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Author : Chunjie Jiang,Shengli Li,Shibiao Wan,Peng Hu,Yongsheng Kevin Li
Publisher : Frontiers Media SA
Page : 237 pages
File Size : 53,5 Mb
Release : 2022-03-03
Category : Science
ISBN : 9782889745739
Author : Yun Dai,Yafeng He,Dong Ren,Huanfa Yi
Publisher : Frontiers Media SA
Page : 156 pages
File Size : 53,6 Mb
Release : 2023-10-25
Category : Medical
ISBN : 9782832536544
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 53,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Anne Le
Publisher : Springer
Page : 186 pages
File Size : 42,6 Mb
Release : 2018-06-26
Category : Medical
ISBN : 9783319777368
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : Manuel Daniel Díaz-Muñoz,Osamu Takeuchi,Simon Fillatreau
Publisher : Frontiers Media SA
Page : 169 pages
File Size : 44,5 Mb
Release : 2022-11-17
Category : Medical
ISBN : 9782832506356
Author : Bruno Guigas,Rinke Stienstra,Tony Jourdan
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 44,8 Mb
Release : 2022-06-23
Category : Medical
ISBN : 9782889764129
Author : Bin Li,Fan Pan
Publisher : Springer
Page : 223 pages
File Size : 48,9 Mb
Release : 2017-09-05
Category : Medical
ISBN : 9789402411706
This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.
Author : Byung Hong Kim,Geoffrey Michael Gadd
Publisher : Cambridge University Press
Page : 509 pages
File Size : 45,9 Mb
Release : 2019-05-16
Category : Medical
ISBN : 9781107171732
Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.
Author : Yongsheng Li
Publisher : Springer Nature
Page : 211 pages
File Size : 52,9 Mb
Release : 2021-03-19
Category : Medical
ISBN : 9789813367852
This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery.
Author : Jie Xu
Publisher : Springer Nature
Page : 657 pages
File Size : 44,9 Mb
Release : 2020-03-17
Category : Medical
ISBN : 9789811532665
This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
Author : Marten A. Hoeksema,Zsolt Czimmerer,Andreas Patsalos
Publisher : Frontiers Media SA
Page : 261 pages
File Size : 55,9 Mb
Release : 2023-12-26
Category : Medical
ISBN : 9782832539590
Author : Anna Ohradanova-Repic,Marianne Boes,Hannes Stockinger
Publisher : Frontiers Media SA
Page : 224 pages
File Size : 44,7 Mb
Release : 2020-05-26
Category : Electronic
ISBN : 9782889637218
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Author : K. Shimizu
Publisher : Elsevier
Page : 496 pages
File Size : 50,7 Mb
Release : 2013-03-26
Category : Science
ISBN : 9781908818201
The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism. Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system
Author : Mitsuru Matsumoto
Publisher : Springer Nature
Page : 252 pages
File Size : 40,7 Mb
Release : 2024-06-29
Category : Electronic
ISBN : 9789819997817
Author : Julianne Zedalis,John Eggebrecht
Publisher : Unknown
Page : 1923 pages
File Size : 52,6 Mb
Release : 2017-10-16
Category : Biology
ISBN : 1947172409
Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
