Non Invasive Monitoring Of Transdermal Drug Delivery

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Non-Invasive Monitoring of Transdermal Drug Delivery

Pasquale Arpaia,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino
Non Invasive Monitoring of Transdermal Drug Delivery Book PDF

Author : Pasquale Arpaia,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino
Publisher : CRC Press
Page : 192 pages
File Size : 49,8 Mb
Release : 2022-03-23
Category : Medical
ISBN : 9781000544855

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Non-Invasive Monitoring of Transdermal Drug Delivery by Pasquale Arpaia,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino Pdf

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Transdermal Drug Delivery Systems

Jonathan Hadgraft
Transdermal Drug Delivery Systems Book PDF

Author : Jonathan Hadgraft
Publisher : CRC Press
Page : 328 pages
File Size : 42,5 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 0367395703

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Transdermal Drug Delivery Systems by Jonathan Hadgraft Pdf

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulatory approval.

Non-Invasive Monitoring of Transdermal Drug Delivery

Pasquale Arpaia,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino
Non Invasive Monitoring of Transdermal Drug Delivery Book PDF

Author : Pasquale Arpaia,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino
Publisher : CRC Press
Page : 203 pages
File Size : 55,6 Mb
Release : 2022-03-23
Category : Medical
ISBN : 9781000544848

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Non-Invasive Monitoring of Transdermal Drug Delivery by Pasquale Arpaia,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino Pdf

The book presents an innovative technology based on injection of a very weak current to trace the quantity of a drug carried immediately after the administration. The book makes the reader familiar with the technology, from the conception through the design of the instrument, up to the preliminary clinical applications. In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are presented. The second chapter describes a screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. The prototyping, validation and characterization of an instrument to measure the amount of drug delivered (DUSM: Drug Under Skin Meter) are presented in chapter three. In the fourth chapter three experimental campaigns, based on the electrical analysis of the biological tissue behavior due to the drug delivery, are reported: (i) laboratory emulation on eggplants, (ii) ex-vivo tests on pig ears, and finally (iii) in-vivo tests on human volunteers. In the fifth chapter a behavioral model, based on Finite Elements and Partial Differential Equation, of an impedance-based measurement system for assessing the drug released under the skin, during transdermal delivering, is proposed. The last chapter is dedicated to present a campaign in order to prove the suitability for insulin therapy applications. This book is intended for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians of transdermal vehiculation.

Handbook of Non-Invasive Drug Delivery Systems

Vitthal S. Kulkarni
Handbook of Non Invasive Drug Delivery Systems Book PDF

Author : Vitthal S. Kulkarni
Publisher : Elsevier
Page : 328 pages
File Size : 42,5 Mb
Release : 2009-12-31
Category : Medical
ISBN : 0815520263

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Handbook of Non-Invasive Drug Delivery Systems by Vitthal S. Kulkarni Pdf

With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Handbook of Non-invasive Drug Delivery Systems

Vitthal S. Kulkarni
Handbook of Non invasive Drug Delivery Systems Book PDF

Author : Vitthal S. Kulkarni
Publisher : William Andrew Pub
Page : 301 pages
File Size : 42,6 Mb
Release : 2009
Category : Medical
ISBN : 0815520255

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Handbook of Non-invasive Drug Delivery Systems by Vitthal S. Kulkarni Pdf

With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Microneedles for Drug and Vaccine Delivery and Patient Monitoring

Ryan F. Donnelly,Thakur Raghu Raj Singh,Eneko Larrañeta,Maeliosa T.C. McCrudden
Microneedles for Drug and Vaccine Delivery and Patient Monitoring Book PDF

Author : Ryan F. Donnelly,Thakur Raghu Raj Singh,Eneko Larrañeta,Maeliosa T.C. McCrudden
Publisher : John Wiley & Sons
Page : 352 pages
File Size : 51,8 Mb
Release : 2018-06-04
Category : Science
ISBN : 9781119305170

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Microneedles for Drug and Vaccine Delivery and Patient Monitoring by Ryan F. Donnelly,Thakur Raghu Raj Singh,Eneko Larrañeta,Maeliosa T.C. McCrudden Pdf

Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.

Imaging Technologies and Transdermal Delivery in Skin Disorders

Chenjie Xu,Xiaomeng Wang,Manojit Pramanik
Imaging Technologies and Transdermal Delivery in Skin Disorders Book PDF

Author : Chenjie Xu,Xiaomeng Wang,Manojit Pramanik
Publisher : John Wiley & Sons
Page : 498 pages
File Size : 46,9 Mb
Release : 2020-03-09
Category : Science
ISBN : 9783527344604

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Imaging Technologies and Transdermal Delivery in Skin Disorders by Chenjie Xu,Xiaomeng Wang,Manojit Pramanik Pdf

Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical presentations, pathophysiological mechanisms, and current clinical practices used to treat diseases affecting the skin are then introduced. Common preclinical models used for studying the mechanisms of diverse skin diseases, validation of novel therapeutic targets, and screening of new drugs to treat these diseases are also covered. The book examines the latest imaging technologies for understanding in vivo skin changes, as well as technologies such as high-resolution ultrasound imaging, quantitative Magnetic Resonance Imaging, high-resolution Optical Coherence Tomography, and emerging hybrid-imaging modalities. It concludes with chapters introducing emerging drug delivery technologies and potential future innovative developments. * Presents up-to-date knowledge of the skin biology and pathologies * Introduces advancements in the topic of imaging technology for tracing the drug delivery process, which is rarely systematically reported by other counterparts * Covers the latest development in three inter-related directions of drug delivery, imaging, and skin disease intersect for skin research * Provides an overview of the latest development of diagnostic and therapeutic technologies for skin diseases Imaging Technologies and Transdermal Delivery in Skin Disorders will be of great interest to analytical chemists, materials scientists, pharmaceutical chemists, clinical chemists, biotechnologists, bioengineers, cosmetics industry, and dermatologists.

