Update On Polymers For Oral Drug Delivery

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Update on Polymers for Oral Drug Delivery

Author : Fang Liu
Publisher : Smithers Rapra
Page : 172 pages
File Size : 45,6 Mb
Release : 2011-12-31
Category : Medical
ISBN : 9781847355386

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Update on Polymers for Oral Drug Delivery by Fang Liu Pdf

The preferred route for drug delivery remains the oral route, but oral drug delivery has now developed beyond traditional dosage forms such as tablets and capsules. Nowadays it is possible to use polymers to allow drugs to be targeted to specific sites in the gastrointestinal tract, and to extend the drug release profile. In addition, polymers can be engineered to allow oral delivery of such complex molecules as proteins, peptides, and even genes. This book gives a comprehensive summary of oral drug delivery systems, both conventional and novel, and the ways in which polymers have been adapted for these systems. Particular attention is devoted to gastrointestinal physiology and the physio-chemical properties of polymers in order to understand the factors affecting their performance in practice. This update will interest everyone involved in the pharmaceutical world, whether in academia or in industry. It will be of particular value to those responsible for designing new oral drug delivery systems involving polymers. It will provide a useful reference text both for researchers and manufacturers, and will also be a helpful introduction for students of all levels to the application of polymers in pharmacy.

Engineering Polymer Systems for Improved Drug Delivery

Author : Rebecca A. Bader,David A. Putnam
Publisher : John Wiley & Sons
Page : 395 pages
File Size : 51,6 Mb
Release : 2014-01-17
Category : Social Science
ISBN : 9781118747803

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Engineering Polymer Systems for Improved Drug Delivery by Rebecca A. Bader,David A. Putnam Pdf

Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.

Polymers for Oral Drug Delivery Technologies

Author : Anilkumar Parambath
Publisher : Elsevier
Page : 0 pages
File Size : 45,8 Mb
Release : 2024-08-01
Category : Medical
ISBN : 9780443137754

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Polymers for Oral Drug Delivery Technologies by Anilkumar Parambath Pdf

Oral delivery?is the most preferred route of the delivery of therapeutics for treating a number of diseases. The challenge of oral drug administration is to assure a predictive and reproducible pharmacokinetic profile of the active pharmaceutical ingredient (API). Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract. This book is divided into two parts, covering the fundamentals of oral drug delivery and the various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. Provides a comprehensive update on the state of polymer technology for oral drug delivery, bringing the reader up-to-speed via a single reference. Covers a range of polymer technology types, including capsule forming polymers, matrix formers, functional polymer coatings and more. Contributions from global experts spanning both academia and industry, offering an interdisciplinary and translational approach to polymers for oral drug delivery.

Update on Polymers for Pulmonary Drug Delivery

Author : Hugh D. C Smyth
Publisher : Smithers Rapra
Page : 302 pages
File Size : 40,8 Mb
Release : 2013-04-30
Category : Medical
ISBN : 9781847356550

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Update on Polymers for Pulmonary Drug Delivery by Hugh D. C Smyth Pdf

Pulmonary drug delivery has been a rapidly expanding field, moving from the traditional propellant based metered dose inhaler delivery of small asthma drugs, to a broader landscape of new devices and novel drugs for local and systemic delivery. The field has greatly expanded yet the tools for pulmonary drug delivery systems have not kept pace with the potential applications. One of the key developments has been the use of polymers to achieve better control of pulmonary drug delivery. This has the potential to expand the toolbox available for researchers in the field to deliver their new chemical entities successfully to the lung. This book reviews the use of polymers in pulmonary drug delivery, encompassing polymers from their use in devices and packaging, in addition to their use as excipients in formulations delivered to the airways. The book is arranged by application and extensively reviews the technical and patent literature. This is the first volume totally dedicated to polymers in pulmonary drug delivery and should be the resource of choice for those in the field, especially managers in the pharma/biotech industry. Naturally, the text will be of great interest to academics and graduate students. Finally, regulatory affiliated scientists will also find this resource invaluable.

Applications of Polymers in Drug Delivery

Author : Ambikanandan Misra,Aliasgar Shahiwala
Publisher : Elsevier
Page : 594 pages
File Size : 46,7 Mb
Release : 2020-10-02
Category : Technology & Engineering
ISBN : 9780128226681

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Applications of Polymers in Drug Delivery by Ambikanandan Misra,Aliasgar Shahiwala Pdf

Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. Explains how polymers can be prepared and utilized for all major drug delivery routes Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects

Polymers for Controlled Drug Delivery

Author : Peter J. Tarcha
Publisher : CRC Press
Page : 300 pages
File Size : 54,5 Mb
Release : 1990-11-21
Category : Medical
ISBN : 0849356520

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Polymers for Controlled Drug Delivery by Peter J. Tarcha Pdf

Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.

