Supermen1

Author : Katalin Balogh,Attila Patocs
Publisher : Springer Science & Business Media
Page : 126 pages
File Size : 47,5 Mb
Release : 2010-07-29
Category : Medical
ISBN : 9781441916648

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SuperMEN1 by Katalin Balogh,Attila Patocs Pdf

The vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . .

Author : Neal Adams,Tony Bedard
Publisher : Unknown
Page : 0 pages
File Size : 48,8 Mb
Release : 2016
Category : COMICS & GRAPHIC NOVELS
ISBN : 1401265030

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Superman by Neal Adams,Tony Bedard Pdf

"From legendary writer/artist Neal Adams comes a threat so epic it will take more than one Man of Steel to handle it in this new 6-issue miniseries! Superman is facing his worst enemies as terror is taking hold of Apokolips. There's also another planet that has been deemed as the New Krypton which is facing some of this evil"--

Author : Ramkrishna Sen
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 45,9 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441959799

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Biosurfactants by Ramkrishna Sen Pdf

The microbial world has given us many surprises including microbes that grow under extremely harsh conditions (122C at 40 MPa), novel metabolisms such as the uranium and perchlorate reduction, and novel chemicals that can be used to control diseases. We continually face new and difficult problems such as the need to transition to more carbon-neutral energy sources and to find eco-friendly chemicals and to find new drugs to treat disease. Will it be possible to tap into the seemingly limitless potential of microbial activity to solve our current and future problems?The answer to this question is probably yes. We are already looking to the microbial world to provide new energy sources, green chemicals to replace those made from petroleum, and new drugs to fight disease. To help us along these paths, we are deciphering how microorganisms interact with each other. We know that microbial populations interact and communicate with each other. The language that microbes use is chemical where small molecules are exchanged among different microbial cells. Sometimes, these chemicals suppress activities of competitors and could be used as antibiotics or may have other therapeutic uses. Other times, the chemicals stimulate complex responses in microbial populations such as fruiting body or biofilm formation. By understanding the conversation that microbes are having among themselves, e. g.

Author : Rahul Jandial
Publisher : Springer Science & Business Media
Page : 150 pages
File Size : 48,8 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441958198

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Frontiers in Brain Repair by Rahul Jandial Pdf

In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the “frontiers” of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries. In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology. In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise.

Author : Andrea Becchetti,Annarosa Arcangeli
Publisher : Springer Science & Business Media
Page : 138 pages
File Size : 53,8 Mb
Release : 2010-12-28
Category : Medical
ISBN : 9781441960665

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Integrins and Ion Channels by Andrea Becchetti,Annarosa Arcangeli Pdf

Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.

Author : Jose Luis Pedraz,Gorka Orive
Publisher : Springer Science & Business Media
Page : 167 pages
File Size : 41,9 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441957863

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Therapeutic Applications of Cell Microencapsulation by Jose Luis Pedraz,Gorka Orive Pdf

The advancement of science is ever more contingent upon the interaction of experts vast amount of scientific information being gathered every day that exceeds the ability of any one scientist to acquire. As an illustration of the frantic pace of scientific disc- more acute in the case of scientific fields at the interface of different and seemingly distant areas of study. Amidst these, the field of cell encapsulation brings together an array of diverse disciplines such as molecular biology and biopolymers, gene therapy and inorganic membranes, stem cell biology and physicochemistry, immunology and nanotechnology. Clearly, such range of topics is too broad for any individual scientist the state-of-the-art in the field of cell encapsulation. At the core of this technology, there is an interaction of physicochemical and biological elements forming three distinct layers of complexity. First, the chemistry of the biopolymer dictates the degree of protein adsorption, vascularization, tox- ity and biocompatibility of the microcapsules. Advances in biopolymer science are providing solutions to overcome existing challenges and to improve microcapsules as delivery vehicles. Second, the choice of cells, and more precisely the plethora of in determining the immune response elicited by the host to implanted microcapsules.

Author : Randy Y.C. Poon
Publisher : Springer Science & Business Media
Page : 157 pages
File Size : 55,5 Mb
Release : 2011-01-11
Category : Medical
ISBN : 9781441961990

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Polyploidization and Cancer by Randy Y.C. Poon Pdf

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

Author : Edwin Michael,Robert C. Spear
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 41,5 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441960641

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Modelling Parasite Transmission and Control by Edwin Michael,Robert C. Spear Pdf

It is clear that many fascinating problems still remain to be addressed in parasite transmission modelling, from better understanding of transmission processes and natural history of infection to investigating the impact of ecological and spatial scales, climate change, host immunity and social behaviour, parasite-host evolutionary dynamics and parasite community ecology on parasite transmission. This book captures some of the advances made in recent years and provides indications of ways forward for addressing these questions by shedding light on developments in conceptual frameworks and modelling tools as well as the emergence of new data forms for aiding model construction, testing and analysis. Another important advance has been the parallel development of robust computationally-intensive statistical methods to allow model testing and parameterization by aiding the fitting of models to complex data. This is an exciting area of work, which we believe will broaden the scope of mathematical modelling in investigating parasite transmission processes. In particular, we expect this advance will now allow modellers to begin the successful development and analysis of mechanistically-rich models of parasite transmission that will facilitate better integration of the variety of mechanisms increasingly recognized as important in simultaneously affecting transmission, including abiotic processes, trophic and evolutionary interactions, movement in space, and behaviour and even physiology of the individual. We foresee a continuing bright future for using mathematical modelling to clarify parasite transmission dynamics and address problems related to effective parasite control. Ultimately, through this improved application of models to research and management, we expect that parasite control would be an achievable goal bringing benefits to a vast number of our fellow human beings.

