Pathophysiology Of Ischemia Reperfusion Injury And Use Of Fingolimod In Cardioprotection

Author : Naseer Ahmed
Publisher : Academic Press
Page : 140 pages
File Size : 55,7 Mb
Release : 2019-05-30
Category : Science
ISBN : 9780128182536

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Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection by Naseer Ahmed Pdf

Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is a deep examination into the mechanisms of myocardial ischemiareperfusion injury and role of fingolimod as a cardioprotective agent through its antioxidant, anti-apoptotic and anti-inflammatory effects. Dr. Ahmed explore the physiology and pathophysiology of myocardial metabolism under normal and ischemic conditions and focused on pharmacological cardioprotection. They provide a concise, yet rigorous discussion of Ischemia-Reperfusion Injury, Myocardial Ischemia during Circulatory Arrest, Myocardial Reperfusion, Myocardial Protection related to Ischemia-Reperfusion Injury and Role of Fingolimod in Cardioprotection. Pathophysiology of Ischemia-Reperfusion Injury and Use of Fingolimod in Cardioprotection is ideal for researchers, cardiovascular scientists, and clinical pharmacologists to further work in this challenging area and apply this knowledge to clinical trials for cardioprotection. Provides detailed and critical analysis of the latest research in the field from molecular basis to potential clinical relevance Examines the effect of fingolimod/sphingosine 1-phosphate in cardioprotection, pointing to future myocardial preventative strategies

Author : Derek Hausenloy,Derek Yellon
Publisher : OUP Oxford
Page : 144 pages
File Size : 44,8 Mb
Release : 2009-08-20
Category : Medical
ISBN : 9780191575488

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Cardioprotection by Derek Hausenloy,Derek Yellon Pdf

Coronary heart disease (CHD) is the leading cause of death worldwide with 3.8 million men and 3.4 million women dying each year. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems. This book focuses on the role of cardioprotection in surgery and the use of pharmacological therapies such as ACE-inhibitors, statins and beta-blockers in order to reduce the myocardial injury sustained by the patient and the significant risk of morbidity and mortality. It includes new cardioprotective strategies aimed at improving the clinical outcomes of patients in these settings, as well as current well-established methods for reducing myocardial injury in acute coronary syndrome patients.

Author : Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang
Publisher : Springer
Page : 259 pages
File Size : 53,9 Mb
Release : 2018-06-29
Category : Medical
ISBN : 9783319901947

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Cerebral Ischemic Reperfusion Injuries (CIRI) by Weijian Jiang,Wengui Yu,Yan Qu,Zhongsong Shi,Benyan Luo,John H. Zhang Pdf

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 45,5 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

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Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : Chrishan S. Samuel,Timothy D. Hewitson
Publisher : Frontiers Media SA
Page : 162 pages
File Size : 50,7 Mb
Release : 2018-01-12
Category : Electronic
ISBN : 9782889453726

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Novel Therapeutic Targets and Emerging Treatments for Fibrosis by Chrishan S. Samuel,Timothy D. Hewitson Pdf

For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs. Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder. This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.

Author : Zhi-Ren Zhang,Yue Li,Jun Pu,Yong Xia,Ming-Ming Wu
Publisher : Frontiers Media SA
Page : 225 pages
File Size : 54,8 Mb
Release : 2022-11-30
Category : Science
ISBN : 9782832508008

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Cardiovascular Toxicity Associated with Cancer Treatment: Strategies for Diagnosis, Management and Cardioprotection by Zhi-Ren Zhang,Yue Li,Jun Pu,Yong Xia,Ming-Ming Wu Pdf

Author : Kenneth V. Honn,Darryl C. Zeldin
Publisher : Springer Nature
Page : 256 pages
File Size : 47,9 Mb
Release : 2019-09-27
Category : Medical
ISBN : 9783030217358

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The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases by Kenneth V. Honn,Darryl C. Zeldin Pdf

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.

Author : Jerold Chun
Publisher : John Wiley & Sons
Page : 836 pages
File Size : 44,8 Mb
Release : 2013-04-01
Category : Science
ISBN : 9780470569054

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Lysophospholipid Receptors by Jerold Chun Pdf

The current state of the science supporting new research in lysophospholipids The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports—ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems—have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectors Enzymes Physiology and pathophysiology Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

Author : Kewal K. Jain
Publisher : Humana
Page : 0 pages
File Size : 50,8 Mb
Release : 2020-08-14
Category : Medical
ISBN : 1493994670

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The Handbook of Neuroprotection by Kewal K. Jain Pdf

