Paraoxonases In Inflammation Infection And Toxicology

Author : Srinivasa T. Reddy
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 49,9 Mb
Release : 2010-03-11
Category : Science
ISBN : 9781607613503

Get Book

Paraoxonases in Inflammation, Infection, and Toxicology by Srinivasa T. Reddy Pdf

The pivotal role of the Paraoxonases (PON) family in a variety of inflammatory diseases, e.g. atherosclerosis, in preventing the toxicity of organophosphorus insecticides and nerve agents and a variety of other compounds has made them an interesting target for both clinicians and scientists alike. Research into the paraoxonase (PON) family of enzymes (PON1, PON2 and PON3) has increased exponentially over the last five years especially following the initiation of paraoxonase conferences.The objectives of the 3rd ICP remains the same as the previous two conferences: to disseminate the latest aspects of research into the genetics, biochemistry, structural biology, regulation of PONs and their roles in inflammatory diseases e.g. atherosclerosis with expert lectures from 20 invited plenary lecturers and another 30-40 short and poster presentations from young investigators.The conference organizers anticipate a global attendance at the conference of between 150- 200 persons. Particular aspects of this conference will include the Bert N La Du Memorial Lecture, 3 Memorial Traveling Fellowships for Young Investigators and a round table discussion on the impact of the latest research on PON. UCLA provides a great venue for students, postdoctoral fellows and clinical scientists to interact with experts in the PON fields of study. The explosion of research into the PON family makes this a timely conference to review recent exciting advances in the field and provide an environment for cross-fertilization of ideas, particularly important for researchers new to the field.

Author : Srinivasa T. Reddy
Publisher : Humana Press
Page : 212 pages
File Size : 51,8 Mb
Release : 2010-10-21
Category : Science
ISBN : 1607613514

Get Book

Paraoxonases in Inflammation, Infection, and Toxicology by Srinivasa T. Reddy Pdf

Author : Ramesh C Gupta
Publisher : Academic Press
Page : 1322 pages
File Size : 40,9 Mb
Release : 2020-03-31
Category : Science
ISBN : 9780128190913

Get Book

Handbook of Toxicology of Chemical Warfare Agents by Ramesh C Gupta Pdf

Handbook of Toxicology of Chemical Warfare Agents, Third Edition, covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, and countermeasures. Expanding on the second edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a new chapter on emergency preparedness, coverage of the chemical warfare agents used in Syria, the use of the Novichok agent in the UK, and more. Unites world-leading experts to bring you cutting-edge, agent-specific information on Chemical Warfare Agents (CWA) and their adverse effects on human and animal health, and the environment Provides you with all the information you need on CWA modes of action, detection, prevention, therapeutic treatment and countermeasures New to this edition: a full update to reflect the most recent advances in the field and new chapters on emergency preparedness, the chemical warfare agents used in Syria, and the use of the Novichok agent in the UK

Author : Jordi Camps
Publisher : Springer
Page : 223 pages
File Size : 54,7 Mb
Release : 2014-07-19
Category : Medical
ISBN : 9783319073200

Get Book

Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics by Jordi Camps Pdf

Oxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress and Inflammation in Non-communicable Diseases: Molecular Mechanisms and Perspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine.

Author : Shannon Marie Murray,Paul Urquhart Cameron
Publisher : Frontiers Media SA
Page : 170 pages
File Size : 48,8 Mb
Release : 2020-12-09
Category : Medical
ISBN : 9782889661671

Get Book

The Role of Dendritic Cells and Monocytes in HIV Infection by Shannon Marie Murray,Paul Urquhart Cameron Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Hong Wang,Cam Patterson
Publisher : John Wiley & Sons
Page : 608 pages
File Size : 44,8 Mb
Release : 2015-03-10
Category : Science
ISBN : 9781118828519

Get Book

Atherosclerosis by Hong Wang,Cam Patterson Pdf

Comprehensive and in-depth in itscoverage, Atherosclerosis: Cellular, Molecular &Biochemical Mechanism and Novel Therapy reviews the recentprogress in atherosclerosis research and offers cutting edgeperspectives from experts in the field. Written by an internationalteam of authors including leading physician-scientists, researchexperts and physicians, chapters are divided into four majorsections, covering risk factors, cellular and molecular mechanisms,biochemical mechanisms and novel and future therapeutics. Atherosclerosis: Cellular, Molecular & BiochemicalMechanism and Novel Therapy analyses recent progress from bothconceptual and technological perspectives, suggesting newdirections for atherosclerosis research and treatment for a growingpopulation of researchers and clinicians in cardiovascular andrelated fields.