Author : Anonim
Publisher : Unknown
Page : 1100 pages
File Size : 53,9 Mb
Release : 1970
Category : Great Britain
ISBN : SRLF:EE0000022012

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The Illustrated London News by Anonim Pdf

Author : Sterling Gates,James Robinson
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 2012-01-24
Category : Comic books, strips, etc
ISBN : 140123187X

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War of the Supermen by Sterling Gates,James Robinson Pdf

The final chapter in the critically acclaimed NEW KRYPTON storyline is collected in this hardcover featuring SUPERMAN: WAR OF THE SUPERMEN #0-4 and a page from SUPERMAN #700!

Author : Victor Zitta
Publisher : Springer
Page : 314 pages
File Size : 53,8 Mb
Release : 2013-11-27
Category : Political Science
ISBN : 9789401768122

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Georg Lukács’ Marxism Alienation, Dialectics, Revolution by Victor Zitta Pdf

Author : G.C. Paikert
Publisher : Springer Science & Business Media
Page : 333 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : History
ISBN : 9789401197175

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The Danube Swabians by G.C. Paikert Pdf

Sedulo curavi humanas actiones non rid ere , non lugere, neque detestari, sed intelligere. SPINOZA This monograph is an attempt to present some information on the fabric and patterns of an ethnic minority group whose destiny was totally deflected by Hitler and his war. The people in question are the Danube Swabians, German populations who were so called because of their habitat in the middle Danube region of east-central and south-eastern Europe. Research for this study was done in 1964 in Hungary, Yugoslavia, Austria and the Federal Republic of Germany, in which countries the author contacted persons of competence and made use of archives and other sources. He also attended the annual con vention of the Danube Swabians in July, 1964 in VIm, Germany. In fact, he himself had a small part in the events which he at tempts to analyze here. From 1934 until 1944 he served in the Hungarian Ministry of Education in Budapest and headed for some years the department for the schooling of national minorities and also the department in charge of Hungary's cultural inter change. He resigned from the former post in 1939, and was ousted from the second when German troops occupied Hungary in March, 1944. His personal recollections relating to the events during and after his tenure (he left Hungary for England in June, 1946) have been used to some extent in this study, especial ly in Chapter X.

Author : G. Wilson Knight
Publisher : Routledge
Page : 361 pages
File Size : 43,5 Mb
Release : 2022-02-10
Category : Drama
ISBN : 9781000530599

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The Golden Labyrinth by G. Wilson Knight Pdf

First published in 1965, The Golden Labyrinth provides a coherent and readable history of the essential nature of British drama in a single volume. The treatment is philosophical and imaginative, and full of enthusiasm and clarity which have made Professor Wilson Knight’s works, of Shakespearian and other interpretations, so famous. The chapters in this book have been organized according to literary periods and will appeal to both students of literature and casual readers.

Author : James Holland
Publisher : Grove Press
Page : 488 pages
File Size : 50,9 Mb
Release : 2024-06-11
Category : History
ISBN : 9780802160591

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Burma '44 by James Holland Pdf

Celebrated historian of World War II James Holland chronicles the astonishing Allied victory at the Battle of the Admin Box in Burma (now Myanmar), a turning point of the war in the Far East In February 1944, in one of the most astonishing battles of World War II, a ragtag collection of British clerks, drivers, doctors, muleteers, and other base troops, stiffened by a few dogged Yorkshiremen and a handful of tank crews, managed to defeat a much larger and sophisticated contingent of some of the finest infantry in the Japanese army on their march towards India. What became known as the Battle of the Admin Box, fought amongst the paddy fields and jungle of Northern Arakan over a fifteen-day period, turned the battle for Burma. Not only was it the first decisive victory for Allied troops against the Japanese, more significantly, it demonstrated how the Japanese could be defeated. Lessons learned in this otherwise insignificant corner of the Far East set up the campaign in Burma that would follow, as General William Slim’s Fourteenth Army finally turned the tide of the war in the East. In Burma ’44, acclaimed World War II historian James Holland offers a dramatic tale of victory against incredible odds. As momentous as the Battle of the Bulge ten months later, the Admin Box was a triumph of human grit and heroism and remains one of the most significant yet underappreciated conflicts of the entire war. In Holland’s hands, it is finally given its proper place in the history of World War II.

Author : Jess Nevins
Publisher : Bloomsbury Publishing USA
Page : 420 pages
File Size : 46,9 Mb
Release : 2017-01-30
Category : Comics & Graphic Novels
ISBN : 9781440854842

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The Evolution of the Costumed Avenger by Jess Nevins Pdf

Using a broad array of historical and literary sources, this book presents an unprecedented detailed history of the superhero and its development across the course of human history. How has the concept of the superhero developed over time? How has humanity's idealization of heroes with superhuman powers changed across millennia—and what superhero themes remain constant? Why does the idea of a superhero remain so powerful and relevant in the modern context, when our real-life technological capabilities arguably surpass the imagined superpowers of superheroes of the past? The Evolution of the Costumed Avenger: The 4,000-Year History of the Superhero is the first complete history of superheroes that thoroughly traces the development of superheroes, from their beginning in 2100 B.C.E. with the Epic of Gilgamesh to their fully entrenched status in modern pop culture and the comic book and graphic novel worlds. The book documents how the two modern superhero archetypes—the Costumed Avengers and the superhuman Supermen—can be traced back more than two centuries; turns a critical, evaluative eye upon the post-Superman history of the superhero; and shows how modern superheroes were created and influenced by sources as various as Egyptian poems, biblical heroes, medieval epics, Elizabethan urban legends, Jacobean masques, Gothic novels, dime novels, the Molly Maguires, the Ku Klux Klan, and pulp magazines. This work serves undergraduate or graduate students writing papers, professors or independent scholars, and anyone interested in learning about superheroes.