The Tumor Stroma

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Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 40,8 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

The Tumor Stroma

Jai Prakash
The Tumor Stroma Book PDF

Author : Jai Prakash
Publisher : CRC Press
Page : 392 pages
File Size : 43,8 Mb
Release : 2022-01-27
Category : Medical
ISBN : 9781000470703

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The Tumor Stroma by Jai Prakash Pdf

The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Marcela Bolontrade,Mariana García
Mesenchymal Stromal Cells as Tumor Stromal Modulators Book PDF

Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Page : 642 pages
File Size : 51,8 Mb
Release : 2016-10-24
Category : Medical
ISBN : 9780128031032

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Mesenchymal Stromal Cells as Tumor Stromal Modulators by Marcela Bolontrade,Mariana García Pdf

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

The Tumor Stroma

Jai Prakash
The Tumor Stroma Book PDF

Author : Jai Prakash
Publisher : CRC Press
Page : 446 pages
File Size : 41,9 Mb
Release : 2022-01-27
Category : Medical
ISBN : 9781000470697

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The Tumor Stroma by Jai Prakash Pdf

The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.

Stromal Immunology

Benjamin M.J Owens,Matthew A. Lakins
Stromal Immunology Book PDF

Author : Benjamin M.J Owens,Matthew A. Lakins
Publisher : Springer
Page : 151 pages
File Size : 52,9 Mb
Release : 2018-08-28
Category : Medical
ISBN : 9783319781273

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Stromal Immunology by Benjamin M.J Owens,Matthew A. Lakins Pdf

Research into and interest in the role of stromal cells in immunology has exploded over the past 15 years. The conventional view that placed non-hematopoietic stromal cells as passive, structural, and supportive entities has now been replaced with an appreciation that these cells have active, dynamic roles during immune responses, and thus impact on the pathophysiology of multiple immune-mediated diseases. This book serves to provide solid grounding in the fundamentals of stromal immunology, focusing on the biological aspects of their function in addition to highlighting key areas for the development of the field in the future. The book is also a unique source of information on emerging concepts that place stromal cells from outside lymphoid organs as major contributors to the biology of diverse conditions, such as rheumatoid arthritis, chronic parasitic infection, inflammatory bowel disease, and cancer.

Physics of Cancer

Claudia Mierke
Physics of Cancer Book PDF

Author : Claudia Mierke
Publisher : Iph001
Page : 500 pages
File Size : 53,9 Mb
Release : 2018-10-24
Category : Science
ISBN : 0750317515

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Physics of Cancer by Claudia Mierke Pdf

This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.

Tumor Organoids

Shay Soker,Aleksander Skardal
Tumor Organoids Book PDF

Author : Shay Soker,Aleksander Skardal
Publisher : Humana Press
Page : 213 pages
File Size : 53,5 Mb
Release : 2017-10-20
Category : Medical
ISBN : 9783319605111

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Tumor Organoids by Shay Soker,Aleksander Skardal Pdf

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

The Heterogeneity of Cancer Metabolism

Anne Le
The Heterogeneity of Cancer Metabolism Book PDF

Author : Anne Le
Publisher : Springer Nature
Page : 283 pages
File Size : 45,9 Mb
Release : 2021-05-20
Category : Medical
ISBN : 9783030657680

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The Heterogeneity of Cancer Metabolism by Anne Le Pdf

This open access volume will introduce recent discoveries in cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, among others. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students.

Tumor-Associated Fibroblasts and their Matrix

Margareta M. Mueller,Norbert E. Fusenig
Tumor Associated Fibroblasts and their Matrix Book PDF

Author : Margareta M. Mueller,Norbert E. Fusenig
Publisher : Springer Science & Business Media
Page : 456 pages
File Size : 55,6 Mb
Release : 2011-07-28
Category : Medical
ISBN : 9400706596

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Tumor-Associated Fibroblasts and their Matrix by Margareta M. Mueller,Norbert E. Fusenig Pdf

During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on “Tumor-associated fibroblasts and their matrix” as part of the series on “Tumor-Microenvironment” is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy.

