Translational Approach To Heart Failure

Author : Jozef Bartunek,Marc Vanderheyden
Publisher : Springer Science & Business Media
Page : 501 pages
File Size : 44,5 Mb
Release : 2013-07-13
Category : Medical
ISBN : 9781461473459

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Translational Approach to Heart Failure by Jozef Bartunek,Marc Vanderheyden Pdf

The refined pathophysiologal understanding of the heart failure syndrome together with the surge of new technological advances led to innovative medical and interventional treatment strategies improving the outcome of heart failure patients. However the complex interplay between the clinical presentation and the array of the interventions requires a coordinated multidisciplinary “heart team” approach involving various specialists in the cardiovascular field including clinicians, interventionalists, surgeons and cardiac intensivists. In this book, opinion leaders will review of state-of-the-art management of heart failure with particular emphasis on burning clinical questions and challenges faced by the heart team. New medical and interventional therapies for chronic and acute heart failure are addressed by bridging bench to bedside translation in science and technology into practical clinical application and guidance.

Author : Endre Zima
Publisher : BoD – Books on Demand
Page : 154 pages
File Size : 49,5 Mb
Release : 2022-03-09
Category : Medical
ISBN : 9781839695056

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Cardiac Arrhythmias by Endre Zima Pdf

Cardiac arrhythmias are common triggers of emergency admission to cardiology or high-dependency departments. Most cases are easy to diagnose and treat, while others may present a challenge to healthcare professionals. A translational approach to arrhythmias links molecular and cellular scientific research with clinical diagnostics and therapeutic methods, which may include both pharmacological and non-pharmacologic treatments. This book presents a comprehensive overview of specific cardiac arrhythmias and discusses translational approaches to their diagnosis and treatment.

Author : Dennis V. Cokkinos
Publisher : Springer
Page : 405 pages
File Size : 55,9 Mb
Release : 2019-01-28
Category : Medical
ISBN : 9783319981864

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Myocardial Preservation by Dennis V. Cokkinos Pdf

This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.

Author : Giorgio Iervasi,Alessandro Pingitore,A.Martin Gerdes,Salman Razvi
Publisher : Springer Nature
Page : 436 pages
File Size : 54,7 Mb
Release : 2020-03-19
Category : Medical
ISBN : 9783030368715

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Thyroid and Heart by Giorgio Iervasi,Alessandro Pingitore,A.Martin Gerdes,Salman Razvi Pdf

In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects – kidney, hormonal pathways systems, brain, muscle, etc – of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists.

Author : Cam Patterson,Monte S. Willis
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 50,6 Mb
Release : 2012-07-04
Category : Medical
ISBN : 9781617798917

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Translational Cardiology by Cam Patterson,Monte S. Willis Pdf

Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.

Author : Maria Dorobanţu,Frank Ruschitzka,Marco Metra
Publisher : Springer
Page : 642 pages
File Size : 52,9 Mb
Release : 2016-12-29
Category : Medical
ISBN : 9783319452371

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Current Approach to Heart Failure by Maria Dorobanţu,Frank Ruschitzka,Marco Metra Pdf

This book is intended to be a link between guidelines and clinical practice, a complementary tool to help physicians to be well informed regarding the important field of heart failure. It will be a useful tool for professionals from all the fields of cardiology: non-invasive cardiology, interventional cardiology, electrophysiology and cardiovascular imaging. The topic of heart failure is continuously changing, with new important information being added constantly. The pathophysiology is better understood and there is a trend for a better characterization of special groups of population, such as oncologic patients with heart failure. The new imaging techniques have become valuable tools for the diagnosis of heart failure, while pharmacological and novel cell and gene treatments have evolved enormously. The challenge for the practitioners is making the right selection of treatment strategy that best fits a patient. This book presents detailed information on the indications, selection and mechanism of action of these treatments, whether they be mechanical circulatory devices or pharmacological treatments. The contemporary pharmacological and non-pharmacological management of heart failure has the main target of early prevention of disease progression and the avoidance of heart transplant. In the era of shortage of donors, prevention is the mainstay of the therapeutic strategy, and this is the main philosophy of our book.

Author : Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo
Publisher : Springer Science & Business Media
Page : 922 pages
File Size : 50,6 Mb
Release : 2009-12-24
Category : Medical
ISBN : 9781846287824

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Acute Heart Failure by Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo Pdf

For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.

