Tight Junctions In Cancer Metastasis

Author : Tracey A. Martin,Wen G. Jiang
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 55,9 Mb
Release : 2013-02-26
Category : Medical
ISBN : 9789400760288

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Tight Junctions in Cancer Metastasis by Tracey A. Martin,Wen G. Jiang Pdf

There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.

Author : Ajaz A. Bhat,Mohammad Haris,Muzafar A. Macha,Punita Dhawan
Publisher : Springer Nature
Page : 203 pages
File Size : 55,9 Mb
Release : 2023-10-12
Category : Science
ISBN : 9789819924158

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Tight Junctions in Inflammation and Cancer by Ajaz A. Bhat,Mohammad Haris,Muzafar A. Macha,Punita Dhawan Pdf

This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists.

Author : Lorenza González-Mariscal
Publisher : Springer Nature
Page : 340 pages
File Size : 49,6 Mb
Release : 2022-05-31
Category : Science
ISBN : 9783030972042

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Tight Junctions by Lorenza González-Mariscal Pdf

This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.

Author : Wen G. Jiang,R.E. Mansel
Publisher : Springer Science & Business Media
Page : 434 pages
File Size : 40,8 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306483882

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Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention by Wen G. Jiang,R.E. Mansel Pdf

This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.

Author : Itzhak D. Goldberg,Eliot M. Rosen
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 43,6 Mb
Release : 1995-11-29
Category : Medical
ISBN : 3764351179

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Epithelial-Mesenchymal Interactions in Cancer by Itzhak D. Goldberg,Eliot M. Rosen Pdf

gar discusses recent studies of the SF gene promoter that may be relevant to understanding the detailed molecular mechanism(s) by which soluble factors regulate SF production. Polverini and Nickoloff discuss another mechanism by which SF may enhance tumor growth, ie., stimulation of angiogenesis, the formation of new blood vessels from pre-existing microvessels. Angiogenesis is required for continued growth of most solid tumors, and provides a mechanism by which the stroma may continue to grow along with the tumor cells. Although endothelial cells are stromal cells, they express a number of epithelial characteristics including (i) epithelial-like tight junctions and junctional proteins; (ii) the ability to organize into flat­ tened tubular structures; (iii) the c-met receptor protein; and (iv) biologic responsiveness to SF. It is, perhaps, not surprising that vascular endothe­ lial cells may both produce and respond to SF in different situations. 'Epithelialness' may be defined in two ways: (i) expression of generic epithelial structures and proteins (eg., specialized junctions, junctional proteins [eg., cadherins, ZOl], cytokeratins); and (ii) production of specific differentiated products (eg., milk proteins by mammary epithelia, renin by renal tubular epithelia of the juxtaglomerular apparatus). Recent studies suggest that SF Ic-met signalling may mediate epithelia­ mesenchyme interconversion, in part by modifying some of the generic epithelial characteristics. Nusrat discusses the effects of SF on the epithelial junctional apparatus. Relatively little is known about whether and how SF regulates cell-specific differentiation.

Author : Wen G. Jiang
Publisher : Springer Science & Business Media
Page : 261 pages
File Size : 47,6 Mb
Release : 2012-09-12
Category : Medical
ISBN : 9789400749269

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Electric Cell-Substrate Impedance Sensing and Cancer Metastasis by Wen G. Jiang Pdf

Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death, cell adhesion and migration, cell invasion and cell-cell interactions, cell toxicity, angiogenesis, cell permeability, signal transduction and cellular behaviour under flow conditions. It is a probe free, highly sensitive, and versatile technology platform. Recent development in the technology has also allowed high throughput, automated analyses. It has been widely explored in chemistry, toxicity, cell biology, cancer biology, and other areas of chemistry, medicinal chemistry, life and medical science. Written by experts in the area of cell impedance sensing, including the Nobel Laureate Dr Ivar Giaever, this books covers the background of electric cell-substrate impedance sensing, their applications in cell based investigations, particularly in the area of cancer biology. This book is the first on this technology platform and will be a highly useful reference for molecular and cell biologists, cancer biologists, chemists and biochemists, clinical researchers who work in the areas of cell biology, molecular biology, toxicology, pharmaceutical industry, life science and medical research.

Author : Richard G. Vile
Publisher : Wiley-Blackwell
Page : 232 pages
File Size : 46,5 Mb
Release : 1995-04-25
Category : Medical
ISBN : UOM:39015034544968

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Cancer Metastasis by Richard G. Vile Pdf

A concise description of the metastasis process and its therapeutic relevance in controlling the clinical outcome of the tumor. Explains why the clinical importance of metastasis could be the most life-threatening element in the tumorigenic procedure.

Author : Alecsandru Ioan Baba,Cornel Cătoi
Publisher : Unknown
Page : 787 pages
File Size : 52,8 Mb
Release : 2007
Category : Electronic books
ISBN : 9732714573

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Comparative Oncology by Alecsandru Ioan Baba,Cornel Cătoi Pdf

Author : Dieter Marmé
Publisher : Springer
Page : 0 pages
File Size : 48,9 Mb
Release : 2019-10-18
Category : Medical
ISBN : 3319336711

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Tumor Angiogenesis by Dieter Marmé Pdf

This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.​

Author : Michael Fromm,Susanne M. Krug
Publisher : MDPI
Page : 432 pages
File Size : 40,7 Mb
Release : 2020-11-20
Category : Medical
ISBN : 9783039433001

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The Tight Junction and Its Proteins: More Than Just a Barrier by Michael Fromm,Susanne M. Krug Pdf

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

Author : R.E. Mansel,Oystein Fodstad,Wen G. Jiang
Publisher : Springer Science & Business Media
Page : 439 pages
File Size : 44,8 Mb
Release : 2007-06-14
Category : Health & Fitness
ISBN : 9781402058660

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Metastasis of Breast Cancer by R.E. Mansel,Oystein Fodstad,Wen G. Jiang Pdf

Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.

Author : Rahul Jandial
Publisher : CRC Press
Page : 312 pages
File Size : 51,8 Mb
Release : 2013-08-08
Category : Medical
ISBN : 1587066599

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Metastatic Cancer: Clinical and Biological Perspectives by Rahul Jandial Pdf

Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 47,5 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

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Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Author : Claudia Mierke
Publisher : Iph001
Page : 500 pages
File Size : 48,7 Mb
Release : 2018-10-24
Category : Science
ISBN : 0750317515

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Physics of Cancer by Claudia Mierke Pdf

This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.

Author : Venkataramana K Sidhaye,Michael Koval
Publisher : Academic Press
Page : 276 pages
File Size : 44,5 Mb
Release : 2017-03-09
Category : Medical
ISBN : 9780128038819

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Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease by Venkataramana K Sidhaye,Michael Koval Pdf

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences