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Author : Val R. Adams Publisher : Springer Science & Business Media Page : 460 pages File Size : 42,5 Mb Release : 2007-10-27 Category : Medical ISBN : 9781592598663
Camptothecins in Cancer Therapy by Val R. Adams Pdf
A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.
Camptothecin and Camptothecin Producing Plants by T. Pullaiah,P.B. Raghavendra,S. Karuppusamy,V. Raveendran,M. Anuradha Pdf
Camptothecin and Camptothecin Producing Plants: Botany, Chemistry, Anticancer Activity and Biotechnology provides updated information on camptothecin yielding plants, chemical diversity of camptothecin, extraction and exploitation methods, biosynthesis, biotechnological production and enhancement for drug delivery, and the pharmacological properties of the drugs. The book focuses on camptothecin anticancer properties based on recent developments of biotechnology. Topics emphasize anticancer activities, biosynthesis, potent derivatives currently undergoing experimental phases, and biotechnological methods to enhance the production. This book is a valuable source for cancer researchers, oncologists, biotechnologists, pharmacologists and members of the biomedical field who are interested in camptothecin and its applicability in cancer treatment. Provides information on camptothecin producing plants and their anticancer properties for the development of new treatments Discusses new applications of camptothecin based on recent biotechnology advancements Presents comprehensive information on the pharmacology of camptothecin for leveraging new anticancer drugs developments
The Camptothecins by Joachim G. Liehr,Beppino C. Giovanella,Claire F. Verschraegen Pdf
The impact of camptothecin and its derivatives on topoiomerase I in studies on nude mice points to anticancer potential that has not yet been fully realized and developed. The 1996 Academy conference research on the camptothecins launched major advances in understanding camptothecin's mechanism of action; the development of new derivatives; and to a second generation of camptothecin-based chemotherapies. These proceedings papers unfold this potential in four areas: mechanisms of action for the natural compound and current derivatives; chemical possibilities of modifying camptothecin; novel derivatives; and novel routes of administration that enhance camptothecin's lactone ring stability, which appears vitally important for maintaining anticancer activity in humans. The science of camptothecin-base anticancer is balanced by clinical and pharmacology topics including drug resistance, new analogs and potential therapies for premature asthma and for bone marrow.
The Camptothecins by Panayotis Pantazis,Beppino C. Giovanella,Mace Rothenberg Pdf
The proceedings of the first major symposium on campothecins, this volume highlights the importance of campothecins as chemotherapeutic agents and emphasizes the use of the xenograft model in research in chemotherapeutics. The xenograft model has been shown to be important both for assessing how human tumors grow in vivo and for providing an experimental system for testing new chemotherapeutic agents. This volume covers all aspects of this promising class of anticancer agents - from basic science to clinical use - and should be of interest to a wide range of research scientists and clinicians.
Camptothecins New Anticancer Agents by Milan Potmesil,Herbert M. Pinedo Pdf
This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigger a cascade of events leading to programmed cell death. Special attention is given to the adverse effects of camptothecin treatment, as well as to prevention and control. The book boasts contributions by some of the most respected authorities in camptothecin research, who have Conducted much of the pre-clinical work which helped to renew interest in camptothecins Discovered and identified the natural product camptothecin and synthesized most of the anlogues Discovered the mechanism of camptothecin cytotoxicity
Bioactive Compounds from Natural Sources by Corrado Tringali Pdf
The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified-natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products
Checkpoint Responses in Cancer Therapy by Wei Dai Pdf
Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
Yuan Lin,Joseph M. Betz,Jasjit S. Bindra,Steven C. Bobzin
Author : Yuan Lin,Joseph M. Betz,Jasjit S. Bindra,Steven C. Bobzin Publisher : Springer Science & Business Media Page : 254 pages File Size : 47,8 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461514558
Drug Discovery and Traditional Chinese Medicine by Yuan Lin,Joseph M. Betz,Jasjit S. Bindra,Steven C. Bobzin Pdf
The "First International Conference on Traditional Chinese Medicine: Science, Regulation and Globalization" was held from August 30 to September 2, 2000 at the University of Maryland at College Park, Maryland. There were approximately 250 participants from the Peoples Republic of China, Taiwan, Hong Kong and the United States. This objective of this conference was to promote international collaboration for the modernization of Traditional Chinese herbal medicines (TCM) and their introduction into the global health care system. It was mainly sponsored by the Ministry of Science and Technology of the People's Republic of China and the NllI National Center for Complementary and Alternative Medicine (NCCAM). It was organized by Dr. William Tai, then director of the Institute of Global Chinese Affairs at the University of Maryland and Dr. Yuan Lin, president of Marco Polo Technologies, Bethesda, MD. This conference was conceived by Dr. Tai two years earlier recognizing that this was an appropriate time and also the unique location of the University of Maryland. Today, there is a growing recognition of the of alternative medicine in modem societies and the rapid loss of importance knowledge about traditional methods for the treatment of the multitude of human illnesses found throughout the world. TCM has been in common use in China for thousands of years; and many of its formulations are well defined.
