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The Transient Structure Of The Amyloid Precursor Protein Cytoplasmic Tail And Phosphorylation Induced Structural Changes Detected By Solution Nuclear Magnetic Resonance Spectroscopy Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of The Transient Structure Of The Amyloid Precursor Protein Cytoplasmic Tail And Phosphorylation Induced Structural Changes Detected By Solution Nuclear Magnetic Resonance Spectroscopy book. This book definitely worth reading, it is an incredibly well-written.
Author : Theresa Ann Ramelot
Publisher : Unknown
Page : 318 pages
File Size : 47,5 Mb
Release : 2001
Category : Electronic
ISBN : CORNELL:31924089542116
Author : Anonim
Publisher : Unknown
Page : 810 pages
File Size : 46,8 Mb
Release : 2001
Category : Dissertations, Academic
ISBN : STANFORD:36105110578692
Author : Anonim
Publisher : Unknown
Page : 816 pages
File Size : 44,9 Mb
Release : 2000
Category : Dissertation abstracts
ISBN : UOM:39015086908152
Author : The Nuclear Magnetic Resonance Society of Japan
Publisher : Springer
Page : 636 pages
File Size : 46,5 Mb
Release : 2017-11-23
Category : Science
ISBN : 9789811059667
This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.
Author : Steve P. Watson,Steve Arkinstall
Publisher : Academic Press
Page : 452 pages
File Size : 47,8 Mb
Release : 1994-02-28
Category : Medical
ISBN : UOM:39015032575279
Catalogues major facts about receptors, G-proteins and effector molecules. Each entry has a common format, using a minimum amount of text, and contains information on the sequence, gene structure, distribution, agonists/antagonists and physiochemical properties of these proteins.
Author : J. Robin Harris,Jon Marles-Wright
Publisher : Springer Nature
Page : 580 pages
File Size : 46,8 Mb
Release : 2020-11-30
Category : Science
ISBN : 9783030589714
This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Andrew J. Dingley,A. J. Dingley,Steven M. Pascal
Publisher : IOS Press
Page : 488 pages
File Size : 41,6 Mb
Release : 2011
Category : Medical
ISBN : 9781607506942
Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful technique for characterization of biomolecular structures at atomic resolution in the solution state. This timely book, entitled "Biomolecular NMR Spectroscopy," focuses on the latest state-of-the-art NMR techniques for characterization of biological macromolecules in the solid and solution state. The editors, Dr. Andrew Dingley (University of Auckland, New Zealand) and Dr. Steven Pascal (Massey University, New Zealand) have organized the book into four sections, covering the following topics: sample preparation, structure and dynamics of proteins, structure and dynamics of nucleic acids and protein-nucleic acid complexes, and rapid and hybrid techniques--
Author : Monika Fuxreiter,Peter Tompa
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 42,9 Mb
Release : 2012-03-07
Category : Medical
ISBN : 9781461406594
Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
Author : Derek J. Chadwick,Kate Widdows
Publisher : John Wiley & Sons
Page : 282 pages
File Size : 51,7 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470514153
How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.
Author : Frances Separovic,Marc-Antoine Sani
Publisher : Unknown
Page : 0 pages
File Size : 42,8 Mb
Release : 2020
Category : Membranes (Biology)
ISBN : 0750325321
The purpose of this book is to describe the methodology and applications of solid-state NMR spectroscopy to studies of membrane proteins, membrane-active peptides and model biological membranes. As well as structural studies, this book contains coverage of membrane interactions and molecular motions. Advances in biological solid-state NMR are very pertinent with high-field developments seeing applications in biological membranes and whole cells. Experts who are leaders in the development and application of biological solid-state NMR are chapter contributors. Part of Biophysical Society-IOP series.
