The 14 Day Rule And Human Embryo Research

Author : Sarah Franklin,Emily Jackson
Publisher : Taylor & Francis
Page : 159 pages
File Size : 40,6 Mb
Release : 2024-05-24
Category : Social Science
ISBN : 9781040036044

Get Book

The 14 Day Rule and Human Embryo Research by Sarah Franklin,Emily Jackson Pdf

This assessment of Britain’s influential 14 day rule governing embryo research explores how and why it became the de facto global standard for research into human fertilisation and embryology, arguing that its influence and stability offers valuable lessons for successful biological translation. One of the most important features of the 14 day rule, the authors claim, is its reliance on sociological as well as ethical, legislative, regulatory and scientific principles. The careful integration of social expectations and perceptions, as well as sociological definitions of the law and morality, into the development of a robust legislative infrastructure of ‘human fertilisation and embryology’, enabled what has come to be known as the Warnock Consensus – a solid and enduring public acceptance that has enabled successive parliamentary approval for controversial areas of scientific research in the UK, such as stem cell research and mitochondrial donation, for over 30 years. These important sociological insights are increasingly relevant to new biotranslational challenges such as human germline gene editing and the use of AI assisted technologies in human reproduction. As the legislation around the 14 day rule begins to be reviewed worldwide, the important lessons we can learn from its global and enduring significance will apply not only to future legislation governing embryo research, but to the future of biological translation more widely. An important volume for those interested in reproductive studies, biogovernance and biological translation, it is suitable for researchers, clinicians and students in medicine, biosciences, sociology, and science and technology studies.

Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on Guidelines for Human Embryonic Stem Cell Research
Publisher : National Academies Press
Page : 224 pages
File Size : 40,9 Mb
Release : 2005-09-15
Category : Medical
ISBN : 9780309096539

Get Book

Guidelines for Human Embryonic Stem Cell Research by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on Guidelines for Human Embryonic Stem Cell Research Pdf

Since 1998, the volume of research being conducted using human embryonic stem (hES) cells has expanded primarily using private funds because of restrictions on the use of federal funds for such research. Given limited federal involvement, privately funded hES cell research has thus far been carried out under a patchwork of existing regulations, many of which were not designed with this research specifically in mind. In addition, hES cell research touches on many ethical, legal, scientific, and policy issues that are of concern to the public. This report provides guidelines for the conduct of hES cell research to address both ethical and scientific concerns. The guidelines are intended to enhance the integrity of privately funded hES cell research by encouraging responsible practices in the conduct of that research.

Author : Graeme Laurie,Edward Dove,Agomoni Ganguli-Mitra,Catriona McMillan,Emily Postan,Nayha Sethi,Annie Sorbie
Publisher : Unknown
Page : 444 pages
File Size : 54,7 Mb
Release : 2021-06-09
Category : Law
ISBN : 9781108576093

Get Book

The Cambridge Handbook of Health Research Regulation by Graeme Laurie,Edward Dove,Agomoni Ganguli-Mitra,Catriona McMillan,Emily Postan,Nayha Sethi,Annie Sorbie Pdf

The definitive reference guide to designing scientifically sound and ethically robust medical research, considering legal, ethical and practical issues.

Author : Great Britain. Committee of Inquiry into Human Fertilisation and Embryology,Mary Warnock
Publisher : Unknown
Page : 128 pages
File Size : 55,7 Mb
Release : 1984
Category : Artificial insemination
ISBN : CORNELL:31924003725896

Get Book

Report of the Committee of Inquiry Into Human Fertilisation and Embryology by Great Britain. Committee of Inquiry into Human Fertilisation and Embryology,Mary Warnock Pdf

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy
Publisher : National Academies Press
Page : 155 pages
File Size : 50,6 Mb
Release : 2020-08-31
Category : Medical
ISBN : 9780309676687

Get Book

Examining the State of the Science of Mammalian Embryo Model Systems by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy Pdf

Because of the recent advances in embryo modeling techniques, and at the request of the Office of Science Policy in the Office of the Director at the National Institutes of Health, the National Academies of Sciences, Engineering, hosted a 1-day public workshop that would explore the state of the science of mammalian embryo model systems. The workshop, which took place on January 17, 2020, featured a combination of presentations, panels, and general discussions, during which panelists and participants offered a broad range of perspectives. Participants considered whether embryo model systems - especially those that use nonhuman primate cells - can be used to predict the function of systems made with human cells. Presentations provided an overview of the current state of the science of in vitro development of human trophoblast. This publication summarizes the presentation and discussion of the workshop.

