Therapeutic Applications Of Cell Microencapsulation

Author : Jose Luis Pedraz,Gorka Orive
Publisher : Springer Science & Business Media
Page : 167 pages
File Size : 54,5 Mb
Release : 2010-12-31
Category : Medical
ISBN : 9781441957863

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Therapeutic Applications of Cell Microencapsulation by Jose Luis Pedraz,Gorka Orive Pdf

The advancement of science is ever more contingent upon the interaction of experts vast amount of scientific information being gathered every day that exceeds the ability of any one scientist to acquire. As an illustration of the frantic pace of scientific disc- more acute in the case of scientific fields at the interface of different and seemingly distant areas of study. Amidst these, the field of cell encapsulation brings together an array of diverse disciplines such as molecular biology and biopolymers, gene therapy and inorganic membranes, stem cell biology and physicochemistry, immunology and nanotechnology. Clearly, such range of topics is too broad for any individual scientist the state-of-the-art in the field of cell encapsulation. At the core of this technology, there is an interaction of physicochemical and biological elements forming three distinct layers of complexity. First, the chemistry of the biopolymer dictates the degree of protein adsorption, vascularization, tox- ity and biocompatibility of the microcapsules. Advances in biopolymer science are providing solutions to overcome existing challenges and to improve microcapsules as delivery vehicles. Second, the choice of cells, and more precisely the plethora of in determining the immune response elicited by the host to implanted microcapsules.

Author : Emmanuel C. Opara
Publisher : Humana
Page : 366 pages
File Size : 43,8 Mb
Release : 2018-06-08
Category : Science
ISBN : 1493981773

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Cell Microencapsulation by Emmanuel C. Opara Pdf

This volume provides a unique forum to review cell microencapsulation in a broad sense by exploring various cell types that have been encapsulated for different purposes, different approaches and devices used for microencapsulation, the biomaterials used in cell microencapsulation, the challenges to the technology, and the current status of its application in different clinical situations. This book is divided in five sections: Section I is an introductory part that discusses historical developments of the technology and its current challenges, as well as the various applications of cell microencapsulation; Section II discusses the main approaches and devices currently used in cell microencapsulation; Section III presents an overview of the various polymeric materials currently in use for cell microencapsulation and the enabling technologies to either monitor or enhance encapsulated cell function; Section IV gives specific examples of the methods used to encapsulate various cell types; and Section V provides an overview of the different clinical situations in which cell microencapsulation has been applied. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Cell Microencapsulation: Methods and Protocols is a valuable reference for researchers, engineers, clinicians, and other healthcare professionals, as well as food technologists who will find detailed descriptions of methods for the microencapsulation of specific cell types and their current of potential clinical and industrial applications. This volume also includes detailed information about the design and manufacture of different devices including large-scale production devices for use in cell microencapsulation.

Author : Eva Maria Brandtner,John Austin Dangerfield
Publisher : Bentham Science Publishers
Page : 195 pages
File Size : 41,7 Mb
Release : 2013-05-31
Category : Medical
ISBN : 9781608057207

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Bioencapsulation of Living Cells for Diverse Medical Applications by Eva Maria Brandtner,John Austin Dangerfield Pdf

Bioencapsulation (or microencapsulation) of cells and their implantation into a body of immunoprotected cells allows researchers to revive a missing or defective function in the cells. Microencapsulated cells have reached the clinic where they have been shown to be safe and efficacious in numerous clinical trials. Cell types that have been encapsulated for therapeutic purposes include hybridomas, islet cells, "platform" cell lines e.g. HEK293 and CHO cells as well as an increasing focus on the encapsulation of stem cells. This e-book explains the different methods used for achieving cell bioencapsulation based on different polymers e.g. alginate, cellulose sulphate and agarose. Other chapters in this book subsequently describe the use of cell encapsulation in cancer therapy to improve on existing chemotherapies by reducing doses and thus side effects while increasing efficacy for long term in vivo production of (i) tumoricidal or virus neutralising antibodies, (ii) insulin to achieve a self regulating treatment for diabetes and (iii) neuron nurturing factors to treat CNS diseases such as epilepsy, disorders like Parkinson's disease, Alzheimer, Amyotrophic lateral sclerosis, Huntington's disease and pathologies caused by trauma and/or ischemic processes. The book also includes a chapter reviewing the genetic engineering of cells to allow controlled production of biotherapeutics from encapsulated cells. This is a unique and timely book which brings together contributions from some of the leading researchers in the field of cell encapsulation. Interested readers are provided an overview of the exciting developments and clinical experiences of researchers with cell bioencapsulation.

Author : Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 42,9 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9781461215868

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Cell Encapsulation Technology and Therapeutics by Willem_M. Kühtreiber,Robert P. Lanza,William L. Chick Pdf

The concept of using encapsulation for the immunoprotection of transplanted cells was introduced for the first time in the 1960s. "[Microencapsulated cells] might be protected from destruction and from partici pation in immunological processes, while the enclosing membrane would be permeable to small molecules of specific cellular product which could then enter the general extracellular compartment of the recipient. For instance, encapsulated endocrine cells might survive and maintain an effective supply of hormone." (Chang, Ph. D. Thesis, McGill University, 1965; Chang et aI., Can J Physiol PharmacoI44:115-128, 1966). We asked Connaught Laboratories, Ltd., in Toronto to put this concept into practice. In 1980, Lim and Sun from Connaught Laboratories reported on the successful implantation of poly-I-Iysine-alginate encapsu lated rat islets into a foreign host. [Lim and Sun, Science 210:908-909, 1980]. Now many groups around the world are making tremendous progress in the encapsulation of a multitude of cell types. Kiihtreiber, Lanza, and Chick have invited many cell encapsulation groups from around the world to contribute to this book. The result is a very useful reference book in this rapidly growing area. With so many excellent au thors describing in detail the different areas of cell encapsulation, my role here will be to briefly discuss a few points.

Author : Nedal Abu-Thabit
Publisher : BoD – Books on Demand
Page : 292 pages
File Size : 41,9 Mb
Release : 2021-01-27
Category : Science
ISBN : 9781839683480

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Nano- and Microencapsulation by Nedal Abu-Thabit Pdf

Nano- or micro-encapsulation is used in many different fields and industries, including pharmaceuticals, cosmetics, food, and agrochemicals. It offers advantages for various applications, especially drug delivery. Nano-encapsulation can help extend and control the release of drugs as well as increase drug bioavailability and efficacy. It improves the precision of targeted drug delivery and allows for fabricating nano-encapsulated drugs for diagnostic and theranaostic applications. This book covers recent advances in fabricating nano-/micro-capsules using natural carriers for therapeutic and diagnostic drug delivery applications as well as rheology and formulations of micro-emulsions for diverse applications. This book is essential for scientists and researchers with diverse backgrounds in chemistry, engineering, material sciences, pharmaceuticals, and drug delivery.

Author : Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick
Publisher : Unknown
Page : 450 pages
File Size : 52,5 Mb
Release : 1999
Category : Animal cell biotechnology
ISBN : 376434010X

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Cell Encapsulation Technology and Therapeutics by Willem M. Kühtreiber,Robert Paul Lanza,William Louis Chick Pdf

Encapsulated cells offer enormous potential for the treatment of human disease. This work includes detailed descriptions of chemical properties of encapsulation materials, purification, biocompatibility issues and experimental protocols.

Author : Viktor Nedovic,Ronnie Willaert
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 50,8 Mb
Release : 2006-04-06
Category : Science
ISBN : 9781402033636

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Applications of Cell Immobilisation Biotechnology by Viktor Nedovic,Ronnie Willaert Pdf

Cell immobilisation biotechnology is a multidisciplinary area, shown to have an important impact on many scientific subdisciplines – including biomedicine, pharmacology, cosmetology, food and agricultural sciences, beverage production, industrial waste treatment, analytical applications, biologics production. "Cell Immobilisation Biotechnology" is an outcome of the editors’ intention to collate the extensive and widespread information on fundamental aspects and applications of immobilisation/encapsulation biotechnology into a comprehensive reference work and to provide an overview of the most recent results and developments in this domain. "Cell Immobilisation Biotechnology" is divided into the two book volumes, FOBI 8A and FOBI 8B. The FOBI 8A volume, Fundamentals of Cell Immobilisation Biotechnology, is dedicated to fundamental aspects of cell immobilisation while the present volume, FOBI 8B, Applications of Cell Immobilisation Biotechnology, deals with diverse applications of this technology.

Author : Anil Dhawan,Robin D. Hughes
Publisher : Humana Press
Page : 0 pages
File Size : 42,6 Mb
Release : 2009-01-28
Category : Science
ISBN : 1588298833

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Hepatocyte Transplantation by Anil Dhawan,Robin D. Hughes Pdf

Due to its efficacy in animal models, cellular therapy using human hepatocytes is being evaluated worldwide as an alternative to organ transplantation in patients with liver-based metabolic disease and acute liver failure. In Hepatocyte Transplantation: Methods and Protocols, an international panel of experts provide up-to-date laboratory and clinical techniques covering the many key areas necessary for successful transplantation, such as cryopreservation, quality assurance, detection of cell engraftment, and the future of the field with the development of foetal hepatoblasts and stem cell derived hepatocytes. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume present brief introductions to the material, lists of the necessary materials and reagents, readily reproducible, step-by-step laboratory protocols, and Notes sections which highlight tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Hepatocyte Transplantation: Methods and Protocols is an ideal guide for researchers setting out in the rapidly progressing field of hepatocyte transplantation, as well as those who already have experience with this new therapy for liver disease.

