The Rise Of Virulence And Antibiotic Resistance In Staphylococcus Aureus

Author : Shymaa Enany,Laura Crotty Alexander
Publisher : BoD – Books on Demand
Page : 226 pages
File Size : 55,7 Mb
Release : 2017-03-08
Category : Medical
ISBN : 9789535129837

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The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus by Shymaa Enany,Laura Crotty Alexander Pdf

Staphylococcus aureus S. aureus is a growing issue both within hospitals and community because of its virulence determinants and the continuing emergence of new strains resistant to antimicrobiotics. In this book, we present the state of the art of S. aureus virulence mechanisms and antibiotic-resistance profiles, providing an unprecedented and comprehensive collection of up-to-date research about the evolution, dissemination, and mechanisms of different staphylococcal antimicrobial resistance patterns alongside bacterial virulence determinants and their impact in the medical field. We include several review chapters to allow readers to better understand the mechanisms of methicillin resistance, glycopeptide resistance, and horizontal gene transfer and the effects of alterations in S. aureus membranes and cell walls on drug resistance. In addition, we include chapters dedicated to unveiling S. aureus pathogenicity with the most current research available on S. aureus exfoliative toxins, enterotoxins, surface proteins, biofilm, and defensive responses of S. aureus to antibiotic treatment.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 19??
Category : Electronic
ISBN : 9535129848

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The Rise of Virulence and Antibiotic Resistance in Staphylococcus Aureus by Anonim Pdf

Author : Anonim
Publisher : BoD – Books on Demand
Page : 254 pages
File Size : 40,7 Mb
Release : 2021-12-08
Category : Medical
ISBN : 9781839627422

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Insights Into Drug Resistance in Staphylococcus aureus by Anonim Pdf

Staphylococcus aureus is a coccus, gram-positive, non-spore forming, and non-motile bacterium. Its commensal and opportunistic capabilities make it able to colonize different sites of animals and humans. Resistance to antibiotics has resulted in development of new strains and new types within strains. Types of methicillin-resistant S. aureus (MRSA) include hospital-acquired MRSA (HA-MRSA), community-acquired MRSA (CA-MRSA), and livestock-acquired MRSA (LA-MRSA). There are also new strains like vancomycin-resistant S. aureus (VRSA) and vancomycin-intermediate S. aureus (VISA). Expansion in resistance is expected to give rise to newer strains resistant to antibiotics such as macrolide (erm gene), tetracycline (tet genes), mupirocin (mupR), and fusidic acid (fusD). Alternative approaches like nanoparticles, bacteriophages, phytochemicals, and more are required to tackle this pathogen. This book contains information on epidemiology, resistance mechanisms, and alternative ways to curtail S. aureus infection, as well as future research opportunities.

Author : Shymaa Enany,Laura Crotty Alexander
Publisher : BoD – Books on Demand
Page : 236 pages
File Size : 47,9 Mb
Release : 2017-03-08
Category : Science
ISBN : 9789535129813

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Frontiers in Staphylococcus aureus by Shymaa Enany,Laura Crotty Alexander Pdf

Staphylococcus was first recognized as a human pathogen in 1880 and was named for its grape cluster-like appearance. In 1884, Staphylococcus aureus was identified and named for its vibrant golden color, which was later found to be the result of golden toxin production. Here, experts examine in-depth patterns of S. aureus colonization and exposures in humans, mammals, and birds that have led to the development of various clinical diseases. The mode of transmission of S. aureus and different methods for its detection in different samples are defined. Conventional antibiotic options to treat this aggressive, multifaceted, and readily adaptable pathogen are becoming limited. Alternative, novel chemotherapeutics to target S. aureus are discussed in the pages within, including herbal medicines, bee products, and modes of delivery.

Author : Etienne Giraud,Ivan Rychlik,Axel Cloeckaert
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 40,5 Mb
Release : 2017-06-01
Category : Electronic book
ISBN : 9782889451814

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Antimicrobial Resistance and Virulence Common Mechanisms by Etienne Giraud,Ivan Rychlik,Axel Cloeckaert Pdf

Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences.

Author : Boyan B. Bonev,Nicholas M. Brown
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 41,9 Mb
Release : 2019-03-14
Category : Science
ISBN : 9781119558200

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Bacterial Resistance to Antibiotics by Boyan B. Bonev,Nicholas M. Brown Pdf

AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.

Author : Fabio Bagnoli,Sanjay Kumar Phogat,Isabelle Bekeredjian-Ding,Rachel McLoughlin
Publisher : Frontiers Media SA
Page : 281 pages
File Size : 55,9 Mb
Release : 2022-02-03
Category : Science
ISBN : 9782889742660

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Fighting an Elusive Enemy: Staphylococcus aureus and its Antibiotic Resistance, Immune-Evasion and Toxic Mechanisms by Fabio Bagnoli,Sanjay Kumar Phogat,Isabelle Bekeredjian-Ding,Rachel McLoughlin Pdf

Topic Editors Dr. Bagnoli and Dr. Phogat are employed by GlaxoSmithKline plc. The other Topic Editors Declare no conflict of interest in relation to the Research Topic theme

Author : Lisa Freeman-Cook,Kevin D. Freeman-Cook,I. Edward Alcamo
Publisher : Infobase Publishing
Page : 183 pages
File Size : 53,9 Mb
Release : 2006
Category : Bacteria
ISBN : 9781438101682

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Staphylococcus Aureus Infections by Lisa Freeman-Cook,Kevin D. Freeman-Cook,I. Edward Alcamo Pdf

Discusses staphylococcus aureus bacteria and the infections they can cause, their diagnosis, treatment, and more.

Author : Busi Siddhardha,Madhu Dyavaiah,Asad Syed
Publisher : Springer Nature
Page : 685 pages
File Size : 42,9 Mb
Release : 2020-03-28
Category : Science
ISBN : 9789811516955

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Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery by Busi Siddhardha,Madhu Dyavaiah,Asad Syed Pdf

This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.

Author : Maria de Lourdes Ribeiro de Souza da Cunha
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 41,9 Mb
Release : 2014
Category : Molecular epidemiology
ISBN : 1631179381

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Staphylococcus Aureus and Coagulase-Negative Staphylococci by Maria de Lourdes Ribeiro de Souza da Cunha Pdf

The book covers updated topics on the genus Staphylococcus, including the latest discoveries. In each chapter, the author discusses the results obtained and published during her 20-plus years as a researcher in this area. The book is divided into eight chapters, with a presentation of the genus Staphylococcus, current classification, general characteristics of these bacteria and the clinical significance of coagulase-negative staphylococci (CoNS), which are often classified as mere blood culture contaminants, but are the etiological agents most commonly associated with neonatal infections and peritonitis in patients undergoing peritoneal dialysis. Coagulase-negative staphylococci can colonize the surface of catheters and produce an extracellular polysaccharide that leads to the formation of biofilms which potentiate their pathogenicity. The book also focuses on the identification of CoNS, virulence factors responsible for the symptoms and severity of infections caused by Staphylococcus spp. These factors include membrane-active toxins, called cytotoxins, and a group of pyrogenic toxin superantigens. Several current aspects related to the virulence of S. aureus and CoNS are discussed, including isolates of different origins, phenotypic and genotypic techniques for the detection of these toxins, and the gene regulation mechanism involved in the expression of these toxins. Another extremely important topic which is discussed is the resistance of these microorganisms to antimicrobial agents. MRSA currently represent a serious threat to public health worldwide due to the rapid dissemination and diversification of pandemic clones. The epidemiology of MRSA infections is discussed highlights the importance of understanding why specific clones predominated in different regions in order to develop more effective control strategies and to choose more appropriate antimicrobial therapy. In this book, the topics are explained in a clear and objective manner and should be useful for postgraduate students, physicians and researchers.

Author : Hassan Hemeg,Hani Ozbak,Farhat Afrin
Publisher : Unknown
Page : 146 pages
File Size : 40,9 Mb
Release : 2019
Category : Microbiology
ISBN : 9781789845921

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Staphylococcus Aureus by Hassan Hemeg,Hani Ozbak,Farhat Afrin Pdf

Staphylococcus aureus strains are an important medical infectious agent that causes a wide range of pathogeneses starting from colonization of the skin and mucosal surface to severe pathogenic effects such as septicemia. The mortality and morbidity from this pathogen are challenging issues for the healthcare premises. Methicillin Resistant Staphylococcus aureus strains (MRSA) are causing severe infections due to the genes that are resistant to several antibiotics including methicillin, aminoglycosides, and others. Recently, there have been several reports related to failure of treatment plans caused by MRSA that led to Vancomycin Intermediate Staphylococcus aureus strains (VISA) or, in sporadic cases, resistance to the drug of choice. This book highlights the new areas for the treatment of MRSA using natural products. The implementation of specific products produced by this organism can help the scientist to obtain a new window for treatments such as anticancer chemotherapy, antioxidants, etc.

Author : Maria Cristina Ossiprandi
Publisher : BoD – Books on Demand
Page : 142 pages
File Size : 51,6 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9789535122227

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Antimicrobial Resistance by Maria Cristina Ossiprandi Pdf

Antibiotic resistance has become a worldwide health issue, globally recognized as the first priority by WHO. Many forms of resistance can spread with remarkable speed and cross international boundaries. World health leaders are devoting efforts to the problem by planning strategies for monitoring the effectiveness of public health interventions and detecting new trends and threats. This volume focuses on the problem from different perspectives, taking into consideration geographical dissemination (soil and water), human medicine (methicillin-resistant Staphylococcus aureus and Klebsiella pneumoniae) and veterinary (Enterococcus spp.) impact and molecular analysis. The purpose of this volume is to provide a useful tool for control and prevention and to discuss useful epidemiological data concerning ways of obtaining an accurate picture of resistance in different communities.

Author : Natalia V. Kirienko,Laurence Rahme,You-Hee Cho
Publisher : Frontiers Media SA
Page : 281 pages
File Size : 46,8 Mb
Release : 2019-12-24
Category : Electronic
ISBN : 9782889632565

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Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria by Natalia V. Kirienko,Laurence Rahme,You-Hee Cho Pdf

Author : Anonim
Publisher : DIANE Publishing
Page : 196 pages
File Size : 47,8 Mb
Release : 1995
Category : Antibacterial agents
ISBN : 9780788130434

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Impacts of Antibiotic-resistant Bacteria by Anonim Pdf

Author : De Lourde Maria
Publisher : Gazelle Book Services, Limited
Page : 139 pages
File Size : 41,5 Mb
Release : 2014-01-01
Category : HEALTH & FITNESS
ISBN : 1633214761

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Staphylococcus Aureus and Coagulase Ne by De Lourde Maria Pdf

The book covers updated topics on the genus Staphylococcus, including the latest discoveries. In each chapter, the author discusses the results obtained and published during her more than 20 years as a researcher in this area. The book is divided into eig