Author : Peter Singer,Stephen Buckle
Publisher : Cambridge University Press
Page : 284 pages
File Size : 48,6 Mb
Release : 1993
Category : Medical
ISBN : 0521435889

Get Book

Embryo Experimentation by Peter Singer,Stephen Buckle Pdf

New developments in reproductive technology have made headlines since the birth of the world's first in vitro fertilization baby in 1978. But is embryo experimentation ethically acceptable? What is the moral status of the early human embryo? And how should a democratic society deal with so controversial an issue, where conflicting views are based on differing religious and philosophical positions? These controversial questions are the subject of this book, which, as a current compendium of ideas and arguments on the subject, makes an original contribution of major importance to this debate. Peter Singer is the author of many books, including Practical Ethics (CUP, 1979), Marx (Hill & Wang, 1980), and Should the Baby Live? (co-authored with Helga Kuhse, Oxford U.P., 1986).

Author : Katrien Devolder
Publisher : OUP Oxford
Page : 176 pages
File Size : 47,7 Mb
Release : 2015-01-22
Category : Philosophy
ISBN : 9780191036224

Get Book

The Ethics of Embryonic Stem Cell Research by Katrien Devolder Pdf

Embryonic stem cell research holds unique promise for developing therapies for currently incurable diseases and conditions, and for important biomedical research. However, the process through which embryonic stem cells are obtained involves the destruction of early human embryos. Katrien Devolder focuses on the tension between the popular view that an embryo should never be deliberately harmed or destroyed, and the view that embryonic stem cell research, because of its enormous promise, must go forward. She provides an in-depth ethical analysis of the major philosophical and political attempts to resolve this tension. One such attempt involves the development of a middle ground position, which accepts only types or aspects of embryonic stem cell research deemed compatible with the view that the embryo has a significant moral status. An example is the position that it can be permissible to derive stem cells from embryos left over from in vitro fertilisation but not from embryos created for research. Others have advocated a technical solution. Several techniques have been proposed for deriving embryonic stem cells, or their functional equivalents, without harming embryos. An example is the induced pluripotent stem cell technique. Through highlighting inconsistencies in the arguments for these positions, Devolder argues that the central tension in the embryonic stem cell debate remains unresolved. This conclusion has important implications for the stem cell debate, as well as for policies inspired by this debate.

Author : United States. Department of Health, Education, and Welfare. Ethics Advisory Board
Publisher : Unknown
Page : 142 pages
File Size : 51,7 Mb
Release : 1979
Category : Fertilization in vitro, Human
ISBN : UOM:39015000854060

Get Book

HEW Support of Research Involving Human in Vitro Fertilization and Embryo Transfer by United States. Department of Health, Education, and Welfare. Ethics Advisory Board Pdf

Author : Benjamin J. Hurlbut
Publisher : Columbia University Press
Page : 376 pages
File Size : 55,5 Mb
Release : 2017-01-31
Category : Medical
ISBN : 9780231542913

Get Book

Experiments in Democracy by Benjamin J. Hurlbut Pdf

Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science. Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

Author : Catriona A. W. McMillan
Publisher : Cambridge University Press
Page : 249 pages
File Size : 48,5 Mb
Release : 2021-04-01
Category : Law
ISBN : 9781108945165

Get Book

The Human Embryo In Vitro by Catriona A. W. McMillan Pdf

The Human Embryo in vitro explores the ways in which UK law engages with embryonic processes under the Human Fertilisation and Embryology Act 1990 (as amended), the intellectual basis of which has not been reconsidered for almost thirty years. McMillan argues that in regulating 'the embryo' – that is, a processual liminal entity in itself - the law is regulating for uncertainty. This book offers a fuller understanding of how complex biological processes of development and growth can be better aligned with a legal framework that purports to pay respect to the embryo while also allowing its destruction. To do so it employs an anthropological concept, liminality, which is itself concerned with revealing the dynamics of process. The implications of this for contemporary regulation of artificial reproduction are fully explored, and recommendations are offered for international regimes on how they can better align biological reality with social policy and law.

