutical, and technological aspects of oral, colonic and rectal, ocular, oral mucosal, dermal and transdermal, nasal, vaginal, and pulmonary delivery routes, providing insight and critical assessment of the many available and emerging modified release drug delivery systems for their current and future value. Topics include:

Author : Jean-Maurice Vergnaud
Publisher : CRC Press
Page : 427 pages
File Size : 47,5 Mb
Release : 1993-07-31
Category : Medical
ISBN : 9781482267358

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Controlled Drug Release Of Oral Dosage Forms by Jean-Maurice Vergnaud Pdf

Numerical analysis of matter transfer is an area that pharmacists find difficult, but which is a technique frequently used in preparing controlled drug release and oral dosage forms. A practical guide which explains how to carry out the numerical analysis of matter transfer - a vital process when examining the formulation of oral dosage forms with controlled drug release. The author models the process of drug delivery using numerical analysis and computerization.

Author : Anonim
Publisher : Springer
Page : 428 pages
File Size : 40,5 Mb
Release : 2011-09-25
Category : Electronic
ISBN : 1461410053

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Controlled Release in Oral Drug Delivery by Anonim Pdf

Author : Nikoletta Fotaki,Sandra Klein
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 50,9 Mb
Release : 2019-12-31
Category : Science
ISBN : 9781118341476

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In Vitro Drug Release Testing of Special Dosage Forms by Nikoletta Fotaki,Sandra Klein Pdf

Guides readers on the proper use of in vitro drug release methodologies in order to evaluate the performance of special dosage forms In the last decade, the application of drug release testing has widened to a variety of novel/special dosage forms. In order to predict the in vivo behavior of such dosage forms, the design and development of the in vitro test methods need to take into account various aspects, including the dosage form design and the conditions at the site of application and the site of drug release. This unique book is the first to cover the field of in vitro release testing of special dosage forms in one volume. Featuring contributions from an international team of experts, it presents the state of the art of the use of in vitro drug release methodologies for assessing special dosage forms’ performances and describes the different techniques required for each one. In Vitro Drug Release Testing of Special Dosage Forms covers the in vitro release testing of: lipid based oral formulations; chewable oral drug products; injectables; drug eluting stents; inhalation products; transdermal formulations; topical formulations; vaginal and rectal delivery systems and ophthalmics. The book concludes with a look at regulatory aspects. Covers both oral and non-oral dosage forms Describes current regulatory conditions for in vitro drug release testing Features contributions from well respected global experts in dissolution testing In Vitro Drug Release Testing of Special Dosage Forms will find a place on the bookshelves of anyone working with special dosage forms, dissolution testing, drug formulation and delivery, pharmaceutics, and regulatory affairs.

Author : Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lawrence Yu,Rao V. Mantri
Publisher : Academic Press
Page : 1178 pages
File Size : 44,7 Mb
Release : 2016-11-08
Category : Medical
ISBN : 9780128026373

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Developing Solid Oral Dosage Forms by Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lawrence Yu,Rao V. Mantri Pdf

Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more. Written and edited by an international team of leading experts with experience and knowledge across industry, academia, and regulatory settings Includes new chapters covering the pharmaceutical applications of surface phenomenon, predictive biopharmaceutics and pharmacokinetics, the development of formulations for drug discovery support, and much more Presents new case studies throughout, and a section completely devoted to regulatory aspects, including global product regulation and international perspectives

Author : Joseph R. Robinson
Publisher : Unknown
Page : 808 pages
File Size : 52,8 Mb
Release : 1978
Category : Controlled release preparations
ISBN : UOM:39015006691334

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Sustained and Controlled Release Drug Delivery Systems by Joseph R. Robinson Pdf

Author : Dey Sanjoy Kumar
Publisher : Independent Aurthor
Page : 0 pages
File Size : 41,5 Mb
Release : 2022-11-13
Category : Medical
ISBN : 1805450727

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Formulation and Evaluation of a Floating Drug Delivery System by Dey Sanjoy Kumar Pdf

