Practical Process Research Development

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Practical Process Research and Development

Neal G. Anderson
Practical Process Research and Development Book PDF

Author : Neal G. Anderson
Publisher : Academic Press
Page : 489 pages
File Size : 54,7 Mb
Release : 2012-04-09
Category : Business & Economics
ISBN : 9780123865373

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Practical Process Research and Development by Neal G. Anderson Pdf

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: . Reflects the current thinking in chemical process R&D for small molecules . Retains similar structure and orientation to the first edition. . Contains approx. 85% new material . Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) . Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) . Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Practical Process Research & Development

Neal G. Anderson
Practical Process Research Development Book PDF

Author : Neal G. Anderson
Publisher : Academic Press
Page : 354 pages
File Size : 47,7 Mb
Release : 2000-03
Category : Science
ISBN : 1483299775

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Practical Process Research & Development by Neal G. Anderson Pdf

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. * Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" * Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more * Includes over 100 tips for rapid process development * Presents guidelines for implementing and troubleshooting processes

Software Process Improvement and Management: Approaches and Tools for Practical Development

Fauzi, Shukor Sanim Mohd
Software Process Improvement and Management Approaches and Tools for Practical Development Book PDF

Author : Fauzi, Shukor Sanim Mohd
Publisher : IGI Global
Page : 284 pages
File Size : 49,5 Mb
Release : 2011-11-30
Category : Computers
ISBN : 9781613501429

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Software Process Improvement and Management: Approaches and Tools for Practical Development by Fauzi, Shukor Sanim Mohd Pdf

Over the past decade, there has been an increase in attention and focus on the discipline of software engineering. Software engineering tools and techniques have been developed to gain more predictable quality improvement results. Process standards such as Capability Maturity Model Integration (CMMI), ISO 9000, Software Process Improvement and Capability dEtermination (SPICE), Agile Methodologies, and others have been proposed to assist organizations to achieve more predictable results by incorporating these proven standards and procedures into their software process. Software Process Improvement and Management: Approaches and Tools for Practical Development offers the latest research and case studies on software engineering and development. The production of new process standards assist organizations and software engineers in adding a measure of predictability to the software process. Companies can gain a decisive competitive advantage by applying these new and theoretical methodologies in real-world scenarios. Researchers, scholars, practitioners, students, and anyone interested in the field of software development and design should access this book as a major compendium of the latest research in the field.

Developing Solid Oral Dosage Forms

Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter
Developing Solid Oral Dosage Forms Book PDF

Author : Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter
Publisher : Academic Press
Page : 978 pages
File Size : 42,7 Mb
Release : 2009-03-10
Category : Medical
ISBN : 008093272X

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Developing Solid Oral Dosage Forms by Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter Pdf

Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies

Practical Aspects of Vaccine Development

Parag Kolhe,Satoshi Ohtake
Practical Aspects of Vaccine Development Book PDF

Author : Parag Kolhe,Satoshi Ohtake
Publisher : Elsevier
Page : 386 pages
File Size : 50,7 Mb
Release : 2021-09-08
Category : Business & Economics
ISBN : 9780128143575

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Practical Aspects of Vaccine Development by Parag Kolhe,Satoshi Ohtake Pdf

Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Clinical Practice Guidelines We Can Trust

Institute of Medicine,Board on Health Care Services,Committee on Standards for Developing Trustworthy Clinical Practice Guidelines
Clinical Practice Guidelines We Can Trust Book PDF

Author : Institute of Medicine,Board on Health Care Services,Committee on Standards for Developing Trustworthy Clinical Practice Guidelines
Publisher : National Academies Press
Page : 217 pages
File Size : 55,8 Mb
Release : 2011-06-16
Category : Medical
ISBN : 9780309216463

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Clinical Practice Guidelines We Can Trust by Institute of Medicine,Board on Health Care Services,Committee on Standards for Developing Trustworthy Clinical Practice Guidelines Pdf

Advances in medical, biomedical and health services research have reduced the level of uncertainty in clinical practice. Clinical practice guidelines (CPGs) complement this progress by establishing standards of care backed by strong scientific evidence. CPGs are statements that include recommendations intended to optimize patient care. These statements are informed by a systematic review of evidence and an assessment of the benefits and costs of alternative care options. Clinical Practice Guidelines We Can Trust examines the current state of clinical practice guidelines and how they can be improved to enhance healthcare quality and patient outcomes. Clinical practice guidelines now are ubiquitous in our healthcare system. The Guidelines International Network (GIN) database currently lists more than 3,700 guidelines from 39 countries. Developing guidelines presents a number of challenges including lack of transparent methodological practices, difficulty reconciling conflicting guidelines, and conflicts of interest. Clinical Practice Guidelines We Can Trust explores questions surrounding the quality of CPG development processes and the establishment of standards. It proposes eight standards for developing trustworthy clinical practice guidelines emphasizing transparency; management of conflict of interest ; systematic review-guideline development intersection; establishing evidence foundations for and rating strength of guideline recommendations; articulation of recommendations; external review; and updating. Clinical Practice Guidelines We Can Trust shows how clinical practice guidelines can enhance clinician and patient decision-making by translating complex scientific research findings into recommendations for clinical practice that are relevant to the individual patient encounter, instead of implementing a one size fits all approach to patient care. This book contains information directly related to the work of the Agency for Healthcare Research and Quality (AHRQ), as well as various Congressional staff and policymakers. It is a vital resource for medical specialty societies, disease advocacy groups, health professionals, private and international organizations that develop or use clinical practice guidelines, consumers, clinicians, and payers.

