Retrometabolic Drug Design And Targeting

Author : Nicholas Bodor,Peter Buchwald
Publisher : John Wiley & Sons
Page : 546 pages
File Size : 41,6 Mb
Release : 2012-08-29
Category : Science
ISBN : 9781118407769

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Retrometabolic Drug Design and Targeting by Nicholas Bodor,Peter Buchwald Pdf

Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

Author : Microsoft Official Academic Course
Publisher : Wiley
Page : 128 pages
File Size : 45,6 Mb
Release : 2012-07-21
Category : Computers
ISBN : 1118510798

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Exam 77-881 Microsoft Word 2010 High School Version with WP V5 Card Set by Microsoft Official Academic Course Pdf

Author : Microsoft Official Academic Course
Publisher : Wiley
Page : 128 pages
File Size : 46,5 Mb
Release : 2012-07-19
Category : Computers
ISBN : 1118508521

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Exam 77-881 Microsoft Word 2010 with Microsoft Office 2010 Evaluation Software Set by Microsoft Official Academic Course Pdf

Author : MOAC
Publisher : Unknown
Page : 128 pages
File Size : 55,5 Mb
Release : 2012-05-04
Category : Electronic
ISBN : 1118436814

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Exam 77-881 Microsoft Word 2010 with Microsoft Office 2010 Evaluation Software with WileyPlus Blackboard Card by MOAC Pdf

Author : Debarshi Kar Mahapatra,Sanjay Kumar Bharti
Publisher : Taylor & Francis
Page : 628 pages
File Size : 46,9 Mb
Release : 2017-11-20
Category : Medical
ISBN : 9781351800235

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Handbook of Research on Medicinal Chemistry by Debarshi Kar Mahapatra,Sanjay Kumar Bharti Pdf

This valuable new book, Handbook of Research on Medicinal Chemistry: Innovations and Methodologies, presents some of the latest advancements in the various fields of combinatorial chemistry, drug discovery, biochemical aspects, pharmacology of medicinal agents, current practical problems, and nutraceuticals. The editors keep the drug molecule as the central component of the volume and aim to explain the associated features essential to exhibiting pharmacological activity. With a unique combination of chapters in biology, clinical aspects, biochemistry, synthetic chemistry, medicine and technology, the volume provides broad exposure to the essential aspect of pharmaceuticals. The volume many important aspects of medicinal chemistry, including techniques in drug discovery pharmacological aspects of natural products chemical mediators: druggable targets advances in medicinal chemistry The field of medicinal chemistry is growing at an unprecedented pace, and this volume takes an interdisciplinary approach, covering a range of new research and new practices in the field. The volume takes into account the latest therapeutic guidelines put forward by the World Health Organization and the U.S Food and Drug Administration.. Topics include: drug design drug discovery natural products and supplements and nutraceuticals pharmaceutical approaches to sexual dysfunction drug resistance parasites new natural compounds and identification of new targets stereochemistry aspects in medicinal chemistry common drug interactions in daily practices Handbook of Research on Medicinal Chemistry: Innovations and Methodologies will be a valuable addition to the bookshelves of pharmaceutical scientists and faculty as well as for industry professionals.

Author : Hans Schreier
Publisher : CRC Press
Page : 320 pages
File Size : 52,7 Mb
Release : 2001-08-09
Category : Medical
ISBN : 9780203908563

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Drug Targeting Technology by Hans Schreier Pdf

Demonstrates how substitution of a variety of ligands can render albumin a versatile targeting tool for selective drug accumulation in various cell populations of the liver! This book discusses physical, chemical, and biological approaches to drug targeting technology, focusing on oral, dispersed system, topical, dermal, transdermal, and inh

Author : Mithun Rudrapal,Chukwuebuka Egbuna
Publisher : Elsevier
Page : 324 pages
File Size : 48,6 Mb
Release : 2022-05-26
Category : Science
ISBN : 9780323914338

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Computer Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches by Mithun Rudrapal,Chukwuebuka Egbuna Pdf

Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches outlines the basic theoretical principles, methodologies and applications of different fundamental and advanced CADD approaches and techniques. Including information on current protocols as well as recent developments in the computational methods, tools and techniques used for rational drug design, the book explains the fundamental aspects of CADD, combining this with a practical understanding of the various in silico approaches used in modern drug discovery processes to assess the field in a comprehensive and systematic manner. Providing up-to-date, information and guidance for scientists, researchers, students and teachers, the book helps readers address specific academic and research related problems using illustrative explanations, examples and case studies, which are systematically reviewed. Highlights in silico approaches to drug design and discovery using computational tools and techniques Details ligand-based and structure-based drug design in a comprehensive and systematic approach Summarizes recent developments in computational drug design strategy as novel approaches of rational drug designing

Author : Anonim
Publisher : Unknown
Page : 1844 pages
File Size : 49,9 Mb
Release : 2000
Category : Medicine
ISBN : OSU:32436010864534

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Cumulated Index Medicus by Anonim Pdf

Author : Claudiu T. Supuran,Jean-Yves Winum
Publisher : John Wiley & Sons
Page : 1040 pages
File Size : 47,5 Mb
Release : 2009-10-22
Category : Medical
ISBN : 0470508159

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Drug Design of Zinc-Enzyme Inhibitors by Claudiu T. Supuran,Jean-Yves Winum Pdf

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Author : Xiaoxiao Qian
Publisher : BoD – Books on Demand
Page : 662 pages
File Size : 45,5 Mb
Release : 2012-11-28
Category : Medical
ISBN : 9789535108726

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Glucocorticoids by Xiaoxiao Qian Pdf

As one class of the most important steroid hormones, glucocorticoids have long been recognised and their therapeutic benefits have been widely used in clinical treatment, especially in anti-inflammation cases. Glucocorticoids regulate various processes in the body including the mobilization of energy stores, immune functions, gene expression, and maintenance of the homeostasis as well as the stress response, this is not surprising that the concept of "glucocorticoids" is mentioned in almost all medical text books that focus on specific organs or systems such as the cardiovascular system, the immune system, and the neuroendocrine system. The book of Glucocorticoids - New Recognition of Our Familiar Friend aims to introduce the latest findings relating to glucocorticoids, either freshly from the laboratory or from clinical case studies, and to open up a new angle of looking at the issue of balancing the therapeutic benefits and side effects brought up by glucocorticoids.

Author : Mino R. Caira,Corina Ionescu
Publisher : Springer Science & Business Media
Page : 422 pages
File Size : 53,9 Mb
Release : 2006-07-10
Category : Medical
ISBN : 9781402041426

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Drug Metabolism by Mino R. Caira,Corina Ionescu Pdf

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Author : Indra K. Reddy
Publisher : CRC Press
Page : 618 pages
File Size : 41,7 Mb
Release : 1995-12-12
Category : Medical
ISBN : 1566762138

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Ocular Theraputics and Drug Delivery by Indra K. Reddy Pdf

Since ocular therapeutics and drug delivery is a subject of interest to specialists from various disciplines such as chemical, biochemical, medical, pharmaceutical, and toxicological, it truly presents a unique situation requiring a multi-disciplinary approach in understanding and addressing various problems. Yet we see that scientists associated with these areas are working, by and large, independently of one another, thus limiting dissemination of knowledge, experience and ideas that would greatly enhance the overall progress in this area of research. Regrettably, the information currently available in ocular therapeutics and drug delivery, though extensive, is still fragmented into various disciplines making meaningful synthesis difficult. Several books are available that cover one or two aspects of the multi-disciplinary fields on an individual basis; however, none is available that covers all of them. The chapters contained in this book are specific to various interrelated areas of ocular therapeutics and drug delivery and are written by acknowledged experts from both academia and industry. The book itself is divided into five parts, namely: (I) overview,basic principles, and methodology; (II) pathopharmacology and clinical applications; (III) chemical/ biochemical approaches to ocular drug delivery; (IV) formulation and drug delivery considerations; and (V) industrial and regulatory considerations. Individual chapters in each section, apart from presenting a concise text, entail an extensive listing of references.

Author : Bruno Villoutreix,Juan Fernandez-Recio,Claudio N. Cavasotto
Publisher : Frontiers Media SA
Page : 157 pages
File Size : 42,9 Mb
Release : 2023-10-24
Category : Science
ISBN : 9782832537572

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Development of COVID-19 Therapies: Lessons Learnt and Ongoing Efforts by Bruno Villoutreix,Juan Fernandez-Recio,Claudio N. Cavasotto Pdf

Massive experimental, computational, and clinical studies have been performed worldwide, and are still ongoing, to understand and characterize Covid-19 molecular basis and transmission mechanisms, to develop diagnostics and vaccines, and to search for small chemical drug candidates and therapeutic proteins and peptides. Impressive results have been obtained for transmission control and vaccines so far, but what is the status of the other therapeutic options? The crisis has exposed different types of weaknesses in biomedical research in many countries. What can we learn from this crisis in the field of drug discovery and development so as to emerge stronger? The Covid-19 crisis has revealed the strengths of modern drug discovery and vaccine development but also exposed different types of weaknesses that would need to be addressed to be better prepared for a possible next global health crisis. These challenges/weaknesses/obstacles are of very different nature and as such hard to tackle. For instance, in addition to the inherent challenging nature of the scientific discovery, some scientists have mentioned insufficient local/national coordination and observed a fragmented drug discovery research, others have underlined a lack of coordination between the academic system and the private sector, an inadequate international global coordination and cooperation, others highlighted insufficient infrastructures, inappropriate financial supports, limited discussions between the scientific community performing the research and the public health authorities, decision makers and the society, while some remarked insufficient education/training about drug discovery and development leading to confusion… The crisis also raised important scientific questions about the technologies that would need to be used during an emergency situation, combined, integrated, or developed so as to accelerate the identification of small molecule drug candidates and of therapeutic peptides/proteins.

Author : Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani
Publisher : CRC Press
Page : 512 pages
File Size : 43,5 Mb
Release : 2019-08-05
Category : Medical
ISBN : 9780429877544

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Nanocarriers for Brain Targeting by Raj K. Keservani,Anil K. Sharma,Rajesh K. Kesharwani Pdf

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Author : Anonim
Publisher : Unknown
Page : 264 pages
File Size : 52,5 Mb
Release : 1995
Category : Drug carriers (Pharmacy)
ISBN : UCR:31210012244925

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Membranes and Barriers by Anonim Pdf