Author : Gurbinder Kaur
Publisher : Springer
Page : 467 pages
File Size : 47,5 Mb
Release : 2017-06-07
Category : Technology & Engineering
ISBN : 9783319560595

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Clinical Applications of Biomaterials by Gurbinder Kaur Pdf

This book examines the most novel and state-of-the-art applications of biomaterials, with chapters that exemplify approaches with targeted drug delivery, diabetes, neurodegenerative diseases and cranioplasty implants. Expert contributors analyze biomaterials such as calcium phosphate, sol-gel and quenched glasses, metallic and polymer implants, bioactive glass, and polymer composites while also covering important areas such as the soft tissue replacement, apatites, bone regeneration and cell encapsulation. This book is appropriate for biomedical engineers, materials scientists, and clinicians who are seeking to implement the most advanced approaches and technologies with their patients.

Author : Jose M. Guisan,Juan M. Bolivar,Fernando López-Gallego,Javier Rocha-Martín
Publisher : Humana
Page : 495 pages
File Size : 46,8 Mb
Release : 2021-01-29
Category : Science
ISBN : 1071602179

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Immobilization of Enzymes and Cells by Jose M. Guisan,Juan M. Bolivar,Fernando López-Gallego,Javier Rocha-Martín Pdf

This fourth edition volume expands on the previous editions with new insights on important aspects to take into accounting when immobilizing enzymes and cells, illustrating outstanding examples that support those aspects, and exploring ways to fabricate and characterize heterogeneous biocatalysts including both immobilized enzymes and cells. The transformation of soluble and usually instable enzymes into heterogeneous and highly stable biocatalysts is strongly emphasized. The chapters in this book cover topics such as the importance of enzyme orientation on the support surface; application and characterization of immobilized enzymes; different functionalization chemistries for the modulation of the immobilized enzyme properties; co-immobilization of multi-enzyme systems; new analytical techniques for the characterization of heterogeneous biocatalysts; protocols for cell entrapment in alginate; preparation and characterization of biofilms; and cell encapsulation technologies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Immobilization of Enzymes and Cells: Methods and Protocols, Fourth Edition is a valuable resource for researchers interested in expanding their knowledge of this developing field.

Author : S Prakash
Publisher : Elsevier
Page : 544 pages
File Size : 42,7 Mb
Release : 2007-05-31
Category : Science
ISBN : 9781845693077

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Artificial Cells, Cell Engineering and Therapy by S Prakash Pdf

Artificial cells, cell engineering and therapy are emerging technologies which will make a significant impact on the future of medicine and healthcare. However, research within the field is vast. This unique book provides a comprehensive study of the most recent advances in the field and its practical applications. The first part of the book offers the reader an introduction to the basics of artificial cell technology with chapters on its origins, design, current status within medicine and future prospects. Part two covers apoptosis, the use of bone marrow stromal cells in myocardial regeneration together with signalling and tissue engineering. Part three discusses artificial cells for therapy, procedures for various clinical conditions and the current status of the discipline within the field. The book concludes with a final section on the role of artificial cells in medicine with particular focus on the use of artificial cells as blood substitutes and their potential use in myocardial regeneration, drug delivery and in treating kidney and bowel diseases, diabetes and cancer. Artificial cells, cell engineering and therapy is a valuable reference for researchers, students and practitioners within the field. Introduces the basics of artificial cell technology Provides a comprehensive study of the most recent advances in artificial cells, cell engineering and cell therapy Discusses the design, engineering and uses of artificial cells

Author : Doaa Hashad
Publisher : BoD – Books on Demand
Page : 220 pages
File Size : 55,5 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9789535122210

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Gene Therapy by Doaa Hashad Pdf

Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression.

Author : Bartosz Tylkowski,Marta Giamberini,Susana Fernandez Prieto
Publisher : Walter de Gruyter GmbH & Co KG
Page : 433 pages
File Size : 55,7 Mb
Release : 2020-04-06
Category : Technology & Engineering
ISBN : 9783110641950

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Microencapsulation by Bartosz Tylkowski,Marta Giamberini,Susana Fernandez Prieto Pdf

Microencapsulations may be found in a number of fields like medicine, drug delivery, biosensing, agriculture, catalysis, intelligent microstructures and in many consumer goods. This new edition of Microencapsulation revises chapters to address the newest innovations in fields and adds three new chapters on the uses of microencapsulations in medicine, agriculture, and consumer products.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 46,7 Mb
Release : 2024-06-28
Category : Electronic
ISBN : 9789814468961

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Stem Cell Bioengineering and Tissue Engineering Microenvironment by Anonim Pdf

Author : Viktor Nedovic,Ronnie Willaert
Publisher : Springer Science & Business Media
Page : 542 pages
File Size : 45,8 Mb
Release : 2013-04-17
Category : Science
ISBN : 9789401716383

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Fundamentals of Cell Immobilisation Biotechnology by Viktor Nedovic,Ronnie Willaert Pdf

Cell Immobilisation Biotechnology Biotechnology is divided into two volumes. The first volume is dedicated to fundamental aspects of cell immobilisation while the second volume deals with the diverse applications of this technology. The first volume, Fundamentals of Cell Immobilisation Biotechnology, comprises 26 chapters arranged into four parts: Materials for cell immobilisation/encapsulation, Methods and technologies for cell immobilisation/encapsulation, Carrier characterisation and bioreactor design, and Physiology of immobilised cells: techniques and mathematical modelling.