This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

Author : Dr. Jyotirmay Biswas,Dr. Chandrashekara. S
Publisher : ChanRe Publishers
Page : 242 pages
File Size : 52,6 Mb
Release : 2021-08-15
Category : Medical
ISBN : 9788195241507

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Inflammation - Volume 1 - 2020 by Dr. Jyotirmay Biswas,Dr. Chandrashekara. S Pdf

'Inflammation book' is published under the aegis of the Society of Inflammation Research, which is an endeavor to disseminate knowledge about inflammation. This book provides the latest information on cutting-edge research concerning inflammation, its fundamentals including the direct and indirect determinants, besides the advanced management protocols employed in clinical practice. This volume of the book deals with basic molecular aspects of antibody response in various inflammatory conditions like sepsis, organ transplantation, role of lipid metabolism in inflammation, followed by detailed description on certain disease entities caused due to inflammation. Each topic is dealt in detail i

Author : Xiyun Yan
Publisher : Springer Nature
Page : 564 pages
File Size : 44,5 Mb
Release : 2020-01-30
Category : Technology & Engineering
ISBN : 9789811514906

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Nanozymology by Xiyun Yan Pdf

This book introduces the new concept of “nanozyme”, which refers to nanomaterials with intrinsic enzymatic activity, rather than nanomaterials with biological enzymes incorporated on the surface. The book presents the cutting-edge advances in nanozyme, with emphasis on state-of-the-art applications in many important fields, such as in the biomedical fields and for environmental protection. The nanozyme is a totally new type of artificial enzyme and exhibits huge advantages over natural enzymes, including greater stability, low cost, versatility, simplicity, and suitability for industry. It is of interest to university researchers, R&D engineers, as well as graduate students in nanoscience and technology, and biology wishing to learn the core principles, methods, and the corresponding applications of “nanozyme”.

Author : Giampaolo Niccoli,Ingo Eitel
Publisher : Academic Press
Page : 400 pages
File Size : 41,7 Mb
Release : 2018-07-20
Category : Medical
ISBN : 9780128133613

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Coronary Microvascular Obstruction in Acute Myocardial Infarction by Giampaolo Niccoli,Ingo Eitel Pdf

Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment Includes the most up-to-date information on CMVO as presented from top experts around the word Provides access to a companion website with extra material, including tables, additional references and instructional videos Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon

Author : Ankit Saneja,Amulya K. Panda,Eric Lichtfouse
Publisher : Springer Nature
Page : 278 pages
File Size : 42,9 Mb
Release : 2020-04-30
Category : Medical
ISBN : 9783030418427

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Sustainable Agriculture Reviews 44 by Ankit Saneja,Amulya K. Panda,Eric Lichtfouse Pdf

This book covers nanotechnology based approaches for improving the therapeutic efficacy of natural products. It critically explores lipid nanoarchitectonics, inorganic particles and nanoemulsion based tools for delivering them. With its chapters from eminent experts working in this discipline, it is ideal for researchers and professionals working in the area.

Author : Pierce A. Grace,RT Mathie
Publisher : Wiley-Blackwell
Page : 400 pages
File Size : 48,6 Mb
Release : 1999-02-04
Category : Medical
ISBN : 0632050217

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Ischaemia-Reperfusion Injury by Pierce A. Grace,RT Mathie Pdf

Ischaemia-Reperfusion Injury is concerned with the consequences of interrupting and restoring blood flow to tissues. Many common clinical conditions are caused by interruption of blood flow to tissues (eg, ischaemic heart disease, peripheral vascular disease, stroke); blood flow is also interrupted deliberately in many surgical procedures (eg, cardiac surgery, arterial surgery, transplant surgery, limb surgery with tourniquet). In treating such conditions or after performing such operations the aim of the clinician is to restore the blood supply to the ischaemic tissue. Paradoxically, restoration of blood flow to ischaemic tissues can lead to further tissue damage with the potential for severe local and systemic injury. This book focuses on the clinical, pathological and biochemical processes involved in ischaemia-reperfusion injury and gives an overview of the strategies that may be adopted to mitigate or prevent such injury. This book will be of interest to both clinicians and scientists who have to deal with or have interest in this difficult but important problem.

Author : S. V. Mahadevan,Gus M. Garmel
Publisher : Cambridge University Press
Page : 911 pages
File Size : 41,6 Mb
Release : 2012-04-10
Category : Medical
ISBN : 9780521747769

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An Introduction to Clinical Emergency Medicine by S. V. Mahadevan,Gus M. Garmel Pdf

Fully-updated edition of this award-winning textbook, arranged by presenting complaints with full-color images throughout. For students, residents, and emergency physicians.