Practical Process Control for Engineers and Technicians

Wolfgang Altmann
Practical Process Control for Engineers and Technicians Book PDF

Author : Wolfgang Altmann
Publisher : Elsevier
Page : 304 pages
File Size : 46,7 Mb
Release : 2005-05-10
Category : Technology & Engineering
ISBN : 008048025X

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Practical Process Control for Engineers and Technicians by Wolfgang Altmann Pdf

This book is aimed at engineers and technicians who need to have a clear, practical understanding of the essentials of process control, loop tuning and how to optimize the operation of their particular plant or process. The reader would typically be involved in the design, implementation and upgrading of industrial control systems. Mathematical theory has been kept to a minimum with the emphasis throughout on practical applications and useful information. This book will enable the reader to: * Specify and design the loop requirements for a plant using PID control * Identify and apply the essential building blocks in automatic control * Apply the procedures for open and closed loop tuning * Tune control loops with significant dead-times * Demonstrate a clear understanding of analog process control and how to tune analog loops * Explain concepts used by major manufacturers who use the most up-to-date technology in the process control field · A practical focus on the optimization of process and plant · Readers develop professional competencies, not just theoretical knowledge · Reduce dead-time with loop tuning techniques

Chemical Engineering Design

Gavin Towler,Ray Sinnott
Chemical Engineering Design Book PDF

Author : Gavin Towler,Ray Sinnott
Publisher : Elsevier
Page : 1321 pages
File Size : 55,7 Mb
Release : 2012-01-25
Category : Technology & Engineering
ISBN : 9780080966601

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Chemical Engineering Design by Gavin Towler,Ray Sinnott Pdf

Chemical Engineering Design, Second Edition, deals with the application of chemical engineering principles to the design of chemical processes and equipment. Revised throughout, this edition has been specifically developed for the U.S. market. It provides the latest US codes and standards, including API, ASME and ISA design codes and ANSI standards. It contains new discussions of conceptual plant design, flowsheet development, and revamp design; extended coverage of capital cost estimation, process costing, and economics; and new chapters on equipment selection, reactor design, and solids handling processes. A rigorous pedagogy assists learning, with detailed worked examples, end of chapter exercises, plus supporting data, and Excel spreadsheet calculations, plus over 150 Patent References for downloading from the companion website. Extensive instructor resources, including 1170 lecture slides and a fully worked solutions manual are available to adopting instructors. This text is designed for chemical and biochemical engineering students (senior undergraduate year, plus appropriate for capstone design courses where taken, plus graduates) and lecturers/tutors, and professionals in industry (chemical process, biochemical, pharmaceutical, petrochemical sectors). New to this edition: Revised organization into Part I: Process Design, and Part II: Plant Design. The broad themes of Part I are flowsheet development, economic analysis, safety and environmental impact and optimization. Part II contains chapters on equipment design and selection that can be used as supplements to a lecture course or as essential references for students or practicing engineers working on design projects. New discussion of conceptual plant design, flowsheet development and revamp design Significantly increased coverage of capital cost estimation, process costing and economics New chapters on equipment selection, reactor design and solids handling processes New sections on fermentation, adsorption, membrane separations, ion exchange and chromatography Increased coverage of batch processing, food, pharmaceutical and biological processes All equipment chapters in Part II revised and updated with current information Updated throughout for latest US codes and standards, including API, ASME and ISA design codes and ANSI standards Additional worked examples and homework problems The most complete and up to date coverage of equipment selection 108 realistic commercial design projects from diverse industries A rigorous pedagogy assists learning, with detailed worked examples, end of chapter exercises, plus supporting data and Excel spreadsheet calculations plus over 150 Patent References, for downloading from the companion website Extensive instructor resources: 1170 lecture slides plus fully worked solutions manual available to adopting instructors

A Practical Guide to Managing Clinical Trials

JoAnn Pfeiffer,Cris Wells
A Practical Guide to Managing Clinical Trials Book PDF

Author : JoAnn Pfeiffer,Cris Wells
Publisher : CRC Press
Page : 292 pages
File Size : 50,7 Mb
Release : 2017-05-18
Category : Mathematics
ISBN : 9781315299778

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A Practical Guide to Managing Clinical Trials by JoAnn Pfeiffer,Cris Wells Pdf

A Practical Guide to Managing Clinical Trials is a basic, comprehensive guide to conducting clinical trials. Designed for individuals working in research site operations, this user-friendly reference guides the reader through each step of the clinical trial process from site selection, to site set-up, subject recruitment, study visits, and to study close-out. Topics include staff roles/responsibilities/training, budget and contract review and management, subject study visits, data and document management, event reporting, research ethics, audits and inspections, consent processes, IRB, FDA regulations, and good clinical practices. Each chapter concludes with a review of key points and knowledge application. Unique to this book is "A View from India," a chapter-by-chapter comparison of clinical trial practices in India versus the U.S. Throughout the book and in Chapter 10, readers will glimpse some of the challenges and opportunities in the emerging and growing market of Indian clinical trials.

