Self Assembling Complexes For Gene Delivery

Self Assembling Complexes For Gene Delivery Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Self Assembling Complexes For Gene Delivery book. This book definitely worth reading, it is an incredibly well-written.

Self-Assembling Complexes for Gene Delivery

Alexander V. Kabanov,Philip L. Felgner,Leonard W. Seymour
Self Assembling Complexes for Gene Delivery Book PDF

Author : Alexander V. Kabanov,Philip L. Felgner,Leonard W. Seymour
Publisher : Wiley-Blackwell
Page : 492 pages
File Size : 46,9 Mb
Release : 1998-05-29
Category : Medical
ISBN : UOM:39015042032857

Get Book

Self-Assembling Complexes for Gene Delivery by Alexander V. Kabanov,Philip L. Felgner,Leonard W. Seymour Pdf

Recent years have witnessed an explosion of activity in the field of gene therapy. Following advances in our understanding of the molecular basis of disease, hopes are high that the tremendous potential market for drugs employing antisense nucleotides and genes will one day be fulfilled. However, many obstacles remain, not least problems in the technology of gene delivery systems. Much of today's research focuses on non-viral approaches to gene delivery. Of particular importance are supramolecular complexes formed between DNA and various natural and synthetic polymers and lipids, otherwise known as 'self-assembling complexes for gene delivery'. In view of this fact, the editors of this volume have assembled an international team of contributors to present up-to-date reviews of the major chemical, biological and clinical aspects of such gene delivery vectors. Reflecting the diversity of research in this field, this book comprehensively covers: * the principles of self-assembly * natural mechanisms for gene delivery to cells * cationic lipids and liposomes * polyelectrolyte DNA complexes * systemic biodistribution of drug delivery systems * targeting of conjugates for gene delivery * new approaches to gene delivery * clinical evaluation Self-assembling Complexes for Gene Delivery is an essential reference for all professionals with an interest in gene and antisense therapy or novel drug delivery systems, including medicinal and pharmaceutical chemists, clinicians, human geneticists, molecular biologists and pharmacologists.

Artificial Self-assembling Systems for Gene Delivery

Philip L. Felgner
Artificial Self assembling Systems for Gene Delivery Book PDF

Author : Philip L. Felgner
Publisher : Unknown
Page : 216 pages
File Size : 55,6 Mb
Release : 1996
Category : Language Arts & Disciplines
ISBN : WISC:89058941451

Get Book

Artificial Self-assembling Systems for Gene Delivery by Philip L. Felgner Pdf

Discusses recent advances in artificial self-assembling systems, including retrotransposon vectors, hairpin ribozymes, triple-helix-forming oligonucleotides, liposome-mediated transfection, and photonic nanostructures. Addresses developing efficient synthetic vectors such as modular self-assembling systems mimicking important features of viral vectors. Presents new developments in synthetic self-assembling gene delivery systems, including innovations in nonviral systems, targeting nucleic acids, ligand-polylysine mediated transfer, dendrimer-mediated transfection, cationic liposomes, and polylysine DNA complexes.

Synthetic DNA Delivery Systems

Dan Luo,W. Mark Saltzman
Synthetic DNA Delivery Systems Book PDF

Author : Dan Luo,W. Mark Saltzman
Publisher : Springer Science & Business Media
Page : 160 pages
File Size : 51,7 Mb
Release : 2003-09-30
Category : Science
ISBN : 0306477017

Get Book

Synthetic DNA Delivery Systems by Dan Luo,W. Mark Saltzman Pdf

DNA delivery into cells is a rapidly developing area in gene therapy and biotechnology. Moreover, it is a powerful research tool to determine gene structure, regulation, and function. Viral methods of DNA delivery are well-characterized and efficient, but little is known about the toxicity and immunogenecity of viral vectors. As a result, non-viral, transfection methods of DNA delivery are of increasing interest. Synthetic DNA Delivery Systems is a comprehensive and current resource on DNA transfection. The use of histidine-rich peptides and polypeptides as DNA delivery systems and self-assembled delivery systems based on cationic lipids and polymers are discussed. Targeted delivery to organelles, tumor cells and dendritic cells comprise an important topic.

Nonviral Vectors for Gene Therapy

Mark A. Findeis
Nonviral Vectors for Gene Therapy Book PDF

Author : Mark A. Findeis
Publisher : Springer Science & Business Media
Page : 399 pages
File Size : 53,5 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592591398

Get Book

Nonviral Vectors for Gene Therapy by Mark A. Findeis Pdf

The purpose of this volume of Methods in Molecular Medicine is to set forth examples of the great variety of techniques and applications that are now emerging in the field of nonviral gene therapy. The book emphasizes not only specific approaches to gene delivery but, in particular, the best current me- ods to prepare, handle, and characterize gene delivery agents. These topics are of very broad importance since gene therapy evolves from its mostly ac- emy-based experimental and clinical research to the ever increasing number of industry-driven programs directed toward commercial development. S- cessful introduction of nonviral gene therapy agents into the clinic should be expected to require rigorous manufacturing and analytical methods that readily meet the regulatory guidelines under which new drug candidates are reviewed for marketing approval. Exactly what those guidelines will prove to be c- tainly depends on the established guidelines for review of both biological and chemical therapeutics. Additionally, many new techniques are being devised and applied to gene therapy research; these techniques will be instrumental in developing and characterizing successful gene delivery agents. Nonviral Vectors for Gene Therapy: Methods and Protocols has two main sections. To start with, there is a series of chapters on specific protocols for the synthesis, characterization, and application of gene delivery agents. S- eral chapters address the topic of materials to bind with DNA to form the compact condensed phases that facilitate cellular delivery.

Macromolecular Self-Assembly

Laurent Billon,Oleg Borisov
Macromolecular Self Assembly Book PDF

Author : Laurent Billon,Oleg Borisov
Publisher : John Wiley & Sons
Page : 290 pages
File Size : 46,6 Mb
Release : 2016-09-06
Category : Technology & Engineering
ISBN : 9781118887127

Get Book

Macromolecular Self-Assembly by Laurent Billon,Oleg Borisov Pdf

This book describes techniques of synthesis and self-assembly of macromolecules for developing new materials and improving functionality of existing ones. Because self-assembly emulates how nature creates complex systems, they likely have the best chance at succeeding in real-world biomedical applications. • Employs synthetic chemistry, physical chemistry, and materials science principles and techniques • Emphasizes self-assembly in solutions (particularly, aqueous solutions) and at solid-liquid interfaces • Describes polymer assembly driven by multitude interactions, including solvophobic, electrostatic, and obligatory co-assembly • Illustrates assembly of bio-hybrid macromolecules and applications in biomedical engineering

Electrostatic Effects in Soft Matter and Biophysics

Christian Holm,Patrick Kékicheff,Rudolf Podgornik
Electrostatic Effects in Soft Matter and Biophysics Book PDF

Author : Christian Holm,Patrick Kékicheff,Rudolf Podgornik
Publisher : Springer Science & Business Media
Page : 529 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401005777

Get Book

Electrostatic Effects in Soft Matter and Biophysics by Christian Holm,Patrick Kékicheff,Rudolf Podgornik Pdf

Soft Condensed Matter commonly deals with materials that are mechanically soft and, more importantly, particularly prone to thermal fluctuation effects. Charged soft matter systems are especially interesting: they can be manufactured artificially as polyelectrolytes to serve as superabsorbers in dypers, as flocculation and retention agents, as thickeners and gelling agents, and as oil-recovery process aids. They are also abundant in living organisms, mostly performing important structural (e.g. membranes) and functional (e.g. DNA) tasks. The book describes the many areas in soft matter and biophysics where electrostatic interactions play an important role. It offers in-depth coverage of recent theoretical approaches, advances in computer simulation, and novel experimental techniques. Readership: Advanced undergraduate level in physics, physical chemistry, and theoretical biochemistry.

Pharmaceutical Perspectives of Nucleic Acid-Based Therapy

Ram I. Mahato,Sung Wan Kim
Pharmaceutical Perspectives of Nucleic Acid Based Therapy Book PDF

Author : Ram I. Mahato,Sung Wan Kim
Publisher : CRC Press
Page : 521 pages
File Size : 43,8 Mb
Release : 2002-06-27
Category : Medical
ISBN : 9780203300961

Get Book

Pharmaceutical Perspectives of Nucleic Acid-Based Therapy by Ram I. Mahato,Sung Wan Kim Pdf

Emphasizing its uses in cancer and cardiovascular and autoimmune diseases, Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in

Polymeric Gene Delivery

Mansoor M. Amiji
Polymeric Gene Delivery Book PDF

Author : Mansoor M. Amiji
Publisher : CRC Press
Page : 707 pages
File Size : 40,6 Mb
Release : 2004-09-29
Category : Medical
ISBN : 9780203500477

Get Book

Polymeric Gene Delivery by Mansoor M. Amiji Pdf

To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry

Gene and Cell Therapy

Nancy Smyth Templeton
Gene and Cell Therapy Book PDF

Author : Nancy Smyth Templeton
Publisher : CRC Press
Page : 1154 pages
File Size : 52,8 Mb
Release : 2008-10-06
Category : Science
ISBN : 9780849387999

Get Book

Gene and Cell Therapy by Nancy Smyth Templeton Pdf

Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Diseases Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Strategies Dendrimer Technologies Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies. The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness. The final section discusses recent clinical trials and regulatory issues surrounding the new technology. This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.

Polyelectrolyte Complexes in the Dispersed and Solid State II

Martin Müller
Polyelectrolyte Complexes in the Dispersed and Solid State II Book PDF

Author : Martin Müller
Publisher : Springer
Page : 269 pages
File Size : 50,6 Mb
Release : 2013-08-23
Category : Technology & Engineering
ISBN : 9783642407468

Get Book

Polyelectrolyte Complexes in the Dispersed and Solid State II by Martin Müller Pdf

Polyelectrolyte Complexes for Tailoring of Wood Fibre Surfaces. Polyelectrolyte Complexes in Flocculation Applications. Spontaneous Assembly and Induced Aggregation of Food Proteins. Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors. Sizing, Shaping and Pharmaceutical Applications of Polyelectrolyte Complex Nanoparticles.

Tissue Engineering And Novel Delivery Systems

Michael J. Yaszemski,Debra J. Trantolo,Kai-Uwe Lewandrowski,Vasif Hasirci,David E. Altobelli,Donald L. Wise
Tissue Engineering And Novel Delivery Systems Book PDF

Author : Michael J. Yaszemski,Debra J. Trantolo,Kai-Uwe Lewandrowski,Vasif Hasirci,David E. Altobelli,Donald L. Wise
Publisher : CRC Press
Page : 819 pages
File Size : 55,6 Mb
Release : 2003-11-04
Category : Medical
ISBN : 9780824757731

Get Book

Tissue Engineering And Novel Delivery Systems by Michael J. Yaszemski,Debra J. Trantolo,Kai-Uwe Lewandrowski,Vasif Hasirci,David E. Altobelli,Donald L. Wise Pdf

Essential to anyone working in the field, this reference focuses on rencent advancements in tissue construction, repair and regeneration—examining developments in gene and drug therapy, the evolution of tissue-engineered products, and new technologies for the design of functional tissues and organ systems.

Polymers in Drug Delivery

Ijeoma F. Uchegbu,Andreas G. Schatzlein
Polymers in Drug Delivery Book PDF

Author : Ijeoma F. Uchegbu,Andreas G. Schatzlein
Publisher : CRC Press
Page : 426 pages
File Size : 45,5 Mb
Release : 2006-05-19
Category : Medical
ISBN : 9781000611243

Get Book

Polymers in Drug Delivery by Ijeoma F. Uchegbu,Andreas G. Schatzlein Pdf

Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera

Nonviral Vectors for Gene Therapy

Mien-Chie Hung,Leaf Huang,Ernst Wagner
Nonviral Vectors for Gene Therapy Book PDF

Author : Mien-Chie Hung,Leaf Huang,Ernst Wagner
Publisher : Elsevier
Page : 456 pages
File Size : 45,7 Mb
Release : 1999-07-01
Category : Science
ISBN : 0080479774

Get Book

Nonviral Vectors for Gene Therapy by Mien-Chie Hung,Leaf Huang,Ernst Wagner Pdf

Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways. Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians. Key Features * Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine * Covers all types of nonviral vectors, from molecular structure to therapeutic application Provides a comprehensive review of synthetic vectors * Includes contributions from major investigators and leading experts in the field

Gene Therapy Protocols

Jeffrey R. Morgan
Gene Therapy Protocols Book PDF

Author : Jeffrey R. Morgan
Publisher : Springer Science & Business Media
Page : 521 pages
File Size : 43,5 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781592591411

Get Book

Gene Therapy Protocols by Jeffrey R. Morgan Pdf

Efforts in gene therapy have grown dramatically in recent years. Basic research as well as clinical activity have made exciting progress and are beg- ning to offer renewed hope that gene therapy may be able to deliver novel approaches for the treatment of inherited as well as such acquired diseases as cardiovascular disease and cancer. With the sequencing of the human genome complete, we now have a comprehensive catalog of genes that further expands the potential role of gene therapy into such new fields as tissue engineering. Central to gene therapy is the process of gene transfer; thus, advances in the technology of gene transfer are at the heart of this field’s progress. Numerous technologies, based on a variety of methods (e.g., viral-mediated, physical/ chemical), have been developed to achieve gene transfer. Some of the earliest methods, such as recombinant retroviruses, are still widely used, have undergone significant improvements, and have given rise to new vectors based on lentiviruses.

Advanced Gene Delivery

Alain Rolland
Advanced Gene Delivery Book PDF

Author : Alain Rolland
Publisher : CRC Press
Page : 300 pages
File Size : 43,5 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303818

Get Book

Advanced Gene Delivery by Alain Rolland Pdf

A practical resource for everyone involved in the gene therapy field and in the design of effective gene delivery systems, this volume presents an overview and update of recent advances in the field of non-viral methods for the in vivo transfer of therapeutic genes to biological targets using conventional routes of administration. Methods to control the spatial and temporal modulation of gene function in vivo as well as the level, duration, specificity, and fidelity of gene expression are described. The rational design and the applications of a variety of non-viral gene delivery systems, such as cationic lipid-, polymer-, and (poly) peptide-based systems, are exemplified for the control of location of therapeutic genes administered by various routes. Current and potential clinical applications of gene-based medicines are presented for the prevention, correction or modulation of diseases. Examples of current applications of plasmid-based systems for genetic vaccination, treatment of genetic disorders such as cystic fibrosis, and treatment of acquired diseases such as cancer are also provided.