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Author : Anonim
Publisher : Unknown
Page : 858 pages
File Size : 47,9 Mb
Release : 1981
Category : Military trucks
ISBN : MINN:31951T00406443J
Author : Christina Annunziata,Kristin Zorn
Publisher : Frontiers Media SA
Page : 99 pages
File Size : 49,9 Mb
Release : 2016-08-05
Category : Medicine (General)
ISBN : 9782889199556
Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
Author : Yasushi Nagata
Publisher : Springer
Page : 254 pages
File Size : 46,9 Mb
Release : 2015-08-06
Category : Medical
ISBN : 9784431548836
This book serves as a practical guide for the use of stereotactic body radiation therapy in clinics. On the basis of more than 10 years of clinical experience with lung cancer, liver cancer and other cancers, a remarkable volume of knowledge has been accumulated. At the same time, great progress in techniques has been achieved. Various new fixing apparatuses, new respiratory regulation techniques, new dose fractionation schedules and new image-guided radiation therapy machines have been developed. This book reviews the history of those developments and reports on various types of toxicities. Review of recent clinical studies is also included. The authors were key members of the JCOG 0403 clinical trials on stereotactic body radiation therapy (SBRT) for both inoperable and operableT1N0M0 primary lung cancer. Readers will learn of the superior outcomes obtained with SBRT for lung cancer and other cancers in terms of local control and toxicities. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists and senior nurses as well as medical oncologists and surgical oncologists who are interested in radiotherapy.
Author : School Mathematics Study Group
Publisher : Unknown
Page : 132 pages
File Size : 47,5 Mb
Release : 1962
Category : Mathematics
ISBN : UIUC:30112121333584
Author : Antonio Tito Fojo
Publisher : Springer Science & Business Media
Page : 629 pages
File Size : 52,5 Mb
Release : 2009-01-14
Category : Medical
ISBN : 9781597453363
This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.
Author : Ignazio Caruana,Francesca Del Bufalo,Rayne Rouce,Shigeki Yagyu ,Paul G. Schlegel
Publisher : Frontiers Media SA
Page : 222 pages
File Size : 55,6 Mb
Release : 2024-06-13
Category : Medical
ISBN : 9782832550410
The development, clinical translation and recent efficacy of novel gene therapies targeting refractory malignancies has led to research that extends this technology to a variety of infectious and rheumatological diseases. Unlike conventional drugs or antibodies, T cells have the potential to target and exert effector function in response to disease in a dynamic manner, acting as a “living drug”. The most efficacious form of gene-modified T cells to date is the chimeric antigen receptor (CAR)-modified T cell, which redirects the specificity of T cells to an antigen expressed by tumor cells. Clinical experience with autologous CAR-T cells, primarily in hematologic malignancies, has underscored the feasibility and safety of the approach, while also demonstrating dramatic and sustained antitumor effects through mechanisms orthogonal to those of traditional anticancer therapies. However, several challenging obstacles must be surmounted in order to improve the broader efficacy of this approach.
Author : Lee E. Ponsky,Donald B. Fuller,Robert M. Meier,Charlie Ma
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 47,6 Mb
Release : 2011-11-19
Category : Medical
ISBN : 3642114954
The treatment of prostate cancer continues to be problematic owing to serious side-effects, including erectile dysfunction and urinary incontinence. Robotic radiosurgery offers a novel, rapid, non-invasive outpatient treatment option that combines robotics, advanced image-guided spatial positioning, and motion detection with submillimeter precision. This book examines all aspects of the treatment of prostate cancer with robotic radiosurgery. It explains how image-guided robotic radiosurgery overcomes the problem of patient motion during radiation therapy by continuously identifying the precise location of the prostate tumor throughout the course of treatment. Hypofractionated radiation delivery by means of robotic radiosurgery systems is also discussed in detail. The book closes by examining other emerging genitourinary applications of robotic radiosurgery. All of the authors are experts in their field who present a persuasive case for this fascinating technique.
Author : Robert James Hayashi,K. Scott Baker,Kirk R. Schultz
Publisher : Frontiers Media SA
Page : 107 pages
File Size : 51,5 Mb
Release : 2021-09-28
Category : Medical
ISBN : 9782889713745
Author : Library of Congress. Copyright Office
Publisher : Unknown
Page : 970 pages
File Size : 52,8 Mb
Release : 1938
Category : Electronic
ISBN : UCAL:B3458526
Author : David Schiff,Patrick Y. Wen
Publisher : Springer Science & Business Media
Page : 454 pages
File Size : 48,9 Mb
Release : 2002-09-15
Category : Medical
ISBN : 9781592593170
In Cancer Neurology in Clinical Practice, leading neuro-oncologists from around the world comprehensively review the neurologic symptoms that cancer patients experience, and show how they should be interpreted and evaluated. Organized by both symptom and organ, the book carefully describes each diagnostic neurologic entity-from symptomatology to diagnostic studies to management and prognosis-and presents each major type of cancer in terms of it neurologic problems and how they should be handled. The role of surgery, radiation, chemotherapy, and other palliative measures are considered for each type of problem. Multidisciplinary and up-to-date, Cancer Neurology in Clinical Practice explains to the busy physicians treating cancer patients the latest findings in neuro-oncology that will help them to focus their differential diagnosis, diagnostic strategy, and treatment plan for the cancer patient with neurologic symptoms and findings.
Author : Anonim
Publisher : Unknown
Page : 1032 pages
File Size : 41,6 Mb
Release : 1936-07
Category : American literature
ISBN : UTEXAS:059172119878251
Author : Duccio Volterrani,Paola A. Erba,H. William Strauss,Giuliano Mariani,Steven M. Larson
Publisher : Springer Nature
Page : 2241 pages
File Size : 51,8 Mb
Release : 2022-10-04
Category : Medical
ISBN : 9783031054945
This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo. Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of updated cases that define and expand the didactic material in the clinical application chapters. Thoroughly updated and revised, the third edition incorporates new clinical evidence validating the use of radionuclides for diagnosis and therapy in oncology, new radiotracers, and the growing integration of imaging modalities into different types of hybrid imaging. With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Third Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.
Author : Anonim
Publisher : Unknown
Page : 242 pages
File Size : 55,8 Mb
Release : 1971
Category : Electronic
ISBN : MINN:31951P01184392P
Author : Anonim
Publisher : Unknown
Page : 614 pages
File Size : 52,5 Mb
Release : 1993
Category : Forest ecology
ISBN : UCBK:C032664855
Item no. 0080-F.
Author : Sara M. Stinchfield
Publisher : Routledge
Page : 362 pages
File Size : 45,9 Mb
Release : 2013-07-04
Category : Medical
ISBN : 9781136310188
This is Volume XX in a series of twenty-one on Cognitive Psychology. Originally published in 1933, this is a psychological study of the various defects of speech and the suggestion that additional facilities are needed for dealing with the speech-handicapped child or adolescent, because of the bearing of speech disorders upon personality, socialization and economic success.