Author : Ola Nosseir,Christopher Hadad
Publisher : American Chemical Society
Page : 210 pages
File Size : 49,7 Mb
Release : 2021-02-24
Category : Science
ISBN : 9780841299108

Get Book

Chemical Warfare Agents and Treatments by Ola Nosseir,Christopher Hadad Pdf

For centuries, nations, armies and civilians have used toxic chemicals for nefarious purposes. Although forbidden from use during warfare, chemical weapons have an unfortunately long history of use as chemical agents of destruction. Accidental or intentional exposure of civilians to toxic chemicals frequently occurs. Chemical Warfare Agents & Treatments provides an overview of different classes of chemical warfare agents, starting from the extremely toxic organophosphorus nerve agents, followed by blister agents, blood agents, pulmonary agents, and incapacitating agents, and finally ending with the least toxic class, riot control agents. The e-book covers the physiological effects caused by these agents, the underlying mechanisms of action, and the available medical treatments (as of the writing of this work).

Author : Anonim
Publisher : Elsevier
Page : 396 pages
File Size : 55,9 Mb
Release : 2024-08-01
Category : Science
ISBN : 9780443297038

Get Book

Advances in Clinical Chemistry by Anonim Pdf

Advances in Clinical Chemistry, Volume 121, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians, and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory

Author : Padraic G. Fallon
Publisher : Springer Science & Business Media
Page : 200 pages
File Size : 44,6 Mb
Release : 2010-05-30
Category : Medical
ISBN : 9781441916013

Get Book

Pathogen-Derived Immunomodulatory Molecules by Padraic G. Fallon Pdf

Pathogen-Derived Immunomodulatory Molecules is a book title that may require some explanation. Pathogens that are present today have evolved following a long association with man and have developed unique strategies that have been optimized by natural selection to subvert the host immunity. As we approach the 200th anniversary of Charles Darwin’s birth, it is appropriate to appreciate that Darwin recognized that pathogens (infections) play a significant and potent role in natural selection, encompassed by the concept “infection begets natural selection”. This book therefore examines the molecules that pathogens produce, which can modulate or usurp the functions of the immune system. The idea of using molecules from pathogens as a therapeutic is an ancient concept in medicine. Such a strategy is exemplified by vaccination, with pathogen molecules employed to induce protective immunity against the given or related species of pathogen. The following chapters explore the concept of using pathogen-derived immune modulating molecules as a therapy. In doing so, they may provide the drug cabinet of the future for treating a spectrum of unrelated disease. Herein, a range of immune modulating molecules or strategies from various pathogens is examined in one volume. The intention of the book was to have chapters addressing immunomodulating molecules from different pathogens. The range of pathogens considered includes bacteria (chapters by Williams, van Strijp and Rooijakkers), viruses (chapters by Bowie, McFadden), protozoan parasites (Aliberti), helminths (Harnett, Fallon), fungi (Sorrell) and parasitic ticks (Anguita). Chapters also address specific immunomodulatory molecules or strategies. The diversity of aspects addressed in the book is highlighted by Lucas and colleagues review of the ‘saga’ of viral serine proteinase inhibitors, with a focus on Serp-1, the first new generation of pathogen immunomodulatory molecule currently in clinical trials. While Elliott and Weinstock have contributed a provocative chapter exploring the use of live parasitic helminth infections as a therapeutic strategy for immune-mediated diseases; indeed trials have already been completed for such an approach. With respect to pathogens usurping an immune pathway, Alcami and colleagues here reviewed the growing number of pathogens that have evolved a range of molecules that can modify many aspects of the chemokine system. This book is timely due to the need to expand the horizons of conventional drug discovery. A trend in the biopharmaceutical pipeline of fewer drugs to market is illustrated by USA FDA in 2007 approving the lowest number of new molecular entities since 1983. As the drug discovery and development industry broadens its search for new drugs to less traditional strategies, this book will be a reference to the potential for exploiting pathogen as a source of the anti-inflammatory drugs of the future. Finally, this book whets the appetite for the reader, whether in academia or industry, to explore opportunities for exploiting pathogens for the discovery of new processes in immunobiology and, ultimately, for development of new therapies for human inflammatory diseases.

Author : Kenneth Maiese
Publisher : Springer Science & Business Media
Page : 283 pages
File Size : 47,5 Mb
Release : 2010-07-29
Category : Medical
ISBN : 9781441915993

Get Book

Forkhead Transcription Factors by Kenneth Maiese Pdf

Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potential of forkhead transcription factors for new therapeutic avenues in multiple disciplines.

Author : Robert E. Anderson,Joe G. Hollyfield,Matthew M LaVail
Publisher : Springer Science & Business Media
Page : 715 pages
File Size : 41,5 Mb
Release : 2010-03-19
Category : Medical
ISBN : 9781441913982

Get Book

Retinal Degenerative Diseases by Robert E. Anderson,Joe G. Hollyfield,Matthew M LaVail Pdf

This is the proceedings of the XIIIth International Symposium on Retinal Degenerations, which will be held in Emeishan, Sichuan, China on September 18 - 23, 2008. The themes will include "Molecular and genetic mechanisms in photoreceptor degeneration", "Age-related macular degeneration", "New diagnostic techniques for retinal degenerations". "Neuroprotection in the prevention of retinal degeneration", "Gene therapy and the correction of gene defects", as well as other emerging topics that may develop over the next few months.

