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Nitric Oxide Donors by Peng George Wang,Tingwei Bill Cai,Naoyuki Taniguchi Pdf
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders by Lucia Morbidelli,Benjamin Bonavida Pdf
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research
Management of Chronic Musculoskeletal Conditions in the Foot and Lower Leg E-Book by Keith Rome,Peter McNair Pdf
Bridging the gap between undergraduate and postgraduate knowledge and experience, this new full colour resource uses an interdisciplinary approach to help manage chronic conditions – osteoarthritis, Achilles tendinopathy, gout, rheumatic diseases, forefoot/rearfoot entities, stress fractures/reactions, cerebral palsy – in the lower limb and foot. Each chapter includes sections on predisposing factors, diagnosis, impairments, function, quality of life and management strategies while highlighting any complex features of a condition which may present. The latest advances are discussed with suggestions for new paths of research – ‘future directions’. The text is further supported by additional commentaries from internationally renowned researchers who highlight the key elements of the work and provide a supplementary perspective of the particular clinical condition. A general view of the patient’s needs is offered throughout, connecting clinical realities to real-world patient experiences. Management of Chronic Conditions in the Foot and Lower Leg is a comprehensive, practical tool that can be used to inform daily decision making in practice as well as to support those who build policy and management strategies in the clinical areas covered. Clear content and structure supported by full colour illustrations Includes less discussed conditions such as gout and cerebral palsy Focus on pain, impairment, function, quality of life and management strategies Critical reflections by experts highlight current clinical practice and thinking in research Provides a sound interpretation of research findings Features patient-reported outcome measures and health related behaviour strategies
Nitric Oxide (Donor/Induced) in Chemosensitization by Benjamin Bonavida Pdf
Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations
Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.
Functionalised Cardiovascular Stents by Gerard Wall,Halina Podbielska,Magdalena Wawrzynska Pdf
Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo. Provides a specific focus on cardiovascular stents Includes a range of topics covering the fundamentals, surface modification and biofunctionalization Provides essential knowledge for researchers on advances in the field
Synthesis of Novel Nitric Oxide Donors and Prodrugs of 5-fluorouracil by Tingwei Cai Pdf
Abstract: This dissertation describes my Ph. D. work that focused on the synthesis and evaluation of novel nitric oxide donors, and the synthesis of derivatives of 5-fluorouracil. In chapter 1, a series of alkyl and aryl N-hydroxyguanidines were synthesized and demonstrated to act as substrates of nitric oxide synthases (NOS). The discovery of these non-amino acid hydroxyguanidines as novel substrates also led to the discovery of a novel-binding mode of NOS. In chapter 2, in order to achieve site specific delivery of nitric oxide (NO), a new class of glycosidase activated NO donors has been developed. Glucose and galactose were covalently coupled to 3-morphorlinosydnonimine (SIN-1), a mesoionic heterocyclic NO donor, via a carbamate linkage at the anomeric position. The beta-glycosides were successfully prepared for these conjugates, while the alfa glycosidic compounds were very unstable. The new stable sugar-NO conjugates could release NO in the presence of glycosidases. Such NO prodrugs may be used as enzyme activated NO donors in biomedical research. In chapter 3, a new sialated diazeniumdiolate has been synthesized and the glycosylation product was exclusively an alfa anomer. This new nitric oxide donor exhibited significantly improved stability as compared to its parent diazeniumdiolate salts and it could be efficiently hydrolyzed by neuraminidase to release nitric oxide with a Km of 0.14 mM. The sialic acid-NO conjugate would be a valuable prodrug that targets NO to influenza viruses. In chapter 4, two classes of prodrugs of 5-fluorouracil (FU) were synthesized. The first type is FU-NO conjugate. The synthesized compounds showed greater cytotoxicities than 5-fluorouracil for DU 145 human prostate and HeLa cancer cells. The second type is carbohydrate-FU conjugate. A new reverse glycosadition was also developed to prepare sugar conjugates. In chapter 5, 7-carboxylindazole, as well as 5- and 6-carboxylindazoles was synthesized. These compounds were designed as isosteres of 7-nitroindazole, a well-known inhibitor of NOS. However, they did not show potent inhibition to NOS.
Ruthenium Complexes by Alvin A. Holder,Lothar Lilge,Wesley R. Browne,Mark A.W. Lawrence,Jimmie L. Bullock, Jr. Pdf
Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.
Bertram G. Katzung,Marieke Kruidering-Hall,Rupa Lalchandani Tuan,Todd W. Vanderah,Anthony J. Trevor
Author : Bertram G. Katzung,Marieke Kruidering-Hall,Rupa Lalchandani Tuan,Todd W. Vanderah,Anthony J. Trevor Publisher : McGraw Hill Professional Page : 608 pages File Size : 53,9 Mb Release : 2021-06-25 Category : Medical ISBN : 9781260117134
Katzung & Trevor's Pharmacology Examination and Board Review, Thirteenth Edition by Bertram G. Katzung,Marieke Kruidering-Hall,Rupa Lalchandani Tuan,Todd W. Vanderah,Anthony J. Trevor Pdf
Score your highest on medical pharmacology courses and board exams with the world’s bestselling pharmacology review book! More than 1,000 Q&A! This authoritative resource from the authors of pharmacology’s most trusted textbook delivers a clear, concise review of fundamental concepts backed by more than 1,000 review questions and answers. With fully up-to-date content, the chapter-based approach facilitates use with course notes or larger texts. Everything you need to excel: 1,000+ board-review type questions Concise discussion of the major concepts that underlie basic principles or specific drug groups in every chapter Two comprehensive 100-question practice exams with answer keys and explanations for correct answers List of high-yield terms and definitions Skill Keeper Questions that help you understand the connections of related topics 180 photos and illustrations―including explanatory figures and tables, and overview diagrams that visually organize drug groups and concepts Checklist of tasks you should be able to perform upon completion of the chapter Summary tables that provide key information about specific drug mechanisms of action and effects, clinical uses, pharmacokinetics, drug interactions, and toxicities Test-taking strategies for improving your test performance
Nitric Oxide Synthase by Seyed Soheil Saeedi Saravi Pdf
Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.
John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin Publisher : Academic Press Page : 2074 pages File Size : 48,5 Mb Release : 2008-09-29 Category : Medical ISBN : 9780080568751
Principles of Bone Biology by John P. Bilezikian,Lawrence G. Raisz,T. John Martin Pdf
Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Methods in Nitric Oxide Research by Martin Feelisch,Jonathan S. Stamler Pdf
This handbook describes methods for the measurement and investigation of nitric oxide. The topics discussed include the metabolism of substrates and cofactors, the detection of nitrogen oxides, the detection of nitrogen oxide synthase activity, and the detection of adducts and reaction products.
Ocular Therapeutics by Thomas Yorio,Abbott Clark,Martin B Wax Pdf
Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future. * Contains information that is vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. * Provides not only information on current approaches to treatment, but also gives the reader a greater understanding as to what may become available for treating a number of important eye diseases. * Historical perspective for each of the topics as well as an important glimpse into the near future to develop an understanding of the new research directions underway. * New insight for drug delivery and for managing devastating diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States