Author : Wilbert S. Aronow,John Arthur McClung
Publisher : Academic Press
Page : 244 pages
File Size : 52,7 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780128026052

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Translational Research in Coronary Artery Disease by Wilbert S. Aronow,John Arthur McClung Pdf

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Author : Institute of Medicine,Board on Global Health,Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries
Publisher : National Academies Press
Page : 483 pages
File Size : 45,9 Mb
Release : 2010-06-29
Category : Medical
ISBN : 9780309157612

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Promoting Cardiovascular Health in the Developing World by Institute of Medicine,Board on Global Health,Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries Pdf

Cardiovascular disease (CVD), once thought to be confined primarily to industrialized nations, has emerged as a major health threat in developing countries. Cardiovascular disease now accounts for nearly 30 percent of deaths in low and middle income countries each year, and is accompanied by significant economic repercussions. Yet most governments, global health institutions, and development agencies have largely overlooked CVD as they have invested in health in developing countries. Recognizing the gap between the compelling evidence of the global CVD burden and the investment needed to prevent and control CVD, the National Heart, Lung, and Blood Institute (NHLBI) turned to the IOM for advice on how to catalyze change. In this report, the IOM recommends that the NHLBI, development agencies, nongovernmental organizations, and governments work toward two essential goals: creating environments that promote heart healthy lifestyle choices and help reduce the risk of chronic diseases, and building public health infrastructure and health systems with the capacity to implement programs that will effectively detect and reduce risk and manage CVD. To meet these goals, the IOM recommends several steps, including improving cooperation and collaboration; implementing effective and feasible strategies; and informing efforts through research and health surveillance. Without better efforts to promote cardiovascular health, global health as a whole will be undermined.

Author : Tao Xu,Jian Gao,Sung Hwan Ki,Emanuela Ricciotti
Publisher : Frontiers Media SA
Page : 1224 pages
File Size : 50,8 Mb
Release : 2022-07-05
Category : Science
ISBN : 9782889747955

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Inflammatory Immune Disease: Molecular Mechanisms, Translational Approaches and Therapeutics by Tao Xu,Jian Gao,Sung Hwan Ki,Emanuela Ricciotti Pdf

Author : Benzhi Cai,Hua Zhu,Naufal Zagidullin
Publisher : Frontiers Media SA
Page : 727 pages
File Size : 44,9 Mb
Release : 2022-01-19
Category : Science
ISBN : 9782889740901

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Cardio-Protection and Heart Repair: New Drugs, Targets and Approaches by Benzhi Cai,Hua Zhu,Naufal Zagidullin Pdf

Author : W. H. Wilson Tang,Frederik H. Verbrugge,Wilfried Mullens
Publisher : Springer Nature
Page : 279 pages
File Size : 44,8 Mb
Release : 2019-08-26
Category : Medical
ISBN : 9783030210335

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Cardiorenal Syndrome in Heart Failure by W. H. Wilson Tang,Frederik H. Verbrugge,Wilfried Mullens Pdf

This comprehensive manual reviews the management of cardiorenal syndrome in heart failure. Chapters are structured in a practically applicable and easy-to-follow format with realistic case vignettes and key clinical management questions and answers, followed by a brief discussion of underlying pathophysiological mechanisms of a patient with cardiorenal syndrome. Building from this case, key questions are posed that are relevant to the clinical management and then potential evidence-based treatment strategies are proposed. Topics covered include loop diuretic resistance in acute and chronic heart failure, abdominal congestion, low output failure and potential diuretic complications due to hyponatremia. Cardiorenal Syndrome in Heart Failure thoroughly reviews cardiorenal syndrome from the perspective of both the cardiologist and nephrologist. Its case-based approach makes it an ideal resource for both practising and trainee cardiology and nephrology practitioners.

Author : Lawrence Kruger,Alan R Light
Publisher : CRC Press
Page : 458 pages
File Size : 44,9 Mb
Release : 2009-11-24
Category : Health & Fitness
ISBN : 9781439812105

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Translational Pain Research by Lawrence Kruger,Alan R Light Pdf

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical

Author : Ragavendra R. Baliga,George A. Mensah
Publisher : Elsevier Health Sciences
Page : 217 pages
File Size : 40,5 Mb
Release : 2022-06-23
Category : Medical
ISBN : 9780323987486

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Translational Research in Cardio-Oncology, An Issue of Heart Failure Clinics by Ragavendra R. Baliga,George A. Mensah Pdf

In this issue of Heart Failure Clinics, guest editors Drs. Ragavendra R Baliga and George A. Mensah bring their considerable expertise to the topic of Translational Research in Cardio-Oncology. Top experts in the field cover key topics such as radiation-induced cardiac dysfunction; training and career development; cardiovascular imaging; CAR-T cell therapy and cardiovascular disease; and more. Contains 12 relevant, practice-oriented topics including cardio-protection of high-risk individuals; myocardial metabolism; amyloidosis; arrhythmic complications associated with cancer therapies; and more. Provides in-depth clinical reviews on translational research in cardio-oncology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Author : Annabelle Rodriguez-Oquendo
Publisher : Academic Press
Page : 354 pages
File Size : 45,7 Mb
Release : 2015-09-07
Category : Science
ISBN : 9780128004746

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Translational Cardiometabolic Genomic Medicine by Annabelle Rodriguez-Oquendo Pdf

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome