Signal Transduction By Reactive Oxygen And Nitrogen Species Pathways And Chemical Principles

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Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

H.J. Forman,J.M. Fukuto,M. Torres
Signal Transduction by Reactive Oxygen and Nitrogen Species Pathways and Chemical Principles Book PDF

Author : H.J. Forman,J.M. Fukuto,M. Torres
Publisher : Springer Science & Business
Page : 411 pages
File Size : 47,8 Mb
Release : 2007-05-08
Category : Science
ISBN : 9780306484124

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Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles by H.J. Forman,J.M. Fukuto,M. Torres Pdf

Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

Therapeutic Potentials of Curcumin for Alzheimer Disease

Akhlaq A Farooqui
Therapeutic Potentials of Curcumin for Alzheimer Disease Book PDF

Author : Akhlaq A Farooqui
Publisher : Springer
Page : 402 pages
File Size : 42,8 Mb
Release : 2016-03-05
Category : Medical
ISBN : 9783319158891

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Therapeutic Potentials of Curcumin for Alzheimer Disease by Akhlaq A Farooqui Pdf

This is the first book on the market that explores the importance of curcumin for the treatment of neurological disorders. It has been estimated that 35.6 million people globally had dementia in 2010 and the prevalence of dementia has been predicted to double every 20 years. Thus, 115.4 million people may be living with dementia in 2050. Alzheimer’s disease (AD) is the leading cause of dementia and is present in 60%–70% of people with dementia. Unless new discoveries are made in the prevention or treatment of AD, the number of cases in the US alone is estimated to increase threefold, to 13.2 million by the year 2050. Thus, it is important to focus on delaying and treating the onset of AD by curcumin may be an important step for controlling AD. Regular consumption of healthy diet containing curcumin enriched foods, moderate exercise, and regular sleep may produce beneficial effects not only on motor and cognitive functions, but also on memory deficits that occur to some extent during normal aging and to a large extent in AD. Delaying the onset and progression of AD and improving its symptoms by few years with regular consumption of curcumin may relieve some of the burden on health care systems. In service of this goal, this volume gives readers a comprehensive and cutting edge description of the importance of curcumin for the treatment of AD in cell culture and animal models in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. It can be used as supplement text for a range of neuroscience and nutrition courses. Clinicians, neuroscientists, neurologists and pharmacologists will find this book useful for understanding molecular aspects of AD treatment by curcumin.

Sturkie's Avian Physiology

Colin G. Scanes,Sami Dridi
Sturkie s Avian Physiology Book PDF

Author : Colin G. Scanes,Sami Dridi
Publisher : Academic Press
Page : 1464 pages
File Size : 48,6 Mb
Release : 2021-11-06
Category : Science
ISBN : 9780323853514

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Sturkie's Avian Physiology by Colin G. Scanes,Sami Dridi Pdf

Sturkie's Avian Physiology, Seventh Edition is the classic comprehensive single volume on the physiology of domestic as well as wild birds. This latest edition is thoroughly revised and updated and features several new chapters with entirely new content on such topics as vision, sensory taste, pain reception, evolution, and domestication. Chapters throughout have been greatly expanded due to the many recent advances in the field. This book is written by international experts in different aspects of avian physiology. For easy reading and searches, this book is structured under a series of themes, beginning with genomic studies, sensory biology and nervous systems, and major organs. The chapters then move on to investigate metabolism, endocrine physiology, reproduction, and finally cross-cutting themes such as stress and rhythms. New chapters on feathers and skin are featured as well. Sturkie’s Avian Physiology, Seventh Edition is an important resource for ornithologists, poultry scientists, and other researchers in avian studies. It is also useful for students in avian or poultry physiology, as well as avian veterinarians. Stands out as the only single volume devoted to bird physiology Features updates, revisions, or additions to each chapter Written and edited by international leaders in avian studies

Feed Efficiency in the Beef Industry

Rodney A. Hill
Feed Efficiency in the Beef Industry Book PDF

Author : Rodney A. Hill
Publisher : John Wiley & Sons
Page : 328 pages
File Size : 47,7 Mb
Release : 2012-06-18
Category : Science
ISBN : 9781118388242

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Feed Efficiency in the Beef Industry by Rodney A. Hill Pdf

