Protein Modifications In Pathogenic Dysregulation Of Signaling

Author : Jun-ichiro Inoue,Mutsuhiro Takekawa
Publisher : Springer
Page : 348 pages
File Size : 46,5 Mb
Release : 2015-09-02
Category : Science
ISBN : 9784431555612

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Protein Modifications in Pathogenic Dysregulation of Signaling by Jun-ichiro Inoue,Mutsuhiro Takekawa Pdf

This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.

Author : Jun-ichiro Inoue,Mutsuhiro Takekawa
Publisher : Unknown
Page : 128 pages
File Size : 43,5 Mb
Release : 2015
Category : Electronic
ISBN : 4431555625

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Protein Modifications in Pathogenic Dysregulation of Signaling by Jun-ichiro Inoue,Mutsuhiro Takekawa Pdf

This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases.

Author : Maurizio Popoli,David Diamond,Gerard Sanacora
Publisher : Springer
Page : 355 pages
File Size : 40,9 Mb
Release : 2014-07-28
Category : Medical
ISBN : 9781493910564

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Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders by Maurizio Popoli,David Diamond,Gerard Sanacora Pdf

Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 40,7 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : K. Aktories,I. Just
Publisher : Springer Science & Business Media
Page : 713 pages
File Size : 52,7 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783662059715

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Bacterial Protein Toxins by K. Aktories,I. Just Pdf

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 41,7 Mb
Release : 2002-12-31
Category : Medical
ISBN : 9781402073403

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Signal Transduction in Cancer by David A. Frank Pdf

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Author : Jonas H. Ellenberg,William C. Koller,James William Langston
Publisher : CRC Press
Page : 600 pages
File Size : 47,7 Mb
Release : 1995-03-01
Category : Medical
ISBN : 0824788230

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Etiology of Parkinson's Disease by Jonas H. Ellenberg,William C. Koller,James William Langston Pdf

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Author : Dong-Hua Yang,Jian-ye Zhang,Lihui Wang
Publisher : Frontiers Media SA
Page : 364 pages
File Size : 41,8 Mb
Release : 2022-11-23
Category : Medical
ISBN : 9782832506950

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RNA and RNA Modification in the Pathogenesis, Diagnosis and Treatment of Cancers by Dong-Hua Yang,Jian-ye Zhang,Lihui Wang Pdf

Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science
Publisher : National Academies Press
Page : 560 pages
File Size : 44,6 Mb
Release : 2011-07-01
Category : Medical
ISBN : 9780309211093

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Critical Needs and Gaps in Understanding Prevention, Amelioration, and Resolution of Lyme and Other Tick-Borne Diseases by Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science Pdf

A single tick bite can have debilitating consequences. Lyme disease is the most common disease carried by ticks in the United States, and the number of those afflicted is growing steadily. If left untreated, the diseases carried by ticks-known as tick-borne diseases-can cause severe pain, fatigue, neurological problems, and other serious health problems. The Institute of Medicine held a workshop October 11-12, 2010, to examine the state of the science in Lyme disease and other tick-borne diseases.

Author : Lars Kaderali,Fabian Theis,Esteban A. Hernandez-Vargas,Vitaly V. Ganusov,Stanca M. Ciupe,Ramit Mehr,Ruy Ribeiro
Publisher : Frontiers Media SA
Page : 290 pages
File Size : 49,8 Mb
Release : 2019-04-09
Category : Electronic
ISBN : 9782889458011

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Integrative Computational Systems Biology Approaches in Immunology and Medicine by Lars Kaderali,Fabian Theis,Esteban A. Hernandez-Vargas,Vitaly V. Ganusov,Stanca M. Ciupe,Ramit Mehr,Ruy Ribeiro Pdf

Author : Jonathan Edward Brammer,Marco Herling,Anjali Mishra,Wael Jarjour
Publisher : Frontiers Media SA
Page : 111 pages
File Size : 47,7 Mb
Release : 2022-10-18
Category : Medical
ISBN : 9782832502693

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Pathogenesis, Treatment, and Future Directions for Rare T-Cell Leukemias by Jonathan Edward Brammer,Marco Herling,Anjali Mishra,Wael Jarjour Pdf

Author : Xiang Cheng,Guo-Ping Shi,Yimei Du,Hui-Hua Li
Publisher : Frontiers Media SA
Page : 180 pages
File Size : 53,6 Mb
Release : 2022-01-25
Category : Science
ISBN : 9782889741694

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Inflammatory Signaling in Cardiovascular Diseases: Pathogenesis and Anti-inflammation Therapy by Xiang Cheng,Guo-Ping Shi,Yimei Du,Hui-Hua Li Pdf

Author : Toshiyuki Fukada,Taiho Kambe
Publisher : MDPI
Page : 293 pages
File Size : 41,7 Mb
Release : 2018-05-04
Category : Electronic
ISBN : 9783038428213

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Zinc Signaling in Physiology and Pathogenesis by Toshiyuki Fukada,Taiho Kambe Pdf

This book is a printed edition of the Special Issue "Zinc Signaling in Physiology and Pathogenesis" that was published in IJMS

Author : M. Walid Qoronfleh,Musthafa Mohamed Essa,Chidambaram Saravana Babu
Publisher : Springer Nature
Page : 347 pages
File Size : 50,8 Mb
Release : 2022-04-08
Category : Medical
ISBN : 9789811597817

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Proteins Associated with Neurodevelopmental Disorders by M. Walid Qoronfleh,Musthafa Mohamed Essa,Chidambaram Saravana Babu Pdf

This book comprehensively reviews the proteins associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It also discusses the interactions of the associated-proteins, like bromodomain-containing proteins (BCPs), kinases, synaptic proteins, scaffolding proteins, transcriptional factors, and DNA-binding proteins at the subcellular and molecular levels. The book also explores the potential of these proteins as a druggable target and a biomarker in the neurodevelopmental disorders. The book further explores the recent advancements in understanding the important role of epigenetic factors in predisposition to these diseases. Lastly, it presents genetic factors that lead to variation in gene expression in these diseases, disorders management via diet intervention and the future potential of stem cell therapy.

Author : Nozomu Mori,Inhee Mook-Jung
Publisher : Springer
Page : 439 pages
File Size : 46,7 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9784431557630

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Aging Mechanisms by Nozomu Mori,Inhee Mook-Jung Pdf

This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.