Peptide And Protein Design For Biopharmaceutical Applications

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Peptide and Protein Design for Biopharmaceutical Applications

Knud Jensen
Peptide and Protein Design for Biopharmaceutical Applications Book PDF

Author : Knud Jensen
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 49,7 Mb
Release : 2009-09-01
Category : Science
ISBN : 0470749717

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Peptide and Protein Design for Biopharmaceutical Applications by Knud Jensen Pdf

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create ‘tailor-made’ peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: Computer modeling of peptides and proteins Peptidomimetics Design and synthesis of cyclic peptides Carbohydrates in peptide and protein design De novo design of peptides and proteins Medical development applications An extended case study – the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

Protein Design

Raphael Guerois,Manuela López de la Paz
Protein Design Book PDF

Author : Raphael Guerois,Manuela López de la Paz
Publisher : Springer Science & Business Media
Page : 303 pages
File Size : 51,8 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781597451161

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Protein Design by Raphael Guerois,Manuela López de la Paz Pdf

Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.

Peptide and Protein Engineering

Olga Iranzo,Ana Cecília Roque
Peptide and Protein Engineering Book PDF

Author : Olga Iranzo,Ana Cecília Roque
Publisher : Humana
Page : 0 pages
File Size : 47,7 Mb
Release : 2020-07-09
Category : Science
ISBN : 1071607197

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Peptide and Protein Engineering by Olga Iranzo,Ana Cecília Roque Pdf

This thorough book aims to present the methods that have enabled the success of peptides and proteins in a wide variety of applications. It opens with a section on chemical tools applied to the production or engineering of peptides and proteins, and concludes with a collection of chapters on biological approaches used to engineer structure and function in peptides and proteins. As a book in the Springer Protocols Handbooks series, chapters include the kind of detailed descriptions and tips necessary for successful results in practice. Authoritative and practical, Peptide and Protein Engineering: From Concepts to Biotechnological Applications will be of great use to scientists in academia and industry seeking a better understanding of the emerging principles and methodologies in peptide and protein engineering.

Peptide Applications in Biomedicine, Biotechnology and Bioengineering

Sotirios Koutsopoulos
Peptide Applications in Biomedicine Biotechnology and Bioengineering Book PDF

Author : Sotirios Koutsopoulos
Publisher : Woodhead Publishing
Page : 656 pages
File Size : 48,9 Mb
Release : 2017-11-16
Category : Technology & Engineering
ISBN : 9780081007426

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Peptide Applications in Biomedicine, Biotechnology and Bioengineering by Sotirios Koutsopoulos Pdf

Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

Peptides

Bernd Gutte
Peptides Book PDF

Author : Bernd Gutte
Publisher : Elsevier
Page : 527 pages
File Size : 55,5 Mb
Release : 1995-10-24
Category : Science
ISBN : 9780080538594

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Peptides by Bernd Gutte Pdf

In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines

Protein and Peptide Mass Spectrometry in Drug Discovery

Michael L. Gross,Guodong Chen,Birendra Pramanik
Protein and Peptide Mass Spectrometry in Drug Discovery Book PDF

Author : Michael L. Gross,Guodong Chen,Birendra Pramanik
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 50,6 Mb
Release : 2011-09-26
Category : Medical
ISBN : 9781118116548

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Protein and Peptide Mass Spectrometry in Drug Discovery by Michael L. Gross,Guodong Chen,Birendra Pramanik Pdf

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

Peptide and Protein Delivery

Chris Van Der Walle
Peptide and Protein Delivery Book PDF

Author : Chris Van Der Walle
Publisher : Academic Press
Page : 380 pages
File Size : 41,9 Mb
Release : 2011-05-12
Category : Science
ISBN : 0123849365

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Peptide and Protein Delivery by Chris Van Der Walle Pdf

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Protein Engineering and Design

Sheldon J. Park,Jennifer R. Cochran
Protein Engineering and Design Book PDF

Author : Sheldon J. Park,Jennifer R. Cochran
Publisher : CRC Press
Page : 434 pages
File Size : 41,7 Mb
Release : 2009-09-25
Category : Medical
ISBN : 9781420076592

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Protein Engineering and Design by Sheldon J. Park,Jennifer R. Cochran Pdf

Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science

Protein Engineering

Raghupathy Sarma
Protein Engineering Book PDF

Author : Raghupathy Sarma
Publisher : Elsevier
Page : 441 pages
File Size : 48,6 Mb
Release : 2012-12-02
Category : Technology & Engineering
ISBN : 9780323150309

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Protein Engineering by Raghupathy Sarma Pdf

Protein Engineering: Applications in Science, Medicine, and Industry deals with the scientific, medical, and industrial applications of protein engineering. Topics range from protein structure and design to mutant analysis and complex systems. Applications such as production of novel antibiotics, genetic transformation of plants, and genetic engineering of bioinsecticides are described. This book is comprised of 25 chapters and begins with an overview of trends and developments in protein chemistry and their relevance to protein engineering, followed by a discussion on protein sequence data banks. Subsequent chapters explore the design and construction of biologically active peptides, including hormones; structural and functional analysis of thermophile proteins; the conformation of diphtheria toxin; and applications of surface-simulation synthesis in protein molecular recognition. The use of oligonucleotide-directed site-specific mutagenesis in functional analysis of the signal peptide for protein secretion is also considered. The results of studies on the mechanism of membrane fusion are presented. This monograph will serve as a useful guide for those who are already working on protein engineering and those who are about to start research in this field.