Feed Efficiency in the Beef Industry provides a thorough and concise overview of feed efficiency in beef cattle. It frames the great importance of feed efficiency to the industry and details the latest findings of the many scientific disciplines that intersect and aim to improve efficient and sustainable production of nutritious beef. The vast majority of production costs are directly tied to feed. With increased demand for grains to feed a rapidly increasing world population and to supply a new demand for alternative fuels, feed costs continue to increase. In recent years, the negative environmental impacts of inefficient feeding have also been realized; as such feed efficiency is an important factor in both economic viability and environmental sustainability of cattle production. Feed Efficiency in the Beef Industry covers a broad range of topics ranging from economic evaluation of feed efficiency to the physiological and genetic bases of efficient conversion of feed to high quality beef. Chapters also look at how a fuller understanding of feed efficiency is leading to new selective breeding efforts to develop more efficient cattle. With wide-ranging coverage from leading international researchers, Feed Efficiency will be a valuable resource for producers who wish to understand the complexities, challenges, and opportunities to reduce their cost of production, for students studying the topic and for researchers and professionals working in the beef industry.

Studies on Men's Health and Fertility

Ashok Agarwal,Robert John Aitken,Juan G Alvarez
Studies on Men s Health and Fertility Book PDF

Author : Ashok Agarwal,Robert John Aitken,Juan G Alvarez
Publisher : Springer Science & Business Media
Page : 671 pages
File Size : 53,8 Mb
Release : 2012-03-17
Category : Science
ISBN : 9781617797750

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Studies on Men's Health and Fertility by Ashok Agarwal,Robert John Aitken,Juan G Alvarez Pdf

Studies on Men’s Health and Fertility provides a comprehensive series of up-to-the-minute reviews addressing the role of oxidative stress in the aetiology of reproductive pathologies in the male. This volume represents by far the most detailed, authoritative review of the field that has been produced to date. The text encompasses the basic science of reactive oxygen species (ROS) production by mammalian spermatozoa, the way in which these highly reactive molecules are processed by the germ line and the physiological significance of this redox activity in the generation of a functional gamete. The factors responsible for perturbing the delicate balance between physiological redox signaling on the one hand and oxidative stress on the other are also extensively reviewed and some of the first clues concerning the underlying mechanisms (age, heat, infection, cryostorage, aberrant lipid metabolism), clearly identified. From a clinical perspective there are chapters setting out the methods we should be using to diagnose oxidative stress in the male germ line, a clinical perspective on the aetiology of this condition and detailed considerations of the most suitable means of ameliorating such stress from a therapeutic point of view. Studies on Men’s Health and Fertility is intended to provide clinicians and scientists with a snap shot of the current status of this exciting, rapidly moving field. The book will be of value to clinicians interested in strategies for the management of oxidative stress in their infertility patients and scientists wishing to understand the molecular mechanisms underpinning the generation of ROS by these cells and its pathophysiological significance. It was not so long ago that the ability of spermatozoa to generate ROS was a hotly disputed topic. With the publication of this book such doubts can finally be laid to rest. There is now no doubt that these cells actively generate ROS, that oxidative stress is a major contributor to defects in male reproductive health and that the successful clinical management of this condition depends on developing a deeper understanding of the underlying molecular mechanisms. In this quest, Studies on Men’s Health and Fertility will be seen as a clear and important milestone.

Gasotransmitters in Plants

Lorenzo Lamattina,Carlos García-Mata
Gasotransmitters in Plants Book PDF

Author : Lorenzo Lamattina,Carlos García-Mata
Publisher : Springer
Page : 334 pages
File Size : 44,6 Mb
Release : 2016-09-01
Category : Science
ISBN : 9783319407135

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Gasotransmitters in Plants by Lorenzo Lamattina,Carlos García-Mata Pdf

This book describes the three gasotransmitters nitric oxide (NO), hydrogen sulphide (H2S) and carbon monoxide (CO) and their function as intracellular signalling molecules in plants. Common properties are shared by NO, H2S and CO: they are beneficial at low concentrations but hazardous in higher amounts; they are small molecules of gas; they can freely cross cell membranes; their effects do not rely on receptors; they are generated enzymatically and their production is regulated; their functions can be mimicked by exogenous application; and their cellular effects may or may not be mediated by second messengers, but have specific cellular and molecular targets. In plants, many aspects of the biology of gasotransmitters remain completely unknown and generate intriguing questions, which will be discussed in this book.

Medical Mineralogy and Geochemistry

Nita Sahai,Martin A. A. Schoonen
Medical Mineralogy and Geochemistry Book PDF

Author : Nita Sahai,Martin A. A. Schoonen
Publisher : Walter de Gruyter GmbH & Co KG
Page : 344 pages
File Size : 54,8 Mb
Release : 2018-12-17
Category : Science
ISBN : 9781501509421

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Medical Mineralogy and Geochemistry by Nita Sahai,Martin A. A. Schoonen Pdf

Volume 64 of Reviews in Mineralogy and Geochemistry presents examples that include the effects of inhaled dust particles in the lung (Huang et al. 2006; Schoonen et al. 2006), biomineralization of bones and teeth (Glimcher et al. 2006), the formation of kidney-stones, the calcification of arteries, the speciation exposure pathways and pathological effects of heavy metal contaminants (Reeder et al. 2006; Plumlee et al. 2006), the transport and fate of prions and pathological viruses in the environment (Schramm et al. 2006), the possible environmental-genetic link in the occurrence of neurodegenerative diseases (Perl and Moalem 2006), the design of biocompatible, bioactive ceramics for use as orthopaedic and dental implants and related tissue engineering applications (Cerruti and Sahai 2006) and the use of oxide-encapsulated living cells for the development of biosensors (Livage and Coradin 2006).

Nitric Oxide Donors

Amedea Seabra
Nitric Oxide Donors Book PDF

Author : Amedea Seabra
Publisher : Academic Press
Page : 364 pages
File Size : 50,8 Mb
Release : 2017-03-17
Category : Medical
ISBN : 9780128134597

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Nitric Oxide Donors by Amedea Seabra Pdf

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

Natural Molecules in Neuroprotection and Neurotoxicity

Marcos Roberto de Oliveira
Natural Molecules in Neuroprotection and Neurotoxicity Book PDF

Author : Marcos Roberto de Oliveira
Publisher : Elsevier
Page : 2202 pages
File Size : 51,5 Mb
Release : 2023-11-24
Category : Science
ISBN : 9780443237645

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Natural Molecules in Neuroprotection and Neurotoxicity by Marcos Roberto de Oliveira Pdf

Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This book is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-related strategies utilized in neuroprotection. Written by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This book provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease. Covers both neuroprotective and neurotoxic outcomes resulted from the exposure of brain cells to natural molecules Analyzes numerous natural compounds, including animal, vegetal, fungal, bacterial, and marine-derived molecules Discusses the effects of the metabolism of microbiota on the biotransformation of natural molecules and the consequences of these processes on brain cells Contains a section focused on the nanotechnology-related strategies utilized to enhance the bioavailability of natural molecules to brain cells

Cigarette Smoke and Oxidative Stress

Barry B. Halliwell,Henrik E. Poulsen
Cigarette Smoke and Oxidative Stress Book PDF

Author : Barry B. Halliwell,Henrik E. Poulsen
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 47,7 Mb
Release : 2007-05-24
Category : Medical
ISBN : 9783540322320

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Cigarette Smoke and Oxidative Stress by Barry B. Halliwell,Henrik E. Poulsen Pdf

The mechanism by which cigarette smoke causes or contributes to inflammatory diseases like chronic obstructive pulmonary disease, cardiovascular disease and cancer remains unclear. Recent developments in our knowledge of cellular signaling suggest that cigarette smoke may cause oxidative stress in cellular systems. The assessment, consequences and possible modulation of these effects are discussed in this book which will interest oncologists and researchers in Biochemistry.

Paraoxonases in Inflammation, Infection, and Toxicology

Srinivasa T. Reddy
Paraoxonases in Inflammation Infection and Toxicology Book PDF

Author : Srinivasa T. Reddy
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 53,8 Mb
Release : 2010-03-11
Category : Science
ISBN : 9781607613503

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Paraoxonases in Inflammation, Infection, and Toxicology by Srinivasa T. Reddy Pdf

The pivotal role of the Paraoxonases (PON) family in a variety of inflammatory diseases, e.g. atherosclerosis, in preventing the toxicity of organophosphorus insecticides and nerve agents and a variety of other compounds has made them an interesting target for both clinicians and scientists alike. Research into the paraoxonase (PON) family of enzymes (PON1, PON2 and PON3) has increased exponentially over the last five years especially following the initiation of paraoxonase conferences.The objectives of the 3rd ICP remains the same as the previous two conferences: to disseminate the latest aspects of research into the genetics, biochemistry, structural biology, regulation of PONs and their roles in inflammatory diseases e.g. atherosclerosis with expert lectures from 20 invited plenary lecturers and another 30-40 short and poster presentations from young investigators.The conference organizers anticipate a global attendance at the conference of between 150- 200 persons. Particular aspects of this conference will include the Bert N La Du Memorial Lecture, 3 Memorial Traveling Fellowships for Young Investigators and a round table discussion on the impact of the latest research on PON. UCLA provides a great venue for students, postdoctoral fellows and clinical scientists to interact with experts in the PON fields of study. The explosion of research into the PON family makes this a timely conference to review recent exciting advances in the field and provide an environment for cross-fertilization of ideas, particularly important for researchers new to the field.