Natural Products in Medicinal Chemistry by Stephen Hanessian Pdf
The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer
Heterocyclic Anticancer Agents by Bimal Krishna Banik,Bubun Banerjee Pdf
Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.
Robert C. Bast, Jr.,John C. Byrd,Carlo M. Croce,Ernest Hawk,Fadlo R. Khuri,Raphael E. Pollock,Apostolia-Maria Tsimberidou,Christopher G. Willett,Cheryl L. Willman
Author : Robert C. Bast, Jr.,John C. Byrd,Carlo M. Croce,Ernest Hawk,Fadlo R. Khuri,Raphael E. Pollock,Apostolia-Maria Tsimberidou,Christopher G. Willett,Cheryl L. Willman Publisher : John Wiley & Sons Page : 9295 pages File Size : 48,6 Mb Release : 2023-03-13 Category : Medical ISBN : 9781119750703
Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,John C. Byrd,Carlo M. Croce,Ernest Hawk,Fadlo R. Khuri,Raphael E. Pollock,Apostolia-Maria Tsimberidou,Christopher G. Willett,Cheryl L. Willman Pdf
Die neueste Ausgabe des Goldstandards in der Krebsforschung und klinischen Onkologie Mit der neu überarbeiteten zehnten Ausgabe von Holland-Frei Cancer Medicine legt ein Team anerkannter Forscher und Ärzte einen umfassenden aktuellen Überblick über die Krebsforschung und die klinische onkologische Praxis vor. Das Werk enthält zeitgemäße und unverzichtbare Informationen aus den Bereichen Epidemiologie, Ätiologie, Krebsbiologie, Immunologie, Prävention, Screening, klinisches Erscheinungsbild, Pathologie, Bildgebung und Therapie. Ausgehend von einem grundlegenden Verständnis der Krebsbiologie stellt Holland-Frei Cancer Medicine eine Verbindung zwischen wissenschaftlichen Prinzipien und klinischer Praxis her. Das Buch enthält Hunderte farbiger Abbildungen und Fotos, Tabellen, Grafiken und Algorithmen, um die im Text erörterten komplexen Inhalte zu ergänzen und zu vertiefen. Das unverzichtbare klinische Lehrbuch ist darauf ausgelegt, die Inhalte mit separaten Zusammenfassungen, zusätzlichen Verweisen und anderen pädagogischen Merkmalen übersichtlich und leicht verständlich zu präsentieren. Außerdem bietet das Werk: * Einen integrierten translationalen Ansatz, der die Krebsbiologie mit dem Krebsmanagement verbindet * Einen starken Fokus auf die multidisziplinäre, forschungsorientierte Patientenversorgung, wodurch bessere Ergebnisse erzielt und der optimale Einsatz aller klinisch geeigneten Therapien ermöglicht werden sollen * Eine Erörterung des neuesten Trends der personalisierten Krebsbehandlung mit molekularer Diagnostik und Therapeutik Die zehnte Auflage von Holland-Frei Cancer Medicine richtet sich nicht nur an medizinische Onkologen, Strahlenonkologen und Internisten, sondern hat auch einen Platz in den Bibliotheken anderer Gesundheitsfachkräfte verdient, die sich mit der Behandlung von Krebspatienten beschäftigen. Dieses Werk wird in Zusammenarbeit mit der American Association for Cancer Research herausgegeben: https://www.aacr.org/
Author : David E Thurston,Paul J M Jackson Publisher : Royal Society of Chemistry Page : 502 pages File Size : 49,9 Mb Release : 2019-07-11 Category : Medical ISBN : 9781788018456
Cytotoxic Payloads for AntibodyDrug Conjugates by David E Thurston,Paul J M Jackson Pdf
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.
Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Publisher : John Wiley & Sons Page : 2008 pages File Size : 53,7 Mb Release : 2017-03-10 Category : Medical ISBN : 9781119000846
Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Principles of Pharmacology by Armen H. Tashjian,Ehrin J. Armstrong Pdf
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, is a primary textbook for a first course in pharmacology. It offers an integrated mechanism-based and systems-based approach, incorporating the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition features content reflecting current research findings, more than 400 full-color illustrations, Drug Summary Tables, and increased coverage of drug metabolism and the treatment of mycobacterial infections.