Author : Konrad Beyreuther,Gotthard Schettler
Publisher : Springer Science & Business Media
Page : 206 pages
File Size : 45,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642842245
Author : Paul Agris
Publisher : Elsevier
Page : 641 pages
File Size : 43,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323144124
Biomolecular Structure and Function covers the proceedings of the 1977 ?Cellular Function and Molecular Structure: Biophysical Approaches to Biological Problems? symposium. It summarizes the application of several biophysical techniques to molecular research in biology. This book starts by describing the use of deuterium-labeled lipids, as monitors of the degree of organization of membrane lipids. It also describes the use of carbon-13-labeled lipids, as indicators of molecular mobility. It explains the lipid-protein interactions involving two integral membrane proteins, mitochondrial cytochrome oxidase and calcium-dependent ATPase of muscle sarcoplasmic reticulum. The book goes on to present NMR studies on the organization and conformation of phospholipids, chloroplast membranes, and erythrocyte membranes. It also presents the ESR study of spectrin-phospholipid associations. It discusses the use of fluorescence probes, electrokinetics, neutron diffraction and ion theory studies of phospholipid-protein association, hormone disease, and senescence effects on prokaryotic and eukaryotic cells. Moreover, this book presents the experiments and phosphorus-31 NMR methodology to simultaneously monitor the intracellular pH and phosphate metabolism in a beating heart, functioning kidney, or an intact living microorganism. This book then describes physical probing of intracellular fluidity and structural changes attending tissue or cell cycles. It also relates relatively narrow lines in the hydrogen-1 NMR spectrum of the extremely viscous complex of the muscle protein troponin and highly polymerized tropomyosin. Structure-function studies of fibrous proteins, such as collagen, actin, and myosin, and active site analysis of enzymes are also presented. Finally, a wide variety of methodologies and technologies is exemplified. This includes proton, carbon, fluorine, phosphorus, and lithium NMR spectroscopy; spin labeling and EPR spectroscopy; chemical studies; light scattering and fluorescence; and electron microscopy.
Author : Roza Maria Kamp,Theodora Choli-Papadopoulou,Brigitte Wittmann-Liebold
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 53,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642592195
"Protein Structure Analysis - Preparation and Characterization" is a compilation of practical approaches to the structural analysis of proteins and peptides. Here, about 20 authors describe and comment on techniques for sensitive protein purification and analysis. These methods are used worldwide in biochemical and biotechnical research currently being carried out in pharmaceu tical and biomedical laboratories or protein sequencing facilities. The chapters have been written by scientists with extensive ex perience in these fields, and the practical parts are well documen ted so that the reader should be able to easily reproduce the described techniques. The methods compiled in this book were demonstrated in student courses and in the EMBO Practical Course on "Microsequence Analysis of Proteins" held in Berlin September 10-15, 1995. The topics also derived from a FEBS Workshop, held in Halkidiki, Thessaloniki, Greece, in April, 1995. Most of the authors participated in these courses as lecturers and tutors and made these courses extremely lively and successful. Since polypeptides greatly vary depending on their specific structure and function, strategies for their structural analysis must for the most part be adapted to each individual protein. Therefore, advantages and limitations of the experimen tal approaches are discussed here critically, so that the reader becomes familiar with problems that might be encountered.
Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 44,6 Mb
Release : 2019-09-12
Category : Science
ISBN : 012816851X
"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
Author : Hartmut Michel
Publisher : CRC Press
Page : 376 pages
File Size : 54,5 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351088176
The precise knowledge of the structure of biological macromolecules forms the basis of understanding their function and their mechanism of action. It also lays the foundation for rational protein and drug design. The only method to obtain this knowledge is still crystallography. At present, the structures of about 400 proteins are known at or nearly at atomic proteins. However, only two of them are membrane proteins or complexes of the membrane proteins. The reasons for the difference is not the crystals of membrane proteins resists forming special problems when being analysed. The reason is that the membrane proteins resist into forming into well-ordered crystals. The intention of this book is to help to produce well-ordered crystals proteins and to provide guidelines, it is aimed at both biochemists and protein crystallographer‘s.