Author : United States. National Bioethics Advisory Commission
Publisher : Unknown
Page : 212 pages
File Size : 47,8 Mb
Release : 2000
Category : Bioethics
ISBN : PURD:32754069797904

Get Book

Ethical Issues in Human Stem Cell Research: Commissioned papers by United States. National Bioethics Advisory Commission Pdf

Author : Arlene Chiu,Mahendra S. Rao
Publisher : Springer Science & Business Media
Page : 455 pages
File Size : 40,6 Mb
Release : 2003-08-01
Category : Science
ISBN : 9781592594238

Get Book

Human Embryonic Stem Cells by Arlene Chiu,Mahendra S. Rao Pdf

A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

Author : Henry T. Greely
Publisher : MIT Press
Page : 395 pages
File Size : 50,5 Mb
Release : 2022-03-01
Category : Technology & Engineering
ISBN : 9780262543880

Get Book

CRISPR People by Henry T. Greely Pdf

What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us? In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos—as dramatic a development in genetics as the 1996 cloning of Dolly the sheep. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention. The two babies, nonidentical twin girls, were the first “CRISPR'd” people ever born (CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing method). Greely not only describes He's experiment and its public rollout (aided by a public relations adviser) but also considers, in a balanced and thoughtful way, the lessons to be drawn both from these CRISPR'd babies and, more broadly, from this kind of human DNA editing—“germline editing” that can be passed on from one generation to the next. Greely doesn't mince words, describing He's experiment as grossly reckless, irresponsible, immoral, and illegal. Although he sees no inherent or unmanageable barriers to human germline editing, he also sees very few good uses for it—other, less risky, technologies can achieve the same benefits. We should consider the implications carefully before we proceed.

Author : Insoo Hyun,Alejandro De Los Angeles
Publisher : Humana
Page : 234 pages
File Size : 42,6 Mb
Release : 2020-08-14
Category : Science
ISBN : 149399526X

Get Book

Chimera Research by Insoo Hyun,Alejandro De Los Angeles Pdf

This volume addresses challenging new questions surrounding stem cell-based chimera research. This book is organized into three parts: Part One provides readers with a summary of different human donor cell types. The chapters in this section discuss ways to evaluate new types of pluripotent stem cells; the derivation of naïve and primed pluripotent stem cells from mouse preimplantation embryos; and the ethical and regulatory complexities of informed consent for the procurement of somatic cells. Part Two discusses methods for generating chimeras. The chapters here look at chick models and human-chick organizer grafts; generating human-pig interspecies chimeras; and techniques for transplanting mouse neural stem cells into a mouse disease model for stroke. Part Three concludes the book with a look at ongoing ethical controversies and new scientific directions. Chapters in this part cover the ethics of crossing the xenobarrier; animal welfare; experimentation with spermatogonial stem cells; and cautious approaches to human-monkey chimera studies to further understand complex human brain disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chimera Research: Methods and Protocols is a valuable resource for scientists interesting in using chimeras as a research tool while also taking into consideration their complex ethical scopes.

Author : Andrea Boggio,Cesare P. R. Romano,Jessica Almqvist
Publisher : Cambridge University Press
Page : 681 pages
File Size : 41,9 Mb
Release : 2020-01-09
Category : Law
ISBN : 9781108499873

Get Book

Human Germline Modification and the Right to Science by Andrea Boggio,Cesare P. R. Romano,Jessica Almqvist Pdf

A survey of the regulation of human germline genome modification in eighteen countries and the emerging international standards.