Author : Jean-Francois Jeannin
Publisher : Springer Science & Business Media
Page : 145 pages
File Size : 44,6 Mb
Release : 2010-07-28
Category : Medical
ISBN : 9781441916037

Get Book

Lipid A in Cancer Therapy by Jean-Francois Jeannin Pdf

Cancer remains a major challenge for modern society. Not only does cancer rank among the first three causes of mortality in most population groups but also the therapeutic options available for most tumor types are limited. The existing ones have limited efficacy, lack specificity and their administration carry major side effects. Hence the urgent need for novel cancer therapies. One of the most promising avenues in research is the use of specific immunotherapy. The notion that the immune system may have important anti-tumor effects has been around for more than a century now. Every major progress in microbiology and immunology has been immediately followed by attempts to apply the new knowledge to the treatment of cancer. Progress has reached a point where it is well established that most cancer patients mount specific T cell responses against their tumors. The molecular identity of the antigens recognized by anti-tumor T cells has been elucidated and several hundreds of tumor-derived antigenic peptides have been discovered. Upon recognition of such peptides presented by self MHC molecules, both CD8 and CD4 T cells are activated, expand to high numbers and differentiate into effective anti-tumor agents. CD8 T cells directly destroy tumor cells and can cause even large tumors to completely regress in experimental mouse models. These observations have spurred intense research activity aimed at designing and testing cancer vaccines. Over 100 years ago Coley successfully used intratumoral injection of killed bacteria to treat sarcomas. The important anti-tumor effects observed in a fraction of these patients fueled major research efforts. These led to major discoveries in the 80s and the 90s. It turns out that bacterial lipopolysaccharides stimulate the production of massive amounts of a cytokine still known today as tumor necrosis factor (TNF-a). They do so by engagement of a rather complex set of interactions culminating in the ligation of a Toll-like receptor, TLR -4. Ensuing signaling through this receptor initiates potent innate immune responses. Unfortunately the clinical use of both TNF-a and LPS can not be generalized due to their very narrow therapeutic margin. Importantly, synthetic Lipid A analogs have been identified that retain useful bioactivity and yet possess only mild toxicity. The relatively large body of information accumulated thus far on the molecular and cellular interactions set in motion by administration of LPS as well as by the synthetic lipid A analogs allow to place this family of bacterially-derived molecules at the crossroads between innate and adaptive immunity. By virtue of this key position, the therapeutic applications being pursued aim at using these compounds either as direct anti-tumor agents or as vaccine adjuvants. The clinical experience acquired so far on these two avenues is asymmetric. Few clinical trials using Lipid A analogs as single anti-cancer agents involving less than 100 patients with advanced cancer have been reported. In contrast, lipid A has been tested in over 300,000 individuals in various vaccines trials, including therapeutic cancer vaccines. Clearly most of the work needed to develop lipid A as effective anti-cancer agents and/or as vaccine adjuvant lies ahead in the near future. This book is a timely contribution and provides a much needed up-to-date overview of the chemical, biological and physiological aspects of lipid A. It should be a beacon to all those involved in this field of research.

Author : Katalin Balogh,Attila Patocs
Publisher : Springer Science & Business Media
Page : 126 pages
File Size : 45,9 Mb
Release : 2010-07-29
Category : Medical
ISBN : 9781441916648

Get Book

SuperMEN1 by Katalin Balogh,Attila Patocs Pdf

The vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . .

Author : Anonim
Publisher : Elsevier
Page : 8639 pages
File Size : 50,5 Mb
Release : 2017-12-01
Category : Science
ISBN : 9780081006122

Get Book

Comprehensive Toxicology by Anonim Pdf

Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Author : Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram
Publisher : Springer Nature
Page : 1160 pages
File Size : 44,5 Mb
Release : 2023-01-31
Category : Medical
ISBN : 9783031073922

Get Book

Biomarkers in Toxicology by Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram Pdf

This handbook of the series Biomarkers in Disease informs comprehensively about all aspects of monitoring and detecting toxicity in the human body and model organisms. Biomarkers for assessing toxicity in diverse organs are presented and different assays and methods are explained. Single compounds and drugs and their toxicity for humans are shown and the methods for detection described. Similar to all the volumes of the Biomarkers in Disease series, the chapters are written by experts in their field, each chapter features key facts summarizing the most important aspects of its respective topic and the definitions of words and terms facilitate the reading and understanding. This handbook is a must-have for researchers in toxicology and biomedicine who analyze the effects of drugs and various other substances in the human body and in model organisms. It also serves as a thorough guide for clinicians and pharmacologists.