The Postgenomic Condition

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The Postgenomic Condition

Jenny Reardon
The Postgenomic Condition Book PDF

Author : Jenny Reardon
Publisher : University of Chicago Press
Page : 320 pages
File Size : 45,7 Mb
Release : 2017-12-29
Category : Philosophy
ISBN : 9780226510453

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The Postgenomic Condition by Jenny Reardon Pdf

The postgenomic condition: an introduction -- The information of life or the life of information? -- Inclusion: can genomics be antiracist? -- Who represents the human genome? What is the human genome? -- Genomics for the people or the rise of the machines? -- Genomics for the 98 percent? -- The genomic open 2.0: the public v. the public -- Life on Third: knowledge and justice after the genome -- Epilogue

Postgenomics

Sarah S. Richardson,Hallam Stevens
Postgenomics Book PDF

Author : Sarah S. Richardson,Hallam Stevens
Publisher : Duke University Press
Page : 304 pages
File Size : 52,6 Mb
Release : 2015-04-15
Category : Science
ISBN : 9780822375449

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Postgenomics by Sarah S. Richardson,Hallam Stevens Pdf

Ten years after the Human Genome Project’s completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences. Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens

Race to the Finish

Jenny Reardon
Race to the Finish Book PDF

Author : Jenny Reardon
Publisher : Princeton University Press
Page : 249 pages
File Size : 47,5 Mb
Release : 2009-02-09
Category : Science
ISBN : 9781400826407

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Race to the Finish by Jenny Reardon Pdf

In the summer of 1991, population geneticists and evolutionary biologists proposed to archive human genetic diversity by collecting the genomes of "isolated indigenous populations." Their initiative, which became known as the Human Genome Diversity Project, generated early enthusiasm from those who believed it would enable huge advances in our understanding of human evolution. However, vocal criticism soon emerged. Physical anthropologists accused Project organizers of reimporting racist categories into science. Indigenous-rights leaders saw a "Vampire Project" that sought the blood of indigenous people but not their well-being. More than a decade later, the effort is barely off the ground. How did an initiative whose leaders included some of biology's most respected, socially conscious scientists become so stigmatized? How did these model citizen-scientists come to be viewed as potential racists, even vampires? This book argues that the long abeyance of the Diversity Project points to larger, fundamental questions about how to understand knowledge, democracy, and racism in an age when expert claims about genomes increasingly shape the possibilities for being human. Jenny Reardon demonstrates that far from being innocent tools for fighting racism, scientific ideas and practices embed consequential social and political decisions about who can define race, racism, and democracy, and for what ends. She calls for the adoption of novel conceptual tools that do not oppose science and power, truth and racist ideologies, but rather draw into focus their mutual constitution.

Bioinformatics in the Post-genomic Era

Jeffrey Augen
Bioinformatics in the Post genomic Era Book PDF

Author : Jeffrey Augen
Publisher : Addison-Wesley Professional
Page : 412 pages
File Size : 40,9 Mb
Release : 2005
Category : Computers
ISBN : STANFORD:36105114316099

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Bioinformatics in the Post-genomic Era by Jeffrey Augen Pdf

A comprehensive treatment of the role of bioinformatics in the emerging world of molecular medicine, for anyone involved in this new field

Race in a Bottle

Jonathan Kahn
Race in a Bottle Book PDF

Author : Jonathan Kahn
Publisher : Columbia University Press
Page : 330 pages
File Size : 53,5 Mb
Release : 2013
Category : Medical
ISBN : 9780231162982

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Race in a Bottle by Jonathan Kahn Pdf

Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was touted as a pathbreaking therapy to treat heart failure in black patients. Kahn reveals that, at the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked. He examines the legal and calls for a more reasoned approach to using race in biomedical research and practice.

The Gene

Hans-Jörg Rheinberger,Staffan Müller-Wille
The Gene Book PDF

Author : Hans-Jörg Rheinberger,Staffan Müller-Wille
Publisher : University of Chicago Press
Page : 156 pages
File Size : 49,7 Mb
Release : 2018-01-26
Category : Science
ISBN : 9780226474786

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The Gene by Hans-Jörg Rheinberger,Staffan Müller-Wille Pdf

Few concepts played a more important role in twentieth-century life sciences than that of the gene. Yet at this moment, the field of genetics is undergoing radical conceptual transformation, and some scientists are questioning the very usefulness of the concept of the gene, arguing instead for more systemic perspectives. The time could not be better, therefore, for Hans-Jörg Rheinberger and Staffan Müller-Wille's magisterial history of the concept of the gene. Though the gene has long been the central organizing theme of biology, both conceptually and as an object of study, Rheinberger and Müller-Wille conclude that we have never even had a universally accepted, stable definition of it. Rather, the concept has been in continual flux—a state that, they contend, is typical of historically important and productive scientific concepts. It is that very openness to change and manipulation, the authors argue, that made it so useful: its very mutability enabled it to be useful while the technologies and approaches used to study and theorize about it changed dramatically.