Molecular Fluorescent Sensors for Cellular Studies

Elizabeth J. New
Molecular Fluorescent Sensors for Cellular Studies Book PDF

Author : Elizabeth J. New
Publisher : John Wiley & Sons
Page : 308 pages
File Size : 52,8 Mb
Release : 2022-08-16
Category : Science
ISBN : 9781119749868

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Molecular Fluorescent Sensors for Cellular Studies by Elizabeth J. New Pdf

Molecular Fluorescent Sensors for Cellular Studies Enables readers to fully understand the fundamentals and chemical principles of fluorescent sensing and the design of fluorescent sensors Fluorescent sensors are able to provide specific chemical information about cells and can be invaluable in understanding processes that underpin health and disease. Molecular Fluorescent Sensors for Cellular Studies provides an avenue into and overview of currently available fluorescent sensing technology and its application to biological imaging. This book aims to help the reader understand the principles of fluorescence and the mechanisms by which fluorescent sensors operate in order to ensure appropriate and optimal use of sensors. Key applications of fluorescent sensing are presented, with explanations not only of how new sensors can be designed, but also how existing sensors can be applied to various biological settings and conditions. Clear and engaging schematics throughout the book explain chemical principles of sensing to the non-expert. Discusses the breadth of fluorescent sensors, from commercially available sensors to those reported in literature which are yet to be used widely Explains how fluorescent sensors operate for appropriate and optimal use from a theoretical standpoint Provides guidance on how to achieve optimal use of fluorescent sensors in practical settings Summarizes the principles behind fluorescent sensors and their design This work will be an invaluable resource for postgraduates and professionals in the fields of microscopy, bioimaging, and diagnostic imaging who wish to harness the information to improve practical applications and to gain key knowledge surrounding the many facets of fluorescent sensing. It is also of interest to medical and biological researchers working across industry, universities and medical institutes.

Inflammation and Oxidative Stress in Neurological Disorders

Akhlaq A. Farooqui
Inflammation and Oxidative Stress in Neurological Disorders Book PDF

Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 47,8 Mb
Release : 2014-01-27
Category : Medical
ISBN : 9783319041117

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Inflammation and Oxidative Stress in Neurological Disorders by Akhlaq A. Farooqui Pdf

Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.

Nitric Oxide

Anonim
Nitric Oxide Book PDF

Author : Anonim
Publisher : Academic Press
Page : 483 pages
File Size : 46,5 Mb
Release : 2014-08-12
Category : Science
ISBN : 9780128004395

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Nitric Oxide by Anonim Pdf

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on nitric oxide. Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels Three-dimensional structures in color Elaborate signaling pathways

Basic Principles and Clinical Significance of Oxidative Stress

Sivakumar Joghi Thatha Gowder
Basic Principles and Clinical Significance of Oxidative Stress Book PDF

Author : Sivakumar Joghi Thatha Gowder
Publisher : BoD – Books on Demand
Page : 330 pages
File Size : 40,7 Mb
Release : 2015-11-11
Category : Science
ISBN : 9789535122005

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Basic Principles and Clinical Significance of Oxidative Stress by Sivakumar Joghi Thatha Gowder Pdf

It is a natural phenomenon for all living organisms in the world to undergo different kinds of stress during their life span. Stress has become a common problem for human beings in this materialistic world. In this period, a publication of any material on stress will be helpful for the human society. The book Basic Principles and Clinical Significance of Oxidative Stress targets all aspects of oxidative stress, including principles, mechanisms, and clinical significance. This book covers four sections: Free Radicals and Oxidative Stress, Natural Compounds as Antioxidants, Antioxidants - Health and Disease, and Oxidative Stress and Therapy. Each of these sections is interwoven with the theoretical aspects and experimental techniques of basic and clinical sciences. This book will be a significant source to scientists, physicians, healthcare professionals, and students who are interested in exploring the effect of stress on human life.