Phospholipid Metabolism In Apoptosis

Author : Peter J. Quinn,Valerian E. Kagan
Publisher : Springer Science & Business Media
Page : 352 pages
File Size : 52,5 Mb
Release : 2006-04-18
Category : Science
ISBN : 9780306479311

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Phospholipid Metabolism in Apoptosis by Peter J. Quinn,Valerian E. Kagan Pdf

The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. The number of publications on the topic has increased from nothing in the early 1980s to more than 10,000 papers annually today. It is now well recognized that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The idea that life requires death seems somewhat paradoxical, but cell suicide is essential for an animal to survive. For example, without selective destruction of “non-self” T cells, an animal would lack immunity. Similarly, meaningful neural connections in the brain are whittled from a mass of cells. Further, developmental cell remodeling during tissue maturation involves programmed cell death as the major mechanism for functional and structural safe transition of undifferentiated cells to more specialized counterparts. Apoptosis research, with roots in biochemistry, developmental and cell biology, genetics, and immunology, embraces this long-ignored natural law. Failure to properly regulate apoptosis can have catastrophic consequences. Cancer and many diseases (AIDS, Alzheimer’s disease, Parkinson’s disease, heart attack, stroke, etc. ) are thought to arise from deregulation of apoptosis. As apoptosis emerges as a key biological regulatory mechanism, it has become harder and harder to keep up with new developments in this field.

Author : James A. Radosevich
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 48,7 Mb
Release : 2018-09-18
Category : Science
ISBN : 9781119432357

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Apoptosis and Beyond by James A. Radosevich Pdf

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Author : James M. Ntambi
Publisher : Academic Press
Page : 566 pages
File Size : 40,9 Mb
Release : 2020-08-09
Category : Science
ISBN : 9780128194058

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Lipid Signaling and Metabolism by James M. Ntambi Pdf

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 46,8 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Author : Tobias Ntuli
Publisher : BoD – Books on Demand
Page : 448 pages
File Size : 55,9 Mb
Release : 2015-12-16
Category : Science
ISBN : 9789535122364

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Cell Death by Tobias Ntuli Pdf

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Author : A. Kuksis
Publisher : Gulf Professional Publishing
Page : 1006 pages
File Size : 52,6 Mb
Release : 2003-09-12
Category : Medical
ISBN : 0444513043

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Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases by A. Kuksis Pdf

The development of advanced methods for isolation, identification and quantification of old and new inositol lipids and inositol phosphtes from natural and synthetic systems has been a major advancing force in phosphoinositol research. The writing of this book was undertaken as an opportunity fo examine the analytical validity of the biochemical transformations that constitute the basis of the lipid signaling pathways.

Author : Ronald Ross Watson,Victor R Preedy,Sherma Zibadi
Publisher : Academic Press
Page : 1504 pages
File Size : 52,6 Mb
Release : 2013-10-26
Category : Science
ISBN : 9780123984678

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Polyphenols in Human Health and Disease by Ronald Ross Watson,Victor R Preedy,Sherma Zibadi Pdf

Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. Explores neuronal protection by polyphenol metabolites and their application to medical care Defines modulation of enzyme actions to help researchers see and study polyphenols’ mechanisms of action, leading to clinical applications Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases

Author : Rossen Donev
Publisher : Academic Press
Page : 358 pages
File Size : 45,7 Mb
Release : 2021-06-02
Category : Science
ISBN : 9780323853187

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Apoptosis in Health and Disease - Part B by Rossen Donev Pdf

Apoptosis in Health and Disease - Part B, Volume 126 in the Advances in Protein Chemistry and Structural Biology focuses on apoptotic responses in numerous conditions - from bacterial and parasite infections, to pathological states such as oxidative stress, pulmonary hypertension, and different cancer types, etc. In addition, the book provides therapeutic strategies for targeting apoptosis. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target the cell death process. Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. Vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. Integrates experimental and computational methods for studying apoptosis in health and different diseases Includes strategies for identification of suitable therapeutic targets Discusses the design of treatments targeting key points in the apoptotic cascade

Author : Erich Gulbins,Irina Petrache
Publisher : Springer Science & Business Media
Page : 264 pages
File Size : 50,9 Mb
Release : 2013-04-11
Category : Medical
ISBN : 9783709113684

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Sphingolipids: Basic Science and Drug Development by Erich Gulbins,Irina Petrache Pdf

Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids’ basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.