Participatory Action Learning and Action Research

Lesley Wood
Participatory Action Learning and Action Research Book PDF

Author : Lesley Wood
Publisher : Routledge
Page : 221 pages
File Size : 49,8 Mb
Release : 2019-10-01
Category : Education
ISBN : 9780429805677

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Participatory Action Learning and Action Research by Lesley Wood Pdf

Participatory Action Learning and Action Research offers a concise yet comprehensive explanation of the theory, practice and process of this emerging paradigm, methodology and theory of learning. PALAR is a transformative, collaborative and democratic process for resolving complex problems within the context of sustainable professional, organisational and community development. The book draws on real-life examples from socially and economically challenged contexts, and features critical reflections on the strengths and challenges of this evolving methodology in relation to the increased interest in community engagement and project-based learning among institutions of higher education. Analysing theory in the context of sustainable professional, organisational and community development, this book: Provides a comprehensive, research-based manual on the use of PALAR within actual research projects. Explains a means of engaging in research that promotes the mobilisation of human potential relevant in a rapidy changing society. Addresses the challenges of doing participatory research within institutions. Provides applied, specific examples of how PALAR can be adapted for use in socially and economically challenged contexts, typical of developing economies. Offers critical reflections by researchers and community participants on the challenges and uses of PALAR. Innovative, and offering clarity on ethics and research questions, Participatory Action Learning and Action Research will be of interest to both emerging and experienced researchers looking to bring about change at a personal, professional, organisational or community level.

Sharpening the Development Process

Oliver Bakewell
Sharpening the Development Process Book PDF

Author : Oliver Bakewell
Publisher : Intrac
Page : 139 pages
File Size : 48,5 Mb
Release : 2003
Category : Community development
ISBN : 1897748787

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Sharpening the Development Process by Oliver Bakewell Pdf

This guide is offered as a contribution to the development community to assist it in its work and facilitate the processes of action and reflection, or 'Praxis'. The purpose of this book is to provide a detailed introduction to the process of developing monitoring and evaluation systems.

Industrial Process Scale-up

Jan Harmsen
Industrial Process Scale up Book PDF

Author : Jan Harmsen
Publisher : Elsevier
Page : 129 pages
File Size : 50,9 Mb
Release : 2013-04-25
Category : Technology & Engineering
ISBN : 9780444627391

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Industrial Process Scale-up by Jan Harmsen Pdf

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

Ali S. Faqi
A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book PDF

Author : Ali S. Faqi
Publisher : Elsevier
Page : 1074 pages
File Size : 52,5 Mb
Release : 2024-02-11
Category : Medical
ISBN : 9780323984621

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A Comprehensive Guide to Toxicology in Nonclinical Drug Development by Ali S. Faqi Pdf

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Practical Process Research and Development

Neal G. Anderson
Practical Process Research and Development Book PDF

Author : Neal G. Anderson
Publisher : Academic Press
Page : 489 pages
File Size : 48,7 Mb
Release : 2012-05-23
Category : Science
ISBN : 9780123865380

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Practical Process Research and Development by Neal G. Anderson Pdf

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights:• Reflects the current thinking in chemical process R&D for small molecules• Retains similar structure and orientation to the first edition. • Contains approx. 85% new material• Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)• Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)• Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

The Research Interview

S. Mann
The Research Interview Book PDF

Author : S. Mann
Publisher : Springer
Page : 325 pages
File Size : 41,9 Mb
Release : 2016-04-29
Category : Language Arts & Disciplines
ISBN : 9781137353368

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The Research Interview by S. Mann Pdf

Research and Qualitative Interviews brings into focus the decisions that the interviewer faces by taking a data-led approach in order to open up choices and decisions in the process of planning for, managing, analysing and representing interviews. The chapters concentrate on the real-time, moment-by-moment nature of interview management and interaction. A key feature of the book is the inclusion of reflexive vignettes that foreground the voices and experience of qualitative researchers (both novices and more expert practitioners). The vignettes demonstrate the importance of reflecting on and learning from interactional experience. In addition, the book provides an overview of different types of interviews, commenting on the orientation and make-up of each type. Overall, this book encourages reflective thinking about the use of research interviews. It distinguishes between reflection, reflective practice and reflexivity. All the chapters focus on recurring choices, dilemmas and puzzles; offering advice in opening out and engaging with these aspects of the research interview.