Controlled Release in Oral Drug Delivery

Author : Clive G. Wilson,Patrick J. Crowley
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 44,9 Mb
Release : 2011-09-22
Category : Medical
ISBN : 1461410045

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Controlled Release in Oral Drug Delivery by Clive G. Wilson,Patrick J. Crowley Pdf

Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.

Pharmaceutical Applications of Polymers for Drug Delivery

Author : David Jones
Publisher : iSmithers Rapra Publishing
Page : 138 pages
File Size : 53,5 Mb
Release : 2004
Category : Medical
ISBN : 1859574793

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Pharmaceutical Applications of Polymers for Drug Delivery by David Jones Pdf

Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.

Natural Polymers for Pharmaceutical Applications

Author : Amit Kumar Nayak,Md Saquib Hasnain,Dilipkumar Pal
Publisher : CRC Press
Page : 186 pages
File Size : 47,6 Mb
Release : 2019-10-16
Category : Business & Economics
ISBN : 9781000586824

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Natural Polymers for Pharmaceutical Applications by Amit Kumar Nayak,Md Saquib Hasnain,Dilipkumar Pal Pdf

This new volume, Natural Polymers for Pharmaceutical Applications, Volume 1: Plant-Derived Polymers, presents some of the latest research on the applications of natural polymers in drug delivery and therapeutics for healthcare benefits. Polymers and their applications from several plants are discussed in depth, including tamarind gum, gum Arabic, natural carbohydrate polymer gum tragacanth, pectin, guar gum and its derivatives, locust bean gum, sterculia gum, okra gum, and others. The use of the polymers derived from plants as potential pharmaceutical excipients is expanding day by day because of their stability in the biological system, drug-releasing capability, drug-targeting abilities, as well as their bioavailability.

Polymers in Drug Delivery

Author : Ijeoma F. Uchegbu,Andreas G. Schatzlein
Publisher : CRC Press
Page : 426 pages
File Size : 54,6 Mb
Release : 2006-05-19
Category : Medical
ISBN : 9781000611243

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Polymers in Drug Delivery by Ijeoma F. Uchegbu,Andreas G. Schatzlein Pdf

Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera

Chitosan in Drug Delivery

Author : Md Saquib Hasnain,Sarwar Beg,Amit Kumar Nayak
Publisher : Academic Press
Page : 557 pages
File Size : 51,6 Mb
Release : 2021-10-26
Category : Medical
ISBN : 9780128193372

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Chitosan in Drug Delivery by Md Saquib Hasnain,Sarwar Beg,Amit Kumar Nayak Pdf

Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery. Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan

Polymeric Drug Delivery Systems

Author : Glen S. Kwon
Publisher : CRC Press
Page : 680 pages
File Size : 50,8 Mb
Release : 2005-04-12
Category : Medical
ISBN : 0824725328

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Polymeric Drug Delivery Systems by Glen S. Kwon Pdf

Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

Oral Drug Delivery for Modified Release Formulations

Author : Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts
Publisher : John Wiley & Sons
Page : 516 pages
File Size : 50,7 Mb
Release : 2022-04-26
Category : Medical
ISBN : 9781119772699

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Oral Drug Delivery for Modified Release Formulations by Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts Pdf

ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation’s oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC) Explains the different types of MR formulations and defines the key terms used in the field Discusses the present status of MR technologies and identifies current gaps in research Includes a summary of regulatory guidelines from both the US and the EU Shares industrial experiences and perspectives on the evaluation of MR dosage formulations Oral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Modeling and Control of Drug Delivery Systems

Author : Ahmad Taher Azar
Publisher : Academic Press
Page : 410 pages
File Size : 40,9 Mb
Release : 2021-02-06
Category : Technology & Engineering
ISBN : 9780128211953

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Modeling and Control of Drug Delivery Systems by Ahmad Taher Azar Pdf

Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Advanced Biopolymeric Systems for Drug Delivery

Author : Amit Kumar Nayak,Md Saquib Hasnain
Publisher : Springer Nature
Page : 390 pages
File Size : 45,7 Mb
Release : 2020-07-11
Category : Technology & Engineering
ISBN : 9783030469238

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Advanced Biopolymeric Systems for Drug Delivery by Amit Kumar Nayak,Md Saquib Hasnain Pdf

This book discusses the recent innovations in the development of various advanced biopolymeric systems, including gels, in situ gels, hydrogels, interpenetrating polymer networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers, stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric micelles, dendrimers, liposomes and scaffolds. It also examines their applications in drug delivery.