Translational Approach To Heart Failure

Author : Jozef Bartunek,Marc Vanderheyden
Publisher : Springer Science & Business Media
Page : 503 pages
File Size : 46,5 Mb
Release : 2013-07-13
Category : Medical
ISBN : 9781461473459

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Translational Approach to Heart Failure by Jozef Bartunek,Marc Vanderheyden Pdf

The refined pathophysiologal understanding of the heart failure syndrome together with the surge of new technological advances led to innovative medical and interventional treatment strategies improving the outcome of heart failure patients. However the complex interplay between the clinical presentation and the array of the interventions requires a coordinated multidisciplinary “heart team” approach involving various specialists in the cardiovascular field including clinicians, interventionalists, surgeons and cardiac intensivists. In this book, opinion leaders will review of state-of-the-art management of heart failure with particular emphasis on burning clinical questions and challenges faced by the heart team. New medical and interventional therapies for chronic and acute heart failure are addressed by bridging bench to bedside translation in science and technology into practical clinical application and guidance.

Author : Wilbert S. Aronow,John Arthur McClung
Publisher : Academic Press
Page : 244 pages
File Size : 44,5 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780128026052

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Translational Research in Coronary Artery Disease by Wilbert S. Aronow,John Arthur McClung Pdf

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Author : Endre Zima
Publisher : BoD – Books on Demand
Page : 154 pages
File Size : 51,8 Mb
Release : 2022-03-09
Category : Medical
ISBN : 9781839695056

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Cardiac Arrhythmias by Endre Zima Pdf

Cardiac arrhythmias are common triggers of emergency admission to cardiology or high-dependency departments. Most cases are easy to diagnose and treat, while others may present a challenge to healthcare professionals. A translational approach to arrhythmias links molecular and cellular scientific research with clinical diagnostics and therapeutic methods, which may include both pharmacological and non-pharmacologic treatments. This book presents a comprehensive overview of specific cardiac arrhythmias and discusses translational approaches to their diagnosis and treatment.

Author : Dennis V. Cokkinos
Publisher : Springer
Page : 405 pages
File Size : 42,8 Mb
Release : 2019-01-28
Category : Medical
ISBN : 9783319981864

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Myocardial Preservation by Dennis V. Cokkinos Pdf

This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of cardiac cell death, cardiac remodelling and cardiac regeneration. Potential future research directions are also proposed, enabling the reader to gain a broad in-depth understanding of the topic. Myocardial Preservation: Translational Research and Clinical Application presents a thorough review of myocardial preservation. Its comprehensive approach provides a valuable reference for cardiology researchers and practising and trainee cardiologists seeking new insight to the topic.

Author : Giorgio Iervasi,Alessandro Pingitore,A.Martin Gerdes,Salman Razvi
Publisher : Springer Nature
Page : 436 pages
File Size : 41,6 Mb
Release : 2020-03-19
Category : Medical
ISBN : 9783030368715

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Thyroid and Heart by Giorgio Iervasi,Alessandro Pingitore,A.Martin Gerdes,Salman Razvi Pdf

In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies – including multicenter studies – have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects – kidney, hormonal pathways systems, brain, muscle, etc – of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists.

Author : Annabelle Rodriguez-Oquendo
Publisher : Academic Press
Page : 354 pages
File Size : 41,5 Mb
Release : 2015-09-07
Category : Science
ISBN : 9780128004746

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Translational Cardiometabolic Genomic Medicine by Annabelle Rodriguez-Oquendo Pdf

Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Author : Maria Dorobanţu,Frank Ruschitzka,Marco Metra
Publisher : Springer
Page : 642 pages
File Size : 47,9 Mb
Release : 2016-12-29
Category : Medical
ISBN : 9783319452371

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Current Approach to Heart Failure by Maria Dorobanţu,Frank Ruschitzka,Marco Metra Pdf

This book is intended to be a link between guidelines and clinical practice, a complementary tool to help physicians to be well informed regarding the important field of heart failure. It will be a useful tool for professionals from all the fields of cardiology: non-invasive cardiology, interventional cardiology, electrophysiology and cardiovascular imaging. The topic of heart failure is continuously changing, with new important information being added constantly. The pathophysiology is better understood and there is a trend for a better characterization of special groups of population, such as oncologic patients with heart failure. The new imaging techniques have become valuable tools for the diagnosis of heart failure, while pharmacological and novel cell and gene treatments have evolved enormously. The challenge for the practitioners is making the right selection of treatment strategy that best fits a patient. This book presents detailed information on the indications, selection and mechanism of action of these treatments, whether they be mechanical circulatory devices or pharmacological treatments. The contemporary pharmacological and non-pharmacological management of heart failure has the main target of early prevention of disease progression and the avoidance of heart transplant. In the era of shortage of donors, prevention is the mainstay of the therapeutic strategy, and this is the main philosophy of our book.

Author : Martin Wehling
Publisher : Academic Press
Page : 364 pages
File Size : 51,8 Mb
Release : 2015-04-02
Category : Science
ISBN : 9780128007211

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Principles of Translational Science in Medicine by Martin Wehling Pdf

Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Author : Michael J. Domanski,Mandeep R. Mehra,Marc A. Pfeffer
Publisher : Oxford University Press
Page : 457 pages
File Size : 43,9 Mb
Release : 2016
Category : Medical
ISBN : 9780198734871

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Oxford Textbook of Advanced Heart Failure and Cardiac Transplantation by Michael J. Domanski,Mandeep R. Mehra,Marc A. Pfeffer Pdf

Heart failure is epidemic throughout the world. A growing incidence and prevalence has resulted in a large population of individuals transitioning to advanced stages of the syndrome and requiring uniquely specialised therapies and cardiac transplantation. i The Oxford Textbook of Advanced Heart Failure and Cardiac Transplantationr is a focused and comprehensive work covering this new and rapidly growing cardiovascular subspecialty. Authored by eminent international experts, it is the authoritative text on advanced heart failure and a central resource for clinicians caring for patients with this condition. By covering a range of characteristics, therapeutic challenges and practical aspects of managing patients, this book provides an in-depth source for cardiologists and other related clinicians. A strong focus on the difficult decision making needed to handle advanced heart failure cases, along with specific knowledge of epidemiology, biology and pathophysiology, creates a key tool for optimally managing these complex patients.

Author : Naranjan S. Dhalla
Publisher : Lippincott Williams & Wilkins
Page : 570 pages
File Size : 49,7 Mb
Release : 1995
Category : Heart Failure, Congestive
ISBN : UOM:39015035021438

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The Failing Heart by Naranjan S. Dhalla Pdf

Author : Elliott M. Antman
Publisher : Elsevier Health Sciences
Page : 833 pages
File Size : 44,8 Mb
Release : 2012-09-17
Category : Medical
ISBN : 9781455737376

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Cardiovascular Therapeutics E-Book by Elliott M. Antman Pdf

Manage cardiovascular problems more effectively with the most comprehensive resource available! A trusted companion to Braunwald's Heart Disease, Cardiovascular Therapeutics, 4th Edition addresses pharmacological, interventional, and surgical management approaches for each type of cardiovascular disease. This practical and clinically focused cardiology reference offers a balanced, complete approach to all of the usual and unusual areas of cardiovascular disease and specific therapies in one concise volume, equipping you to make the best choices for every patient. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Understand current approaches to treating and managing cardiovascular patients for long-term health, for complex problems, and for unusual cardiac events. Benefit from the substantial experience of Elliott M. Antman, MD, Marc S. Sabatine, MD, and a host of other respected authorities, who provide practical, evidence-based rationales for all of today's clinical therapies. Expand your knowledge beyond pharmacologic interventions with complete coverage of the most effective interventional and device therapies being used today. Easily reference Braunwald's Heart Disease, 9th Edition for further information on topics of interest. Make the best use of the latest genetic and molecular therapies as well as advanced therapies for heart failure. Cut right to the answers you need with an enhanced focus on clinically relevant information and a decreased emphasis on pathophysiology. Stay current with ACC/AHA/ESC guidelines and the best ways to implement them in clinical practice. Get an enhanced visual perspective with an all-new, full-color design throughout.

Author : Tao Xu,Jian Gao,Sung Hwan Ki,Emanuela Ricciotti
Publisher : Frontiers Media SA
Page : 1224 pages
File Size : 44,5 Mb
Release : 2022-07-05
Category : Science
ISBN : 9782889747955

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Inflammatory Immune Disease: Molecular Mechanisms, Translational Approaches and Therapeutics by Tao Xu,Jian Gao,Sung Hwan Ki,Emanuela Ricciotti Pdf

Author : W. H. Wilson Tang,Frederik H. Verbrugge,Wilfried Mullens
Publisher : Springer Nature
Page : 279 pages
File Size : 54,8 Mb
Release : 2019-08-26
Category : Medical
ISBN : 9783030210335

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Cardiorenal Syndrome in Heart Failure by W. H. Wilson Tang,Frederik H. Verbrugge,Wilfried Mullens Pdf

This comprehensive manual reviews the management of cardiorenal syndrome in heart failure. Chapters are structured in a practically applicable and easy-to-follow format with realistic case vignettes and key clinical management questions and answers, followed by a brief discussion of underlying pathophysiological mechanisms of a patient with cardiorenal syndrome. Building from this case, key questions are posed that are relevant to the clinical management and then potential evidence-based treatment strategies are proposed. Topics covered include loop diuretic resistance in acute and chronic heart failure, abdominal congestion, low output failure and potential diuretic complications due to hyponatremia. Cardiorenal Syndrome in Heart Failure thoroughly reviews cardiorenal syndrome from the perspective of both the cardiologist and nephrologist. Its case-based approach makes it an ideal resource for both practising and trainee cardiology and nephrology practitioners.

Author : Anonim
Publisher : Elsevier
Page : 2800 pages
File Size : 43,9 Mb
Release : 2017-11-27
Category : Medical
ISBN : 9780128051542

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Encyclopedia of Cardiovascular Research and Medicine by Anonim Pdf

Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.

Author : Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo
Publisher : Springer Science & Business Media
Page : 931 pages
File Size : 48,8 Mb
Release : 2009-12-24
Category : Medical
ISBN : 9781846287824

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Acute Heart Failure by Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo Pdf

For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.