The Metals Of Life

Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
Publisher : Springer
Page : 628 pages
File Size : 52,7 Mb
Release : 2016-02-09
Category : Science
ISBN : 9783319217567

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The Alkali Metal Ions: Their Role for Life by Astrid Sigel,Helmut Sigel,Roland K. O. Sigel Pdf

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

Author : Eleanor Crabb,Elaine A. Moore
Publisher : Royal Society of Chemistry
Page : 0 pages
File Size : 47,6 Mb
Release : 2010
Category : Biochemistry
ISBN : 184973061X

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Metals and Life by Eleanor Crabb,Elaine A. Moore Pdf

The material in this book is designed to be used either as part of an undergraduate chemistry programme, or for self-directed study. --

Author : David Raymond Williams
Publisher : Unknown
Page : 186 pages
File Size : 46,5 Mb
Release : 1971
Category : Medical
ISBN : MINN:31951P00706609U

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The Metals of Life by David Raymond Williams Pdf

Author : Astrid Sigel,Helmut Sigel,Roland K.O. Sigel
Publisher : Springer Science & Business Media
Page : 603 pages
File Size : 52,6 Mb
Release : 2014-01-27
Category : Science
ISBN : 9789400775008

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Interrelations between Essential Metal Ions and Human Diseases by Astrid Sigel,Helmut Sigel,Roland K.O. Sigel Pdf

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
Page : 640 pages
File Size : 44,6 Mb
Release : 2019-01-14
Category : Science
ISBN : 9783110526981

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Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by Peggy L. Carver Pdf

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Author : Peter M. H. Kroneck,Martha Sosa Torres
Publisher : de Gruyter
Page : 0 pages
File Size : 47,8 Mb
Release : 2021
Category : Business & Economics
ISBN : 3110588900

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Metals, Microbes, and Minerals by Peter M. H. Kroneck,Martha Sosa Torres Pdf

One of the biggest questions in today's biochemistry is how biological molecules became essential for the processes that occur within living cells. This new book from outstanding Metal Ions in Life Science series gives an overview about biochemical

Author : Peter Kroneck,Martha Sosa Torres
Publisher : Walter de Gruyter GmbH & Co KG
Page : 386 pages
File Size : 40,7 Mb
Release : 2021-01-18
Category : Science
ISBN : 9783110589771

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Metals, Microbes, and Minerals - The Biogeochemical Side of Life by Peter Kroneck,Martha Sosa Torres Pdf

One of the biggest questions in today's biochemistry is how biological molecules became essential for the processes that occur within living cells. This new book from outstanding Metal Ions in Life Science series gives an overview about biochemical evolution of organic molecules and metabolic pathways in living systems and outlines the vital biochemical processes in microbial cells in which metals are involved.

Author : Eleanor Crabb,Elaine A. Moore
Publisher : Royal Society of Chemistry
Page : 0 pages
File Size : 50,6 Mb
Release : 2010
Category : Science
ISBN : 1849730598

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Metals and Life by Eleanor Crabb,Elaine A. Moore Pdf

The book covers how organisms acquire metals, their transport and storage, illustrated by such diverse examples as iron in the human body, and structures such as shells and teeth. The volume contains In-text questions with answers, full colour diagrams and revision exercises on an associated website www.rsc.org/metalsandlife.

Author : Jerome O. Nriagu,Eric P. Skaar
Publisher : MIT Press
Page : 501 pages
File Size : 49,7 Mb
Release : 2024-06-11
Category : Medical
ISBN : 9780262552486

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Trace Metals and Infectious Diseases by Jerome O. Nriagu,Eric P. Skaar Pdf

Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang

Author : Astrid Sigel,Helmut Sigel,Roland KO Sigel
Publisher : Springer Science & Business Media
Page : 590 pages
File Size : 45,8 Mb
Release : 2013-02-26
Category : Science
ISBN : 9789400751798

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Cadmium: From Toxicity to Essentiality by Astrid Sigel,Helmut Sigel,Roland KO Sigel Pdf

Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 50,8 Mb
Release : 2020
Category : Electronic
ISBN : 3110588897

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TRANSITION METALS AND SULFUR by Anonim Pdf

Author : Martha Sosa Torres,Peter Kroneck
Publisher : Walter de Gruyter GmbH & Co KG
Page : 500 pages
File Size : 45,6 Mb
Release : 2020-04-06
Category : Science
ISBN : 9783110589757

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Transition Metals and Sulfur – A Strong Relationship for Life by Martha Sosa Torres,Peter Kroneck Pdf

Metal-Sulfur clusters play an essential role in living organisms through the unique character of sulfur-metal bonding. The new volume in prestigious Metal Ions in Life Sciences explores different transition metal complexes with sulfur, their biosynthesis and biological functions in regulation of gene expression, catalysis of important metabolic reactions and protein structure arrangement.

Author : Celso Gomes,Michel Rautureau
Publisher : Springer Nature
Page : 668 pages
File Size : 43,7 Mb
Release : 2021-05-18
Category : Science
ISBN : 9783030657062

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Minerals latu sensu and Human Health by Celso Gomes,Michel Rautureau Pdf

This volume provides a comprehensive academic review of both positive and negative effects of minerals on human health and quality of life. The book adopts the concept of mineral latu sensu (mineral l.s.), which encompasses a broad spectrum of natural, inorganic, solid, and crystalline, of natural and inorganic chemical elements (metals and metalloids), of modified natural minerals, of biominerals, and of syntetic minerals, all products that branch across the disciplines of earth, soil, environmental, materials, nutrition, and health sciences. Using this broad framework, the authors are able to provide a multidisciplinary assessment on many types of minerals which can be essential, beneficial and hazardous to human health, covering applications in medical geology, medical hydrology or balneotherapy, pharmacology, chemistry, nutrition, and biophysics. The book performs historical analyses of the uses of minerals for therapeutic and cosmetic purposes to better understand current trends and developments in mineral research and human health. The book will be of interest to students, public health officials, environmental agencies and researchers from various disciplines, as well as scientific societies and organizations focusing on medical geology, health resort medicine (crenotherapy, hydrotherapy and climatotherapy), and on pharmaceutical, cosmetic and biomedical applications.

Author : Peter Kroneck,Martha Sosa Torres
Publisher : Walter de Gruyter GmbH & Co KG
Page : 464 pages
File Size : 53,7 Mb
Release : 2021-01-18
Category : Science
ISBN : 9783110588934

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Metals, Microbes, and Minerals - The Biogeochemical Side of Life by Peter Kroneck,Martha Sosa Torres Pdf

Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes; in fact, it is an old wisdom that metals are indispensable for life. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in numerous interconnecting research fields.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
Publisher : National Academies Press
Page : 765 pages
File Size : 54,9 Mb
Release : 1989-01-01
Category : Medical
ISBN : 9780309039949

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Diet and Health by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health Pdf

Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.