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The Role Of Ncrnas Non Coding Rnas In Regulating Tumor Immune Microenvironment Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of The Role Of Ncrnas Non Coding Rnas In Regulating Tumor Immune Microenvironment book. This book definitely worth reading, it is an incredibly well-written.
Author : Yanyan Tang,Shiv K. Gupta,Zong Sheng Guo
Publisher : Frontiers Media SA
Page : 446 pages
File Size : 43,6 Mb
Release : 2022-09-14
Category : Science
ISBN : 9782889769575
Author : Alfons Navarro
Publisher : Humana
Page : 387 pages
File Size : 44,8 Mb
Release : 2021-06-24
Category : Medical
ISBN : 1071615807
This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
Author : Hui Ling,George A. Calin
Publisher : Elsevier Inc. Chapters
Page : 510 pages
File Size : 46,7 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9780128061220
The discovery of microRNA (miRNA) involvement in cancer a decade ago, and the more recent findings of long non-coding RNAs in human diseases, challenged the long-standing view that RNAs without protein-coding potential are simply “junk” transcription within the human genome. These findings evidently changed the dogma that “DNA makes RNA makes protein” by showing that RNAs themselves can be essential regulators of cellular function and play key roles in cancer development. MiRNAs are evolutionarily conserved short single-stranded transcripts of 19–24 nucleotides in length. They do not code for proteins, but change the final output of protein-coding genes by regulating their transcriptional and/or translation process. Ultraconserved genes (UCGs) are non-coding RNAs with longer length (>200bp) that are transcribed from the ultraconserved genomic region. Both miRNAs and UCGs are located within cancer-associated genomic regions (CAGRs) and can act as tumor suppressors or oncogenes. In this chapter, we present principles and concepts that have been identified over the last decade with respect to our understanding of the function of non-coding RNAs, and summarize recent findings on the role of miRNAs and UCGs in cancer development. Finally, we will conclude by discussing the translational potential of this knowledge into clinical settings such as cancer diagnosis, prognosis and treatment.
Author : Subash Gupta,Kishore Challagundla
Publisher : Academic Press
Page : 479 pages
File Size : 45,8 Mb
Release : 2022-01-19
Category : Science
ISBN : 9780128245514
Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference
Author : M.R.S. Rao
Publisher : Springer
Page : 323 pages
File Size : 52,5 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9789811052033
This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 44,6 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author : Shuai Jiang
Publisher : Academic Press
Page : 316 pages
File Size : 43,5 Mb
Release : 2022-05-15
Category : Medical
ISBN : 0323855040
Advances in Non-coding RNAs in Cancer-Biology and Immunology is a resource for three major types of non-coding RNAs including microRNA, LnRNA and piRNA. It covers machinery of non-coding RNAs, including microRNA, LnRNA and piRNA, and the identification of targets of these non-coding RNAs, and the identification of physiological and pathological roles of miRNAs, LnRNAs and piRNAs in immunology and cancer biology. The aberrant expressions of these non-coding RNAs within the cells cause various abnormalities and diseases including cancer and immune system-associated diseases. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. Advances in Non-coding RNAs in Cancer-Biology and Immunology introduces basic ideas of miRNAs, LnRNAs and piRNAs, along with their detailed bio-processing steps, critical functions in the development of tumorigenesis and controlling immune cell responses, which benefits for identifying different classes of non-coding RNAs and their targets, identifying new members of these non-coding RNAs and predicting the possible functions of these molecules. It captures the essence of the pioneering work of some of the world's leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs, LnRNAs, piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. Provides a unified cutting-edge resource for non-coding RNAs including miRNAs LnRNAs, and piRNAs, their physiological and pathological roles and potential applications Showcases high-throughput technologies and other approaches for discovery of these non-coding RNAs and their downstream targets Unveils the diverse molecular mechanisms by which miRNAs, LnRNAs and piRNAs regulate gene expression in animal cells Showcases recent discoveries on involvement of these non-coding RNAs in different biological processes and diseases as well as their possible use in diagnosis Reports breakthroughs in the use of these non-coding RNAs for diagnosis and personalized therapy
Author : Volker A. Erdmann,Jan Barciszewski
Publisher : Springer Science & Business Media
Page : 460 pages
File Size : 52,9 Mb
Release : 2010-09-02
Category : Medical
ISBN : 9783642121685
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
Author : Cesar Lopez-Camarillo,Laurence A. Marchat
Publisher : CRC Press
Page : 426 pages
File Size : 43,7 Mb
Release : 2013-02-22
Category : Medical
ISBN : 9781466576773
MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th
Author : Muller Fabbri
Publisher : Springer Science & Business Media
Page : 287 pages
File Size : 47,7 Mb
Release : 2013-10-28
Category : Medical
ISBN : 9781461484448
The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.
Author : Massimo Negrini,George A. Calin,Carlo M. Croce
Publisher : Academic Press
Page : 434 pages
File Size : 50,6 Mb
Release : 2022-02-18
Category : Science
ISBN : 9780128232743
MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators. Provides fundamental and translational chapters that facilitate the acquisition of knowledge needed to design and perform innovative miRNA-related research studies Synthesizes current research, with a critical review on the field Offers in-depth research by leading experts in the field
Author : Arshi Malik,Sarah Afaq,Mohammed Tarique
Publisher : Springer Nature
Page : 249 pages
File Size : 53,8 Mb
Release : 2021-08-01
Category : Medical
ISBN : 9789811575648
This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.
Author : Stefan Jurga,Jan Barciszewski
Publisher : Springer Nature
Page : 545 pages
File Size : 41,5 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9783030447434
This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
Author : Maria Pia Felli,Lisa M. Minter,Eleni Anastasiadou
Publisher : Frontiers Media SA
Page : 291 pages
File Size : 41,7 Mb
Release : 2022-01-05
Category : Science
ISBN : 9782889719464
Author : Yi Feng,Lin Zhang
Publisher : Humana
Page : 0 pages
File Size : 50,5 Mb
Release : 2016-01-01
Category : Medical
ISBN : 1493933760
This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Long Non-Coding RNAs: Methods and Protocols is a must-have for molecular biologists, cell and developmental biologists, specialists who conduct disease-oriented research, and bioinformatics experts who seek a better understanding on lncRNA expression and function by computational analysis of the massive sequencing data that are rapidly accumulating in recent years.