Author : Mark P. Mattson
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 45,8 Mb
Release : 2007-10-27
Category : Science
ISBN : 9781592598038

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Membrane Microdomain Signaling by Mark P. Mattson Pdf

Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

Author : Ralph N. Martins,Charles S. Brennan,Binosha Fernando,Margaret A. Brennan,Stephanie J. Fuller
Publisher : John Wiley & Sons
Page : 548 pages
File Size : 55,6 Mb
Release : 2019-07-10
Category : Technology & Engineering
ISBN : 9781119356783

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Neurodegeneration and Alzheimer's Disease by Ralph N. Martins,Charles S. Brennan,Binosha Fernando,Margaret A. Brennan,Stephanie J. Fuller Pdf

Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.

Author : Rodrigo Valenzuela Baez
Publisher : BoD – Books on Demand
Page : 100 pages
File Size : 52,6 Mb
Release : 2020-06-03
Category : Science
ISBN : 9781789844580

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Advances in Lipid Metabolism by Rodrigo Valenzuela Baez Pdf

This edited volume is a collection of reviewed and relevant research chapters concerning developments within the field of lipid metabolism. It includes scholarly contributions from experts in the field that cover such topics as roles of lipids in cancer, analytical tools for lipid assessment in biological assays, plant lipid metabolism, the effect of nanoparticles on lipid peroxidation in plants, and fatty acid compositions in fermented fish products. This book provides a thorough overview of the latest research efforts by international authors on lipid metabolism, and opens new possible research paths for further novel developments.

Author : Kazuyuki Akasaka,Hitoshi Matsuki
Publisher : Springer
Page : 730 pages
File Size : 51,6 Mb
Release : 2015-07-14
Category : Medical
ISBN : 9789401799188

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High Pressure Bioscience by Kazuyuki Akasaka,Hitoshi Matsuki Pdf

This volume covers both the basic concepts and theory of bio-macromolecules under pressure and the various frontiers in high-pressure bioscience and biotechnology. A century has passed since Bridgman discovered the irreversible coagulation of egg white by applying pressure at 700 atmospheres in 1914. Today we are able to monitor pressure-dependent changes in protein structure as a reversible process even at atomic scale with modern spectroscopic techniques. We can study the fluctuating reality of protein structures as designed by nature, which is the basis for all dynamism of life on earth. We are currently facing a new era of high-pressure bioscience, in which pressure is no longer an “odd” or “foreign” variable to life, but rather an integrated part of it. Pressure is used as a crucial variable for disclosing the secrets of nature and as a powerful new tool for enhancing certain reactions in bio-macromolecules and even in living cells for our practical and industrial needs. A dramatic advancement of high-pressure bioscience both in the basic and the applied sciences is thus anticipated in near future, for which sharing the current advanced knowledge on structure and dynamics of bio-macromolecules under pressure among researchers in both fields is crucial. This book serves as a valuable resource not only for those working directly in a pressure-related field, but also for those working in many other fields of the biosciences. Particularly, the basic part of it is intended to serve as a classical text book on high-pressure bioscience to a wide audience including students and researchers in both basic and applied fields in years to come. Readers can focus on topics of immediate interest first, but may wish to go over other chapters if interest arises in a later occasion.

Author : Jian Yu,Manoj Kumar Kashyap,Zhizhuang Joe Zhao,Hubing Shi
Publisher : Frontiers Media SA
Page : 112 pages
File Size : 43,5 Mb
Release : 2024-04-18
Category : Medical
ISBN : 9782832548073

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Linking cellular metabolism to hematological malignancies, volume II by Jian Yu,Manoj Kumar Kashyap,Zhizhuang Joe Zhao,Hubing Shi Pdf

Author : Michel M.J. Modo,Jeff W.M. Bulte
Publisher : CRC Press
Page : 490 pages
File Size : 51,9 Mb
Release : 2007-03-28
Category : Medical
ISBN : 9781000654424

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Molecular and Cellular MR Imaging by Michel M.J. Modo,Jeff W.M. Bulte Pdf

The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and