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Author : Carolyn H. Lee
Publisher : Unknown
Page : 156 pages
File Size : 51,8 Mb
Release : 1996
Category : Electronic
ISBN : UCSD:31822023280902
Author : Esteban Domingo,Colin R. Parrish,John J. Holland
Publisher : Elsevier
Page : 573 pages
File Size : 47,6 Mb
Release : 2008-06-23
Category : Science
ISBN : 9780080564968
New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Author : Esteban Domingo
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 41,6 Mb
Release : 2006-02-19
Category : Medical
ISBN : 9783540263975
Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.
Author : Asit K Pattnaik,Michael A Whitt
Publisher : World Scientific
Page : 640 pages
File Size : 51,7 Mb
Release : 2014-12-30
Category : Science
ISBN : 9789814635356
Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents. Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included. This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis. Contents:Overview of Rhabdo– and Filoviruses (Asit K Pattnaik and Michael A Whitt)Rhabdovirus Structure (Ming Luo)The Pathway of VSV Entry into Cells (Shem Johnson and Jean Gruenberg)Rhabdovirus Glycoproteins (Yves Gaudin and Michael A Whitt)VSV RNA Transcription and Replication (Jacques Perrault)Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, and Asit K Pattnaik)Cytopathogenesis of Rhabdoviruses (Douglas S Lyles)Assembly and Budding of Rhabdo– and Filoviruses (Ziying Han and Ronald N Harty)Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose and David K Clarke)Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell)Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl, and Andreas Frick)Evolution of Rhabdo– and Filoviruses (Isabel S Novella, John B Presloid, and R Travis Taylor)Emerging Rhabdoviruses (Imke Steffen and Graham Simmons)Rabies Virus Replication and Pathogenesis (Andrew W Hudacek and Matthias J Schnell)Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann)Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai, and Zhen F Fu)Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel R Beniac, Melissa J Rabb, and Lindsey L Lamboo)Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga and Hideki Ebihara)Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler, and Kartik Chandran)Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflubé, and Elke Muhlberger)Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe, and Daisy W Leung)Vaccines and Antivirals for Filoviruses (Chad E Mire and Thomas W Geisbe) Readership: Investigators, graduate students, and post-graduate researchers in the field of RNA virology. Key Features:The book describes the most recent advances in our understanding of cellular and molecular aspects of replication and pathogenic mechanisms of these two important viral pathogensUnlike other existing textbooks published earlier, this book brings together several major topics of research such as replication, host response to viral replication and viral countermeasures, viral evolution and emerging viruses, viral vectors, vaccines and antivirals, etcThe chapters in the book are written by renowned researchers in these fieldsKeywords:Negative-Strand RNA Virus;Mononegavirales;Rhabdovirus;Filovirus;VSV;Rabies Virus;Marburg Virus;Ebola Virus;Replication and Transcription;Virus Structure;Viral Pathogenesis;Epidemiology;Virus Entry;Virus Assembly and Budding;Cytopathogenesis;Neuronal Tracers;Viral Vectors;Oncolytic Viruses;Evolution;Emerging Viruses;Innate Immune Responses;Vaccines;Antivirals
Author : Paul F. Torrence
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 54,9 Mb
Release : 2005-08-05
Category : Medical
ISBN : 9780471716709
Antiviral Drug Discovery gives readers a cutting-edge view of how chemical concepts are being mobilized to develop novel approaches that will effectively confront emerging diseases and biowarfare. Among the many topics discussed are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. Each chapter discusses hypothetical strategies for the discovery of relevant antiviral agents, recent findings related to biochemistry or drug discovery, and advances in the further development of established leads in the area. Timely and informative, this book clearly delineates the efforts being made to develop new and effective broad-spectrum antiviral agents.
Author : Esteban Domingo,Peter Schuster
Publisher : Springer
Page : 357 pages
File Size : 45,5 Mb
Release : 2016-03-18
Category : Medical
ISBN : 9783319238982
This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.
Author : D.J. Rowlands
Publisher : Gulf Professional Publishing
Page : 176 pages
File Size : 40,9 Mb
Release : 2003-01-24
Category : Science
ISBN : 0444513027
"Foot-and-Mouth Disease Virus (FMDV), the cause of these dramatic consequences, is one of the smallest animal viruses, yet is often quoted as being the most infectious agent known. This book, for the first time, presents the story of FMDV as written by world experts on the virus. Initial chapters describe the structure of the virus and what is known of the molecular mechanisms that enable it to replicate faster than any other known animal virus. Anti-FMD vaccines are made in vast quantities and can be extremely effective for disease control. However, the ability of the virus to change rapidly is a constant headache for vaccine manufacturers. Both vaccine production and virus evolution are reviewed comprehensively. In addition to vaccination, disease control requires accurate and sensitive diagnostic procedures and effective hygiene measures. Modern molecular epidemiology and the measures available for infection control are described in further chapters." "Finally, the role of wildlife in the spread and maintenance of FMD is discussed."--BOOK JACKET.