Tumor Microenvironment

Dietmar W. Siemann
Tumor Microenvironment Book PDF

Author : Dietmar W. Siemann
Publisher : John Wiley & Sons
Page : 407 pages
File Size : 40,9 Mb
Release : 2011-06-24
Category : Science
ISBN : 9781119956921

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Tumor Microenvironment by Dietmar W. Siemann Pdf

The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.

Gynecologic and Urologic Pathology

Maria Rosaria Raspollini,Antonio Lopez-Beltran
Gynecologic and Urologic Pathology Book PDF

Author : Maria Rosaria Raspollini,Antonio Lopez-Beltran
Publisher : Cambridge University Press
Page : 433 pages
File Size : 52,7 Mb
Release : 2019-02-21
Category : Medical
ISBN : 9781107170452

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Gynecologic and Urologic Pathology by Maria Rosaria Raspollini,Antonio Lopez-Beltran Pdf

This book highlights the similarities and differences in the pathology of the genital and urinary tracts in males and females.

Biomarkers of the Tumor Microenvironment

Lars A. Akslen,Randolph S. Watnick
Biomarkers of the Tumor Microenvironment Book PDF

Author : Lars A. Akslen,Randolph S. Watnick
Publisher : Springer
Page : 534 pages
File Size : 41,7 Mb
Release : 2017-08-02
Category : Medical
ISBN : 9783319391472

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Biomarkers of the Tumor Microenvironment by Lars A. Akslen,Randolph S. Watnick Pdf

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

Arthur Zimmermann
Tumors and Tumor Like Lesions of the Hepatobiliary Tract Book PDF

Author : Arthur Zimmermann
Publisher : Springer
Page : 0 pages
File Size : 53,7 Mb
Release : 2016-11-02
Category : Medical
ISBN : 3319269542

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract by Arthur Zimmermann Pdf

This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

Cancer Drug Delivery Systems Based on the Tumor Microenvironment

Yasuhiro Matsumura,David Tarin
Cancer Drug Delivery Systems Based on the Tumor Microenvironment Book PDF

Author : Yasuhiro Matsumura,David Tarin
Publisher : Springer Nature
Page : 325 pages
File Size : 54,9 Mb
Release : 2020-01-07
Category : Medical
ISBN : 9784431568803

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Cancer Drug Delivery Systems Based on the Tumor Microenvironment by Yasuhiro Matsumura,David Tarin Pdf

This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.

FNA Cytology of Soft Tissue and Bone Tumors

H.A. Domanski,C.S. Walther
FNA Cytology of Soft Tissue and Bone Tumors Book PDF

Author : H.A. Domanski,C.S. Walther
Publisher : Karger Medical and Scientific Publishers
Page : 192 pages
File Size : 50,8 Mb
Release : 2017-07-27
Category : Medical
ISBN : 9783318060775

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FNA Cytology of Soft Tissue and Bone Tumors by H.A. Domanski,C.S. Walther Pdf

Fine-needle aspiration cytology (FNAC) has been commonly used to follow up on previously treated sarcomas or to confirm soft tissue and bone metastases of carcinomas, melanomas or lymphomas. Its role as the first-line approach in the diagnosis of primary soft tissue and bone tumors has increased due to progress of less invasive diagnostic procedures and the growing availability of diagnostic ancillary tests. This comprehensive and richly-illustrated volume presents cytomorphology of all common neoplastic soft tissue and bone lesions but also of rare tumors largely described in case reports. Key points for cytological features, differential diagnosis, and the use of ancillary tests are discussed and illustrated in order to facilitate the diagnostic work-up in FNA samples. The volume is organized on the basis of the most recent WHO classification used in surgical pathology in order to provide a practical guide for modern cytologic diagnosis of surgical soft tissue and bone pathology. It is aimed mainly at surgical pathologists and cytopathologists, but also at orthopedic surgeons and clinical oncologists.