Transdermal Drug Delivery

Kevin Ita
Transdermal Drug Delivery Book PDF

Author : Kevin Ita
Publisher : Academic Press
Page : 324 pages
File Size : 41,5 Mb
Release : 2020-06-12
Category : Business & Economics
ISBN : 9780128225516

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Transdermal Drug Delivery by Kevin Ita Pdf

Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful. Captures the most recent advancements and challenges in the field of transdermal drug delivery Covers both passive and active transdermal drug delivery strategies Explores a selection of state-of-the-art transdermal drug delivery systems

Handbook of Cosmetic Science and Technology

André O. Barel,Marc Paye,Howard I. Maibach
Handbook of Cosmetic Science and Technology Book PDF

Author : André O. Barel,Marc Paye,Howard I. Maibach
Publisher : CRC Press
Page : 1040 pages
File Size : 55,9 Mb
Release : 2005-11-04
Category : Medical
ISBN : 9780849354830

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Handbook of Cosmetic Science and Technology by André O. Barel,Marc Paye,Howard I. Maibach Pdf

Ranging from studies on the structure and function of the skin to research on a wide array of cosmetic compounds, this Second Edition updates readers on the latest regulatory guidelines, new cosmetic ingredients, state-of-the-art safety assessment technologies, and anticipated trends in the market-keeping pace with rapid advancements in chemistry, physics, biology, cosmetology, and toxicology to stand alone as the foremost guide to the subject.

Skin Barrier Function

T. Agner
Skin Barrier Function Book PDF

Author : T. Agner
Publisher : Karger Medical and Scientific Publishers
Page : 164 pages
File Size : 40,9 Mb
Release : 2016-02-04
Category : Medical
ISBN : 9783318055863

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Skin Barrier Function by T. Agner Pdf

Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.

Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement

Nina Dragicevic,Howard I. Maibach
Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement Book PDF

Author : Nina Dragicevic,Howard I. Maibach
Publisher : Springer
Page : 496 pages
File Size : 47,6 Mb
Release : 2017-05-04
Category : Medical
ISBN : 9783662532737

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Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement by Nina Dragicevic,Howard I. Maibach Pdf

Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, and also students.​

Toxicology of the Skin

Nancy A. Monteiro-Riviere
Toxicology of the Skin Book PDF

Author : Nancy A. Monteiro-Riviere
Publisher : CRC Press
Page : 450 pages
File Size : 51,8 Mb
Release : 2010-02-17
Category : Medical
ISBN : 9781420079180

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Toxicology of the Skin by Nancy A. Monteiro-Riviere Pdf

This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr

Dermatokinetics of Therapeutic Agents

S. Narasimha Murthy
Dermatokinetics of Therapeutic Agents Book PDF

Author : S. Narasimha Murthy
Publisher : CRC Press
Page : 228 pages
File Size : 48,6 Mb
Release : 2011-04-15
Category : Medical
ISBN : 9781439804780

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Dermatokinetics of Therapeutic Agents by S. Narasimha Murthy Pdf

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents. Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents Drug Delivery Approaches to Modulate Dermatokinetics of Drugs Conventional Methods of Cutaneous Drug Sampling Cutaneous Microdialysis Sampling Substrates by Skin Permeabilization Spectroscopic Techniques in Dermatokinetics Studies Regulatory Perspective of Dermatokinetic Studies

Focal Controlled Drug Delivery

Abraham J. Domb,Wahid Khan
Focal Controlled Drug Delivery Book PDF

Author : Abraham J. Domb,Wahid Khan
Publisher : Springer Science & Business Media
Page : 700 pages
File Size : 46,5 Mb
Release : 2014-02-17
Category : Medical
ISBN : 9781461494348

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Focal Controlled Drug Delivery by Abraham J. Domb,Wahid Khan Pdf

The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

CMBEBIH 2017

Almir Badnjevic
CMBEBIH 2017 Book PDF

Author : Almir Badnjevic
Publisher : Springer
Page : 806 pages
File Size : 55,5 Mb
Release : 2017-03-14
Category : Technology & Engineering
ISBN : 9789811041662

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CMBEBIH 2017 by Almir Badnjevic Pdf

This volume presents the proceedings of the International Conference on Medical and Biological Engineering held from 16 to 18 March 2017 in Sarajevo, Bosnia and Herzegovina. Focusing on the theme of ‘Pursuing innovation. Shaping the future’, it highlights the latest advancements in Biomedical Engineering and also presents the latest findings, innovative solutions and emerging challenges in this field. Topics include: - Biomedical Signal Processing - Biomedical Imaging and Image Processing - Biosensors and Bioinstrumentation - Bio-Micro/Nano Technologies - Biomaterials - Biomechanics, Robotics and Minimally Invasive Surgery - Cardiovascular, Respiratory and Endocrine Systems Engineering - Neural and Rehabilitation Engineering - Molecular, Cellular and Tissue Engineering - Bioinformatics and Computational Biology - Clinical Engineering and Health Technology Assessment - Health Informatics, E-Health and Telemedicine - Biomedical Engineering Education - Pharmaceutical Engineering