Post-Genomic Cardiology

José Marín-García
Post Genomic Cardiology Book PDF

Author : José Marín-García
Publisher : Academic Press
Page : 935 pages
File Size : 42,5 Mb
Release : 2014-05-09
Category : Medical
ISBN : 9780124046429

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Post-Genomic Cardiology by José Marín-García Pdf

In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Principles of Gender-Specific Medicine

Marianne J. Legato
Principles of Gender Specific Medicine Book PDF

Author : Marianne J. Legato
Publisher : Academic Press
Page : 792 pages
File Size : 46,5 Mb
Release : 2017-05-15
Category : Medical
ISBN : 9780128035429

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Principles of Gender-Specific Medicine by Marianne J. Legato Pdf

The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation. This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness. Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols

Biocapital

Kaushik Sunder Rajan
Biocapital Book PDF

Author : Kaushik Sunder Rajan
Publisher : Duke University Press
Page : 360 pages
File Size : 50,9 Mb
Release : 2006-04-24
Category : Business & Economics
ISBN : 0822337207

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Biocapital by Kaushik Sunder Rajan Pdf

DIVAn ethnography about the work of genome scientists, entrepreneurs, and policy makers in biotech drug development in the United States and India./div

Malaria: Drugs, Disease and Post-genomic Biology

David Sullivan,Sanjeev Krishna
Malaria Drugs Disease and Post genomic Biology Book PDF

Author : David Sullivan,Sanjeev Krishna
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 42,9 Mb
Release : 2006-01-09
Category : Medical
ISBN : 9783540290889

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Malaria: Drugs, Disease and Post-genomic Biology by David Sullivan,Sanjeev Krishna Pdf

Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.

Integrative Physiology in the Proteomics and Post-Genomics Age

Wolfgang Walz
Integrative Physiology in the Proteomics and Post Genomics Age Book PDF

Author : Wolfgang Walz
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 45,6 Mb
Release : 2007-11-10
Category : Medical
ISBN : 9781592599257

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Integrative Physiology in the Proteomics and Post-Genomics Age by Wolfgang Walz Pdf

There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

Weighing the Future

Natali Valdez
Weighing the Future Book PDF

Author : Natali Valdez
Publisher : Univ of California Press
Page : 289 pages
File Size : 40,7 Mb
Release : 2021-12-14
Category : Social Science
ISBN : 9780520380158

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Weighing the Future by Natali Valdez Pdf

Epigenetics, the study of heritable changes in gene expression, has been heralded as one of the most promising new fields of scientific inquiry. Current large-scale studies selectively draw on epigenetics to connect behavioral choices made by pregnant people, such as diet and exercise, to health risks for future generations. As the first ethnography of its kind, Weighing the Future examines the sociopolitical implications of ongoing pregnancy trials in the United States and the United Kingdom, illuminating how processes of scientific knowledge production are linked to capitalism, surveillance, and environmental reproduction. Natali Valdez argues that a focus on individual behavior rather than social environments ignores the vital impacts of systemic racism. The environments we imagine to shape our genes, bodies, and future health are intimately tied to race, gender, and structures of inequality. This groundbreaking book makes the case that science, and how we translate it, is a reproductive project that requires feminist vigilance. Instead of fixating on a future at risk, this book brings attention to the present at stake.

Clostridia

Holger Brüggemann,Gerhard Gottschalk
Clostridia Book PDF

Author : Holger Brüggemann,Gerhard Gottschalk
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 44,6 Mb
Release : 2009
Category : Science
ISBN : 1904455387

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Clostridia by Holger Brüggemann,Gerhard Gottschalk Pdf

"In this book internationally recognized Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research." --Book Jacket.

Personalized Medicine

Barbara Prainsack
Personalized Medicine Book PDF

Author : Barbara Prainsack
Publisher : NYU Press
Page : 288 pages
File Size : 46,9 Mb
Release : 2017-12-19
Category : Medical
ISBN : 9781479856909

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Personalized Medicine by Barbara Prainsack Pdf

Inside today's data-driven personalized medicine, and the time, effort, and information required from patients to make it a reality Medicine has been personal long before the concept of “personalized medicine” became popular. Health professionals have always taken into consideration the individual characteristics of their patients when diagnosing, and treating them. Patients have cared for themselves and for each other, contributed to medical research, and advocated for new treatments. Given this history, why has the notion of personalized medicine gained so much traction at the beginning of the new millennium? Personalized Medicine investigates the recent movement for patients’ involvement in how they are treated, diagnosed, and medicated; a movement that accompanies the increasingly popular idea that people should be proactive, well-informed participants in their own healthcare. While it is often the case that participatory practices in medicine are celebrated as instances of patient empowerment or, alternatively, are dismissed as cases of patient exploitation, Barbara Prainsack challenges these views to illustrate how personalized medicine can give rise to a technology-focused individualism, yet also present new opportunities to strengthen solidarity. Facing the future, this book reveals how medicine informed by digital, quantified, and computable information is already changing the personalization movement, providing a contemporary twist on how medical symptoms or ailments are shared and discussed in society. Bringing together empirical work and critical scholarship from medicine, public health, data governance, bioethics, and digital sociology, Personalized Medicine analyzes the challenges of personalization driven by patient work and data. This compelling volume proposes an understanding that uses novel technological practices to foreground the needs and interests of patients, instead of being ruled by them.

Systems Biology

Lilia Alberghina,Hans V. Westerhoff
Systems Biology Book PDF

Author : Lilia Alberghina,Hans V. Westerhoff
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 50,7 Mb
Release : 2007-10-04
Category : Computers
ISBN : 3540742697

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Systems Biology by Lilia Alberghina,Hans V. Westerhoff Pdf

For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.