The Cerebral Microvasculature

Author : Howard M. Eisenberg
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468437522

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The Cerebral Microvasculature by Howard M. Eisenberg Pdf

As traced by Uichael Bradbury in his recently published monograph, The Concept of a BZood-Brain Barrier, the idea of a scientific challenge is just about as old as the twentieth century. Curiously, it remains undefined. Is it a structure or structures as some use the term, or is it a reciprocal per meability, a force-flow relationship, as do others, or is it a group of processes, some more specialized than others? Depend ing upon the observer, the method, and what is observed, it seems to be each of these or all. This Symposium takes as its focus of interest the micro vasculature of the brain and includes considerations of blood flow, the properties of vessel walls and the control of flow and permeability. In addition perturbations that change the characteristics of the flow of materials are given attention. By changing the usual focus of interest, the organizers, Drs. Suddith and Eisenberg, have given a fresh outlook to the subject and now, by publication of the Proceedings, have arranged for wide availability of these interesting papers. Keasley Welch v PREFACE A symposium on the cerebral microvasculature and its function in the blood-brain barrier was held at The University of Texas Medical Branch, Galveston, in the summer of 1979. Investigators from the United States and Europe met to discuss their recent work.

Author : Howard M. Eisenberg
Publisher : Unknown
Page : 364 pages
File Size : 43,9 Mb
Release : 1979
Category : Electronic
ISBN : 1468437534

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The cerebral Microvasculature by Howard M. Eisenberg Pdf

Author : Texas) World Congress for Microcirculation (2d : 1979 : Galveston
Publisher : Unknown
Page : 128 pages
File Size : 50,5 Mb
Release : 1980
Category : Blood-brain barrier
ISBN : OCLC:960943229

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The Cerebral Microvasculature by Texas) World Congress for Microcirculation (2d : 1979 : Galveston Pdf

Author : Marilyn J. Cipolla
Publisher : Biota Publishing
Page : 82 pages
File Size : 40,5 Mb
Release : 2016-07-28
Category : Medical
ISBN : 9781615047239

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The Cerebral Circulation by Marilyn J. Cipolla Pdf

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Author : Xinchun Jin,Dmitriy N. Atochin,Junlei Chang,Wenlan Liu,Xiaoxing Xiong
Publisher : Frontiers Media SA
Page : 145 pages
File Size : 53,7 Mb
Release : 2022-06-29
Category : Science
ISBN : 9782889764518

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Cell-Cell Interactions Controlling Cerebral Microvasculature under Physiological and Pathophysiological Conditions by Xinchun Jin,Dmitriy N. Atochin,Junlei Chang,Wenlan Liu,Xiaoxing Xiong Pdf

Author : Jorge Cervós-Navarro,Emmanuel Fritschka
Publisher : Raven Press (ID)
Page : 510 pages
File Size : 45,6 Mb
Release : 1981
Category : Brain
ISBN : UCAL:B4513764

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Cerebral Microcirculation and Metabolism by Jorge Cervós-Navarro,Emmanuel Fritschka Pdf

Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Page : 412 pages
File Size : 50,7 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781498766579

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Translational Research in Traumatic Brain Injury by Daniel Laskowitz,Gerald Grant Pdf

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Author : Enrico Agabiti-Rosei,Anthony M. Heagerty,Damiano Rizzoni
Publisher : Springer Nature
Page : 215 pages
File Size : 40,6 Mb
Release : 2020-10-03
Category : Medical
ISBN : 9783030478018

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Microcirculation in Cardiovascular Diseases by Enrico Agabiti-Rosei,Anthony M. Heagerty,Damiano Rizzoni Pdf

This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.

Author : Anonim
Publisher : Elsevier
Page : 2800 pages
File Size : 46,8 Mb
Release : 2017-11-27
Category : Medical
ISBN : 9780128051542

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Encyclopedia of Cardiovascular Research and Medicine by Anonim Pdf

Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.

Author : Frithjof Hammersen,K. Messmer
Publisher : Unknown
Page : 120 pages
File Size : 54,9 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015017752976

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Cerebral Microcirculation by Frithjof Hammersen,K. Messmer Pdf

Author : Sukriti Nag
Publisher : Springer Science & Business Media
Page : 543 pages
File Size : 49,9 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781592594191

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Blood'Brain Barrier by Sukriti Nag Pdf

Blood–brain barrier (BBB) breakdown leading to cerebral edema occurs in many brain diseases—such as trauma, stroke, inflammation, infection, and tumors—and is an important factor in the mortality arising from these con- tions. Despite the importance of the BBB in the pathogenesis of these diseases, the molecular mechanisms occurring at the BBB are not completely und- stood. In the last decade a number of molecules have been identified not only in endothelial cells, but also in astrocytes, pericytes, and the perivascular cells that interact with endothelium to maintain cerebral homeostasis. However, the precise cellular interactions at a molecular level in steady states and d- eases have still to be determined. The introduction of new research techniques during the last decade or so provide an opportunity to study the molecular mec- nisms occurring at the BBB in diseases. The Blood–Brain Barrier: Biology and Research Protocols provides the reader with details of selected morphologic, permeability, transport, in vitro, and molecular techniques for BBB studies, all written by experts in the field. Each part is preceded by a review that emphasizes the advantages and pitfalls of particular techniques, as well as offering much relevant current information. The techniques provided will be helpful to both beginners in BBB research and those more experienced investigators who wish to add a specific technique to those already available in their laboratories.

Author : Leonardo Pantoni,Philip B. Gorelick
Publisher : Cambridge University Press
Page : 375 pages
File Size : 42,9 Mb
Release : 2014-05
Category : Medical
ISBN : 9781107031661

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Cerebral Small Vessel Disease by Leonardo Pantoni,Philip B. Gorelick Pdf

Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.

Author : Peter Lanzer
Publisher : Springer
Page : 5004 pages
File Size : 47,5 Mb
Release : 2015-03-30
Category : Medical
ISBN : 3642370772

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PanVascular Medicine by Peter Lanzer Pdf

​Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.

Author : Basil F. Matta,David K. Menon,Martin Smith
Publisher : Cambridge University Press
Page : 128 pages
File Size : 53,8 Mb
Release : 2011-10-13
Category : Medical
ISBN : 9781139499859

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Core Topics in Neuroanaesthesia and Neurointensive Care by Basil F. Matta,David K. Menon,Martin Smith Pdf

Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.

Author : Robert D. Stevens,Tarek Sharshar,E. Wesley Ely
Publisher : Cambridge University Press
Page : 457 pages
File Size : 40,7 Mb
Release : 2013-09-19
Category : Medical
ISBN : 9781107434424

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Brain Disorders in Critical Illness by Robert D. Stevens,Tarek Sharshar,E. Wesley Ely Pdf

Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.