The Plasma Cell Report

Author : Meletios A. Dimopoulos,Thierry Facon,Evangelos Terpos
Publisher : Springer
Page : 245 pages
File Size : 49,6 Mb
Release : 2018-02-16
Category : Medical
ISBN : 9783319255866

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Multiple Myeloma and Other Plasma Cell Neoplasms by Meletios A. Dimopoulos,Thierry Facon,Evangelos Terpos Pdf

This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management.

Author : Morie A. Gertz,S. Vincent Rajkumar
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 44,6 Mb
Release : 2013-10-01
Category : Medical
ISBN : 9781461485209

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Multiple Myeloma by Morie A. Gertz,S. Vincent Rajkumar Pdf

This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.

Author : Joel Geiderman
Publisher : Greenleaf Book Group
Page : 294 pages
File Size : 42,6 Mb
Release : 2024-01-15
Category : Fiction
ISBN : 9781632997968

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The Plasma Cell Report by Joel Geiderman Pdf

“Whatever Can Go Forward Can Go Backward.” In May 1987, a scientific discovery that threatened to destroy society became a dire crisis. The Presidential Commission on the Plasma Cell Project examined the circumstances surrounding this matter and presents its findings to the American people. When a woman who appears to be in her late twenties yet claims to be sixty-three-years-old is admitted to a Cincinnati hospital, Dr. Philip Insbrook is convinced she is suffering from some form of mental illness. However, as he spends more time with the mysterious and beautiful patient and investigates her background, not only does he find himself falling in love, but he is also forced to accept an undeniable truth: Katie Shepard is inexplicably reverse aging. Insbrook, a brilliant physician, forms ideas as to the cause of Katie’s condition and races to find a solution. Katie and Insbrook attract the attention of several powerful government agencies, most notably the White House and the National Security Agency (NSA), which begin considering the potential ramifications of exploiting Katie’s condition to induce reverse aging at a population level—a top-secret program the White House designates the Plasma Cell Project. While ethical and practical questions about the global impact of a population that never ages arise, the paranoid and politically faltering president becomes drawn to the possibilities, but unbeknownst to him, the NSA has different ideas. The Plasma Cell Report is a fast-paced, thought-provoking novel about a not-so-distant scientific breakthrough that could forever change life as we know it.

Author : Sanjay Saint,Vineet Chopra
Publisher : Oxford University Press, USA
Page : 609 pages
File Size : 46,9 Mb
Release : 2018
Category : Medical
ISBN : 9780190862800

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The Saint-Chopra Guide to Inpatient Medicine by Sanjay Saint,Vineet Chopra Pdf

Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010.

Author : Edward F. McCarthy,Frank J. Frassica
Publisher : Cambridge University Press
Page : 385 pages
File Size : 54,8 Mb
Release : 2014-11-20
Category : Medical
ISBN : 9781107041233

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Pathology of Bone and Joint Disorders Print and Online Bundle by Edward F. McCarthy,Frank J. Frassica Pdf

Fully updated new edition covering all aspects of bone and joint diseases in one easily readable volume. Color illustrations throughout.

Author : Aldo M. Roccaro,Irene M. Ghobrial
Publisher : Springer
Page : 361 pages
File Size : 46,5 Mb
Release : 2016-10-01
Category : Medical
ISBN : 9783319403205

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Plasma Cell Dyscrasias by Aldo M. Roccaro,Irene M. Ghobrial Pdf

This book provides a concise overview of the state of the art in the biology and treatment of plasma cell malignancies, a heterogeneous group of diseases primarily characterized by the presence of clonal plasma cells within the bone marrow or extramedullary sites. The plasma cell dyscrasias investigated include monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma, plasmacytoma, immunoglobulin deposition diseases (primary amyloidosis and systemic light and heavy chain deposition diseases), and Waldenström’s macroglobulinemia. In the case of multiple myeloma, the coverage ranges from genomic aberrations and microRNAs to treatment for different patient groups, upcoming novel therapies, immunotherapy, and transplantation. The book reflects the significant research advances achieved in this field during the past few years, which have enhanced our understanding of the molecular mechanisms responsible for the pathogenesis of plasma cell dyscrasias.

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 881 pages
File Size : 54,6 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Author : F. Eun-Hyung Lee,Jens Wrammert,Simone Cenci
Publisher : Frontiers Media SA
Page : 139 pages
File Size : 53,5 Mb
Release : 2020-12-23
Category : Medical
ISBN : 9782889662661

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Advances in Plasma Cells in Health and Disease by F. Eun-Hyung Lee,Jens Wrammert,Simone Cenci Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Giuseppe d'Onofrio,Gina Zini
Publisher : John Wiley & Sons
Page : 805 pages
File Size : 44,8 Mb
Release : 2014-12-03
Category : Medical
ISBN : 9781118442609

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Morphology of Blood Disorders by Giuseppe d'Onofrio,Gina Zini Pdf

Morphology of Blood Disorders, 2nd edition is an outstanding atlas with over 800 high-quality digital images, covering the whole spectrum of blood and bone marrow morphology, with particular emphasis on malignant haematology. Originally written in the Italian language by two world leaders in the field, the book has been expertly translated by the renowned haematologist and teacher, Barbara Bain. This book explores the major topics of haematological pathology, blending classical teaching with up-to-date WHO classification and terminology. Each image in this book is derived from material obtained for diagnostic purposes from patients with serious haematological conditions. Morphological details are supplemented by detailed descriptions of the output and role of automated instruments in disorders of the blood. Morphology of Blood Disorders, 2nd edition is an essential reference source for diagnosis in the haematology laboratory, designed to be the go-to guide for anyone with an interest in blood cell morphology.

Author : Geiderman
Publisher : Unknown
Page : 0 pages
File Size : 47,5 Mb
Release : 2024-01-15
Category : Fiction
ISBN : 1632997959

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The Plasma Cell Report by Geiderman Pdf

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 41,8 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Derek Raghavan,Manmeet S. Ahluwalia,Charles D. Blanke,Jubilee Brown,Edward S. Kim,Gregory H. Reaman,Mikkael A. Sekeres
Publisher : John Wiley & Sons
Page : 1296 pages
File Size : 55,6 Mb
Release : 2017-03-03
Category : Medical
ISBN : 9781119196211

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Textbook of Uncommon Cancer by Derek Raghavan,Manmeet S. Ahluwalia,Charles D. Blanke,Jubilee Brown,Edward S. Kim,Gregory H. Reaman,Mikkael A. Sekeres Pdf

The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression

Author : Michael Andreeff
Publisher : Unknown
Page : 424 pages
File Size : 45,8 Mb
Release : 1986
Category : Science
ISBN : STANFORD:36105038010794

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Clinical Cytometry by Michael Andreeff Pdf

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 50,7 Mb
Release : 2015
Category : Electronic
ISBN : OCLC:1368438387

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The Origin of the Plasma Cell Heterogeneity by Anonim Pdf

Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the "active" in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases.

Author : Eckart W. Wunder,Philippe R. Henon
Publisher : Springer Science & Business Media
Page : 285 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642757174

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Peripheral Blood Stem Cell Autografts by Eckart W. Wunder,Philippe R. Henon Pdf

The monograph edited by Drs. Wunder and Henon on "Peripheral Blood Stem Cell Autogtafts" is extremely useful as well as timely. It covers the "state of the arts" with respect to the use of hemopoietic stem cells collected from the peripheral blood for the reconstitution of hematopoiesis after myeloablative therapy. If is is accepted that hematopoietic function in the mammalian organism is the result of stem cell seeding of an appropriate stromal matrix, then the use of blood derived stem cells for hematopoietic reconstitution represents the "physiological form" of the (re) establishment of a hematopoietic bone marrow. All observations to date are compatible with the assumption that stem cells migrate via the blood stream from extraembryonic hematopoietic tissue to the fetal liver to establish there a first intraembryonic site of blood cell formation and especially of stem cell replication and proliferation. This fetal liver tissue appears then to be the major source for the seeding offetal bone marrow stroma as it develops sequentially in all the bones of the skeleton - in other words during most of the entire embryonic development. There is a very high concentration of stem cells in the blood of the embryo (more than 20000 CFU-GM per ml in the 22nd week) and the stem cells in cord blood seem to be the "tail end" of a dramatic "stem cell traffic" in the embryo to establish the hemopoietic as well as lymphopoietic tissue.