The Organic Chemistry Of Drug Synthesis

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The Organic Chemistry of Drug Synthesis, Volume 7

Daniel Lednicer
The Organic Chemistry of Drug Synthesis Volume 7 Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 49,7 Mb
Release : 2007-12-14
Category : Science
ISBN : 9780470180662

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The Organic Chemistry of Drug Synthesis, Volume 7 by Daniel Lednicer Pdf

The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.

The Organic Chemistry of Drug Synthesis

Daniel Lednicer,Lester A. Mitscher
The Organic Chemistry of Drug Synthesis Book PDF

Author : Daniel Lednicer,Lester A. Mitscher
Publisher : Wiley-Interscience
Page : 276 pages
File Size : 45,7 Mb
Release : 1977
Category : Medical
ISBN : UOM:39015018351109

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The Organic Chemistry of Drug Synthesis by Daniel Lednicer,Lester A. Mitscher Pdf

Volume 4 of this series is addressed primarily at practitioners in the field who seek a quick overview of the synthetic routes which have been used to access specific classes of therapeutic agents. This volume covers the chemistry of those compounds which have been granted a United States Adopted Name (USAN) in the five years between 1983 and 1987.

The Organic Chemistry of Drug Design and Drug Action

Richard B. Silverman
The Organic Chemistry of Drug Design and Drug Action Book PDF

Author : Richard B. Silverman
Publisher : Elsevier
Page : 650 pages
File Size : 46,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080513379

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The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman Pdf

Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization

An Introduction to Drug Synthesis

Graham L. Patrick
An Introduction to Drug Synthesis Book PDF

Author : Graham L. Patrick
Publisher : Oxford University Press, USA
Page : 587 pages
File Size : 54,7 Mb
Release : 2015
Category : Science
ISBN : 9780198708438

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An Introduction to Drug Synthesis by Graham L. Patrick Pdf

'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Strategies for Organic Drug Synthesis and Design

Daniel Lednicer
Strategies for Organic Drug Synthesis and Design Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 700 pages
File Size : 50,9 Mb
Release : 2009-03-04
Category : Science
ISBN : 0470399597

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Strategies for Organic Drug Synthesis and Design by Daniel Lednicer Pdf

This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

The Organic Chemistry of Drug Design and Drug Action

Richard B. Silverman,Mark W. Holladay
The Organic Chemistry of Drug Design and Drug Action Book PDF

Author : Richard B. Silverman,Mark W. Holladay
Publisher : Academic Press
Page : 537 pages
File Size : 50,5 Mb
Release : 2014-03-29
Category : Medical
ISBN : 9780123820310

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The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman,Mark W. Holladay Pdf

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Art of Drug Synthesis

Douglas S. Johnson,Jie Jack Li
The Art of Drug Synthesis Book PDF

Author : Douglas S. Johnson,Jie Jack Li
Publisher : John Wiley & Sons
Page : 295 pages
File Size : 47,6 Mb
Release : 2013-02-26
Category : Science
ISBN : 9781118678466

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The Art of Drug Synthesis by Douglas S. Johnson,Jie Jack Li Pdf

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

The Organic Chemistry of Drug Synthesis, Volume 5

Daniel Lednicer
The Organic Chemistry of Drug Synthesis Volume 5 Book PDF

Author : Daniel Lednicer
Publisher : John Wiley & Sons
Page : 238 pages
File Size : 44,9 Mb
Release : 1994-12-13
Category : Science
ISBN : 0471589594

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The Organic Chemistry of Drug Synthesis, Volume 5 by Daniel Lednicer Pdf

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

The Organic Chemistry of Drug Design and Drug Action

Richard B. Silverman
The Organic Chemistry of Drug Design and Drug Action Book PDF

Author : Richard B. Silverman
Publisher : Academic Press
Page : 660 pages
File Size : 55,6 Mb
Release : 2004-01-12
Category : Medical
ISBN : 0126437327

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The Organic Chemistry of Drug Design and Drug Action by Richard B. Silverman Pdf

Drug discovery, design and development. Receptors. Enzymes. Enzyme inhibition and inactivation. DNA-interactive agents. Drug metabolism. Prodrugs and drug delivery systems.

The Organic Chemistry of Drug Synthesis, 6 Volume Set

Daniel Lednicer,Lester A. Mitscher
The Organic Chemistry of Drug Synthesis 6 Volume Set Book PDF

Author : Daniel Lednicer,Lester A. Mitscher
Publisher : Wiley-Interscience
Page : 0 pages
File Size : 44,9 Mb
Release : 1998-11-18
Category : Science
ISBN : 0471333700

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The Organic Chemistry of Drug Synthesis, 6 Volume Set by Daniel Lednicer,Lester A. Mitscher Pdf

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

Drug Synthesis Book Set

Jie Jack Li,Douglas S. Johnson
Drug Synthesis Book Set Book PDF

Author : Jie Jack Li,Douglas S. Johnson
Publisher : John Wiley & Sons
Page : 0 pages
File Size : 53,9 Mb
Release : 2015-11-23
Category : Science
ISBN : 1119185653

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Drug Synthesis Book Set by Jie Jack Li,Douglas S. Johnson Pdf

This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis, The Art of Drug Synthesis, Modern Drug Synthesis, and Innovative Drug Synthesis. This book set will be enormously useful to pharmaceutical industry labs, research scientists in lead optimization and process development, and graduate students and courses in organic chemistry, synthetic organic chemistry, heterocyclic chemistry, medicinal chemistry, and drug synthesis courses.

The Organic Chemistry of Drug Synthesis, 4 Volume Set

Daniel Lednicer,Lester A. Mitscher
The Organic Chemistry of Drug Synthesis 4 Volume Set Book PDF

Author : Daniel Lednicer,Lester A. Mitscher
Publisher : Wiley-Interscience
Page : 0 pages
File Size : 55,7 Mb
Release : 1991-01-16
Category : Science
ISBN : 0471531766

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The Organic Chemistry of Drug Synthesis, 4 Volume Set by Daniel Lednicer,Lester A. Mitscher Pdf

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

Contemporary Drug Synthesis

Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Contemporary Drug Synthesis Book PDF

Author : Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Publisher : John Wiley & Sons
Page : 238 pages
File Size : 40,6 Mb
Release : 2004-12-27
Category : Science
ISBN : 9780471686736

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Contemporary Drug Synthesis by Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth Pdf

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Exercises in Organic Synthesis Based on Synthetic Drugs

Marcus Vinícius Nora de Souza
Exercises in Organic Synthesis Based on Synthetic Drugs Book PDF

Author : Marcus Vinícius Nora de Souza
Publisher : Bentham Science Publishers
Page : 250 pages
File Size : 45,8 Mb
Release : 2020-12-23
Category : Science
ISBN : 9789811487545

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Exercises in Organic Synthesis Based on Synthetic Drugs by Marcus Vinícius Nora de Souza Pdf

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment. Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development. Key Features: - Presents information about different techniques and strategies for the synthesis of organic compounds - Covers a broad range of biologically active compounds - Easy to read topical presentation - Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry - Wide range of bibliographic references for further reading and exercises presented, Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.

Innovative Drug Synthesis

Jie Jack Li,Douglas S. Johnson
Innovative Drug Synthesis Book PDF

Author : Jie Jack Li,Douglas S. Johnson
Publisher : John Wiley & Sons
Page : 358 pages
File Size : 45,5 Mb
Release : 2015-12-14
Category : Science
ISBN : 9781118820056

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Innovative Drug Synthesis by Jie Jack Li,Douglas S. Johnson Pdf

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery