Stretch Intensity And The Inflammatory Response A Paradigm Shift

Author : Nikos C. Apostolopoulos
Publisher : Springer
Page : 231 pages
File Size : 49,8 Mb
Release : 2018-12-27
Category : Science
ISBN : 9783319968001

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Stretch Intensity and the Inflammatory Response: A Paradigm Shift by Nikos C. Apostolopoulos Pdf

In this manuscript, practitioners and students who are concerned with sports and rehabilitation medicine, kinesiology, as well as coaches and athletes, are introduced to numerous concepts, including mechanotransduction, inflammation, pro- and anti-inflammatory cytokines, calpains, the extracellular matrix, neutrophils and macrophages, and their relevance to stretching, particularly stretching intensity. Although the quantitative parameters of training, duration, and frequency are important, it is the qualitative criterion of intensity (“how much”) that the author suggests is ultimately of greater concern. Intensity, the rate and magnitude of force, may be responsible for the proper recovery, regeneration, and adaptation of the musculoskeletal tissues from training, competition, or rehabilitation from injuries. Research suggests that too much force results in the stimulation of an inflammatory response, one associated with a biochemical feedback emerging from a mechanical stimulus. The intent of this manuscript is twofold: to initiate the discussion of the importance of stretching intensity with regard to proper recovery, regeneration, and adaptation, and to suggest that researchers need to explore its potential role in addressing numerous inflammatory (RA) and non-inflammatory (OA, recurrent tendinitis etc.) musculoskeletal conditions as well.

Author : Waliza Ansar,Shyamasree Ghosh
Publisher : Springer
Page : 301 pages
File Size : 49,5 Mb
Release : 2016-03-23
Category : Medical
ISBN : 9788132226802

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Biology of C Reactive Protein in Health and Disease by Waliza Ansar,Shyamasree Ghosh Pdf

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Author : Institute of Medicine,National Research Council,Commission on Behavioral and Social Sciences and Education,Panel on Musculoskeletal Disorders and the Workplace
Publisher : National Academies Press
Page : 511 pages
File Size : 49,6 Mb
Release : 2001-06-24
Category : Business & Economics
ISBN : 9780309072847

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Musculoskeletal Disorders and the Workplace by Institute of Medicine,National Research Council,Commission on Behavioral and Social Sciences and Education,Panel on Musculoskeletal Disorders and the Workplace Pdf

Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.

Author : Laurence E. Holt,Thomas E. Pelham,Jason Holt
Publisher : Springer Science & Business Media
Page : 166 pages
File Size : 50,5 Mb
Release : 2009-11-27
Category : Medical
ISBN : 9781603271059

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Flexibility: A Concise Guide by Laurence E. Holt,Thomas E. Pelham,Jason Holt Pdf

Here is a definitive guide to flexibility that revises the conceptual framework of the field. From the conceptual foundations of research to the practical applications of stretching techniques in a number of domains, this book provides a fresh perspective on flexibility, one that challenges current thinking and professional practice. It covers all major types of flexibility technique and training, with an emphasis on when and how to use each method safely and effectively. Specific applications to rehabilitation, sport, fitness, and dance make this book an invaluable resource for all practitioners and professionals in the field of human movement.

Author : Alexander Mauro
Publisher : Raven Press (ID)
Page : 582 pages
File Size : 50,8 Mb
Release : 1979
Category : Medical
ISBN : UOM:39015015064226

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Muscle Regeneration by Alexander Mauro Pdf

Author : Bruna Corradetti
Publisher : Springer
Page : 241 pages
File Size : 44,9 Mb
Release : 2016-11-30
Category : Technology & Engineering
ISBN : 9783319454337

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The Immune Response to Implanted Materials and Devices by Bruna Corradetti Pdf

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Author : Sarah J. Woodruff Atkinson,Carol Kennedy Armbruster,Ellen M. Evans
Publisher : Unknown
Page : 417 pages
File Size : 45,9 Mb
Release : 2021
Category : Exercise
ISBN : 9781492589839