Methods in Protein Design

Anonim
Methods in Protein Design Book PDF

Author : Anonim
Publisher : Academic Press
Page : 539 pages
File Size : 47,6 Mb
Release : 2013-02-14
Category : Science
ISBN : 9780123946294

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Methods in Protein Design by Anonim Pdf

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers methods in protein design and it has chapters on such topics as protein switch engineering by domain insertion, evolution based design of proteins, and computationally designed proteins. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers methods in protein design Contains chapters with such topics as protein switch engineering by domain insertion, evolution-based design of proteins, and computationally designed proteins

Molecular Design and Modeling

John Joseph Langone
Molecular Design and Modeling Book PDF

Author : John Joseph Langone
Publisher : Gulf Professional Publishing
Page : 864 pages
File Size : 44,6 Mb
Release : 1991
Category : Antigen-antibody reactions
ISBN : 012182103X

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Molecular Design and Modeling by John Joseph Langone Pdf

Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.

Fusion Protein Technologies for Biopharmaceuticals

Stefan R. Schmidt
Fusion Protein Technologies for Biopharmaceuticals Book PDF

Author : Stefan R. Schmidt
Publisher : John Wiley & Sons
Page : 995 pages
File Size : 53,8 Mb
Release : 2013-01-28
Category : Medical
ISBN : 9781118354582

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Fusion Protein Technologies for Biopharmaceuticals by Stefan R. Schmidt Pdf

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

Pharmaceutical Formulation Development of Peptides and Proteins

Lars Hovgaard,Sven Frokjaer,Marco van de Weert
Pharmaceutical Formulation Development of Peptides and Proteins Book PDF

Author : Lars Hovgaard,Sven Frokjaer,Marco van de Weert
Publisher : CRC Press
Page : 392 pages
File Size : 55,9 Mb
Release : 2012-11-14
Category : Medical
ISBN : 9781439853894

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Pharmaceutical Formulation Development of Peptides and Proteins by Lars Hovgaard,Sven Frokjaer,Marco van de Weert Pdf

The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therap

Physical Methods to Characterize Pharmaceutical Proteins

James N. Herron,Wim Jiskoot,Daan J.A. Crommelin
Physical Methods to Characterize Pharmaceutical Proteins Book PDF

Author : James N. Herron,Wim Jiskoot,Daan J.A. Crommelin
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 55,7 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781489910790

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Physical Methods to Characterize Pharmaceutical Proteins by James N. Herron,Wim Jiskoot,Daan J.A. Crommelin Pdf

Proteins are still gaining importance in the pharmaceutical world, where they are used to improve our arsenal of therapeutic drugs and vaccines and as diagnostic tools. Proteins are different from "traditional" low-molecular-weight drugs. As a group, they exhibit a number of biopharmaceutical and formulation problems. These problems have drawn considerable interest from both industrial and aca demic environments, forcing pharmaceutical scientists to explore a domain previ ously examined only by peptide and protein chemists. Biopharmaceutical aspects of proteins, e.g., low oral bioavailability, have been extensively investigated. Although all possible conventional routes of ad ministration have been examined for proteins, no real, generally applicable alter native to parenteral administration in order to achieve systemic effects has yet been discovered. Several of these biopharmaceutical options have been discussed in Volume 4 of this series, Biological Barriers to Protein Delivery. Proteins are composed of many amino acids, several of which are notorious for their chemical instability. Rational design of formulations that optimize the native structure and/or bioactivity of a protein is therefore of great importance when long shelf life is required, as it is for pharmaceutical products. This issue has also been examined in two prior volumes of this series: Volume 2: Stability of Protein Pharmaceuticals (Part A) and Volume 5: Stability and Characterization of Protein and Peptide Drugs.

Biologically Active Peptides

David B. Weiner,William V. Williams
Biologically Active Peptides Book PDF

Author : David B. Weiner,William V. Williams
Publisher : CRC Press
Page : 382 pages
File Size : 43,6 Mb
Release : 1993-11-04
Category : Medical
ISBN : 0877629358

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Biologically Active Peptides by David B. Weiner,William V. Williams Pdf

Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.