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Author : Benzhi Cai,Hua Zhu,Naufal Zagidullin
Publisher : Frontiers Media SA
Page : 727 pages
File Size : 46,9 Mb
Release : 2022-01-19
Category : Science
ISBN : 9782889740901
Author : Institute of Medicine,Board on Global Health,Committee on Preventing the Global Epidemic of Cardiovascular Disease: Meeting the Challenges in Developing Countries
Publisher : National Academies Press
Page : 483 pages
File Size : 50,9 Mb
Release : 2010-06-29
Category : Medical
ISBN : 9780309157612
Cardiovascular disease (CVD), once thought to be confined primarily to industrialized nations, has emerged as a major health threat in developing countries. Cardiovascular disease now accounts for nearly 30 percent of deaths in low and middle income countries each year, and is accompanied by significant economic repercussions. Yet most governments, global health institutions, and development agencies have largely overlooked CVD as they have invested in health in developing countries. Recognizing the gap between the compelling evidence of the global CVD burden and the investment needed to prevent and control CVD, the National Heart, Lung, and Blood Institute (NHLBI) turned to the IOM for advice on how to catalyze change. In this report, the IOM recommends that the NHLBI, development agencies, nongovernmental organizations, and governments work toward two essential goals: creating environments that promote heart healthy lifestyle choices and help reduce the risk of chronic diseases, and building public health infrastructure and health systems with the capacity to implement programs that will effectively detect and reduce risk and manage CVD. To meet these goals, the IOM recommends several steps, including improving cooperation and collaboration; implementing effective and feasible strategies; and informing efforts through research and health surveillance. Without better efforts to promote cardiovascular health, global health as a whole will be undermined.
Author : Tomas A. Salerno,Marco Ricci
Publisher : John Wiley & Sons
Page : 344 pages
File Size : 49,9 Mb
Release : 2008-04-15
Category : Medical
ISBN : 9781405178433
Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.
Author : Weili He,José Pinheiro,Olga M. Kuznetsova
Publisher : Springer
Page : 416 pages
File Size : 47,7 Mb
Release : 2014-10-15
Category : Medical
ISBN : 9781493911004
This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.
Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
Publisher : Springer
Page : 274 pages
File Size : 41,8 Mb
Release : 2017-10-27
Category : Medical
ISBN : 9783319561066
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Author : Alexandre Mebazaa,Mihai Gheorghiade,Faiez Zannad,Joseph E. Parrillo
Publisher : Springer Science & Business Media
Page : 931 pages
File Size : 41,8 Mb
Release : 2009-12-24
Category : Medical
ISBN : 9781846287824
For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.
Author : Institute of Medicine,Board on the Health of Select Populations,Committee on Social Security Cardiovascular Disability Criteria
Publisher : National Academies Press
Page : 304 pages
File Size : 41,6 Mb
Release : 2010-12-04
Category : Medical
ISBN : 9780309156981
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Author : Wenyong Tan
Publisher : BoD – Books on Demand
Page : 164 pages
File Size : 49,6 Mb
Release : 2018-11-14
Category : Medical
ISBN : 9781789842371
Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.
Author : Koichiro Niwa,Harald Kaemmerer
Publisher : Springer
Page : 333 pages
File Size : 46,8 Mb
Release : 2017-02-09
Category : Medical
ISBN : 9784431560715
This is the first textbook to focus on Aortopathy, a new clinical concept for a form of vasculopathy. The first section of the book starts from discussing general concept and history of Aortopathy, and then deals with its pathophysiology, manifestation, intrinsic factor, clinical implication, management and prevention. The second part closely looks at various disorders of the Aortopathy such as bicuspid aortic valve and coarctation of aorta. The book editors have published a lot of works on the topic and have been collecting relating data in the field of congenital heart disease for the past 20 years, thus present the book with confidence. The topic - an association of aortic pathophysiological abnormality, aortic dilation and aorto-left ventricular interaction - is getting more and more attention among cardiovascular physicians. This is the first book to refer for cardiologists, pediatric cardiologists, surgeons, ACHD specialists, etc. to acquire thorough knowledge on Aortopathy.
Author : Michele Emdin,Alberto Giannoni,Claudio Passino
Publisher : Springer
Page : 287 pages
File Size : 47,7 Mb
Release : 2016-11-25
Category : Medical
ISBN : 9783319263540
This book systematically focuses on central sleep apneas, analyzing their relationship especially with heart failure and discussing recent research results and emerging treatment strategies based on feedback modulation. The opening chapters present historical background information on Cheyne-Stokes respiration (CSR), clarify terminology, and explain the mechanics and chemistry of respiration. Following a description of the physiology of respiration, the pathophysiology underlying central apneas in different disorders and particularly in heart failure is discussed. The similarities and differences of obstructive and central apneas are then considered. The book looks beyond the concept of sleep apnea to daytime CSR and periodic breathing during effort and contrasts the opposing views of CSR as a compensatory phenomenon or as detrimental to the failing heart. The diagnostic tools currently in use for the detection of CSR are thoroughly reviewed, with guidance on interpretation of findings. The book concludes by describing the various forms of treatment that are available for CSR and by explaining how to select patients for treatment.
Author : Divya Vohora,Gursharan Singh
Publisher : Academic Press
Page : 526 pages
File Size : 44,5 Mb
Release : 2017-11-14
Category : Medical
ISBN : 9780128020982
Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery
Author : Joep Perk,Peter Mathes,Helmut Gohlke,Irene Hellemans,Catherine Monpère,Hannah McGee,Philippe Sellier,Hugo Saner
Publisher : Springer Science & Business Media
Page : 540 pages
File Size : 49,6 Mb
Release : 2007-09-18
Category : Medical
ISBN : 1846289939
The aim of this textbook is to give guidance in prevention, lifestyle counselling and rehabilitation for cardiologists, other physicians and many different categories of health professionals in cardiac rehabilitation teams.
Author : Naranjan S. Dhalla,Heinz Rupp,Aubie Angel,Grant N. Pierce
Publisher : Springer Science & Business Media
Page : 639 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461504535
Pathophysiology of Cardiovascular Disease has been divided into four sections that focus on heart dysfunction and its associated characteristics (hypertrophy, cardiomyopathy and failure); vascular dysfunction and disease; ischemic heart disease; and novel therapeutic interventions. This volume is a compendium of different approaches to understanding cardiovascular disease and identifying the proteins, pathways and processes that impact it.
Author : American Association of Cardiovascular & Pulmonary Rehabilitation
Publisher : Human Kinetics
Page : 294 pages
File Size : 54,9 Mb
Release : 2004
Category : Heart
ISBN : 0736048642
This edition addresses the cost effectiveness of interventions that educate and motivate patients to assume personal responsibility for long-term disease prevention.
Author : Derek Hausenloy,Derek Yellon
Publisher : OUP Oxford
Page : 144 pages
File Size : 47,9 Mb
Release : 2009-08-20
Category : Medical
ISBN : 9780191575488
Coronary heart disease (CHD) is the leading cause of death worldwide with 3.8 million men and 3.4 million women dying each year. Cardioprotection refers to the prevention of CHD and the clinical improvement in patients suffering from cardiovascular problems. This book focuses on the role of cardioprotection in surgery and the use of pharmacological therapies such as ACE-inhibitors, statins and beta-blockers in order to reduce the myocardial injury sustained by the patient and the significant risk of morbidity and mortality. It includes new cardioprotective strategies aimed at improving the clinical outcomes of patients in these settings, as well as current well-established methods for reducing myocardial injury in acute coronary syndrome patients.