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Fitness and Wellness in Canada by Sarah J. Woodruff Atkinson,Carol Kennedy Armbruster,Ellen M. Evans Pdf

"Developed specifically for the Canadian audience and written for first-year undergraduate students taking a general education fitness and wellness course, Fitness and Wellness in Canada: A Way of Life uses an engaging learning environment to provide students with the tools they need to become fit and well for life. In addition to providing students with an overview of the health-related components of fitness, Fitness and Wellness in Canada: A Way of Life teaches students how to embrace healthy eating and enjoy being physically active. Students learn how to establish fitness and wellness goals for now and throughout their lives. They learn how to manage stress, reduce the risk of metabolic syndrome and cancer, remain free from addiction, and develop a healthy sexuality"--

Author : Armbruster, Carol K.,Evans, Ellen,Sherwood-Laughlin, Catherine
Publisher : Human Kinetics
Page : 417 pages
File Size : 53,8 Mb
Release : 2018-07-27
Category : Health & Fitness
ISBN : 9781492552666

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Fitness and Wellness by Armbruster, Carol K.,Evans, Ellen,Sherwood-Laughlin, Catherine Pdf

The physical and mental health concepts presented in Fitness and Wellness: A Way of Life will point readers toward a healthy lifestyle. The guidance on topics such as fitness, nutrition, weight management, stress management, and sexual health can lead students to a better quality of life.

Author : Matthijs Blankesteijn,Raffaele Altara
Publisher : Academic Press
Page : 220 pages
File Size : 47,7 Mb
Release : 2014-12-05
Category : Medical
ISBN : 9780128004852

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Inflammation in Heart Failure by Matthijs Blankesteijn,Raffaele Altara Pdf

Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 722 pages
File Size : 51,9 Mb
Release : 1999-05-13
Category : Medical
ISBN : 9780309173186

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Military Strategies for Sustainment of Nutrition and Immune Function in the Field by Institute of Medicine,Committee on Military Nutrition Research Pdf

Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 44,5 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

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Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Author : Michael Gleeson,Nicolette Bishop,Neil Walsh
Publisher : Routledge
Page : 581 pages
File Size : 54,5 Mb
Release : 2013-06-26
Category : Medical
ISBN : 9781136455858

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Exercise Immunology by Michael Gleeson,Nicolette Bishop,Neil Walsh Pdf

Exercise immunology is an important, emerging sub-discipline within exercise physiology, concerned with the relationship between exercise, immune function and infection risk. This book offers a comprehensive, up-to-date and evidence-based introduction to exercise immunology, including the physiological and molecular mechanisms that determine immune function and the implications for health and performance in sport and everyday life. Written by a team of leading exercise physiologists, the book describes the characteristics of the immune system and how its components are organised to form an immune response. It explains the physiological basis of the relationship between stress, physical activity, immune function and infection risk, and identifies the ways in which exercise and nutrition interact with immune function in athletes and non-athletes. The book shows students how to evaluate the strengths and limitations of the evidence linking physical activity, immune system integrity and health, and explains why exercise is associated with anti-inflammatory effects that are potentially beneficial to long-term health. Every chapter includes useful features, such as clear summaries, definitions of key terms, discussions of seminal research studies and practical guidelines for athletes on ways to minimise infection risk, with additional learning resources available on a companion website. This is an essential textbook for any course on exercise immunology or advanced exercise physiology.

Author : Linn Karlsson
Publisher : Linköping University Electronic Press
Page : 96 pages
File Size : 50,7 Mb
Release : 2017-05-04
Category : Electronic
ISBN : 9789176855188

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Chronic Pain and Exercise by Linn Karlsson Pdf

Chronic pain is common in western countries and entails considerable consequences for the afflicted individuals as well as for the society. Furthermore, chronic pain is complex including an advanced interplay between biological-, psychological- and social aspects. Treatment of chronic pain attempts to decrease pain intensity and increase physical-, psychological- and social functioning. However, the treatment of chronic pain is still not optimized. Different types of physical activity and exercise (PA&E) are commonly applied as non-pharmacological treatment strategies for chronic pain, but the most efficient type and dose of PA&E are unclear. In addition, adherence to prescribed PA&E is often troublesome, which further complicates the application of PA&E as treatment for chronic pain. The aim of this thesis is to increase the knowledge about PA&E as treatment for chronic pain regarding pain intensity, biochemical substances, adherence and attitudes. The findings of this thesis were that a long-term, home-based PA&E intervention comprising strength exercises as well as stretch exercises decreased pain intensity and increased function in women with chronic neck- and shoulder pain. Using microdialysis technique, differences in pain modulatory biochemical substances were found, before the intervention, in painful trapezius muscle compared to pain-free trapezius muscle. In addition, alterations in pain modulatory substances in painful trapezius muscle after the intervention were found, which possibly could imply peripheral physiological effects of PA&E. Furthermore, psychological factors could be associated to the effects of and adherence to the PA&E intervention. An intention to be physically active were expressed by patients with chronic pain, but a discordance between the intention and PA&E-behaviour were evident, even though the PA&E were experienced as valuable. In conclusion, this thesis strengthens the importance of PA&E as treatment for chronic pain. Especially, this thesis increases the knowledge about; possible peripheral pain inhibitory effects after long-term exercise; how psychological factors might affect the results of PA&E; and also about important behavioural aspects that might affect adherence to prescribed PA&E. This thesis highlights the need of more research on physiological pain inhibitory effects of long-term PA&E in chronic pain. Furthermore, improved methods for ensured adherence to prescribed PA&E are necessary in order to optimize the effect of PA&E as treatment for chronic pain.

Author : Walter Gottlieb Land
Publisher : Springer
Page : 870 pages
File Size : 47,6 Mb
Release : 2018-10-09
Category : Medical
ISBN : 9783319786551

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Damage-Associated Molecular Patterns in Human Diseases by Walter Gottlieb Land Pdf

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

Author : Michael Gleeson
Publisher : Elsevier Health Sciences
Page : 338 pages
File Size : 42,5 Mb
Release : 2006-01-01
Category : Medical
ISBN : 9780443101182

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Immune Function in Sport and Exercise by Michael Gleeson Pdf

This title is directed primarily towards health care professionals outside of the United States. Designed to help readers understand and evaluate the relationship between exercise, immune function and infection risk, this book presents evidence for the "J-shaped" relationship between exercise load and infection risk. It also describes the components of the human immune system and key functions that protect the body from disease, the impact of acute and chronic psychological stress on immune function, and practical guidelines for minimizing the risk of immunodepression and infection in athletes. Further chapters explore different ways of measuring immune function, as well as the effects of heavy training on innate and specific (acquired) immunity, exercise in environmental extremes, and nutrition. Connections between exercise, infection risk, and immune function in special populations (elderly, obese, diabetic and HIV patients) are also addressed. Authored by a team of highly experienced experts. The "J-shaped" relationship between exercise load and infection risk is described, backed by current research and evidence. Components of the immune system and normal immune function are explained in detail, as well as methods for measuring immune function. The impact of acute and chronic psychological stress on immune function is presented, along with suggestions for minimizing the risk of immunodepression and infection in athletes. The effects of heavy training, exercise in environmental extremes, and nutrition are discussed with regard to their impact on innate and specific (acquired) immunity. Immune function in special populations (elderly, obese, diabetic and HIV patients) is also addressed, exploring links between exercise and infection risk in these groups. Evidence-based coverage includes a list of references in each chapter, as well as suggestions for further reading that direct readers to important texts and review articles. Information is presented in an easily accessible format, following a logical progression of material. LEach chapter begins with a list of learning objectives and ends with a list of key points to reinforce learning. A glossary at the end of the book defines all key terms and abbreviations.