Author : Esteban Domingo
Publisher : Academic Press
Page : 426 pages
File Size : 41,7 Mb
Release : 2019-11-06
Category : Science
ISBN : 9780128163320
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes
Author : B. W. J. Mahy
Publisher : Springer Science & Business Media
Page : 185 pages
File Size : 45,8 Mb
Release : 2005-10-28
Category : Medical
ISBN : 9783540271093
Foot-and-mouth disease (FMD) has been recognized in printed records dating from the sixteenth century, and since the eradication of rinderpest (cattle plague) in the early part of the twentieth century it has been rec- nized as the most important and feared disease of cattle and other dom- tic livestock. The beginning of the twenty-first century brought the worst outbreak of FMD ever experienced in England, which had been completely free of the disease for 33 years. This tragic epidemic, which spread to Northern Ireland, Scotland, France and the Netherlands with severe e- nomic consequences, emphasized the need for further research into better methods for the detection and control of the disease. FMD is caused by a small RNA virus which is highly contagious and can survive in meat and other animal products for long periods at normal pH levels. The virus typically infects cloven-hoofed animals, including c- tle, goats, pigs and sheep, as well as a wide range of non-domesticated a- mals in regions of the world where FMD virus is endemic, such as the Af- can continent. There are seven recognized serotypes of FMD virus, with numerous subtypes, and as a consequence vaccine production and administration is complex and a major debate surrounds every disease outbreak regarding the relative merits of vaccination as opposed to the slaughter of all infected animals.
Author : Anonim
Publisher : Academic Press
Page : 2138 pages
File Size : 54,8 Mb
Release : 2016-04-14
Category : Science
ISBN : 9780128004265
Encyclopedia of Evolutionary Biology, Four Volume Set is the definitive go-to reference in the field of evolutionary biology. It provides a fully comprehensive review of the field in an easy to search structure. Under the collective leadership of fifteen distinguished section editors, it is comprised of articles written by leading experts in the field, providing a full review of the current status of each topic. The articles are up-to-date and fully illustrated with in-text references that allow readers to easily access primary literature. While all entries are authoritative and valuable to those with advanced understanding of evolutionary biology, they are also intended to be accessible to both advanced undergraduate and graduate students. Broad topics include the history of evolutionary biology, population genetics, quantitative genetics; speciation, life history evolution, evolution of sex and mating systems, evolutionary biogeography, evolutionary developmental biology, molecular and genome evolution, coevolution, phylogenetic methods, microbial evolution, diversification of plants and fungi, diversification of animals, and applied evolution. Presents fully comprehensive content, allowing easy access to fundamental information and links to primary research Contains concise articles by leading experts in the field that ensures current coverage of each topic Provides ancillary learning tools like tables, illustrations, and multimedia features to assist with the comprehension process
Author : Francisco Sobrino,Esteban Domingo
Publisher : CRC Press
Page : 600 pages
File Size : 49,5 Mb
Release : 2019-04-30
Category : Medical
ISBN : 9781420037968
The shock following the recent outbreak of foot-and-mouth disease (FMD) in the UK dispelled the notion that this disease was permanently under control and could be forgotten. FMD proved to be an endemic disease in many countries and continues to pose a major threat to animal health worldwide. The development of more effective and socially acceptabl
Author : Anonim
Publisher : Unknown
Page : 1860 pages
File Size : 50,6 Mb
Release : 1997
Category : Medicine
ISBN : MINN:31951D01567139I
Author : Shane Crotty
Publisher : Unknown
Page : 936 pages
File Size : 43,5 Mb
Release : 2001
Category : Electronic
ISBN : UCAL:X82447
Author : R. A. Dixon,Maria J. Harrison,Marilyn J. Roossinck
Publisher : Unknown
Page : 258 pages
File Size : 46,8 Mb
Release : 1999
Category : Botanical chemistry
ISBN : WISC:89095330874
Contents of the Proceedings focus on plant metabolism and biochemistry, plant genetics and evolution, and plant microbe interactions.
Author : Esteban Domingo
Publisher : Unknown
Page : 188 pages
File Size : 42,9 Mb
Release : 2001
Category : Medical
ISBN : 1587060108