Pericyte Biology In Disease

Author : Alexander Birbrair
Publisher : Springer
Page : 355 pages
File Size : 53,5 Mb
Release : 2019-05-30
Category : Science
ISBN : 9783030169084

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Pericyte Biology in Disease by Alexander Birbrair Pdf

This volume explores pericytes' roles under distinct pathological conditions, ranging from tumors, ALS, Alzheimer’s disease, Multiple Sclerosis, stroke, diabetes, atherosclerosis, muscular dystrophies and more. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology – Novel Concepts, Pericyte Biology in Disease presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cell biology and clinicians involved with these specific diseases.

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 283 pages
File Size : 51,8 Mb
Release : 2021-04-08
Category : Science
ISBN : 9783030621292

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Biology of Pericytes – Recent Advances by Alexander Birbrair Pdf

Pericytes were originally discovered and named more than hundred years ago as contractile cells around the blood vessel endothelial cells. Due to the lack of exclusive markers, pericytes are now defined by a combination of location, morphology and gene expression. Pericytes are attracting increasing attention as important regulators during development and during normal and disturbed organ function. In recent years, remarkable progress has been made in the identification and characterization of pericytes subpopulations and their amazing functions using state-of-art techniques. These advantages facilitated identification of molecular basis of interaction between these cells with several other more well studied cell types, and revealed key signals derived from pericytes involved in homeostasis, regeneration, and disease regulation. In the last ten years, several unexpected roles of pericytes have been discovered. It has been demonstrated that pericytes from different tissues differ in their properties as well as functions. Even more, pericytes are heterogeneous also within the same organ. This book is will describe the major contributions of pericytes to different organs biology in physiological and pathological conditions. The book will teach the readers about this so special cell type that 10 years ago was almost completely forgotten, and it was associated basically only with vascular stability. Recently, it become a very hot topic to work in. Several articles in Nature, Science and Cell have been and are being currently published about this cell type. These recent works are revealing how important those cells are for before unimaginable biological processes. Thus, this book will update us on what are the most novel functions attributed to these cells. Also, will introduce to the young generation all the history about these cells from when they were discovered in different organs till where we are now in this field. So it will be a great book for both cell biology students as well as researchers that will have an update on these cells biology in different organs.

Author : Alexander Birbrair
Publisher : Springer
Page : 170 pages
File Size : 40,9 Mb
Release : 2018-12-06
Category : Science
ISBN : 9783030026011

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Pericyte Biology - Novel Concepts by Alexander Birbrair Pdf

This volume explores novel concepts of pericyte biology. The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on what we know so far about the pericytes. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology in Disease, Pericyte Biology - Novel Concepts presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific diseases.

Author : Alexander Birbrair
Publisher : Unknown
Page : 277 pages
File Size : 49,6 Mb
Release : 2019
Category : Epithelial cells
ISBN : 303011094X

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Pericyte Biology in Different Organs by Alexander Birbrair Pdf

The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology - Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.

Author : Alexander Birbrair
Publisher : Unknown
Page : 0 pages
File Size : 50,6 Mb
Release : 2021
Category : Electronic
ISBN : 3030621308

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Biology of Pericytes - Recent Advances by Alexander Birbrair Pdf

Pericytes were originally discovered and named more than hundred years ago as contractile cells around the blood vessel endothelial cells. Due to the lack of exclusive markers, pericytes are now defined by a combination of location, morphology and gene expression. Pericytes are attracting increasing attention as important regulators during development and during normal and disturbed organ function. In recent years, remarkable progress has been made in the identification and characterization of pericytes subpopulations and their amazing functions using state-of-art techniques. These advantages facilitated identification of molecular basis of interaction between these cells with several other more well studied cell types, and revealed key signals derived from pericytes involved in homeostasis, regeneration, and disease regulation. In the last ten years, several unexpected roles of pericytes have been discovered. It has been demonstrated that pericytes from different tissues differ in their properties as well as functions. Even more, pericytes are heterogeneous also within the same organ. This book is will describe the major contributions of pericytes to different organs biology in physiological and pathological conditions. The book will teach the readers about this so special cell type that 10 years ago was almost completely forgotten, and it was associated basically only with vascular stability. Recently, it become a very hot topic to work in. Several articles in Nature, Science and Cell have been and are being currently published about this cell type. These recent works are revealing how important those cells are for before unimaginable biological processes. Thus, this book will update us on what are the most novel functions attributed to these cells. Also, will introduce to the young generation all the history about these cells from when they were discovered in different organs till where we are now in this field. So it will be a great book for both cell biology students as well as researchers that will have an update on these cells biology in different organs.

Author : Alexander Birbrair
Publisher : Springer
Page : 277 pages
File Size : 53,8 Mb
Release : 2019-04-01
Category : Science
ISBN : 9783030110932

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Pericyte Biology in Different Organs by Alexander Birbrair Pdf

The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.

Author : Beverly A. Teicher,Lee M. Ellis
Publisher : Springer Science & Business Media
Page : 559 pages
File Size : 44,8 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9781597451840

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Antiangiogenic Agents in Cancer Therapy by Beverly A. Teicher,Lee M. Ellis Pdf

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

Author : Anonim
Publisher : Elsevier
Page : 256 pages
File Size : 49,7 Mb
Release : 1995-10-17
Category : Medical
ISBN : 0080538495

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Pathobiology of Alzheimer's Disease by Anonim Pdf

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field. With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease. Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research. * * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective * A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease. * Up-to-date research data * Clear illustrations complement the text

Author : Matthias Clauss,Georg Breier
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 48,6 Mb
Release : 2004-11-22
Category : Medical
ISBN : 3764364599

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Mechanisms of Angiogenesis by Matthias Clauss,Georg Breier Pdf

Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Author : H.A. Domanski,C.S. Walther
Publisher : Karger Medical and Scientific Publishers
Page : 192 pages
File Size : 43,7 Mb
Release : 2017-07-27
Category : Medical
ISBN : 9783318060775

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FNA Cytology of Soft Tissue and Bone Tumors by H.A. Domanski,C.S. Walther Pdf

Fine-needle aspiration cytology (FNAC) has been commonly used to follow up on previously treated sarcomas or to confirm soft tissue and bone metastases of carcinomas, melanomas or lymphomas. Its role as the first-line approach in the diagnosis of primary soft tissue and bone tumors has increased due to progress of less invasive diagnostic procedures and the growing availability of diagnostic ancillary tests. This comprehensive and richly-illustrated volume presents cytomorphology of all common neoplastic soft tissue and bone lesions but also of rare tumors largely described in case reports. Key points for cytological features, differential diagnosis, and the use of ancillary tests are discussed and illustrated in order to facilitate the diagnostic work-up in FNA samples. The volume is organized on the basis of the most recent WHO classification used in surgical pathology in order to provide a practical guide for modern cytologic diagnosis of surgical soft tissue and bone pathology. It is aimed mainly at surgical pathologists and cytopathologists, but also at orthopedic surgeons and clinical oncologists.

Author : Yuping Wang
Publisher : Biota Publishing
Page : 126 pages
File Size : 47,9 Mb
Release : 2017-06-23
Category : Medical
ISBN : 9781615047512

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Vascular Biology of the Placenta by Yuping Wang Pdf

The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

Author : Mirko HH Schmidt,Stefan Liebner
Publisher : Springer
Page : 401 pages
File Size : 40,7 Mb
Release : 2015-10-08
Category : Medical
ISBN : 9781493929078

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Endothelial Signaling in Development and Disease by Mirko HH Schmidt,Stefan Liebner Pdf

This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Author : Nagwa El-Badri
Publisher : Springer Nature
Page : 374 pages
File Size : 50,5 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9783030553593

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Regenerative Medicine and Stem Cell Biology by Nagwa El-Badri Pdf

This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.

Author : Gert Fricker,Melanie Ott,Anne Mahringer
Publisher : Springer
Page : 163 pages
File Size : 52,5 Mb
Release : 2014-10-24
Category : Science
ISBN : 9783662437872

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The Blood Brain Barrier (BBB) by Gert Fricker,Melanie Ott,Anne Mahringer Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Author : Miao He,Giordano Lippi,Jiangteng Lu
Publisher : Frontiers Media SA
Page : 255 pages
File Size : 44,7 Mb
Release : 2022-02-04
Category : Science
ISBN : 9782889743360

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Cell Type Diversity in the Nervous System: From Genes to Function by Miao He,Giordano Lippi,Jiangteng Lu Pdf