The high level of patient compliance in taking oral dosage forms is due to the ease of administration and handling of these forms [1]. Development of a successful oral controlled release formulation requires an understanding of three aspects: (a) gastrointestinal physiology (b) physiochemical properties of the drug and (c) dosage form characteristics [2]. In the development of oral controlled drug delivery system, one of the main challenges is to modify the GI transit time [1]. Using controlled release technology, oral delivery for 24 h(hours) is possible for many drugs; however, the substance must be well absorbed throughout the whole gastrointestinal tract. A significant obstacle may arise if there is a narrow window for drug absorption in the gastro intestinal tract (GIT), if a stability problem exists in gastrointestinal fluids, or the drug is poorly soluble in the intestine or acts locally in the stomach. Thus, the real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of the drugs for more than 12 h, but to prolong the presence of the dosage forms in the stomach or somewhere in the upper intestine until the entire drug is released over the desired period of time [3].

Author : Jeremy C. Wright,Diane J. Burgess
Publisher : Springer Science & Business Media
Page : 560 pages
File Size : 48,8 Mb
Release : 2012-01-29
Category : Medical
ISBN : 9781461405542

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Long Acting Injections and Implants by Jeremy C. Wright,Diane J. Burgess Pdf

Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.

Author : Ali R. Rajabi-Siahboomi
Publisher : Springer
Page : 396 pages
File Size : 46,6 Mb
Release : 2017-05-26
Category : Medical
ISBN : 9781493970124

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Multiparticulate Drug Delivery by Ali R. Rajabi-Siahboomi Pdf

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery. The book will cover market trends, potential benefits and formulation challenges for various types of multiparticulate systems. Drug solubility, dose, chemistry and therapeutic indications as well as excipient suitability coupled with manufacturing methods will be fully covered. Key approaches for taste-masking, delayed release and extended release of multiparticulates systems are of significant interest, especially their in-vivo and in-vitro performance. In addition, the principles of scale-up, QbD, and regulatory aspects of common materials used in this technology will be explained, as well as recent advances in materials and equipment enabling robust, flexible and cost-effective manufacture. Case studies illustrating best practices will also make the book a valuable resource to pharmaceutical scientists in industry and academia.

Author : Ron Liu
Publisher : CRC Press
Page : 686 pages
File Size : 44,8 Mb
Release : 2008-01-18
Category : Medical
ISBN : 9781420009552

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Water-Insoluble Drug Formulation by Ron Liu Pdf

Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone, or completely derail, important new drug development. Even much-needed reformulation of currently marketed products can be significantly affected by these challenges. Water Insolubility is the Primary Culprit in over 40% of New Drug Development Failures The most comprehensive resource on the topic, this second edition of Water Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the text also features six brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behavior, early phase formulation strategies, lipid based systems for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.

Author : Fang Liu
Publisher : Smithers Rapra
Page : 172 pages
File Size : 53,5 Mb
Release : 2011-12-31
Category : Medical
ISBN : 9781847355386

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Update on Polymers for Oral Drug Delivery by Fang Liu Pdf

The preferred route for drug delivery remains the oral route, but oral drug delivery has now developed beyond traditional dosage forms such as tablets and capsules. Nowadays it is possible to use polymers to allow drugs to be targeted to specific sites in the gastrointestinal tract, and to extend the drug release profile. In addition, polymers can be engineered to allow oral delivery of such complex molecules as proteins, peptides, and even genes. This book gives a comprehensive summary of oral drug delivery systems, both conventional and novel, and the ways in which polymers have been adapted for these systems. Particular attention is devoted to gastrointestinal physiology and the physio-chemical properties of polymers in order to understand the factors affecting their performance in practice. This update will interest everyone involved in the pharmaceutical world, whether in academia or in industry. It will be of particular value to those responsible for designing new oral drug delivery systems involving polymers. It will provide a useful reference text both for researchers and manufacturers, and will also be a helpful introduction for students of all levels to the application of polymers in pharmacy.